Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001245200                                                           20     299
NP_000240                                                              20     299
XP_005265218                                                           20     299
NP_056999                                                              18    1482
NP_853629                                                              18    1482
NP_001121185                                                           18    1482
NP_079059                                                              17    3301
NP_056445                                                              17    3301
XP_006718392                                                           17    3301
XP_006718390                                                           17    3301
XP_006718389                                                           17    3301
XP_005253195                                                           17    3301
XP_006712474                                                           17    3301
NP_005844                                                              17    4312
NP_001239126                                                           17    4312
NP_001121619                                                           16    5631
NP_001061                                                              16    5631
NP_000258                                                              16    5631
NP_001035957                                                           16    5631
XP_006721991                                                           16    5631
XP_006721990                                                           16    5631
XP_006721989                                                           16    5631
XP_005258041                                                           16    5631
XP_006721988                                                           16    5631
XP_006721987                                                           16    5631
XP_006721986                                                           16    5631
XP_005258040                                                           16    5631
XP_006721985                                                           16    5631
XP_005257280                                                           16    5631
XP_005257279                                                           16    5631
XP_005264070                                                           16    5631
NP_057521                                                              16    5631
NP_789795                                                              16    5631
NP_001047                                                              16    5631
NP_612355                                                              16    7355
NP_055558                                                              16    7355
NP_001094060                                                           16    7355
NP_078837                                                              16    7355
NP_001159749                                                           16    7355
NP_001007232                                                           16    7355
NP_055697                                                              16    7355
NP_001159748                                                           16    7355
XP_006726657                                                           16    7355
XP_006725285                                                           16    7355
XP_005266580                                                           16    7355
XP_006719929                                                           16    7355
XP_005248098                                                           16    7355
XP_006713998                                                           16    7355
XP_006713997                                                           16    7355
XP_005264733                                                           16    7355
XP_005264732                                                           16    7355
XP_005263588                                                           16    7355
NP_000979                                                              16    7355
NP_057297                                                              15    9605
NP_525128                                                              15    9605
NP_001888                                                              15    9605
NP_001241657                                                           15    9605
NP_001241658                                                           15    9605
NP_001121598                                                           15    9605
NP_055746                                                              15    9605
XP_005258727                                                           15    9605
XP_005258726                                                           15    9605
XP_005254846                                                           15    9605
XP_005253197                                                           15    9605
NP_001035792                                                           15    9605
NP_065954                                                              15    9605
>NP_001245200
          Length = 687

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  RLDETVLNR 9
          RLDETV+NR
Sbjct: 10 RLDETVVNR 18
>NP_000240
          Length = 756

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  RLDETVLNR 9
          RLDETV+NR
Sbjct: 10 RLDETVVNR 18
>XP_005265218
          Length = 687

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  RLDETVLNR 9
          RLDETV+NR
Sbjct: 10 RLDETVVNR 18
>NP_056999
          Length = 558

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  LDETVLNR 9
          LDET LNR
Sbjct: 48 LDETALNR 55
>NP_853629
          Length = 553

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  LDETVLNR 9
          LDET LNR
Sbjct: 48 LDETALNR 55
>NP_001121185
          Length = 553

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  LDETVLNR 9
          LDET LNR
Sbjct: 48 LDETALNR 55
>NP_079059
          Length = 902

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RLDETVLNR 9
           RL+ET LNR
Sbjct: 813 RLNETNLNR 821
>NP_056445
          Length = 807

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   DETVLNR 9
           DET+LNR
Sbjct: 121 DETLLNR 127
>XP_006718392
          Length = 766

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RLDETVLNR 9
           RL+ET LNR
Sbjct: 677 RLNETNLNR 685
>XP_006718390
          Length = 846

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RLDETVLNR 9
           RL+ET LNR
Sbjct: 757 RLNETNLNR 765
>XP_006718389
          Length = 864

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RLDETVLNR 9
           RL+ET LNR
Sbjct: 775 RLNETNLNR 783
>XP_005253195
          Length = 864

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RLDETVLNR 9
           RL+ET LNR
Sbjct: 775 RLNETNLNR 783
>XP_006712474
          Length = 689

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  DETVLNR 9
          DET+LNR
Sbjct: 5  DETLLNR 11
>NP_005844
          Length = 483

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LDETVLNR 9
           L++TVLNR
Sbjct: 442 LNQTVLNR 449
>NP_001239126
          Length = 482

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LDETVLNR 9
           L++TVLNR
Sbjct: 441 LNQTVLNR 448
>NP_001121619
          Length = 593

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RLDETVL 7
           RLDET+L
Sbjct: 103 RLDETML 109
>NP_001061
          Length = 451

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   LDETVLNR 9
           LD T LNR
Sbjct: 205 LDNTALNR 212
>NP_000258
          Length = 2818

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RLDETVL 7
           RLDET+L
Sbjct: 103 RLDETML 109
>NP_001035957
          Length = 2839

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RLDETVL 7
           RLDET+L
Sbjct: 103 RLDETML 109
>XP_006721991
          Length = 1632

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RLDETVL 7
           RLDET+L
Sbjct: 103 RLDETML 109
>XP_006721990
          Length = 2823

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RLDETVL 7
           RLDET+L
Sbjct: 103 RLDETML 109
>XP_006721989
          Length = 2823

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RLDETVL 7
           RLDET+L
Sbjct: 103 RLDETML 109
>XP_005258041
          Length = 2836

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RLDETVL 7
           RLDET+L
Sbjct: 103 RLDETML 109
>XP_006721988
          Length = 2846

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RLDETVL 7
           RLDET+L
Sbjct: 103 RLDETML 109
>XP_006721987
          Length = 2849

