Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006209                                                              19     665
XP_006713721                                                           19     665
NP_597719                                                              18    1482
NP_001036066                                                           18    1482
NP_001275511                                                           18    1482
XP_006713568                                                           18    1482
XP_006713567                                                           18    1482
NP_899236                                                              16    7355
NP_056363                                                              16    7355
NP_001138241                                                           16    7355
NP_001138242                                                           16    7355
NP_037431                                                              16    7355
NP_001265539                                                           16    7355
NP_002457                                                              16    7355
NP_057330                                                              16    7355
XP_005259026                                                           16    7355
XP_005274017                                                           16    7355
XP_006715232                                                           16    7355
XP_005249382                                                           16    7355
XP_005249381                                                           16    7355
XP_005249380                                                           16    7355
XP_005249379                                                           16    7355
XP_005249377                                                           16    7355
XP_005249376                                                           16    7355
XP_005249375                                                           16    7355
XP_005249374                                                           16    7355
XP_005249373                                                           16    7355
XP_005249372                                                           16    7355
XP_005249371                                                           16    7355
XP_005249370                                                           16    7355
XP_005249369                                                           16    7355
XP_005249368                                                           16    7355
XP_005249367                                                           16    7355
NP_009117                                                              15    9605
NP_003165                                                              15    9605
NP_068506                                                              15    9605
NP_001247421                                                           15    9605
NP_001247423                                                           15    9605
NP_075050                                                              15    9605
NP_001247422                                                           15    9605
NP_002897                                                              15    9605
NP_001247424                                                           15    9605
XP_005260321                                                           15    9605
XP_005260320                                                           15    9605
XP_006723758                                                           15    9605
XP_006723757                                                           15    9605
XP_006723756                                                           15    9605
XP_006723755                                                           15    9605
XP_006723754                                                           15    9605
XP_006723753                                                           15    9605
XP_005260319                                                           15    9605
XP_006717559                                                           15    9605
XP_006717558                                                           15    9605
XP_006717557                                                           15    9605
XP_006717556                                                           15    9605
XP_005252630                                                           15    9605
XP_005252629                                                           15    9605
XP_005252628                                                           15    9605
XP_005252627                                                           15    9605
XP_005252626                                                           15    9605
XP_005252625                                                           15    9605
XP_005252624                                                           15    9605
XP_005252623                                                           15    9605
XP_005252622                                                           15    9605
XP_006717555                                                           15    9605
XP_005252621                                                           15    9605
XP_005265644                                                           15    9605
XP_006713482                                                           15    9605
>NP_006209
          Length = 1068

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RKALALDKT 9
            RK LALDKT
Sbjct: 1023 RKTLALDKT 1031
>XP_006713721
          Length = 1068

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RKALALDKT 9
            RK LALDKT
Sbjct: 1023 RKTLALDKT 1031
>NP_597719
          Length = 770

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   RKALALDKT 9
           +KALALD+T
Sbjct: 406 KKALALDET 414
>NP_001036066
          Length = 439

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   RKALALDKT 9
           +KALALD+T
Sbjct: 406 KKALALDET 414
>NP_001275511
          Length = 653

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   RKALALDKT 9
           +KALALD+T
Sbjct: 406 KKALALDET 414
>XP_006713568
          Length = 434

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   RKALALDKT 9
           +KALALD+T
Sbjct: 406 KKALALDET 414
>XP_006713567
          Length = 447

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   RKALALDKT 9
           +KALALD+T
Sbjct: 406 KKALALDET 414
>NP_899236
          Length = 5497

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    KALALDKT 9
            KAL L+KT
Sbjct: 2253 KALVLEKT 2260
>NP_056363
          Length = 5171

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    KALALDKT 9
            KAL L+KT
Sbjct: 1927 KALVLEKT 1934
>NP_001138241
          Length = 5675

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    KALALDKT 9
            KAL L+KT
Sbjct: 2431 KALVLEKT 2438
>NP_001138242
          Length = 5537

