Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006715                                                              20     509
NP_005913                                                              20     509
XP_005267046                                                           20     509
XP_005267045                                                           20     509
NP_001254711                                                           17    2528
NP_001254712                                                           17    2528
NP_060219                                                              17    2528
XP_006718323                                                           17    2528
XP_005253071                                                           17    2528
XP_005253069                                                           17    2528
XP_005253068                                                           17    2528
XP_006718322                                                           17    2528
XP_005253066                                                           17    2528
NP_001229285                                                           17    3301
NP_001229286                                                           17    3301
NP_004820                                                              17    3301
NP_001138929                                                           17    3301
NP_001138930                                                           17    3301
NP_060218                                                              17    4312
NP_060497                                                              16    7355
NP_001128360                                                           16    7355
NP_006178                                                              16    7355
NP_940931                                                              16    7355
NP_056311                                                              16    7355
XP_006721943                                                           16    7355
XP_006721942                                                           16    7355
XP_005253946                                                           16    7355
XP_005252552                                                           16    7355
XP_006717527                                                           16    7355
XP_006717526                                                           16    7355
XP_005252551                                                           16    7355
XP_006717525                                                           16    7355
XP_006717524                                                           16    7355
XP_005252547                                                           16    7355
XP_005252546                                                           16    7355
XP_006717523                                                           16    7355
XP_006717522                                                           16    7355
XP_006717521                                                           16    7355
XP_006717520                                                           16    7355
XP_005271224                                                           16    7355
NP_057006                                                              15    9605
NP_958815                                                              15    9605
NP_001123237                                                           15    9605
NP_149418                                                              15    9605
NP_001139281                                                           15    9605
NP_001070654                                                           15    9605
NP_079005                                                              15    9605
NP_001120859                                                           15    9605
NP_001120861                                                           15    9605
NP_036279                                                              15    9605
NP_001170847                                                           15    9605
NP_001120860                                                           15    9605
NP_001120858                                                           15    9605
NP_001157939                                                           15    9605
XP_006726588                                                           15    9605
XP_006726586                                                           15    9605
XP_006726479                                                           15    9605
XP_003960379                                                           15    9605
XP_006726466                                                           15    9605
XP_006724887                                                           15    9605
XP_006723449                                                           15    9605
XP_005255486                                                           15    9605
XP_005255485                                                           15    9605
XP_005255484                                                           15    9605
XP_006720966                                                           15    9605
XP_006718170                                                           15    9605
XP_006718169                                                           15    9605
XP_006718168                                                           15    9605
XP_006718167                                                           15    9605
XP_006718166                                                           15    9605
XP_006718165                                                           15    9605
XP_005264835                                                           15    9605
XP_006712969                                                           15    9605
XP_005276144                                                           15    9605
XP_003846716                                                           15    9605
XP_005275995                                                           15    9605
NP_001264985                                                           15    9605
>NP_006715
          Length = 1558

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RERASRALG 9
           RERAS+ALG
Sbjct: 809 RERASKALG 817
>NP_005913
          Length = 1608

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RERASRALG 9
           RERAS+ALG
Sbjct: 809 RERASKALG 817
>XP_005267046
          Length = 1554

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RERASRALG 9
           RERAS+ALG
Sbjct: 809 RERASKALG 817
>XP_005267045
          Length = 1604

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RERASRALG 9
           RERAS+ALG
Sbjct: 809 RERASKALG 817
>NP_001254711
          Length = 1301

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RERASRALG 9
          RER +RA+G
Sbjct: 16 RERGARAMG 24
>NP_001254712
          Length = 1179

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RERASRALG 9
          RER +RA+G
Sbjct: 16 RERGARAMG 24
>NP_060219
          Length = 1208

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RERASRALG 9
          RER +RA+G
Sbjct: 16 RERGARAMG 24
>XP_006718323
          Length = 1119

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RERASRALG 9
          RER +RA+G
Sbjct: 16 RERGARAMG 24
>XP_005253071
          Length = 1208

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RERASRALG 9
          RER +RA+G
Sbjct: 16 RERGARAMG 24
>XP_005253069
          Length = 1238

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RERASRALG 9
          RER +RA+G
Sbjct: 16 RERGARAMG 24
>XP_005253068
          Length = 1269

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RERASRALG 9
          RER +RA+G
Sbjct: 16 RERGARAMG 24
>XP_006718322
          Length = 1298

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RERASRALG 9
          RER +RA+G
Sbjct: 16 RERGARAMG 24
>XP_005253066
          Length = 1298