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RLDETVL 7
           RLDET+L
Sbjct: 103 RLDETML 109
>XP_006721986
          Length = 2854

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  RLDETVL 7
          RLDET+L
Sbjct: 90 RLDETML 96
>XP_005258040
          Length = 2857

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RLDETVL 7
           RLDET+L
Sbjct: 103 RLDETML 109
>XP_006721985
          Length = 2867

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RLDETVL 7
           RLDET+L
Sbjct: 103 RLDETML 109
>XP_005257280
          Length = 298

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  LDETVLNR 9
          LD T LNR
Sbjct: 52 LDNTALNR 59
>XP_005257279
          Length = 460

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   LDETVLNR 9
           LD T LNR
Sbjct: 214 LDNTALNR 221
>XP_005264070
          Length = 298

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RLDETVLNR 9
           ++DETVL++
Sbjct: 217 KVDETVLDK 225
>NP_057521
          Length = 451

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   LDETVLNR 9
           LD T LNR
Sbjct: 205 LDNTALNR 212
>NP_789795
          Length = 307

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RLDETVLNR 9
           ++DETVL++
Sbjct: 226 KVDETVLDK 234
>NP_001047
          Length = 296

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RLDETVLNR 9
           ++DETVL++
Sbjct: 215 KVDETVLDK 223
>NP_612355
          Length = 634

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RLDETVL 7
           +LDETVL
Sbjct: 280 QLDETVL 286
>NP_055558
          Length = 1395

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LDETVLN 8
           LD TVLN
Sbjct: 618 LDSTVLN 624
>NP_001094060
          Length = 1395

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LDETVLN 8
           LD TVLN
Sbjct: 618 LDSTVLN 624
>NP_078837
          Length = 864

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RLDETVLNR 9
           RLDET+ ++
Sbjct: 788 RLDETIKDK 796
>NP_001159749
          Length = 606

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLDETV 6
           RLDETV
Sbjct: 121 RLDETV 126
>NP_001007232
          Length = 646

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLDETV 6
           RLDETV
Sbjct: 161 RLDETV 166
>NP_055697
          Length = 638

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLDETV 6
           RLDETV
Sbjct: 153 RLDETV 158
>NP_001159748
          Length = 639

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLDETV 6
           RLDETV
Sbjct: 154 RLDETV 159
>XP_006726657
          Length = 633

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RLDETVL 7
           +LDETVL
Sbjct: 280 QLDETVL 286
>XP_006725285
          Length = 633

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RLDETVL 7
           +LDETVL
Sbjct: 280 QLDETVL 286
>XP_005266580
          Length = 452

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RLDETVLNR 9
           RLDET+ ++
Sbjct: 376 RLDETIKDK 384
>XP_006719929
          Length = 804

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RLDETVLNR 9
           RLDET+ ++
Sbjct: 728 RLDETIKDK 736
>XP_005248098
          Length = 1310

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LDETVLN 8
           LD TVLN
Sbjct: 509 LDSTVLN 515
>XP_006713998
          Length = 1332

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LDETVLN 8
           LD TVLN
Sbjct: 618 LDSTVLN 624
>XP_006713997
          Length = 1419

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LDETVLN 8
           LD TVLN
Sbjct: 618 LDSTVLN 624
>XP_005264733
          Length = 607

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLDETV 6
           RLDETV
Sbjct: 122 RLDETV 127
>XP_005264732
          Length = 645

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLDETV 6
           RLDETV
Sbjct: 160 RLDETV 165
>XP_005263588
          Length = 667

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RLDETVL 7
           +LDETVL
Sbjct: 280 QLDETVL 286
>NP_000979
          Length = 136

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  LDETVLNR 9
          LD+TV+N+
Sbjct: 91 LDKTVVNK 98
>NP_057297
          Length = 581

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RLDETV 6
           RLDET+
Sbjct: 348 RLDETI 353
>NP_525128
          Length = 72

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  DETVLNR 9
          DE++LNR
Sbjct: 63 DESLLNR 69
>NP_001888
          Length = 2322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RLDETVLN 8
            RLD TVL+
Sbjct: 2062 RLDPTVLD 2069
>NP_001241657
          Length = 144

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LDETVLN 8
           LDE VLN
Sbjct: 114 LDEMVLN 120
>NP_001241658
          Length = 144

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LDETVLN 8
           LDE VLN
Sbjct: 114 LDEMVLN 120
>NP_001121598
          Length = 144

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LDETVLN 8
           LDE VLN
Sbjct: 114 LDEMVLN 120
>NP_055746
          Length = 881

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DETVLNR 9
           DE++LNR
Sbjct: 99  DESLLNR 105
>XP_005258727
          Length = 881

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DETVLNR 9
           DE++LNR
Sbjct: 99  DESLLNR 105
>XP_005258726
          Length = 881

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DETVLNR 9
           DE++LNR
Sbjct: 99  DESLLNR 105
>XP_005254846
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RLDETV 6
           RLDET+
Sbjct: 118 RLDETI 123
>XP_005253197
          Length = 786

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DETVLNR 9
           DET LNR
Sbjct: 699 DETNLNR 705
>NP_001035792
          Length = 72

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  DETVLNR 9
          DE++LNR
Sbjct: 63 DESLLNR 69
>NP_065954
          Length = 922

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LDETVL 7
           LDETVL
Sbjct: 238 LDETVL 243
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.320    0.139    0.361 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 473,806
Number of extensions: 733
Number of successful extensions: 66
Number of sequences better than 10000.0: 66
Number of HSP's gapped: 66
Number of HSP's successfully gapped: 66
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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