Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_055726                                                              18    1135
NP_001164231                                                           17    3301
NP_001164232                                                           17    3301
NP_055185                                                              17    3301
NP_000797                                                              17    3301
NP_001121115                                                           17    3301
NP_001121116                                                           17    3301
NP_001121117                                                           17    3301
NP_001121120                                                           17    3301
NP_004646                                                              17    4312
NP_714916                                                              17    4312
XP_005257776                                                           17    4312
NP_444511                                                              16    5631
NP_001229241                                                           16    5631
NP_659456                                                              16    5631
NP_001157934                                                           16    5631
NP_001132986                                                           16    5631
NP_001132987                                                           16    5631
XP_005262125                                                           16    5631
NP_065188                                                              16    7355
NP_001027566                                                           16    7355
NP_001027567                                                           16    7355
NP_940971                                                              16    7355
NP_055975                                                              16    7355
NP_071940                                                              16    7355
NP_060517                                                              16    7355
NP_001074003                                                           16    7355
XP_005254452                                                           16    7355
XP_005254451                                                           16    7355
XP_005268066                                                           16    7355
XP_005266116                                                           16    7355
XP_005267118                                                           16    7355
XP_006715581                                                           16    7355
XP_006715580                                                           16    7355
XP_006715579                                                           16    7355
XP_005268536                                                           16    7355
NP_001449                                                              15    9605
NP_001120959                                                           15    9605
NP_001128530                                                           15    9605
NP_004077                                                              15    9605
NP_644670                                                              15    9605
NP_004438                                                              15    9605
NP_777576                                                              15    9605
NP_055318                                                              15    9605
NP_612373                                                              15    9605
XP_006720136                                                           15    9605
XP_006719406                                                           15    9605
XP_006719120                                                           15    9605
XP_005253397                                                           15    9605
XP_005253396                                                           15    9605
XP_006719093                                                           15    9605
XP_006715973                                                           15    9605
XP_005263396                                                           15    9605
XP_005263395                                                           15    9605
XP_005248043                                                           15    9605
XP_006713958                                                           15    9605
NP_065824                                                              15    9605
NP_001106832                                                           15    9605
>NP_055726
          Length = 961

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QTVDSGLRL 9
           QTVDSGL L
Sbjct: 764 QTVDSGLPL 772
>NP_001164231
          Length = 566

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   QTVDSGLRL 9
           Q  DSGLRL
Sbjct: 299 QAEDSGLRL 307
>NP_001164232
          Length = 533

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   QTVDSGLRL 9
           Q  DSGLRL
Sbjct: 299 QAEDSGLRL 307
>NP_055185
          Length = 567

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   QTVDSGLRL 9
           Q  DSGLRL
Sbjct: 300 QAEDSGLRL 308
>NP_000797
          Length = 456

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QTVDSGL 7
           QTVDSG+
Sbjct: 223 QTVDSGI 229
>NP_001121115
          Length = 456

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QTVDSGL 7
           QTVDSG+
Sbjct: 223 QTVDSGI 229
>NP_001121116
          Length = 456

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QTVDSGL 7
           QTVDSG+
Sbjct: 223 QTVDSGI 229
>NP_001121117
          Length = 456

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QTVDSGL 7
           QTVDSG+
Sbjct: 223 QTVDSGI 229
>NP_001121120
          Length = 456

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QTVDSGL 7
           QTVDSG+
Sbjct: 223 QTVDSGI 229
>NP_004646
          Length = 843

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QTVDSGLR 8
           +TVDSG R
Sbjct: 265 ETVDSGYR 272
>NP_714916
          Length = 507

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QTVDSGLRL 9
           +TVD GL++
Sbjct: 108 ETVDEGLKI 116
>XP_005257776
          Length = 778

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QTVDSGLR 8
           +TVDSG R
Sbjct: 265 ETVDSGYR 272
>NP_444511
          Length = 599

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TVDSGLRL 9
           T DSGLR+
Sbjct: 552 TSDSGLRM 559
>NP_001229241
          Length = 546

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VDSGLRL 9
           VD+GLRL
Sbjct: 414 VDTGLRL 420
>NP_659456
          Length = 582

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VDSGLRL 9
           VD+GLRL
Sbjct: 450 VDTGLRL 456
>NP_001157934
          Length = 5335

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    QTVDSGLRL 9
            +TVDSG  L
Sbjct: 5315 ETVDSGTEL 5323
>NP_001132986
          Length = 571

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TVDSGLRL 9
           T DSGLR+
Sbjct: 539 TSDSGLRM 546
>NP_001132987
          Length = 432

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TVDSGLRL 9
           T DSGLR+
Sbjct: 385 TSDSGLRM 392
>XP_005262125
          Length = 465

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TVDSGLRL 9
           T DSGLR+
Sbjct: 418 TSDSGLRM 425
>NP_065188
          Length = 1221

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QTVDSGLRL 9
           +++D GLRL
Sbjct: 506 ESLDEGLRL 514
>NP_001027566
          Length = 1193

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QTVDSGLRL 9
           +++D GLRL
Sbjct: 478 ESLDEGLRL 486
>NP_001027567
          Length = 1222

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QTVDSGLRL 9
           +++D GLRL
Sbjct: 478 ESLDEGLRL 486
>NP_940971
          Length = 1250

