Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

XP_006715945                                                           18    1482
XP_006715944                                                           18    1482
NP_001267724                                                           18    1482
NP_001267723                                                           18    1482
NP_004436                                                              18    1482
NP_004251                                                              18    1935
NP_004091                                                              17    2528
NP_742103                                                              17    2528
NP_742101                                                              17    2528
NP_004345                                                              17    2528
NP_003588                                                              17    2528
NP_001171187                                                           17    2528
NP_001171189                                                           17    2528
XP_006715436                                                           17    2528
XP_005266910                                                           17    2528
XP_005266909                                                           17    2528
XP_005266908                                                           17    2528
XP_005266907                                                           17    2528
XP_005246236                                                           17    2528
NP_055535                                                              17    3301
XP_005270358                                                           17    3301
NP_002302                                                              17    4312
NP_039269                                                              17    4312
XP_006721959                                                           17    4312
XP_005258028                                                           17    4312
XP_005258027                                                           17    4312
NP_002412                                                              16    5631
NP_001139410                                                           16    5631
NP_001003841                                                           16    5631
NP_001607                                                              16    5631
NP_060386                                                              16    5631
NP_060251                                                              16    5631
NP_001265509                                                           16    5631
NP_001265508                                                           16    5631
XP_005249849                                                           16    5631
NP_001137461                                                           16    7355
XP_005271201                                                           16    7355
XP_006710441                                                           16    7355
XP_005270554                                                           16    7355
NP_001137459                                                           16    7355
NP_001137460                                                           16    7355
NP_055558                                                              15    9605
NP_001094060                                                           15    9605
NP_004123                                                              15    9605
NP_006749                                                              15    9605
NP_001171131                                                           15    9605
NP_060134                                                              15    9605
NP_002198                                                              15    9605
NP_065754                                                              15    9605
NP_001041445                                                           15    9605
NP_005551                                                              15    9605
XP_006726862                                                           15    9605
XP_006723991                                                           15    9605
XP_006723861                                                           15    9605
XP_006723860                                                           15    9605
XP_006723859                                                           15    9605
XP_005271769                                                           15    9605
XP_005248098                                                           15    9605
XP_006713998                                                           15    9605
XP_006713997                                                           15    9605
>XP_006715945
          Length = 1022

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   CTASDVAQ 9
           CT SDVAQ
Sbjct: 976 CTFSDVAQ 983
>XP_006715944
          Length = 1022

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   CTASDVAQ 9
           CT SDVAQ
Sbjct: 976 CTFSDVAQ 983
>NP_001267724
          Length = 729

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   CTASDVAQ 9
           CT SDVAQ
Sbjct: 683 CTFSDVAQ 690
>NP_001267723
          Length = 729

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   CTASDVAQ 9
           CT SDVAQ
Sbjct: 683 CTFSDVAQ 690
>NP_004436
          Length = 1022

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   CTASDVAQ 9
           CT SDVAQ
Sbjct: 976 CTFSDVAQ 983
>NP_004251
          Length = 1208

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RCTASDVAQ 9
           R TASDVAQ
Sbjct: 646 RRTASDVAQ 654
>NP_004091
          Length = 639

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  CTASDVAQ 9
          CT SDV+Q
Sbjct: 16 CTESDVSQ 23
>NP_742103
          Length = 639

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  CTASDVAQ 9
          CT SDV+Q
Sbjct: 16 CTESDVSQ 23
>NP_742101
          Length = 616

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  CTASDVAQ 9
          CT SDV+Q
Sbjct: 16 CTESDVSQ 23
>NP_004345
          Length = 344

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RCTASDV 7
           +CTASD+
Sbjct: 132 KCTASDI 138
>NP_003588
          Length = 512

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   CTASDVAQ 9
           CTA+DV Q
Sbjct: 133 CTATDVLQ 140
>NP_001171187
          Length = 495

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   CTASDVAQ 9
           CTA+DV Q
Sbjct: 116 CTATDVLQ 123
>NP_001171189
          Length = 495

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   CTASDVAQ 9
           CTA+DV Q
Sbjct: 116 CTATDVLQ 123
>XP_006715436
          Length = 585

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  CTASDVAQ 9
          CT SDV+Q
Sbjct: 16 CTESDVSQ 23
>XP_005266910
          Length = 616

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  CTASDVAQ 9
          CT SDV+Q
Sbjct: 16 CTESDVSQ 23
>XP_005266909
          Length = 620

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  CTASDVAQ 9
          CT SDV+Q
Sbjct: 16 CTESDVSQ 23
>XP_005266908
          Length = 645

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  CTASDVAQ 9
          CT SDV+Q
Sbjct: 16 CTESDVSQ 23
>XP_005266907
          Length = 645

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  CTASDVAQ 9
          CT SDV+Q
Sbjct: 16 CTESDVSQ 23
>XP_005246236
          Length = 495

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   CTASDVAQ 9
           CTA+DV Q
Sbjct: 116 CTATDVLQ 123
>NP_055535
          Length = 1235

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   CTASDVAQ 9
           C A+DVAQ
Sbjct: 552 CEAADVAQ 559
>XP_005270358
          Length = 1204

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   CTASDVAQ 9
           C A+DVAQ
Sbjct: 552 CEAADVAQ 559
>NP_002302
          Length = 949

