Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005219                                                              18    1135
NP_001030312                                                           17    4312
NP_065880                                                              17    4312
NP_001129392                                                           17    4312
NP_001193486                                                           17    4312
XP_005251580                                                           17    4312
XP_006726511                                                           16    5631
XP_006721874                                                           16    5631
XP_006721873                                                           16    5631
XP_006721872                                                           16    5631
XP_006721870                                                           16    5631
XP_006721869                                                           16    5631
XP_006716291                                                           16    5631
XP_006710245                                                           16    5631
NP_620706                                                              16    7355
NP_003066                                                              16    7355
NP_001123892                                                           16    7355
NP_998760                                                              16    7355
NP_060876                                                              16    7355
NP_001008537                                                           16    7355
XP_006724709                                                           16    7355
XP_006724708                                                           16    7355
XP_005255418                                                           16    7355
XP_005269161                                                           16    7355
XP_005269160                                                           16    7355
XP_005269159                                                           16    7355
XP_005269158                                                           16    7355
XP_005268818                                                           16    7355
XP_005268817                                                           16    7355
NP_001156621                                                           15    9605
NP_001156623                                                           15    9605
NP_001156619                                                           15    9605
NP_001156624                                                           15    9605
NP_004947                                                              15    9605
NP_001156620                                                           15    9605
NP_001156622                                                           15    9605
NP_055731                                                              15    9605
NP_006729                                                              15    9605
NP_001257475                                                           15    9605
NP_009131                                                              15    9605
NP_056265                                                              15    9605
NP_001036059                                                           15    9605
XP_005260721                                                           15    9605
XP_005254913                                                           15    9605
XP_005254912                                                           15    9605
XP_005254911                                                           15    9605
XP_005254910                                                           15    9605
XP_005254909                                                           15    9605
XP_005254908                                                           15    9605
XP_005254907                                                           15    9605
XP_005254906                                                           15    9605
XP_005254905                                                           15    9605
XP_005254904                                                           15    9605
XP_005254903                                                           15    9605
XP_005254902                                                           15    9605
XP_005254901                                                           15    9605
XP_005254900                                                           15    9605
XP_005254899                                                           15    9605
XP_005254898                                                           15    9605
XP_005254897                                                           15    9605
XP_006720441                                                           15    9605
XP_006720440                                                           15    9605
XP_006720439                                                           15    9605
XP_005254896                                                           15    9605
XP_006715980                                                           15    9605
XP_005249693                                                           15    9605
XP_005249692                                                           15    9605
NP_001009608                                                           15    9605
>NP_005219
          Length = 1210

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   IPASEISS 9
           IPASEISS
Sbjct: 918 IPASEISS 925
>NP_001030312
          Length = 236

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  RIPASEIS 8
          R+PASE S
Sbjct: 62 RVPASETS 69
>NP_065880
          Length = 1423

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    IPASEISS 9
            IPAS ISS
Sbjct: 1125 IPASSISS 1132
>NP_001129392
          Length = 1165

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    IPASEISS 9
            IPAS ISS
Sbjct: 1125 IPASSISS 1132
>NP_001193486
          Length = 1386

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    IPASEISS 9
            IPAS ISS
Sbjct: 1088 IPASSISS 1095
>XP_005251580
          Length = 1422

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    IPASEISS 9
            IPAS ISS
Sbjct: 1124 IPASSISS 1131
>XP_006726511
          Length = 531

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   PASEISS 9
           PASE+SS
Sbjct: 101 PASELSS 107
>XP_006721874
          Length = 1399

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RIPASEISS 9
           RIP SE+ S
Sbjct: 120 RIPESELGS 128
>XP_006721873
          Length = 1409

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RIPASEISS 9
           RIP SE+ S
Sbjct: 120 RIPESELGS 128
>XP_006721872
          Length = 2037

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RIPASEISS 9
          RIP SE+ S
Sbjct: 83 RIPESELGS 91
>XP_006721870
          Length = 2064