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    KALALDKT 9
            KAL L+KT
Sbjct: 2293 KALVLEKT 2300
>NP_037431
          Length = 358

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RKALALD 7
           RKALA+D
Sbjct: 214 RKALAVD 220
>NP_001265539
          Length = 676

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RKALALD 7
           RK+LALD
Sbjct: 559 RKSLALD 565
>NP_002457
          Length = 700

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RKALALD 7
           RK+LALD
Sbjct: 583 RKSLALD 589
>NP_057330
          Length = 270

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   KALALDKT 9
           KALALD++
Sbjct: 166 KALALDES 173
>XP_005259026
          Length = 212

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   KALALDKT 9
           KALALD++
Sbjct: 166 KALALDES 173
>XP_005274017
          Length = 358

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RKALALD 7
           RKALA+D
Sbjct: 214 RKALAVD 220
>XP_006715232
          Length = 7498

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    KALALDKT 9
            KAL L+KT
Sbjct: 4339 KALVLEKT 4346
>XP_005249382
          Length = 5732

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    KALALDKT 9
            KAL L+KT
Sbjct: 2464 KALVLEKT 2471
>XP_005249381
          Length = 7281

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    KALALDKT 9
            KAL L+KT
Sbjct: 4013 KALVLEKT 4020
>XP_005249380
          Length = 7607

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    KALALDKT 9
            KAL L+KT
Sbjct: 4339 KALVLEKT 4346
>XP_005249379
          Length = 7633

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    KALALDKT 9
            KAL L+KT
Sbjct: 4365 KALVLEKT 4372
>XP_005249377
          Length = 7640

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    KALALDKT 9
            KAL L+KT
Sbjct: 4372 KALVLEKT 4379
>XP_005249376
          Length = 7647

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    KALALDKT 9
            KAL L+KT
Sbjct: 4379 KALVLEKT 4386
>XP_005249375
          Length = 7680

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    KALALDKT 9
            KAL L+KT
Sbjct: 4412 KALVLEKT 4419
>XP_005249374
          Length = 7709

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    KALALDKT 9
            KAL L+KT
Sbjct: 4550 KALVLEKT 4557
>XP_005249373
          Length = 7723

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    KALALDKT 9
            KAL L+KT
Sbjct: 4455 KALVLEKT 4462
>XP_005249372
          Length = 7785

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    KALALDKT 9
            KAL L+KT
Sbjct: 4517 KALVLEKT 4524
>XP_005249371
          Length = 7788

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    KALALDKT 9
            KAL L+KT
Sbjct: 4550 KALVLEKT 4557
>XP_005249370
          Length = 7794

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    KALALDKT 9
            KAL L+KT
Sbjct: 4550 KALVLEKT 4557
>XP_005249369
          Length = 7797

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    KALALDKT 9
            KAL L+KT
Sbjct: 4529 KALVLEKT 4536
>XP_005249368
          Length = 7812

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    KALALDKT 9
            KAL L+KT
Sbjct: 4550 KALVLEKT 4557
>XP_005249367
          Length = 7818

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    KALALDKT 9
            KAL L+KT
Sbjct: 4550 KALVLEKT 4557
>NP_009117
          Length = 2442

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KALALDK 8
           +ALALDK
Sbjct: 606 EALALDK 612
>NP_003165
          Length = 1788

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RKALALDKT 9
           +KALA D+T
Sbjct: 362 QKALAKDQT 370
>NP_068506
          Length = 2214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RKALALDKT 9
           +KALA D+T
Sbjct: 788 QKALAKDQT 796
>NP_001247421
          Length = 604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RKALALDK 8
           RKAL LD+
Sbjct: 370 RKALELDQ 377
>NP_001247423
          Length = 447

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RKALALDK 8
           RKAL LD+
Sbjct: 234 RKALELDQ 241
>NP_075050
          Length = 624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   KALALDK 8
           KAL LDK
Sbjct: 507 KALGLDK 513
>NP_001247422
          Length = 604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RKALALDK 8
           RKAL LD+
Sbjct: 370 RKALELDQ 377
>NP_002897
          Length = 583

