Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000312                                                              18    1135
NP_001191102                                                           17    3301
NP_733827                                                              17    3301
NP_001028750                                                           17    3301
NP_037389                                                              17    3301
NP_872346                                                              17    4312
XP_006724804                                                           17    4312
XP_006724803                                                           17    4312
XP_005262451                                                           17    4312
NP_036558                                                              16    7355
NP_653295                                                              16    7355
XP_005258622                                                           16    7355
NP_001155155                                                           15    9605
NP_733764                                                              15    9605
NP_653273                                                              15    9605
NP_001138890                                                           15    9605
NP_001276330                                                           15    9605
NP_001158001                                                           15    9605
NP_003427                                                              15    9605
XP_006724234                                                           15    9605
XP_005261462                                                           15    9605
XP_006723521                                                           15    9605
XP_005259268                                                           15    9605
XP_006723426                                                           15    9605
XP_006723425                                                           15    9605
NP_001158002                                                           15    9605
NP_001276331                                                           15    9605
NP_001157999                                                           15    9605
NP_009065                                                              15    9605

>NP_000312
          Length = 928

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RILVSIGKS 9
           RILVSIG+S
Sbjct: 830 RILVSIGES 838



>NP_001191102
          Length = 496

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  RILVSIGKS 9
          ++LVS+G+S
Sbjct: 35 KVLVSVGRS 43



>NP_733827
          Length = 464

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  RILVSIGKS 9
          ++LVS+G+S
Sbjct: 35 KVLVSVGRS 43



>NP_001028750
          Length = 496

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  RILVSIGKS 9
          ++LVS+G+S
Sbjct: 35 KVLVSVGRS 43



>NP_037389
          Length = 496

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  RILVSIGKS 9
          ++LVS+G+S
Sbjct: 35 KVLVSVGRS 43



>NP_872346
          Length = 861

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RILVSIGK 8
           RIL S+GK
Sbjct: 436 RILASVGK 443



>XP_006724804
          Length = 854

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RILVSIGK 8
           RIL S+GK
Sbjct: 473 RILASVGK 480



>XP_006724803
          Length = 894

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RILVSIGK 8
           RIL S+GK
Sbjct: 473 RILASVGK 480



>XP_005262451
          Length = 898

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RILVSIGK 8
           RIL S+GK
Sbjct: 473 RILASVGK 480



>NP_036558
          Length = 1217

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   RILVSIGK 8
           R+L+ +GK
Sbjct: 958 RVLIGVGK 965



>NP_653295
          Length = 536

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  RILVSIG 7
          RILVS+G
Sbjct: 48 RILVSLG 54



>XP_005258622
          Length = 592

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RILVSIG 7
           RILVS+G
Sbjct: 104 RILVSLG 110



>NP_001155155
          Length = 1060

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LVSIGKS 9
           L+S+GKS
Sbjct: 564 LISLGKS 570



>NP_733764
          Length = 815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LVSIGKS 9
           L+S+GKS
Sbjct: 319 LISLGKS 325



>NP_653273
          Length = 1139

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LVSIGKS 9
           L+S+GKS
Sbjct: 643 LISLGKS 649



>NP_001138890
          Length = 2481

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    RILVSIG 7
            R+LVS+G
Sbjct: 1177 RVLVSLG 1183



>NP_001276330
          Length = 658

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  RILVSIG 7
          R+LVS+G
Sbjct: 48 RLLVSVG 54



>NP_001158001
          Length = 115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  RILVSIG 7
          R+LVS+G
Sbjct: 60 RLLVSVG 66



>NP_003427
          Length = 670

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  RILVSIG 7
          R+LVS+G
Sbjct: 48 RLLVSVG 54



>XP_006724234
          Length = 2363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    RILVSIG 7
            R+LVS+G
Sbjct: 1059 RVLVSLG 1065



>XP_005261462
          Length = 2473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    RILVSIG 7
            R+LVS+G
Sbjct: 1177 RVLVSLG 1183



>XP_006723521
          Length = 425

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RILVSIGKS 9
          R LVS+G+S
Sbjct: 43 RNLVSLGRS 51



>XP_005259268
          Length = 670

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  RILVSIG 7
          R+LVS+G
Sbjct: 60 RLLVSVG 66



>XP_006723426
          Length = 670

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  RILVSIG 7
          R+LVS+G
Sbjct: 48 RLLVSVG 54



>XP_006723425
          Length = 670

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  RILVSIG 7
          R+LVS+G
Sbjct: 48 RLLVSVG 54



>NP_001158002
          Length = 390

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  RILVSIG 7
          R+LVS+G
Sbjct: 60 RLLVSVG 66



>NP_001276331
          Length = 616

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  RILVSIG 7
          R+LVS+G
Sbjct: 6  RLLVSVG 12



>NP_001157999
          Length = 123

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  RILVSIG 7
          R+LVS+G
Sbjct: 60 RLLVSVG 66



>NP_009065
          Length = 682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  RILVSIG 7
          R+LVS+G
Sbjct: 60 RLLVSVG 66



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.323    0.142    0.347 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 424,677
Number of extensions: 808
Number of successful extensions: 29
Number of sequences better than 10000.0: 29
Number of HSP's gapped: 29
Number of HSP's successfully gapped: 29
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)