Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001186028                                                           18    1482
NP_001186026                                                           18    1482
NP_001186027                                                           18    1482
NP_001186025                                                           18    1482
NP_003924                                                              18    1482
NP_001273393                                                           18    1482
NP_004645                                                              17    4312
NP_690904                                                              17    4312
NP_690902                                                              17    4312
NP_690903                                                              17    4312
NP_001185792                                                           17    4312
NP_003906                                                              17    4312
NP_690905                                                              17    4312
NP_004314                                                              16    5631
NP_001165886                                                           16    5631
NP_001034680                                                           16    5631
NP_001034679                                                           16    5631
NP_060786                                                              16    5631
XP_005272733                                                           16    5631
XP_005272732                                                           16    5631
XP_006722848                                                           16    5631
NP_001001952                                                           16    5631
NP_037471                                                              16    7355
NP_001005270                                                           16    7355
NP_659475                                                              16    7355
NP_003669                                                              16    7355
NP_001002878                                                           16    7355
NP_001002879                                                           16    7355
NP_001002877                                                           16    7355
NP_690047                                                              16    7355
NP_001072990                                                           16    7355
NP_001257943                                                           16    7355
NP_004977                                                              16    7355
XP_005261858                                                           16    7355
XP_005261857                                                           16    7355
XP_005261856                                                           16    7355
XP_006724410                                                           16    7355
XP_005261855                                                           16    7355
XP_005261854                                                           16    7355
XP_006720204                                                           16    7355
XP_006720203                                                           16    7355
XP_006720202                                                           16    7355
XP_006720201                                                           16    7355
XP_005270845                                                           16    7355
NP_001072989                                                           16    7355
NP_006827                                                              15    9605
NP_001073922                                                           15    9605
NP_055381                                                              15    9605
NP_689936                                                              15    9605
NP_001004487                                                           15    9605
>NP_001186028
          Length = 1124

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   SEALCVLL 9
           SEALCV+L
Sbjct: 737 SEALCVVL 744
>NP_001186026
          Length = 1152

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   SEALCVLL 9
           SEALCV+L
Sbjct: 765 SEALCVVL 772
>NP_001186027
          Length = 1129

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   SEALCVLL 9
           SEALCV+L
Sbjct: 742 SEALCVVL 749
>NP_001186025
          Length = 1116

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   SEALCVLL 9
           SEALCV+L
Sbjct: 729 SEALCVVL 736
>NP_003924
          Length = 1187

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   SEALCVLL 9
           SEALCV+L
Sbjct: 800 SEALCVVL 807
>NP_001273393
          Length = 1169

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   SEALCVLL 9
           SEALCV+L
Sbjct: 782 SEALCVVL 789
>NP_004645
          Length = 2555

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    EALCVLL 9
            +ALCVLL
Sbjct: 2073 DALCVLL 2079
>NP_690904
          Length = 537

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  QSEALCVLL 9
          +S+ LCVLL
Sbjct: 25 KSDPLCVLL 33
>NP_690902
          Length = 537

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  QSEALCVLL 9
          +S+ LCVLL
Sbjct: 25 KSDPLCVLL 33
>NP_690903
          Length = 537

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  QSEALCVLL 9
          +S+ LCVLL
Sbjct: 25 KSDPLCVLL 33
>NP_001185792
          Length = 536

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  QSEALCVLL 9
          +S+ LCVLL
Sbjct: 25 KSDPLCVLL 33
>NP_003906
          Length = 542

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  QSEALCVLL 9
          +S+ LCVLL
Sbjct: 30 KSDPLCVLL 38
>NP_690905
          Length = 537

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  QSEALCVLL 9
          +S+ LCVLL
Sbjct: 25 KSDPLCVLL 33
>NP_004314
          Length = 345

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QSEALCVL 8
           Q+EALC L
Sbjct: 267 QAEALCKL 274
>NP_001165886
          Length = 230

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QSEALCVL 8
           Q+EALC L
Sbjct: 152 QAEALCKL 159
>NP_001034680
          Length = 2554

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    EALCVLL 9
            +ALC+LL
Sbjct: 2072 DALCILL 2078
>NP_001034679
          Length = 2570

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    EALCVLL 9
            +ALC+LL
Sbjct: 2072 DALCILL 2078
>NP_060786
          Length = 615

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   QSEALCVLL 9
           QSEA C LL
Sbjct: 549 QSEAGCCLL 557
>XP_005272733
          Length = 2559

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    EALCVLL 9
            +ALC+LL
Sbjct: 2077 DALCILL 2083
>XP_005272732
          Length = 2575

