Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_733751                                                              20     299
XP_006716142                                                           20     299
XP_005250088                                                           20     299
XP_006716141                                                           20     299
XP_005250085                                                           20     299
XP_006716140                                                           20     299
XP_005250084                                                           20     299
XP_005250083                                                           20     299
XP_005250082                                                           20     299
NP_003325                                                              17    3301
NP_695012                                                              17    3301
XP_005272707                                                           17    3301
XP_005272706                                                           17    3301
XP_005272705                                                           17    3301
NP_055835                                                              17    4312
NP_001275932                                                           17    4312
NP_001034438                                                           16    5631
NP_001034437                                                           16    5631
NP_009124                                                              16    5631
NP_848665                                                              16    5631
NP_065075                                                              16    5631
XP_006714136                                                           16    5631
XP_005246749                                                           16    5631
XP_005246746                                                           16    5631
XP_005264262                                                           16    5631
NP_001120729                                                           16    5631
NP_997320                                                              16    7355
NP_056234                                                              16    7355
NP_991331                                                              16    7355
NP_001265125                                                           16    7355
NP_001131073                                                           16    7355
NP_079216                                                              16    7355
NP_006343                                                              16    7355
XP_005274542                                                           16    7355
XP_005253612                                                           16    7355
XP_005273708                                                           16    7355
XP_006716465                                                           16    7355
XP_005273707                                                           16    7355
XP_005273063                                                           16    7355
NP_115803                                                              15    9605
NP_001157941                                                           15    9605
NP_001157940                                                           15    9605
NP_861974                                                              15    9605
NP_848663                                                              15    9605
NP_115971                                                              15    9605
NP_060899                                                              15    9605
NP_036475                                                              15    9605
NP_835260                                                              15    9605
XP_006725524                                                           15    9605
XP_006725523                                                           15    9605
XP_005276828                                                           15    9605
XP_006726279                                                           15    9605
XP_005254320                                                           15    9605
XP_006714722                                                           15    9605
XP_006714721                                                           15    9605
XP_006714524                                                           15    9605
XP_005248331                                                           15    9605
XP_006714523                                                           15    9605
XP_005248329                                                           15    9605
XP_005248328                                                           15    9605
XP_006714522                                                           15    9605
XP_006714521                                                           15    9605
XP_006714520                                                           15    9605
XP_005248327                                                           15    9605
XP_005248326                                                           15    9605
XP_006714519                                                           15    9605
NP_031390                                                              15    9605
NP_892022                                                              15    9605
>NP_733751
          Length = 4911

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    QYSNNIST 8
            QYSNNIST
Sbjct: 4279 QYSNNIST 4286
>XP_006716142
          Length = 4927

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    QYSNNIST 8
            QYSNNIST
Sbjct: 4295 QYSNNIST 4302
>XP_005250088
          Length = 4928

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    QYSNNIST 8
            QYSNNIST
Sbjct: 4296 QYSNNIST 4303
>XP_006716141
          Length = 4959

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    QYSNNIST 8
            QYSNNIST
Sbjct: 4327 QYSNNIST 4334
>XP_005250085
          Length = 4979

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    QYSNNIST 8
            QYSNNIST
Sbjct: 4351 QYSNNIST 4358
>XP_006716140
          Length = 4982

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    QYSNNIST 8
            QYSNNIST
Sbjct: 4350 QYSNNIST 4357
>XP_005250084
          Length = 4982

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    QYSNNIST 8
            QYSNNIST
Sbjct: 4350 QYSNNIST 4357
>XP_005250083
          Length = 4982

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    QYSNNIST 8
            QYSNNIST
Sbjct: 4350 QYSNNIST 4357
>XP_005250082
          Length = 4983

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    QYSNNIST 8
            QYSNNIST
Sbjct: 4351 QYSNNIST 4358
>NP_003325
          Length = 1058

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QYSNNI 6
           QYSNNI
Sbjct: 717 QYSNNI 722
>NP_695012
          Length = 1058

