Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              21     175
XP_005271621                                                           21     175
XP_006718907                                                           21     175
XP_006718906                                                           21     175
XP_005271619                                                           21     175
XP_005271618                                                           21     175
NP_075043                                                              17    4312
XP_005267190                                                           17    4312
XP_005267189                                                           17    4312
XP_005267187                                                           17    4312
XP_005267185                                                           17    4312
XP_005267184                                                           17    4312
NP_009055                                                              17    4312
NP_055861                                                              16    7355
NP_001002814                                                           16    7355
NP_079427                                                              16    7355
NP_001018098                                                           16    7355
NP_060154                                                              16    7355
NP_060550                                                              16    7355
NP_065872                                                              16    7355
XP_006718581                                                           16    7355
XP_005273986                                                           16    7355
XP_006718580                                                           16    7355
XP_005273985                                                           16    7355
XP_005273983                                                           16    7355
XP_006718579                                                           16    7355
XP_005273982                                                           16    7355
XP_005272230                                                           16    7355
XP_005272229                                                           16    7355
XP_005272228                                                           16    7355
NP_006074                                                              16    7355
NP_001025030                                                           16    7355
NP_001171899                                                           15    9605
NP_056150                                                              15    9605
NP_009160                                                              15    9605
NP_001036171                                                           15    9605
NP_001036170                                                           15    9605
NP_005112                                                              15    9605
NP_001184043                                                           15    9605
NP_001184042                                                           15    9605
XP_006724183                                                           15    9605
XP_006724182                                                           15    9605
XP_006724181                                                           15    9605
XP_006724180                                                           15    9605
XP_006719370                                                           15    9605
XP_006719369                                                           15    9605
XP_006719368                                                           15    9605
NP_001184029                                                           15    9605
NP_001013645                                                           15    9605
>NP_000042
          Length = 3056

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   QSSMNVFND 9
           QSSMN+FND
Sbjct: 852 QSSMNLFND 860
>XP_005271621
          Length = 2708

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   QSSMNVFND 9
           QSSMN+FND
Sbjct: 504 QSSMNLFND 512
>XP_006718907
          Length = 3050

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   QSSMNVFND 9
           QSSMN+FND
Sbjct: 852 QSSMNLFND 860
>XP_006718906
          Length = 3056

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   QSSMNVFND 9
           QSSMN+FND
Sbjct: 852 QSSMNLFND 860
>XP_005271619
          Length = 3056

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   QSSMNVFND 9
           QSSMN+FND
Sbjct: 852 QSSMNLFND 860
>XP_005271618
          Length = 3056

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   QSSMNVFND 9
           QSSMN+FND
Sbjct: 852 QSSMNLFND 860
>NP_075043
          Length = 1241

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  QSSMNVFN 8
          QSS+N+F+
Sbjct: 18 QSSLNIFS 25
>XP_005267190
          Length = 3424

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QSSMNVFND 9
           Q S+NV ND
Sbjct: 922 QVSLNVLND 930
>XP_005267189
          Length = 3425

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QSSMNVFND 9
           Q S+NV ND
Sbjct: 936 QVSLNVLND 944
>XP_005267187
          Length = 3433

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QSSMNVFND 9
           Q S+NV ND
Sbjct: 931 QVSLNVLND 939
>XP_005267185
          Length = 3437

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QSSMNVFND 9
           Q S+NV ND
Sbjct: 935 QVSLNVLND 943
>XP_005267184
          Length = 3438

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QSSMNVFND 9
           Q S+NV ND
Sbjct: 936 QVSLNVLND 944
>NP_009055
          Length = 3433

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QSSMNVFND 9
           Q S+NV ND
Sbjct: 931 QVSLNVLND 939
>NP_055861
          Length = 2677

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QSSMNVFND 9
           QSS N+F +
Sbjct: 691 QSSKNIFTE 699
>NP_001002814
          Length = 1283

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SSMNVFND 9
           SS+N+F D
Sbjct: 500 SSLNLFED 507
>NP_079427
          Length = 649

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SSMNVFND 9
           SS+N+F D
Sbjct: 500 SSLNLFED 507
>NP_001018098
          Length = 3628

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    QSSMNVFND 9
            +S +NVFN+
Sbjct: 2393 KSCLNVFNN 2401
>NP_060154
          Length = 3710

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    QSSMNVFND 9
            +S +NVFN+
Sbjct: 2350 KSCLNVFNN 2358
>NP_060550
          Length = 3585

