Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004324                                                              19     665
XP_005250103                                                           19     665
XP_005250102                                                           19     665
NP_002871                                                              18    1935
XP_005265417                                                           18    1935
XP_005265416                                                           18    1935
XP_005265415                                                           18    1935
XP_005265414                                                           18    1935
XP_005265412                                                           18    1935
NP_996816                                                              16    5631
NP_001243125                                                           16    5631
NP_001645                                                              16    5631
NP_078787                                                              16    5631
NP_065073                                                              16    5631
XP_006724592                                                           16    5631
XP_006715582                                                           16    5631
NP_061947                                                              16    7355
NP_848599                                                              16    7355
NP_001275896                                                           16    7355
NP_001275894                                                           16    7355
NP_077817                                                              16    7355
NP_066022                                                              16    7355
NP_001275893                                                           16    7355
XP_006723369                                                           16    7355
XP_005247869                                                           16    7355
XP_006713830                                                           16    7355
XP_005247867                                                           16    7355
XP_005247863                                                           16    7355
XP_005247862                                                           16    7355
XP_005247861                                                           16    7355
XP_005247860                                                           16    7355
XP_005247859                                                           16    7355
XP_006713081                                                           16    7355
NP_002372                                                              15    9605
NP_003820                                                              15    9605
NP_001248335                                                           15    9605
NP_055178                                                              15    9605
NP_001248336                                                           15    9605
NP_001264984                                                           15    9605
NP_775821                                                              15    9605
XP_005266395                                                           15    9605
XP_006716955                                                           15    9605
XP_005251680                                                           15    9605
XP_006716954                                                           15    9605
XP_006716953                                                           15    9605
XP_006716952                                                           15    9605
XP_006716951                                                           15    9605
XP_006716950                                                           15    9605
XP_006716949                                                           15    9605
XP_006716948                                                           15    9605
XP_005251679                                                           15    9605
XP_005251455                                                           15    9605
XP_005251456                                                           15    9605
XP_005251454                                                           15    9605
>NP_004324
          Length = 766

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QLQAFTNEV 9
           QLQAF NEV
Sbjct: 494 QLQAFKNEV 502
>XP_005250103
          Length = 758

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QLQAFTNEV 9
           QLQAF NEV
Sbjct: 494 QLQAFKNEV 502
>XP_005250102
          Length = 767

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QLQAFTNEV 9
           QLQAF NEV
Sbjct: 494 QLQAFKNEV 502
>NP_002871
          Length = 648

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   QLQAFTNEV 9
           Q QAF NEV
Sbjct: 386 QFQAFRNEV 394
>XP_005265417
          Length = 494

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   QLQAFTNEV 9
           Q QAF NEV
Sbjct: 386 QFQAFRNEV 394
>XP_005265416
          Length = 534

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   QLQAFTNEV 9
           Q QAF NEV
Sbjct: 272 QFQAFRNEV 280
>XP_005265415
          Length = 567

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   QLQAFTNEV 9
           Q QAF NEV
Sbjct: 305 QFQAFRNEV 313
>XP_005265414
          Length = 615

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   QLQAFTNEV 9
           Q QAF NEV
Sbjct: 353 QFQAFRNEV 361
>XP_005265412
          Length = 648

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   QLQAFTNEV 9
           Q QAF NEV
Sbjct: 386 QFQAFRNEV 394
>NP_996816
          Length = 5202

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    LQAFTN 7
            LQAFTN
Sbjct: 4795 LQAFTN 4800
>NP_001243125
          Length = 609

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QLQAFTNEV 9
           Q QAF NE+
Sbjct: 350 QAQAFKNEM 358
>NP_001645
          Length = 606

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QLQAFTNEV 9
           Q QAF NE+
Sbjct: 347 QAQAFKNEM 355
>NP_078787
          Length = 603

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QLQAFTNEV 9
           +LQA T+EV
Sbjct: 165 ELQALTDEV 173
>NP_065073
          Length = 2177

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    QLQAFTNEV 9
            Q+QA+TN V
Sbjct: 2112 QIQAWTNMV 2120
>XP_006724592
          Length = 611

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QLQAFTNEV 9
           Q QAF NE+
Sbjct: 352 QAQAFKNEM 360
>XP_006715582
          Length = 2106

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    QLQAFTNEV 9
            Q+QA+TN V
Sbjct: 2041 QIQAWTNMV 2049
>NP_061947
          Length = 685

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  QLQAFTNE 8
          QLQ F NE
Sbjct: 33 QLQEFINE 40
>NP_848599
          Length = 3092

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    QLQAFTNE 8
            QLQ F NE
Sbjct: 2684 QLQLFINE 2691
>NP_001275896
          Length = 445

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QAFTNEV 9
           QAFTN++
Sbjct: 415 QAFTNDL 421
>NP_001275894
          Length = 577

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QAFTNEV 9
           QAFTN++
Sbjct: 547 QAFTNDL 553
>NP_077817
          Length = 597