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QYSNNI 6
           QYSNNI
Sbjct: 717 QYSNNI 722
>XP_005272707
          Length = 1058

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QYSNNI 6
           QYSNNI
Sbjct: 717 QYSNNI 722
>XP_005272706
          Length = 1064

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QYSNNI 6
           QYSNNI
Sbjct: 723 QYSNNI 728
>XP_005272705
          Length = 1109

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QYSNNI 6
           QYSNNI
Sbjct: 768 QYSNNI 773
>NP_055835
          Length = 1323

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YSNNISTF 9
           +SNNIS F
Sbjct: 699 HSNNISIF 706
>NP_001275932
          Length = 1256

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YSNNISTF 9
           +SNNIS F
Sbjct: 632 HSNNISIF 639
>NP_001034438
          Length = 493

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YSNNISTF 9
           Y+N I+TF
Sbjct: 419 YANTINTF 426
>NP_001034437
          Length = 493

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YSNNISTF 9
           Y+N I+TF
Sbjct: 419 YANTINTF 426
>NP_009124
          Length = 324

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QYSNNI 6
           QYSNN+
Sbjct: 134 QYSNNL 139
>NP_848665
          Length = 420

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  YSNNIST 8
          +SNN+ST
Sbjct: 90 FSNNLST 96
>NP_065075
          Length = 831

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QYSNNIS 7
           QY+NNI+
Sbjct: 754 QYANNIT 760
>XP_006714136
          Length = 347

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QYSNNI 6
           QYSNN+
Sbjct: 157 QYSNNL 162
>XP_005246749
          Length = 381

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QYSNNIS 7
           QY+NNI+
Sbjct: 304 QYANNIT 310
>XP_005246746
          Length = 898

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QYSNNIS 7
           QY+NNI+
Sbjct: 821 QYANNIT 827
>XP_005264262
          Length = 543

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YSNNISTF 9
           Y+N I+TF
Sbjct: 469 YANTINTF 476
>NP_001120729
          Length = 831

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QYSNNIS 7
           QY+NNI+
Sbjct: 754 QYANNIT 760
>NP_997320
          Length = 4471

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    YSNNISTF 9
            Y NNI+ F
Sbjct: 3820 YDNNITPF 3827
>NP_056234
          Length = 2828

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   QYSNNIST 8
           QYS  IST
Sbjct: 458 QYSQTIST 465
>NP_991331
          Length = 531

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QYSNNIS 7
           QYS+N+S
Sbjct: 457 QYSHNLS 463
>NP_001265125
          Length = 522

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QYSNNIS 7
           QYS+N+S
Sbjct: 448 QYSHNLS 454
>NP_001131073
          Length = 422

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QYSNNIS 7
           QYS+N+S
Sbjct: 372 QYSHNLS 378
>NP_079216
          Length = 1870

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YSNNISTF 9
           YS+ ISTF
Sbjct: 969 YSHYISTF 976
>NP_006343
          Length = 522

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QYSNNIS 7
           QYS+N+S
Sbjct: 448 QYSHNLS 454
>XP_005274542
          Length = 2853

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   QYSNNIST 8
           QYS  IST
Sbjct: 483 QYSQTIST 490
>XP_005253612
          Length = 4589

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    YSNNISTF 9
            Y NNI+ F
Sbjct: 3938 YDNNITPF 3945
>XP_005273708
          Length = 1032

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YSNNISTF 9
           YS+ ISTF
Sbjct: 683 YSHYISTF 690
>XP_006716465
          Length = 1826

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YSNNISTF 9
           YS+ ISTF
Sbjct: 969 YSHYISTF 976
>XP_005273707
          Length = 1847

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YSNNISTF 9
           YS+ ISTF
Sbjct: 969 YSHYISTF 976
>XP_005273063
          Length = 522

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QYSNNIS 7
           QYS+N+S
Sbjct: 448 QYSHNLS 454
>NP_115803
          Length = 1156

