Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001155973                                                           20     390
NP_055903                                                              20     390
NP_828847                                                              17    3301
NP_001001924                                                           17    4312
NP_001001925                                                           17    4312
NP_563615                                                              17    4312
XP_005273640                                                           17    4312
XP_005273639                                                           17    4312
XP_005273638                                                           17    4312
XP_005273637                                                           17    4312
XP_005273636                                                           17    4312
XP_005273635                                                           17    4312
XP_005273634                                                           17    4312
XP_005265360                                                           17    4312
XP_006713305                                                           17    4312
XP_005265358                                                           17    4312
XP_006713304                                                           17    4312
XP_005265356                                                           17    4312
XP_006713302                                                           17    4312
XP_006713301                                                           17    4312
XP_006713300                                                           17    4312
XP_006713299                                                           17    4312
XP_006713298                                                           17    4312
NP_004509                                                              16    5631
NP_742106                                                              16    5631
NP_742105                                                              16    5631
NP_742104                                                              16    5631
NP_742107                                                              16    5631
XP_006723855                                                           16    5631
XP_006723854                                                           16    5631
XP_006723853                                                           16    5631
XP_006723852                                                           16    5631
XP_006723851                                                           16    5631
XP_006723850                                                           16    5631
NP_005844                                                              16    7355
NP_001239126                                                           16    7355
NP_060127                                                              16    7355
XP_005264437                                                           16    7355
NP_982261                                                              16    7355
NP_001002243                                                           16    7355
NP_660305                                                              15    9605
NP_036284                                                              15    9605
NP_001014440                                                           15    9605
XP_006724480                                                           15    9605
XP_005261978                                                           15    9605
XP_006724479                                                           15    9605
XP_005261975                                                           15    9605
XP_006724478                                                           15    9605
XP_006713041                                                           15    9605
XP_006710605                                                           15    9605
>NP_001155973
          Length = 1833

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   QTILSRTDL 9
           QT+LSRTDL
Sbjct: 605 QTLLSRTDL 613
>NP_055903
          Length = 1723

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   QTILSRTDL 9
           QT+LSRTDL
Sbjct: 605 QTLLSRTDL 613
>NP_828847
          Length = 509

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   QTILSRTD 8
           +T+LSRTD
Sbjct: 100 KTLLSRTD 107
>NP_001001924
          Length = 1270

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QTILSRT 7
           QT+LSRT
Sbjct: 550 QTVLSRT 556
>NP_001001925
          Length = 1216

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QTILSRT 7
           QT+LSRT
Sbjct: 550 QTVLSRT 556
>NP_563615
          Length = 775

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TILSRTD 8
           T+LSRTD
Sbjct: 717 TLLSRTD 723
>XP_005273640
          Length = 969

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QTILSRT 7
           QT+LSRT
Sbjct: 550 QTVLSRT 556
>XP_005273639
          Length = 1216

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QTILSRT 7
           QT+LSRT
Sbjct: 550 QTVLSRT 556
>XP_005273638
          Length = 1228

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QTILSRT 7
           QT+LSRT
Sbjct: 550 QTVLSRT 556
>XP_005273637
          Length = 1228

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QTILSRT 7
           QT+LSRT
Sbjct: 550 QTVLSRT 556
>XP_005273636
          Length = 1270

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QTILSRT 7
           QT+LSRT
Sbjct: 550 QTVLSRT 556
>XP_005273635
          Length = 1282

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QTILSRT 7
           QT+LSRT
Sbjct: 550 QTVLSRT 556
>XP_005273634
          Length = 1282

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QTILSRT 7
           QT+LSRT
Sbjct: 550 QTVLSRT 556
>XP_005265360
          Length = 1442

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  QTILSRTDL 9
          QTI+ R+DL
Sbjct: 40 QTIIPRSDL 48
>XP_006713305
          Length = 1456

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  QTILSRTDL 9
          QTI+ R+DL
Sbjct: 40 QTIIPRSDL 48
>XP_005265358
          Length = 1461

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  QTILSRTDL 9
          QTI+ R+DL
Sbjct: 78 QTIIPRSDL 86
>XP_006713304
          Length = 1468

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  QTILSRTDL 9
          QTI+ R+DL
Sbjct: 85 QTIIPRSDL 93
>XP_005265356
          Length = 1481

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  QTILSRTDL 9
          QTI+ R+DL
Sbjct: 85 QTIIPRSDL 93
>XP_006713302
          Length = 1494

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  QTILSRTDL 9
          QTI+ R+DL
Sbjct: 78 QTIIPRSDL 86
>XP_006713301
          Length = 1494