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RKALALDK 8
           RKAL LD+
Sbjct: 370 RKALELDQ 377
>NP_001247424
          Length = 257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  RKALALDK 8
          RKAL LD+
Sbjct: 23 RKALELDQ 30
>XP_005260321
          Length = 2365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KALALDK 8
           +ALALDK
Sbjct: 606 EALALDK 612
>XP_005260320
          Length = 2370

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KALALDK 8
           +ALALDK
Sbjct: 606 EALALDK 612
>XP_006723758
          Length = 2386

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KALALDK 8
           +ALALDK
Sbjct: 606 EALALDK 612
>XP_006723757
          Length = 2404

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KALALDK 8
           +ALALDK
Sbjct: 606 EALALDK 612
>XP_006723756
          Length = 2442

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KALALDK 8
           +ALALDK
Sbjct: 606 EALALDK 612
>XP_006723755
          Length = 2442

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KALALDK 8
           +ALALDK
Sbjct: 606 EALALDK 612
>XP_006723754
          Length = 2442

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KALALDK 8
           +ALALDK
Sbjct: 606 EALALDK 612
>XP_006723753
          Length = 2442

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KALALDK 8
           +ALALDK
Sbjct: 606 EALALDK 612
>XP_005260319
          Length = 2442

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KALALDK 8
           +ALALDK
Sbjct: 606 EALALDK 612
>XP_006717559
          Length = 1866

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RKALALDKT 9
           +KALA D+T
Sbjct: 440 QKALAKDQT 448
>XP_006717558
          Length = 1908

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RKALALDKT 9
           +KALA D+T
Sbjct: 440 QKALAKDQT 448
>XP_006717557
          Length = 1940

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RKALALDKT 9
           +KALA D+T
Sbjct: 472 QKALAKDQT 480
>XP_006717556
          Length = 2024

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RKALALDKT 9
           +KALA D+T
Sbjct: 556 QKALAKDQT 564
>XP_005252630
          Length = 2256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RKALALDKT 9
           +KALA D+T
Sbjct: 788 QKALAKDQT 796
>XP_005252629
          Length = 2256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RKALALDKT 9
           +KALA D+T
Sbjct: 788 QKALAKDQT 796
>XP_005252628
          Length = 2256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RKALALDKT 9
           +KALA D+T
Sbjct: 788 QKALAKDQT 796
>XP_005252627
          Length = 2256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RKALALDKT 9
           +KALA D+T
Sbjct: 788 QKALAKDQT 796
>XP_005252626
          Length = 2260

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RKALALDKT 9
           +KALA D+T
Sbjct: 834 QKALAKDQT 842
>XP_005252625
          Length = 2277

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RKALALDKT 9
           +KALA D+T
Sbjct: 809 QKALAKDQT 817
>XP_005252624
          Length = 2292

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RKALALDKT 9
           +KALA D+T
Sbjct: 866 QKALAKDQT 874
>XP_005252623
          Length = 2302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RKALALDKT 9
           +KALA D+T
Sbjct: 834 QKALAKDQT 842
>XP_005252622
          Length = 2308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RKALALDKT 9
           +KALA D+T
Sbjct: 866 QKALAKDQT 874
>XP_006717555
          Length = 2328

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RKALALDKT 9
           +KALA D+T
Sbjct: 860 QKALAKDQT 868
>XP_005252621
          Length = 2334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RKALALDKT 9
           +KALA D+T
Sbjct: 866 QKALAKDQT 874
>XP_005265644
          Length = 624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   KALALDK 8
           KAL LDK
Sbjct: 507 KALGLDK 513
>XP_006713482
          Length = 624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   KALALDK 8
           KAL LDK
Sbjct: 507 KALGLDK 513
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.126    0.312 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 376,599
Number of extensions: 569
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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