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RERASRALG 9
          RER +RA+G
Sbjct: 16 RERGARAMG 24
>NP_001229285
          Length = 209

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   RERASRA 7
           RERASRA
Sbjct: 189 RERASRA 195
>NP_001229286
          Length = 192

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   RERASRA 7
           RERASRA
Sbjct: 172 RERASRA 178
>NP_004820
          Length = 304

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   RERASRA 7
           RERASRA
Sbjct: 284 RERASRA 290
>NP_001138929
          Length = 303

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   RERASRA 7
           RERASRA
Sbjct: 283 RERASRA 289
>NP_001138930
          Length = 287

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   RERASRA 7
           RERASRA
Sbjct: 267 RERASRA 273
>NP_060218
          Length = 425

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RERASRALG 9
           R+R SR+LG
Sbjct: 282 RDRRSRSLG 290
>NP_060497
          Length = 1039

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RERASRALG 9
           R+RA+ ALG
Sbjct: 786 RQRAAGALG 794
>NP_001128360
          Length = 1358

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    RERASRAL 8
            RE+A+RAL
Sbjct: 1311 REQAARAL 1318
>NP_006178
          Length = 1087

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  ERASRALG 9
          E+A RALG
Sbjct: 27 EKARRALG 34
>NP_940931
          Length = 1503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    RERASRALG 9
            RER   ALG
Sbjct: 1256 RERTGEALG 1264
>NP_056311
          Length = 1812

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RERASRALG 9
            R+RASR  G
Sbjct: 1768 RDRASRGRG 1776
>XP_006721943
          Length = 1456

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    RERASRALG 9
            RER   ALG
Sbjct: 1256 RERTGEALG 1264
>XP_006721942
          Length = 1503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    RERASRALG 9
            RER   ALG
Sbjct: 1256 RERTGEALG 1264
>XP_005253946
          Length = 1089

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  ERASRALG 9
          E+A RALG
Sbjct: 27 EKARRALG 34
>XP_005252552
          Length = 701

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RERASRALG 9
           R+RA+ ALG
Sbjct: 437 RQRAAGALG 445
>XP_006717527
          Length = 721

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RERASRALG 9
           R+RA+ ALG
Sbjct: 457 RQRAAGALG 465
>XP_006717526
          Length = 753

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RERASRALG 9
           R+RA+ ALG
Sbjct: 489 RQRAAGALG 497
>XP_005252551
          Length = 902

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RERASRALG 9
           R+RA+ ALG
Sbjct: 638 RQRAAGALG 646
>XP_006717525
          Length = 1062

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RERASRALG 9
           R+RA+ ALG
Sbjct: 798 RQRAAGALG 806
>XP_006717524
          Length = 1072

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RERASRALG 9
           R+RA+ ALG
Sbjct: 819 RQRAAGALG 827
>XP_005252547
          Length = 1078

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RERASRALG 9
           R+RA+ ALG
Sbjct: 814 RQRAAGALG 822
>XP_005252546
          Length = 1083

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RERASRALG 9
           R+RA+ ALG
Sbjct: 819 RQRAAGALG 827
>XP_006717523
          Length = 1095

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RERASRALG 9
           R+RA+ ALG
Sbjct: 831 RQRAAGALG 839
>XP_006717522
          Length = 1098

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RERASRALG 9
           R+RA+ ALG
Sbjct: 834 RQRAAGALG 842
>XP_006717521
          Length = 1099

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RERASRALG 9
           R+RA+ ALG
Sbjct: 846 RQRAAGALG 854
>XP_006717520
          Length = 1110

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RERASRALG 9
           R+RA+ ALG
Sbjct: 846 RQRAAGALG 854
>XP_005271224
          Length = 102

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  ERASRALG 9
          ERA RA+G
Sbjct: 83 ERAMRAVG 90
>NP_057006
          Length = 373

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ERASRALG 9
           ERA +A+G
Sbjct: 341 ERAKKAMG 348
>NP_958815
          Length = 371

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RERASR 6
           RERASR
Sbjct: 328 RERASR 333
>NP_001123237
          Length = 373

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ERASRALG 9
           ERA +A+G
Sbjct: 341 ERAKKAMG 348
>NP_149418
          Length = 424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RERASRALG 9
          RER ++A+G
Sbjct: 49 RERLAQAIG 57
>NP_001139281
          Length = 2036