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  QTILSRTDL 9
          QTI+ R+DL
Sbjct: 78 QTIIPRSDL 86
>XP_006713300
          Length = 1500

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  QTILSRTDL 9
          QTI+ R+DL
Sbjct: 85 QTIIPRSDL 93
>XP_006713299
          Length = 1501

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  QTILSRTDL 9
          QTI+ R+DL
Sbjct: 85 QTIIPRSDL 93
>XP_006713298
          Length = 1501

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  QTILSRTDL 9
          QTI+ R+DL
Sbjct: 85 QTIIPRSDL 93
>NP_004509
          Length = 844

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TILSRTDL 9
           T LSRTDL
Sbjct: 349 TNLSRTDL 356
>NP_742106
          Length = 841

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TILSRTDL 9
           T LSRTDL
Sbjct: 349 TNLSRTDL 356
>NP_742105
          Length = 872

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TILSRTDL 9
           T LSRTDL
Sbjct: 349 TNLSRTDL 356
>NP_742104
          Length = 854

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TILSRTDL 9
           T LSRTDL
Sbjct: 349 TNLSRTDL 356
>NP_742107
          Length = 393

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TILSRTDL 9
           T LSRTDL
Sbjct: 349 TNLSRTDL 356
>XP_006723855
          Length = 856

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TILSRTDL 9
           T LSRTDL
Sbjct: 349 TNLSRTDL 356
>XP_006723854
          Length = 858

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TILSRTDL 9
           T LSRTDL
Sbjct: 349 TNLSRTDL 356
>XP_006723853
          Length = 868

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TILSRTDL 9
           T LSRTDL
Sbjct: 349 TNLSRTDL 356
>XP_006723852
          Length = 876

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TILSRTDL 9
           T LSRTDL
Sbjct: 349 TNLSRTDL 356
>XP_006723851
          Length = 885

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TILSRTDL 9
           T LSRTDL
Sbjct: 349 TNLSRTDL 356
>XP_006723850
          Length = 886

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TILSRTDL 9
           T LSRTDL
Sbjct: 349 TNLSRTDL 356
>NP_005844
          Length = 483

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QTILSRTD 8
           QT+L+R D
Sbjct: 444 QTVLNRAD 451
>NP_001239126
          Length = 482

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QTILSRTD 8
           QT+L+R D
Sbjct: 443 QTVLNRAD 450
>NP_060127
          Length = 909

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   QTILSRTDL 9
           +TIL+++DL
Sbjct: 492 ETILTKSDL 500
>XP_005264437
          Length = 937

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   QTILSRTDL 9
           +TIL+++DL
Sbjct: 492 ETILTKSDL 500
>NP_982261
          Length = 936

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   QTILSRTDL 9
           +TIL+++DL
Sbjct: 492 ETILTKSDL 500
>NP_001002243
          Length = 908

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   QTILSRTDL 9
           +TIL+++DL
Sbjct: 492 ETILTKSDL 500
>NP_660305
          Length = 523

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QTILSRTD 8
           +T+LSR D
Sbjct: 285 KTVLSRAD 292
>NP_036284
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TILSRTD 8
           T+LSR+D
Sbjct: 326 TVLSRSD 332
>NP_001014440
          Length = 253

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TILSRTDL 9
           TIL+RT L
Sbjct: 203 TILARTSL 210
>XP_006724480
          Length = 178

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TILSRTDL 9
           TIL+RT L
Sbjct: 128 TILARTSL 135
>XP_005261978
          Length = 185

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TILSRTDL 9
           TIL+RT L
Sbjct: 135 TILARTSL 142
>XP_006724479
          Length = 204

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TILSRTDL 9
           TIL+RT L
Sbjct: 163 TILARTSL 170
>XP_005261975
          Length = 253

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TILSRTDL 9
           TIL+RT L
Sbjct: 203 TILARTSL 210
>XP_006724478
          Length = 272

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TILSRTDL 9
           TIL+RT L
Sbjct: 231 TILARTSL 238
>XP_006713041
          Length = 396

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QTILSRTD 8
           +T+LSR D
Sbjct: 158 KTVLSRAD 165
>XP_006710605
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TILSRTD 8
           T+LSR+D
Sbjct: 326 TVLSRSD 332
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.319    0.131    0.321 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 337,647
Number of extensions: 505
Number of successful extensions: 50
Number of sequences better than 10000.0: 50
Number of HSP's gapped: 50
Number of HSP's successfully gapped: 50
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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