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RIPASEISS 9
           RIP SE+ S
Sbjct: 120 RIPESELGS 128
>XP_006721869
          Length = 2074

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RIPASEISS 9
           RIP SE+ S
Sbjct: 120 RIPESELGS 128
>XP_006716291
          Length = 568

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   PASEISS 9
           PASE+SS
Sbjct: 101 PASELSS 107
>XP_006710245
          Length = 327

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   PASEISS 9
           PASE+SS
Sbjct: 101 PASELSS 107
>NP_620706
          Length = 1130

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IPASEISS 9
           IPASEI +
Sbjct: 216 IPASEIEA 223
>NP_003066
          Length = 1214

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IPASEISS 9
           IPASEI +
Sbjct: 216 IPASEIEA 223
>NP_001123892
          Length = 1152

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IPASEISS 9
           IPASEI +
Sbjct: 216 IPASEIEA 223
>NP_998760
          Length = 167

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RIPASEISS 9
          R+PA E+S+
Sbjct: 22 RLPARELSA 30
>NP_060876
          Length = 5412

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    RIPASEISS 9
            R+P ++ISS
Sbjct: 3376 RLPVTDISS 3384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    RIPASEISS 9
            R+P +++SS
Sbjct: 1696 RLPVTDVSS 1704

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    RIPASEISS 9
            R+P +++SS
Sbjct: 1792 RLPVTDVSS 1800

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    RIPASEISS 9
            R+P +++SS
Sbjct: 3920 RLPVTDVSS 3928
>NP_001008537
          Length = 1516

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RIPASEISS 9
           RIP+ EIS+
Sbjct: 640 RIPSIEISA 648
>XP_006724709
          Length = 1486

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RIPASEISS 9
           RIP+ EIS+
Sbjct: 640 RIPSIEISA 648
>XP_006724708
          Length = 1486

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RIPASEISS 9
           RIP+ EIS+
Sbjct: 640 RIPSIEISA 648
>XP_005255418
          Length = 453

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IPASEISS 9
           IPA E+SS
Sbjct: 415 IPACELSS 422
>XP_005269161
          Length = 1151

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IPASEISS 9
           IPASEI +
Sbjct: 216 IPASEIEA 223
>XP_005269160
          Length = 1213

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IPASEISS 9
           IPASEI +
Sbjct: 216 IPASEIEA 223
>XP_005269159
          Length = 1244

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IPASEISS 9
           IPASEI +
Sbjct: 216 IPASEIEA 223
>XP_005269158
          Length = 1245

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IPASEISS 9
           IPASEI +
Sbjct: 216 IPASEIEA 223
>XP_005268818
          Length = 154

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RIPASEISS 9
          R+PA E+S+
Sbjct: 22 RLPARELSA 30
>XP_005268817
          Length = 156

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RIPASEISS 9
          R+PA E+S+
Sbjct: 22 RLPARELSA 30
>NP_001156621
          Length = 459

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  PASEISS 9
          P SEISS
Sbjct: 77 PCSEISS 83
>NP_001156623
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  PASEISS 9
          P SEISS
Sbjct: 37 PCSEISS 43
>NP_001156619
          Length = 454

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   PASEISS 9
           P SEISS
Sbjct: 95  PCSEISS 101
>NP_001156624
          Length = 374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  PASEISS 9
          P SEISS
Sbjct: 55 PCSEISS 61
>NP_004947
          Length = 477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   PASEISS 9
           P SEISS
Sbjct: 95  PCSEISS 101
>NP_001156620
          Length = 459

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  PASEISS 9
          P SEISS
Sbjct: 77 PCSEISS 83
>NP_001156622
          Length = 437

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  PASEISS 9
          P SEISS
Sbjct: 55 PCSEISS 61
>NP_055731
          Length = 1503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  PASEISS 9
          PA+E+SS
Sbjct: 39 PAAEVSS 45
>NP_006729
          Length = 2817

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    PASEISS 9
            PASE+S+
Sbjct: 2804 PASEVSA 2810
>NP_001257475
          Length = 1434

