Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005219                                                              19     869
NP_004565                                                              17    2528
NP_536340                                                              17    2528
NP_536341                                                              17    2528
NP_001243711                                                           17    2528
NP_001185642                                                           17    2528
NP_001243751                                                           17    2528
XP_006722018                                                           17    2528
XP_006722017                                                           17    2528
XP_006722016                                                           17    2528
XP_006722015                                                           17    2528
XP_006722014                                                           17    2528
XP_006722013                                                           17    2528
XP_006722012                                                           17    2528
NP_775899                                                              17    3301
NP_079092                                                              17    4312
NP_001120652                                                           16    5631
NP_000251                                                              16    5631
XP_006718624                                                           16    5631
XP_005274069                                                           16    5631
XP_006718623                                                           16    5631
XP_006718622                                                           16    5631
XP_006718621                                                           16    5631
NP_066566                                                              16    7355
NP_006166                                                              16    7355
NP_001248392                                                           16    7355
NP_932326                                                              16    7355
NP_078918                                                              16    7355
NP_001248393                                                           16    7355
NP_997074                                                              16    7355
NP_001248394                                                           16    7355
NP_997078                                                              16    7355
NP_997077                                                              16    7355
NP_997079                                                              16    7355
NP_997080                                                              16    7355
NP_003806                                                              16    7355
XP_005269924                                                           16    7355
XP_005269922                                                           16    7355
XP_006717933                                                           16    7355
XP_005269921                                                           16    7355
NP_919268                                                              16    7355
NP_000229                                                              15    9605
NP_742053                                                              15    9605
NP_001036065                                                           15    9605
NP_840101                                                              15    9605
NP_612376                                                              15    9605
NP_009112                                                              15    9605
NP_110406                                                              15    9605
NP_001265848                                                           15    9605
NP_775115                                                              15    9605
XP_006725123                                                           15    9605
XP_006725122                                                           15    9605
XP_006723056                                                           15    9605
XP_005256367                                                           15    9605
XP_006716746                                                           15    9605
XP_005272413                                                           15    9605
XP_006716745                                                           15    9605
XP_006716744                                                           15    9605
XP_005272410                                                           15    9605
XP_005272409                                                           15    9605
XP_006716040                                                           15    9605
>NP_005219
          Length = 1210

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   AKLLGAEE 9
           AKLLGAEE
Sbjct: 859 AKLLGAEE 866
>NP_004565
          Length = 478

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   KLLGAEE 9
           KLLGAEE
Sbjct: 174 KLLGAEE 180
>NP_536340
          Length = 274

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   KLLGAEE 9
           KLLGAEE
Sbjct: 155 KLLGAEE 161
>NP_536341
          Length = 459

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   KLLGAEE 9
           KLLGAEE
Sbjct: 155 KLLGAEE 161
>NP_001243711
          Length = 493

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   KLLGAEE 9
           KLLGAEE
Sbjct: 189 KLLGAEE 195
>NP_001185642
          Length = 470

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   KLLGAEE 9
           KLLGAEE
Sbjct: 166 KLLGAEE 172
>NP_001243751
          Length = 331

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3  KLLGAEE 9
          KLLGAEE
Sbjct: 27 KLLGAEE 33
>XP_006722018
          Length = 331

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3  KLLGAEE 9
          KLLGAEE
Sbjct: 27 KLLGAEE 33
>XP_006722017
          Length = 331

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3  KLLGAEE 9
          KLLGAEE
Sbjct: 27 KLLGAEE 33
>XP_006722016
          Length = 331

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3  KLLGAEE 9
          KLLGAEE
Sbjct: 27 KLLGAEE 33
>XP_006722015
          Length = 360

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3  KLLGAEE 9
          KLLGAEE
Sbjct: 56 KLLGAEE 62
>XP_006722014
          Length = 379

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3  KLLGAEE 9
          KLLGAEE
Sbjct: 75 KLLGAEE 81
>XP_006722013
          Length = 384

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3  KLLGAEE 9
          KLLGAEE
Sbjct: 80 KLLGAEE 86
>XP_006722012
          Length = 483

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   KLLGAEE 9
           KLLGAEE
Sbjct: 179 KLLGAEE 185
>NP_775899
          Length = 4462

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  AKLLGAEE 9
          +KL+GAEE
Sbjct: 28 SKLIGAEE 35
>NP_079092
          Length = 569

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RAKLLGAEE 9
           +AKLL AEE
Sbjct: 167 KAKLLRAEE 175
>NP_001120652
          Length = 2175

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    KLLGAEE 9
            KLLG+EE
Sbjct: 1721 KLLGSEE 1727
>NP_000251
          Length = 2215

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    KLLGAEE 9
            KLLG+EE
Sbjct: 1759 KLLGSEE 1765
>XP_006718624
          Length = 2177

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    KLLGAEE 9
            KLLG+EE
Sbjct: 1721 KLLGSEE 1727
>XP_005274069
          Length = 2176

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    KLLGAEE 9
            KLLG+EE
Sbjct: 1720 KLLGSEE 1726
>XP_006718623
          Length = 2189

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    KLLGAEE 9
            KLLG+EE
Sbjct: 1720 KLLGSEE 1726
>XP_006718622
          Length = 2190

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    KLLGAEE 9
            KLLG+EE
Sbjct: 1721 KLLGSEE 1727
>XP_006718621
          Length = 2225