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RCTASDV 7
           RCTA+D+
Sbjct: 403 RCTANDL 409
>NP_039269
          Length = 1009

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RCTASDV 7
           RCTA+D+
Sbjct: 403 RCTANDL 409
>XP_006721959
          Length = 958

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RCTASDV 7
           RCTA+D+
Sbjct: 412 RCTANDL 418
>XP_005258028
          Length = 1009

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RCTASDV 7
           RCTA+D+
Sbjct: 403 RCTANDL 409
>XP_005258027
          Length = 1018

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RCTASDV 7
           RCTA+D+
Sbjct: 412 RCTANDL 418
>NP_002412
          Length = 469

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  RCTASDVAQ 9
          RC   DVAQ
Sbjct: 91 RCGVPDVAQ 99
>NP_001139410
          Length = 403

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  RCTASDVAQ 9
          RC   DVAQ
Sbjct: 25 RCGVPDVAQ 33
>NP_001003841
          Length = 634

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RCTASDVA 8
           RC ASD A
Sbjct: 366 RCNASDPA 373
>NP_001607
          Length = 513

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RCTASD 6
           RCTA+D
Sbjct: 400 RCTAAD 405
>NP_060386
          Length = 290

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   CTASDVA 8
           CTA DVA
Sbjct: 117 CTAYDVA 123
>NP_060251
          Length = 490

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RCTASD 6
           RCTA+D
Sbjct: 366 RCTAAD 371
>NP_001265509
          Length = 405

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RCTASD 6
           RCTA+D
Sbjct: 292 RCTAAD 297
>NP_001265508
          Length = 513

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RCTASD 6
           RCTA+D
Sbjct: 400 RCTAAD 405
>XP_005249849
          Length = 490

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RCTASD 6
           RCTA+D
Sbjct: 366 RCTAAD 371
>NP_001137461
          Length = 638

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   CTASDVAQ 9
           C+A DVA+
Sbjct: 303 CSAQDVAR 310
>XP_005271201
          Length = 715

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   CTASDVAQ 9
           C+A DVA+
Sbjct: 380 CSAQDVAR 387
>XP_006710441
          Length = 627

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   CTASDVAQ 9
           C+A DVA+
Sbjct: 292 CSAQDVAR 299
>XP_005270554
          Length = 715

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   CTASDVAQ 9
           C+A DVA+
Sbjct: 380 CSAQDVAR 387
>NP_001137459
          Length = 667

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   CTASDVAQ 9
           C+A DVA+
Sbjct: 332 CSAQDVAR 339
>NP_001137460
          Length = 638

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   CTASDVAQ 9
           C+A DVA+
Sbjct: 303 CSAQDVAR 310
>NP_055558
          Length = 1395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   RCTASDV 7
           +C ASDV
Sbjct: 960 QCAASDV 966
>NP_001094060
          Length = 1395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   RCTASDV 7
           +C ASDV
Sbjct: 960 QCAASDV 966
>NP_004123
          Length = 560

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   CTASDVA 8
           C+A DVA
Sbjct: 276 CSAQDVA 282
>NP_006749
          Length = 240

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1  RCTASDV 7
          RC  SDV
Sbjct: 66 RCAVSDV 72
>NP_001171131
          Length = 534

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   CTASDVA 8
           C+A DVA
Sbjct: 250 CSAQDVA 256
>NP_060134
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   TASDVAQ 9
           TA+D+AQ
Sbjct: 160 TAADIAQ 166
>NP_002198
          Length = 1035

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RCTASDVAQ 9
           RCT  D+A+
Sbjct: 96  RCTELDMAR 104
>NP_065754
          Length = 493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   RCTASDVAQ 9
           RC   D+AQ
Sbjct: 151 RCAFDDMAQ 159
>NP_001041445
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   CTASDVA 8
           C+A DVA
Sbjct: 353 CSAQDVA 359
>NP_005551
          Length = 3695

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2    CTASDV 7
            CT SDV
Sbjct: 1090 CTGSDV 1095
>XP_006726862
          Length = 240

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1  RCTASDV 7
          RC  SDV
Sbjct: 66 RCAVSDV 72
>XP_006723991
          Length = 240

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1  RCTASDV 7
          RC  SDV
Sbjct: 66 RCAVSDV 72
>XP_006723861
          Length = 2300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2    CTASDV 7
            CT SDV
Sbjct: 1090 CTGSDV 1095
>XP_006723860
          Length = 2586

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2    CTASDV 7
            CT SDV
Sbjct: 1090 CTGSDV 1095
>XP_006723859
          Length = 3700

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2    CTASDV 7
            CT SDV
Sbjct: 1090 CTGSDV 1095
>XP_005271769
          Length = 677

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1  RCTASD 6
          RC ASD
Sbjct: 19 RCVASD 24
>XP_005248098
          Length = 1310

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   RCTASDV 7
           +C ASDV
Sbjct: 851 QCAASDV 857
>XP_006713998
          Length = 1332

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   RCTASDV 7
           +C ASDV
Sbjct: 960 QCAASDV 966
>XP_006713997
          Length = 1419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   RCTASDV 7
           +C ASDV
Sbjct: 960 QCAASDV 966
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.319    0.116    0.345 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 432,112
Number of extensions: 447
Number of successful extensions: 60
Number of sequences better than 10000.0: 60
Number of HSP's gapped: 60
Number of HSP's successfully gapped: 60
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package