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    EALCVLL 9
            +ALC+LL
Sbjct: 2077 DALCILL 2083
>XP_006722848
          Length = 604

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   QSEALCVLL 9
           QSEA C LL
Sbjct: 538 QSEAGCCLL 546
>NP_001001952
          Length = 313

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SEALCVLL 9
           S+ LCVLL
Sbjct: 138 SQKLCVLL 145
>NP_037471
          Length = 507

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SEALCVLL 9
           + ALC+LL
Sbjct: 145 ANALCILL 152
>NP_001005270
          Length = 309

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SEALCVLL 9
           S +LC+LL
Sbjct: 135 SHSLCILL 142
>NP_659475
          Length = 740

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QSEALCVLL 9
           QS+ +C+LL
Sbjct: 196 QSDDICLLL 204
>NP_003669
          Length = 683

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QSEALCVLL 9
           Q + LCVLL
Sbjct: 625 QLQRLCVLL 633
>NP_001002878
          Length = 683

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QSEALCVLL 9
           Q + LCVLL
Sbjct: 625 QLQRLCVLL 633
>NP_001002879
          Length = 683

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QSEALCVLL 9
           Q + LCVLL
Sbjct: 625 QLQRLCVLL 633
>NP_001002877
          Length = 683

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QSEALCVLL 9
           Q + LCVLL
Sbjct: 625 QLQRLCVLL 633
>NP_690047
          Length = 140

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  ALCVLL 9
          ALCVLL
Sbjct: 36 ALCVLL 41
>NP_001072990
          Length = 1306

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QSEALCVL 8
           + EALCV+
Sbjct: 298 EDEALCVV 305
>NP_001257943
          Length = 1329

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QSEALCVL 8
           + EALCV+
Sbjct: 298 EDEALCVV 305
>NP_004977
          Length = 1300

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QSEALCVL 8
           + EALCV+
Sbjct: 298 EDEALCVV 305
>XP_005261858
          Length = 344

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QSEALCVLL 9
           Q + LCVLL
Sbjct: 286 QLQRLCVLL 294
>XP_005261857
          Length = 410

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QSEALCVLL 9
           Q + LCVLL
Sbjct: 352 QLQRLCVLL 360
>XP_005261856
          Length = 694

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QSEALCVLL 9
           Q + LCVLL
Sbjct: 636 QLQRLCVLL 644
>XP_006724410
          Length = 694

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QSEALCVLL 9
           Q + LCVLL
Sbjct: 636 QLQRLCVLL 644
>XP_005261855
          Length = 694

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QSEALCVLL 9
           Q + LCVLL
Sbjct: 636 QLQRLCVLL 644
>XP_005261854
          Length = 694

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QSEALCVLL 9
           Q + LCVLL
Sbjct: 636 QLQRLCVLL 644
>XP_006720204
          Length = 1298

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QSEALCVL 8
           + EALCV+
Sbjct: 298 EDEALCVV 305
>XP_006720203
          Length = 1328

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QSEALCVL 8
           + EALCV+
Sbjct: 298 EDEALCVV 305
>XP_006720202
          Length = 1329

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QSEALCVL 8
           + EALCV+
Sbjct: 298 EDEALCVV 305
>XP_006720201
          Length = 1357

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QSEALCVL 8
           + EALCV+
Sbjct: 298 EDEALCVV 305
>XP_005270845
          Length = 509

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SEALCVLL 9
           + ALC+LL
Sbjct: 145 ANALCILL 152
>NP_001072989
          Length = 1357

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QSEALCVL 8
           + EALCV+
Sbjct: 298 EDEALCVV 305
>NP_006827
          Length = 2671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   EALCVL 8
           EALCV+
Sbjct: 645 EALCVI 650
>NP_001073922
          Length = 2190

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   EALCVLL 9
           EALC LL
Sbjct: 182 EALCSLL 188
>NP_055381
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   SEALCVLL 9
           S  LCVLL
Sbjct: 137 SPGLCVLL 144
>NP_689936
          Length = 374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  QSEALCVL 8
          QS+ +C+L
Sbjct: 73 QSQLICIL 80
>NP_001004487
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   SEALCVLL 9
           S  LCVLL
Sbjct: 137 SHRLCVLL 144
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.327    0.134    0.376 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 601,231
Number of extensions: 690
Number of successful extensions: 50
Number of sequences better than 10000.0: 50
Number of HSP's gapped: 50
Number of HSP's successfully gapped: 50
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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