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    PASEISS 9
            PASE+S+
Sbjct: 1421 PASEVSA 1427
>NP_009131
          Length = 2813

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    PASEISS 9
            PASE+S+
Sbjct: 2800 PASEVSA 2806
>NP_056265
          Length = 634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RIPASEI 7
           +IPASE+
Sbjct: 567 QIPASEV 573
>NP_001036059
          Length = 503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RIPASEI 7
           +IPASE+
Sbjct: 436 QIPASEV 442
>XP_005260721
          Length = 243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IPASEIS 8
           +PASE+S
Sbjct: 169 LPASELS 175
>XP_005254913
          Length = 1441

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    PASEISS 9
            PASE+S+
Sbjct: 1428 PASEVSA 1434
>XP_005254912
          Length = 1442

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    PASEISS 9
            PASE+S+
Sbjct: 1429 PASEVSA 1435
>XP_005254911
          Length = 1473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    PASEISS 9
            PASE+S+
Sbjct: 1460 PASEVSA 1466
>XP_005254910
          Length = 1523

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    PASEISS 9
            PASE+S+
Sbjct: 1510 PASEVSA 1516
>XP_005254909
          Length = 1536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    PASEISS 9
            PASE+S+
Sbjct: 1523 PASEVSA 1529
>XP_005254908
          Length = 1536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    PASEISS 9
            PASE+S+
Sbjct: 1523 PASEVSA 1529
>XP_005254907
          Length = 2590

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    PASEISS 9
            PASE+S+
Sbjct: 2577 PASEVSA 2583
>XP_005254906
          Length = 2675

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    PASEISS 9
            PASE+S+
Sbjct: 2662 PASEVSA 2668
>XP_005254905
          Length = 2793

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    PASEISS 9
            PASE+S+
Sbjct: 2780 PASEVSA 2786
>XP_005254904
          Length = 2802

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    PASEISS 9
            PASE+S+
Sbjct: 2789 PASEVSA 2795
>XP_005254903
          Length = 2820

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    PASEISS 9
            PASE+S+
Sbjct: 2807 PASEVSA 2813
>XP_005254902
          Length = 2835

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    PASEISS 9
            PASE+S+
Sbjct: 2822 PASEVSA 2828
>XP_005254901
          Length = 2842

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    PASEISS 9
            PASE+S+
Sbjct: 2829 PASEVSA 2835
>XP_005254900
          Length = 2843

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    PASEISS 9
            PASE+S+
Sbjct: 2830 PASEVSA 2836
>XP_005254899
          Length = 2861

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    PASEISS 9
            PASE+S+
Sbjct: 2848 PASEVSA 2854
>XP_005254898
          Length = 2874

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    PASEISS 9
            PASE+S+
Sbjct: 2861 PASEVSA 2867
>XP_005254897
          Length = 2876

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    PASEISS 9
            PASE+S+
Sbjct: 2863 PASEVSA 2869
>XP_006720441
          Length = 2881

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    PASEISS 9
            PASE+S+
Sbjct: 2868 PASEVSA 2874
>XP_006720440
          Length = 2882

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    PASEISS 9
            PASE+S+
Sbjct: 2869 PASEVSA 2875
>XP_006720439
          Length = 2882

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    PASEISS 9
            PASE+S+
Sbjct: 2869 PASEVSA 2875
>XP_005254896
          Length = 2883

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    PASEISS 9
            PASE+S+
Sbjct: 2870 PASEVSA 2876
>XP_006715980
          Length = 634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RIPASEI 7
           +IPASE+
Sbjct: 567 QIPASEV 573
>XP_005249693
          Length = 477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   PASEISS 9
           P SEISS
Sbjct: 95  PCSEISS 101
>XP_005249692
          Length = 477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   PASEISS 9
           P SEISS
Sbjct: 95  PCSEISS 101
>NP_001009608
          Length = 408

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IPASEIS 8
           +PASE+S
Sbjct: 334 LPASELS 340
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.302    0.116    0.281 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 599,709
Number of extensions: 967
Number of successful extensions: 71
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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