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QTVDSGLRL 9
           +++D GLRL
Sbjct: 506 ESLDEGLRL 514
>NP_055975
          Length = 525

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  TVDSGLRL 9
          T+D+GLR+
Sbjct: 71 TLDNGLRV 78
>NP_071940
          Length = 938

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   QTVDSGLRL 9
           +++D+GLRL
Sbjct: 282 RSLDTGLRL 290
>NP_060517
          Length = 420

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TVDSGLRL 9
           T DSG++L
Sbjct: 318 TTDSGIKL 325
>NP_001074003
          Length = 2214

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QTVDSGL 7
           +TVDSG+
Sbjct: 623 ETVDSGM 629
>XP_005254452
          Length = 2188

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QTVDSGL 7
           +TVDSG+
Sbjct: 623 ETVDSGM 629
>XP_005254451
          Length = 2214

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QTVDSGL 7
           +TVDSG+
Sbjct: 623 ETVDSGM 629
>XP_005268066
          Length = 1172

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   QTVDSGLRL 9
           +++D+GLRL
Sbjct: 516 RSLDTGLRL 524
>XP_005266116
          Length = 563

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  TVDSGLRL 9
          T+D+GLR+
Sbjct: 71 TLDNGLRV 78
>XP_005267118
          Length = 1222

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QTVDSGLRL 9
           +++D GLRL
Sbjct: 507 ESLDEGLRL 515
>XP_006715581
          Length = 1223

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QTVDSGLRL 9
           +++D GLRL
Sbjct: 479 ESLDEGLRL 487
>XP_006715580
          Length = 1249

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QTVDSGLRL 9
           +++D GLRL
Sbjct: 505 ESLDEGLRL 513
>XP_006715579
          Length = 1251

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QTVDSGLRL 9
           +++D GLRL
Sbjct: 507 ESLDEGLRL 515
>XP_005268536
          Length = 539

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TVDSGLRL 9
           T DSG++L
Sbjct: 437 TTDSGIKL 444
>NP_001449
          Length = 2725

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QTVDSGL 7
           QTVD+G+
Sbjct: 301 QTVDAGV 307
>NP_001120959
          Length = 2692

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QTVDSGL 7
           QTVD+G+
Sbjct: 301 QTVDAGV 307
>NP_001128530
          Length = 550

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TVDSGLR 8
           TVD+G+R
Sbjct: 257 TVDAGVR 263
>NP_004077
          Length = 550

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TVDSGLR 8
           TVD+G+R
Sbjct: 257 TVDAGVR 263
>NP_644670
          Length = 541

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  QTVDSGLR 8
          QTV  GLR
Sbjct: 22 QTVTGGLR 29
>NP_004438
          Length = 822

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  TVDSGLR 8
          TVD G+R
Sbjct: 83 TVDDGIR 89
>NP_777576
          Length = 1749

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    TVDSGLRL 9
            TVD+GL L
Sbjct: 1453 TVDTGLPL 1460
>NP_055318
          Length = 2785

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    VDSGLRL 9
            ++SGLRL
Sbjct: 2084 IESGLRL 2090
>NP_612373
          Length = 845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QTVDSGL 7
           +TVD+GL
Sbjct: 255 ETVDAGL 261
>XP_006720136
          Length = 550

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TVDSGLR 8
           TVD+G+R
Sbjct: 257 TVDAGVR 263
>XP_006719406
          Length = 2380

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    VDSGLRL 9
            ++SGLRL
Sbjct: 2084 IESGLRL 2090
>XP_006719120
          Length = 822

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  TVDSGLR 8
          TVD G+R
Sbjct: 83 TVDDGIR 89
>XP_005253397
          Length = 822

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  TVDSGLR 8
          TVD G+R
Sbjct: 83 TVDDGIR 89
>XP_005253396
          Length = 833

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TVDSGLR 8
           TVD G+R
Sbjct: 94  TVDDGIR 100
>XP_006719093
          Length = 471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VDSGLRL 9
           VDSGL++
Sbjct: 453 VDSGLKI 459
>XP_006715973
          Length = 2632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QTVDSGL 7
           QTVD+G+
Sbjct: 301 QTVDAGV 307
>XP_005263396
          Length = 732

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QTVDSGL 7
           +TVD+GL
Sbjct: 142 ETVDAGL 148
>XP_005263395
          Length = 766

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QTVDSGL 7
           +TVD+GL
Sbjct: 176 ETVDAGL 182
>XP_005248043
          Length = 669

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  QTVDSGL 7
          Q+VDSG+
Sbjct: 62 QSVDSGI 68
>XP_006713958
          Length = 693

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  QTVDSGL 7
          Q+VDSG+
Sbjct: 62 QSVDSGI 68
>NP_065824
          Length = 693

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  QTVDSGL 7
          Q+VDSG+
Sbjct: 62 QSVDSGI 68
>NP_001106832
          Length = 693

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  QTVDSGL 7
          Q+VDSG+
Sbjct: 62 QSVDSGI 68
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.317    0.135    0.352 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 490,080
Number of extensions: 636
Number of successful extensions: 58
Number of sequences better than 10000.0: 58
Number of HSP's gapped: 58
Number of HSP's successfully gapped: 58
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package