Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001002021                                                           17    4312
NP_002617                                                              17    4312
XP_005261194                                                           17    4312
XP_005261193                                                           17    4312
XP_005261192                                                           17    4312
XP_006724075                                                           17    4312
XP_006724074                                                           17    4312
NP_001661                                                              16    5631
XP_006724314                                                           16    5631
XP_006724313                                                           16    5631
XP_006724312                                                           16    5631
XP_006724311                                                           16    5631
XP_006724310                                                           16    5631
XP_006724309                                                           16    5631
XP_005261301                                                           16    5631
XP_006724308                                                           16    5631
XP_005261300                                                           16    5631
XP_006724307                                                           16    5631
XP_005261299                                                           16    5631
XP_006724306                                                           16    5631
NP_071913                                                              16    7355
NP_001035059                                                           16    7355
NP_001265168                                                           16    7355
NP_001265165                                                           16    7355
NP_002556                                                              16    7355
NP_116170                                                              16    7355
NP_008837                                                              16    7355
NP_001265167                                                           16    7355
NP_000594                                                              15    9605
NP_955373                                                              15    9605
NP_001036009                                                           15    9605
NP_001036010                                                           15    9605
NP_003564                                                              15    9605
XP_006723268                                                           15    9605
XP_005259506                                                           15    9605
XP_006723267                                                           15    9605
XP_006722332                                                           15    9605
XP_006716064                                                           15    9605
XP_006716063                                                           15    9605
>NP_001002021
          Length = 830

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QVRQLRGGS 9
           +  QLRGGS
Sbjct: 419 EATQLRGGS 427
>NP_002617
          Length = 780

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QVRQLRGGS 9
           +  QLRGGS
Sbjct: 369 EATQLRGGS 377
>XP_005261194
          Length = 751

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QVRQLRGGS 9
           +  QLRGGS
Sbjct: 340 EATQLRGGS 348
>XP_005261193
          Length = 774

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QVRQLRGGS 9
           +  QLRGGS
Sbjct: 363 EATQLRGGS 371
>XP_005261192
          Length = 803

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QVRQLRGGS 9
           +  QLRGGS
Sbjct: 392 EATQLRGGS 400
>XP_006724075
          Length = 830

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QVRQLRGGS 9
           +  QLRGGS
Sbjct: 419 EATQLRGGS 427
>XP_006724074
          Length = 853

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QVRQLRGGS 9
           +  QLRGGS
Sbjct: 442 EATQLRGGS 450
>NP_001661
          Length = 962

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QVRQLRG 7
           +VRQLRG
Sbjct: 395 RVRQLRG 401
>XP_006724314
          Length = 656

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QVRQLRG 7
           +VRQLRG
Sbjct: 395 RVRQLRG 401
>XP_006724313
          Length = 661

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QVRQLRG 7
           +VRQLRG
Sbjct: 395 RVRQLRG 401
>XP_006724312
          Length = 667

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QVRQLRG 7
           +VRQLRG
Sbjct: 395 RVRQLRG 401
>XP_006724311
          Length = 893

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QVRQLRG 7
           +VRQLRG
Sbjct: 332 RVRQLRG 338
>XP_006724310
          Length = 899

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QVRQLRG 7
           +VRQLRG
Sbjct: 332 RVRQLRG 338
>XP_006724309
          Length = 922

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QVRQLRG 7
           +VRQLRG
Sbjct: 313 RVRQLRG 319
>XP_005261301
          Length = 929

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QVRQLRG 7
           +VRQLRG
Sbjct: 395 RVRQLRG 401
>XP_006724308
          Length = 935

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QVRQLRG 7
           +VRQLRG
Sbjct: 395 RVRQLRG 401
>XP_005261300
          Length = 956

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QVRQLRG 7
           +VRQLRG
Sbjct: 395 RVRQLRG 401
>XP_006724307
          Length = 986

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QVRQLRG 7
           +VRQLRG
Sbjct: 395 RVRQLRG 401
>XP_005261299
          Length = 998

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QVRQLRG 7
           +VRQLRG
Sbjct: 395 RVRQLRG 401
>XP_006724306
          Length = 1004

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QVRQLRG 7
           +VRQLRG
Sbjct: 395 RVRQLRG 401
>NP_071913
          Length = 562

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QVRQLRGGS 9
           Q RQL GG+
Sbjct: 394 QDRQLEGGA 402
>NP_001035059
          Length = 533

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QVRQLRGG 8
           Q+RQ RGG
Sbjct: 498 QLRQDRGG 505
>NP_001265168
          Length = 509

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QVRQLRGG 8
           Q+RQ RGG
Sbjct: 474 QLRQDRGG 481
>NP_001265165
          Length = 533

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QVRQLRGG 8
           Q+RQ RGG
Sbjct: 498 QLRQDRGG 505
>NP_002556
          Length = 365

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QVRQLRGG 8
           Q+RQL GG
Sbjct: 316 QLRQLCGG 323
>NP_116170
          Length = 565

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QVRQLRGG 8
           Q+RQ RGG
Sbjct: 530 QLRQDRGG 537
>NP_008837
          Length = 565

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QVRQLRGG 8
           Q+RQ RGG
Sbjct: 530 QLRQDRGG 537
>NP_001265167
          Length = 541

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QVRQLRGG 8
           Q+RQ RGG
Sbjct: 506 QLRQDRGG 513
>NP_000594
          Length = 1203

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    QVRQLRG 7
            Q RQLRG
Sbjct: 1181 QERQLRG 1187
>NP_955373
          Length = 920

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   QVRQLRGG 8
           Q+R  RGG
Sbjct: 519 QIRDWRGG 526
>NP_001036009
          Length = 1624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RQLRGG 8
           R+LRGG
Sbjct: 291 RELRGG 296
>NP_001036010
          Length = 1557

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RQLRGG 8
           R+LRGG
Sbjct: 224 RELRGG 229
>NP_003564
          Length = 1587

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RQLRGG 8
           R+LRGG
Sbjct: 254 RELRGG 259
>XP_006723268
          Length = 920

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   QVRQLRGG 8
           Q+R  RGG
Sbjct: 519 QIRDWRGG 526
>XP_005259506
          Length = 933

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   QVRQLRGG 8
           Q+R  RGG
Sbjct: 532 QIRDWRGG 539
>XP_006723267
          Length = 947

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   QVRQLRGG 8
           Q+R  RGG
Sbjct: 546 QIRDWRGG 553
>XP_006722332
          Length = 376

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QVRQLRGG 8
           Q+ Q+RGG
Sbjct: 127 QLLQIRGG 134
>XP_006716064
          Length = 997

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   QVRQLRG 7
           Q RQLRG
Sbjct: 975 QERQLRG 981
>XP_006716063
          Length = 1203

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    QVRQLRG 7
            Q RQLRG
Sbjct: 1181 QERQLRG 1187
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.319    0.137    0.371 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 638,953
Number of extensions: 997
Number of successful extensions: 39
Number of sequences better than 10000.0: 39
Number of HSP's gapped: 39
Number of HSP's successfully gapped: 39
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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