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    KLLGAEE 9
            KLLG+EE
Sbjct: 1756 KLLGSEE 1762
>NP_066566
          Length = 555

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RAKLLGAEE 9
          +AKL+G +E
Sbjct: 43 KAKLIGIDE 51
>NP_006166
          Length = 1695

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RAKLLGAEE 9
           R KL+GA++
Sbjct: 795 RGKLIGAKD 803
>NP_001248392
          Length = 1731

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RAKLLGAEE 9
           R KL+GA++
Sbjct: 830 RGKLIGAKD 838
>NP_932326
          Length = 1730

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RAKLLGAEE 9
           R KL+GA++
Sbjct: 830 RGKLIGAKD 838
>NP_078918
          Length = 581

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RAKLLGA 7
           RA+LLGA
Sbjct: 210 RARLLGA 216
>NP_001248393
          Length = 824

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RAKLLGAEE 9
           R  LLGA+E
Sbjct: 658 RVDLLGAQE 666
>NP_997074
          Length = 772

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RAKLLGAEE 9
           R  LLGA+E
Sbjct: 648 RVDLLGAQE 656
>NP_001248394
          Length = 796

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RAKLLGAEE 9
           R  LLGA+E
Sbjct: 648 RVDLLGAQE 656
>NP_997078
          Length = 838

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RAKLLGAEE 9
           R  LLGA+E
Sbjct: 648 RVDLLGAQE 656
>NP_997077
          Length = 839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RAKLLGAEE 9
           R  LLGA+E
Sbjct: 648 RVDLLGAQE 656
>NP_997079
          Length = 862

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RAKLLGAEE 9
           R  LLGA+E
Sbjct: 648 RVDLLGAQE 656
>NP_997080
          Length = 863

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RAKLLGAEE 9
           R  LLGA+E
Sbjct: 648 RVDLLGAQE 656
>NP_003806
          Length = 814

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RAKLLGAEE 9
           R  LLGA+E
Sbjct: 648 RVDLLGAQE 656
>XP_005269924
          Length = 1627

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RAKLLGAEE 9
           R KL+GA++
Sbjct: 830 RGKLIGAKD 838
>XP_005269922
          Length = 1695

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RAKLLGAEE 9
           R KL+GA++
Sbjct: 794 RGKLIGAKD 802
>XP_006717933
          Length = 1696

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RAKLLGAEE 9
           R KL+GA++
Sbjct: 830 RGKLIGAKD 838
>XP_005269921
          Length = 1696

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RAKLLGAEE 9
           R KL+GA++
Sbjct: 795 RGKLIGAKD 803
>NP_919268
          Length = 657

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RAKLLGAEE 9
           +AKL G EE
Sbjct: 279 KAKLSGVEE 287
>NP_000229
          Length = 1159

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LLGAEE 9
          LLGAEE
Sbjct: 86 LLGAEE 91
>NP_742053
          Length = 888

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LLGAEE 9
          LLGAEE
Sbjct: 86 LLGAEE 91
>NP_001036065
          Length = 821

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LLGAEE 9
           LLGAEE
Sbjct: 515 LLGAEE 520
>NP_840101
          Length = 292

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   KLLGAE 8
           KLLGAE
Sbjct: 138 KLLGAE 143
>NP_612376
          Length = 671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LLGAEE 9
          LLGAEE
Sbjct: 78 LLGAEE 83
>NP_009112
          Length = 833

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LLGAEE 9
           LLGAEE
Sbjct: 515 LLGAEE 520
>NP_110406
          Length = 994

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LLGAEE 9
          LLGAEE
Sbjct: 86 LLGAEE 91
>NP_001265848
          Length = 958

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LLGAEE 9
          LLGAEE
Sbjct: 86 LLGAEE 91
>NP_775115
          Length = 905

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LLGAEE 9
          LLGAEE
Sbjct: 86 LLGAEE 91
>XP_006725123
          Length = 671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LLGAEE 9
          LLGAEE
Sbjct: 78 LLGAEE 83
>XP_006725122
          Length = 671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LLGAEE 9
          LLGAEE
Sbjct: 78 LLGAEE 83
>XP_006723056
          Length = 801

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LLGAEE 9
           LLGAEE
Sbjct: 515 LLGAEE 520
>XP_005256367
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   KLLGAE 8
           KLLGAE
Sbjct: 138 KLLGAE 143
>XP_006716746
          Length = 99

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LLGAEE 9
          LLGAEE
Sbjct: 78 LLGAEE 83
>XP_005272413
          Length = 99

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LLGAEE 9
          LLGAEE
Sbjct: 78 LLGAEE 83
>XP_006716745
          Length = 112

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LLGAEE 9
          LLGAEE
Sbjct: 78 LLGAEE 83
>XP_006716744
          Length = 671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LLGAEE 9
          LLGAEE
Sbjct: 78 LLGAEE 83
>XP_005272410
          Length = 671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LLGAEE 9
          LLGAEE
Sbjct: 78 LLGAEE 83
>XP_005272409
          Length = 671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LLGAEE 9
          LLGAEE
Sbjct: 78 LLGAEE 83
>XP_006716040
          Length = 1137

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LLGAEE 9
          LLGAEE
Sbjct: 86 LLGAEE 91
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.308    0.129    0.318 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 464,539
Number of extensions: 865
Number of successful extensions: 61
Number of sequences better than 10000.0: 61
Number of HSP's gapped: 61
Number of HSP's successfully gapped: 61
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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