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   SNNISTF 9
           +NN++TF
Sbjct: 919 NNNVATF 925
>NP_001157941
          Length = 188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YSNNISTF 9
           +SN  STF
Sbjct: 110 FSNEFSTF 117
>NP_001157940
          Length = 404

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YSNNISTF 9
           +SN  STF
Sbjct: 110 FSNEFSTF 117
>NP_861974
          Length = 224

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YSNNISTF 9
           +SN  STF
Sbjct: 110 FSNEFSTF 117
>NP_848663
          Length = 441

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  YSNNIS 7
          YSNNI+
Sbjct: 84 YSNNIT 89
>NP_115971
          Length = 1604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QYSNNIST 8
           ++S+NIST
Sbjct: 460 KFSDNIST 467
>NP_060899
          Length = 2624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    SNNISTF 9
            +NN++TF
Sbjct: 1551 TNNVNTF 1557
>NP_036475
          Length = 1086

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YSNNIS 7
           YSNNI+
Sbjct: 388 YSNNIT 393
>NP_835260
          Length = 2839

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    YSNNISTF 9
            YS N S+F
Sbjct: 1523 YSRNFSSF 1530
>XP_006725524
          Length = 2584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    SNNISTF 9
            +NN++TF
Sbjct: 1551 TNNVNTF 1557
>XP_006725523
          Length = 2623

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    SNNISTF 9
            +NN++TF
Sbjct: 1551 TNNVNTF 1557
>XP_005276828
          Length = 2584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    SNNISTF 9
            +NN++TF
Sbjct: 1551 TNNVNTF 1557
>XP_006726279
          Length = 2623

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    SNNISTF 9
            +NN++TF
Sbjct: 1551 TNNVNTF 1557
>XP_005254320
          Length = 155

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YSNNISTF 9
           +SN  STF
Sbjct: 102 FSNEFSTF 109
>XP_006714722
          Length = 2584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    SNNISTF 9
            +NN++TF
Sbjct: 1551 TNNVNTF 1557
>XP_006714721
          Length = 2623

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    SNNISTF 9
            +NN++TF
Sbjct: 1551 TNNVNTF 1557
>XP_006714524
          Length = 955

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YSNNIS 7
           YSNNI+
Sbjct: 257 YSNNIT 262
>XP_005248331
          Length = 1086

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YSNNIS 7
           YSNNI+
Sbjct: 388 YSNNIT 393
>XP_006714523
          Length = 2542

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    YSNNISTF 9
            YS N S+F
Sbjct: 1192 YSRNFSSF 1199
>XP_005248329
          Length = 2699

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    YSNNISTF 9
            YS N S+F
Sbjct: 1349 YSRNFSSF 1356
>XP_005248328
          Length = 2699

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    YSNNISTF 9
            YS N S+F
Sbjct: 1349 YSRNFSSF 1356
>XP_006714522
          Length = 2719

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    YSNNISTF 9
            YS N S+F
Sbjct: 1369 YSRNFSSF 1376
>XP_006714521
          Length = 2781

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    YSNNISTF 9
            YS N S+F
Sbjct: 1431 YSRNFSSF 1438
>XP_006714520
          Length = 2802

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    YSNNISTF 9
            YS N S+F
Sbjct: 1452 YSRNFSSF 1459
>XP_005248327
          Length = 2839

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    YSNNISTF 9
            YS N S+F
Sbjct: 1523 YSRNFSSF 1530
>XP_005248326
          Length = 2873

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    YSNNISTF 9
            YS N S+F
Sbjct: 1523 YSRNFSSF 1530
>XP_006714519
          Length = 2873

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    YSNNISTF 9
            YS N S+F
Sbjct: 1523 YSRNFSSF 1530
>NP_031390
          Length = 217

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YSNNISTF 9
           +SN  STF
Sbjct: 102 FSNEFSTF 109
>NP_892022
          Length = 1086

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YSNNIS 7
           YSNNI+
Sbjct: 388 YSNNIT 393
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.310    0.119    0.324 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 507,870
Number of extensions: 942
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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