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RERASRAL 8
            RER +RAL
Sbjct: 1537 REREARAL 1544
>NP_001070654
          Length = 2003

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RERASRAL 8
            RER +RAL
Sbjct: 1504 REREARAL 1511
>NP_079005
          Length = 1995

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RERASRAL 8
            RER +RAL
Sbjct: 1496 REREARAL 1503
>NP_001120859
          Length = 424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RERASRALG 9
          RER ++A+G
Sbjct: 49 RERLAQAIG 57
>NP_001120861
          Length = 424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RERASRALG 9
          RER ++A+G
Sbjct: 49 RERLAQAIG 57
>NP_036279
          Length = 424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RERASRALG 9
          RER ++A+G
Sbjct: 49 RERLAQAIG 57
>NP_001170847
          Length = 422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RERASRALG 9
          RER ++A+G
Sbjct: 49 RERLAQAIG 57
>NP_001120860
          Length = 424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RERASRALG 9
          RER ++A+G
Sbjct: 49 RERLAQAIG 57
>NP_001120858
          Length = 424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RERASRALG 9
          RER ++A+G
Sbjct: 49 RERLAQAIG 57
>NP_001157939
          Length = 424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RERASRALG 9
          RER ++A+G
Sbjct: 49 RERLAQAIG 57
>XP_006726588
          Length = 745

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RERASRALG 9
          RER ++A+G
Sbjct: 49 RERLAQAIG 57
>XP_006726586
          Length = 422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RERASRALG 9
          RER ++A+G
Sbjct: 49 RERLAQAIG 57
>XP_006726479
          Length = 401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RERASRALG 9
          RER ++A+G
Sbjct: 24 RERLAQAIG 32
>XP_003960379
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RERASRALG 9
          RER ++A+G
Sbjct: 49 RERLAQAIG 57
>XP_006726466
          Length = 1310

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RERASRAL 8
           RER+ RAL
Sbjct: 135 RERSCRAL 142
>XP_006724887
          Length = 373

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ERASRALG 9
           ERA +A+G
Sbjct: 341 ERAKKAMG 348
>XP_006723449
          Length = 2003

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RERASRAL 8
            RER +RAL
Sbjct: 1504 REREARAL 1511
>XP_005255486
          Length = 285

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RERASR 6
           RERASR
Sbjct: 242 RERASR 247
>XP_005255485
          Length = 285

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RERASR 6
           RERASR
Sbjct: 242 RERASR 247
>XP_005255484
          Length = 318

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RERASR 6
           RERASR
Sbjct: 275 RERASR 280
>XP_006720966
          Length = 318

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RERASR 6
           RERASR
Sbjct: 275 RERASR 280
>XP_006718170
          Length = 422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RERASRALG 9
          RER ++A+G
Sbjct: 49 RERLAQAIG 57
>XP_006718169
          Length = 422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RERASRALG 9
          RER ++A+G
Sbjct: 49 RERLAQAIG 57
>XP_006718168
          Length = 422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RERASRALG 9
          RER ++A+G
Sbjct: 49 RERLAQAIG 57
>XP_006718167
          Length = 422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RERASRALG 9
          RER ++A+G
Sbjct: 49 RERLAQAIG 57
>XP_006718166
          Length = 422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RERASRALG 9
          RER ++A+G
Sbjct: 49 RERLAQAIG 57
>XP_006718165
          Length = 422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RERASRALG 9
          RER ++A+G
Sbjct: 49 RERLAQAIG 57
>XP_005264835
          Length = 541

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RERASRALG 9
          RER ++A+G
Sbjct: 73 RERLAQAIG 81
>XP_006712969
          Length = 1310

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RERASRAL 8
           RER+ RAL
Sbjct: 135 RERSCRAL 142
>XP_005276144
          Length = 348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RERASRALG 9
          RER ++A+G
Sbjct: 58 RERLAQAIG 66
>XP_003846716
          Length = 517

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RERASRALG 9
          RER ++A+G
Sbjct: 49 RERLAQAIG 57
>XP_005275995
          Length = 488

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RERASRAL 8
           RER+ RAL
Sbjct: 135 RERSCRAL 142
>NP_001264985
          Length = 424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RERASRALG 9
          RER ++A+G
Sbjct: 49 RERLAQAIG 57
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.318    0.128    0.327 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 301,521
Number of extensions: 496
Number of successful extensions: 77
Number of sequences better than 10000.0: 77
Number of HSP's gapped: 77
Number of HSP's successfully gapped: 77
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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