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QAFTNEV 9
           QAFTN++
Sbjct: 567 QAFTNDL 573
>NP_066022
          Length = 2564

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QLQAFT 6
           QLQAFT
Sbjct: 347 QLQAFT 352
>NP_001275893
          Length = 579

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QAFTNEV 9
           QAFTN++
Sbjct: 549 QAFTNDL 555
>XP_006723369
          Length = 2394

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QLQAFT 6
           QLQAFT
Sbjct: 347 QLQAFT 352
>XP_005247869
          Length = 373

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QAFTNEV 9
           QAFTN++
Sbjct: 308 QAFTNDL 314
>XP_006713830
          Length = 456

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QAFTNEV 9
           QAFTN++
Sbjct: 391 QAFTNDL 397
>XP_005247867
          Length = 480

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QAFTNEV 9
           QAFTN++
Sbjct: 415 QAFTNDL 421
>XP_005247863
          Length = 597

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QAFTNEV 9
           QAFTN++
Sbjct: 567 QAFTNDL 573
>XP_005247862
          Length = 598

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QAFTNEV 9
           QAFTN++
Sbjct: 567 QAFTNDL 573
>XP_005247861
          Length = 612

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QAFTNEV 9
           QAFTN++
Sbjct: 547 QAFTNDL 553
>XP_005247860
          Length = 632

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QAFTNEV 9
           QAFTN++
Sbjct: 567 QAFTNDL 573
>XP_005247859
          Length = 632

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QAFTNEV 9
           QAFTN++
Sbjct: 567 QAFTNDL 573
>XP_006713081
          Length = 3964

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    QLQAFTNE 8
            QLQ F NE
Sbjct: 3556 QLQLFINE 3563
>NP_002372
          Length = 486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QLQAFTNE 8
           QLQA+T++
Sbjct: 136 QLQAYTDK 143
>NP_003820
          Length = 2041

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   LQAFTNE 8
           LQ FTN+
Sbjct: 436 LQGFTNQ 442
>NP_001248335
          Length = 2037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   LQAFTNE 8
           LQ FTN+
Sbjct: 436 LQGFTNQ 442
>NP_055178
          Length = 4579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    QLQAFTNEV 9
            QL+  TN+V
Sbjct: 4515 QLEGLTNDV 4523
>NP_001248336
          Length = 2008

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   LQAFTNE 8
           LQ FTN+
Sbjct: 436 LQGFTNQ 442
>NP_001264984
          Length = 4432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    QLQAFTNEV 9
            QL+  TN+V
Sbjct: 4368 QLEGLTNDV 4376
>NP_775821
          Length = 1326

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QLQAFTNE 8
           +LQA TNE
Sbjct: 122 ELQAKTNE 129
>XP_005266395
          Length = 4588

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    QLQAFTNEV 9
            QL+  TN+V
Sbjct: 4524 QLEGLTNDV 4532
>XP_006716955
          Length = 1099

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   LQAFTNE 8
           LQ FTN+
Sbjct: 436 LQGFTNQ 442
>XP_005251680
          Length = 2000

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   LQAFTNE 8
           LQ FTN+
Sbjct: 436 LQGFTNQ 442
>XP_006716954
          Length = 2008

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   LQAFTNE 8
           LQ FTN+
Sbjct: 436 LQGFTNQ 442
>XP_006716953
          Length = 2031

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   LQAFTNE 8
           LQ FTN+
Sbjct: 436 LQGFTNQ 442
>XP_006716952
          Length = 2037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   LQAFTNE 8
           LQ FTN+
Sbjct: 436 LQGFTNQ 442
>XP_006716951
          Length = 2041

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   LQAFTNE 8
           LQ FTN+
Sbjct: 436 LQGFTNQ 442
>XP_006716950
          Length = 2070

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   LQAFTNE 8
           LQ FTN+
Sbjct: 436 LQGFTNQ 442
>XP_006716949
          Length = 2070

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   LQAFTNE 8
           LQ FTN+
Sbjct: 436 LQGFTNQ 442
>XP_006716948
          Length = 2070

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   LQAFTNE 8
           LQ FTN+
Sbjct: 436 LQGFTNQ 442
>XP_005251679
          Length = 2070

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   LQAFTNE 8
           LQ FTN+
Sbjct: 436 LQGFTNQ 442
>XP_005251455
          Length = 1334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QLQAFTNE 8
           +LQA TNE
Sbjct: 122 ELQAKTNE 129
>XP_005251456
          Length = 1334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QLQAFTNE 8
           +LQA TNE
Sbjct: 122 ELQAKTNE 129
>XP_005251454
          Length = 1334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QLQAFTNE 8
           +LQA TNE
Sbjct: 122 ELQAKTNE 129
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.124    0.313 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 473,995
Number of extensions: 711
Number of successful extensions: 54
Number of sequences better than 10000.0: 54
Number of HSP's gapped: 54
Number of HSP's successfully gapped: 54
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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