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    QSSMNVFND 9
            +S +NVFN+
Sbjct: 2350 KSCLNVFNN 2358
>NP_065872
          Length = 3753

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    QSSMNVFND 9
            +S +NVFN+
Sbjct: 2393 KSCLNVFNN 2401
>XP_006718581
          Length = 260

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SSMNVFN 8
           SSM VFN
Sbjct: 139 SSMEVFN 145
>XP_005273986
          Length = 260

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SSMNVFN 8
           SSM VFN
Sbjct: 139 SSMEVFN 145
>XP_006718580
          Length = 260

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SSMNVFN 8
           SSM VFN
Sbjct: 139 SSMEVFN 145
>XP_005273985
          Length = 260

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SSMNVFN 8
           SSM VFN
Sbjct: 139 SSMEVFN 145
>XP_005273983
          Length = 277

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SSMNVFN 8
           SSM VFN
Sbjct: 156 SSMEVFN 162
>XP_006718579
          Length = 296

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SSMNVFN 8
           SSM VFN
Sbjct: 175 SSMEVFN 181
>XP_005273982
          Length = 329

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SSMNVFN 8
           SSM VFN
Sbjct: 208 SSMEVFN 214
>XP_005272230
          Length = 2706

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QSSMNVFND 9
           QSS N+F +
Sbjct: 691 QSSKNIFTE 699
>XP_005272229
          Length = 2706

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QSSMNVFND 9
           QSS N+F +
Sbjct: 691 QSSKNIFTE 699
>XP_005272228
          Length = 2706

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QSSMNVFND 9
           QSS N+F +
Sbjct: 691 QSSKNIFTE 699
>NP_006074
          Length = 557

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   QSSMNVFND 9
           ++ MN+F D
Sbjct: 313 EADMNIFED 321
>NP_001025030
          Length = 260

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SSMNVFN 8
           SSM VFN
Sbjct: 139 SSMEVFN 145
>NP_001171899
          Length = 486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   QSSMNVFND 9
           QSS N F D
Sbjct: 358 QSSYNPFED 366
>NP_056150
          Length = 2210

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    SSMNVFND 9
            S MN+F D
Sbjct: 1118 SVMNIFKD 1125
>NP_009160
          Length = 486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   QSSMNVFND 9
           QSS N F D
Sbjct: 358 QSSYNPFED 366
>NP_001036171
          Length = 112

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  SMNVFND 9
          SMN F+D
Sbjct: 87 SMNTFSD 93
>NP_001036170
          Length = 159

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  SMNVFND 9
          SMN F+D
Sbjct: 87 SMNTFSD 93
>NP_005112
          Length = 2174

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    QSSMNVFND 9
            +S MN+F D
Sbjct: 1079 ESVMNLFKD 1087
>NP_001184043
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  SMNVFND 9
          SMN F+D
Sbjct: 60 SMNTFSD 66
>NP_001184042
          Length = 563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  SMNVFND 9
          SMN F+D
Sbjct: 87 SMNTFSD 93
>XP_006724183
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   QSSMNVFND 9
           QSS N F D
Sbjct: 317 QSSYNPFED 325
>XP_006724182
          Length = 486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   QSSMNVFND 9
           QSS N F D
Sbjct: 358 QSSYNPFED 366
>XP_006724181
          Length = 486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   QSSMNVFND 9
           QSS N F D
Sbjct: 358 QSSYNPFED 366
>XP_006724180
          Length = 486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   QSSMNVFND 9
           QSS N F D
Sbjct: 358 QSSYNPFED 366
>XP_006719370
          Length = 2076

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   SSMNVFND 9
           S MN+F D
Sbjct: 984 SVMNIFKD 991
>XP_006719369
          Length = 2200

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    SSMNVFND 9
            S MN+F D
Sbjct: 1108 SVMNIFKD 1115
>XP_006719368
          Length = 2209

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    SSMNVFND 9
            S MN+F D
Sbjct: 1117 SVMNIFKD 1124
>NP_001184029
          Length = 132

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  SMNVFND 9
          SMN F+D
Sbjct: 60 SMNTFSD 66
>NP_001013645
          Length = 222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   QSSMNVFN 8
           QSS  VFN
Sbjct: 143 QSSRRVFN 150
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.309    0.117    0.304 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 321,035
Number of extensions: 394
Number of successful extensions: 49
Number of sequences better than 10000.0: 49
Number of HSP's gapped: 49
Number of HSP's successfully gapped: 49
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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