Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_055750                                                              17    4312
NP_001094790                                                           17    4312
XP_006711286                                                           17    4312
XP_005245025                                                           17    4312
XP_005245024                                                           17    4312
XP_006711285                                                           17    4312
XP_006711284                                                           17    4312
XP_006711283                                                           17    4312
XP_006711282                                                           17    4312
XP_006711281                                                           17    4312
XP_006711280                                                           17    4312
XP_006711279                                                           17    4312
XP_006711278                                                           17    4312
XP_006711277                                                           17    4312
XP_005245023                                                           17    4312
XP_006711276                                                           17    4312
XP_006711275                                                           17    4312
NP_001240781                                                           16    5631
NP_006585                                                              16    5631
NP_001240782                                                           16    5631
NP_001153780                                                           16    5631
NP_055549                                                              16    5631
NP_114121                                                              16    5631
NP_005040                                                              16    5631
XP_006723973                                                           16    5631
XP_006719943                                                           16    5631
XP_006719942                                                           16    5631
XP_005266629                                                           16    5631
XP_005266627                                                           16    5631
XP_005266626                                                           16    5631
XP_005266625                                                           16    5631
XP_005270439                                                           16    5631
XP_005270438                                                           16    5631
XP_006710159                                                           16    5631
NP_005384                                                              16    7355
NP_001073948                                                           16    7355
NP_036291                                                              16    7355
NP_001156729                                                           16    7355
NP_001171164                                                           16    7355
XP_006714732                                                           16    7355
NP_001137447                                                           16    7355
NP_001153699                                                           15    9605
NP_079413                                                              15    9605
NP_001231118                                                           15    9605
NP_001231121                                                           15    9605
NP_055564                                                              15    9605
NP_001231119                                                           15    9605
NP_001231120                                                           15    9605
NP_001231122                                                           15    9605
NP_001160051                                                           15    9605
NP_001243183                                                           15    9605
NP_001243181                                                           15    9605
NP_001965                                                              15    9605
NP_001243182                                                           15    9605
NP_001243184                                                           15    9605
NP_001079                                                              15    9605
XP_006720764                                                           15    9605
XP_005254752                                                           15    9605
XP_006720763                                                           15    9605
XP_006720762                                                           15    9605
XP_005254751                                                           15    9605
XP_006720406                                                           15    9605
XP_006720405                                                           15    9605
XP_006720404                                                           15    9605
XP_006720403                                                           15    9605
XP_006720402                                                           15    9605
XP_006720401                                                           15    9605
XP_006720400                                                           15    9605
XP_006720399                                                           15    9605
XP_005273939                                                           15    9605
NP_115879                                                              15    9605
>NP_055750
          Length = 1048

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   QKMEISCSL 9
           +++EISC+L
Sbjct: 990 KRIEISCAL 998
>NP_001094790
          Length = 424

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KMEISCSL 9
           +ME++CSL
Sbjct: 108 EMELACSL 115
>XP_006711286
          Length = 1021

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   QKMEISCSL 9
           +++EISC+L
Sbjct: 963 KRIEISCAL 971
>XP_005245025
          Length = 1156

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    QKMEISCSL 9
            +++EISC+L
Sbjct: 1098 KRIEISCAL 1106
>XP_005245024
          Length = 1177

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    QKMEISCSL 9
            +++EISC+L
Sbjct: 1119 KRIEISCAL 1127
>XP_006711285
          Length = 1193

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    QKMEISCSL 9
            +++EISC+L
Sbjct: 1135 KRIEISCAL 1143
>XP_006711284
          Length = 1193

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    QKMEISCSL 9
            +++EISC+L
Sbjct: 1135 KRIEISCAL 1143
>XP_006711283
          Length = 1193

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    QKMEISCSL 9
            +++EISC+L
Sbjct: 1135 KRIEISCAL 1143
>XP_006711282
          Length = 1227

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    QKMEISCSL 9
            +++EISC+L
Sbjct: 1169 KRIEISCAL 1177
>XP_006711281
          Length = 1233

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    QKMEISCSL 9
            +++EISC+L
Sbjct: 1175 KRIEISCAL 1183
>XP_006711280
          Length = 1251

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    QKMEISCSL 9
            +++EISC+L
Sbjct: 1193 KRIEISCAL 1201
>XP_006711279
          Length = 1254

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    QKMEISCSL 9
            +++EISC+L
Sbjct: 1196 KRIEISCAL 1204
>XP_006711278
          Length = 1256

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    QKMEISCSL 9
            +++EISC+L
Sbjct: 1198 KRIEISCAL 1206
>XP_006711277
          Length = 1280

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    QKMEISCSL 9
            +++EISC+L
Sbjct: 1243 KRIEISCAL 1251
>XP_005245023
          Length = 1281

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    QKMEISCSL 9
            +++EISC+L
Sbjct: 1223 KRIEISCAL 1231
>XP_006711276
          Length = 1283

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    QKMEISCSL 9
            +++EISC+L
Sbjct: 1225 KRIEISCAL 1233
>XP_006711275
          Length = 1301

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    QKMEISCSL 9
            +++EISC+L
Sbjct: 1243 KRIEISCAL 1251
>NP_001240781
          Length = 739

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QKMEISCSL 9
           QK+E+ C L
Sbjct: 331 QKVEVLCEL 339
>NP_006585
          Length = 739

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QKMEISCSL 9
           QK+E+ C L
Sbjct: 331 QKVEVLCEL 339
>NP_001240782
          Length = 640

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QKMEISCSL 9
           QK+E+ C L
Sbjct: 232 QKVEVLCEL 240
>NP_001153780
          Length = 707

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   QKMEISCS 8
           +K+E++CS
Sbjct: 418 RKLEVACS 425
>NP_055549
          Length = 303

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   MEISCSL 9
           MEISC L
Sbjct: 98  MEISCRL 104
>NP_114121
          Length = 719

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   QKMEISCS 8
           +K+E++CS
Sbjct: 430 RKLEVACS 437
>NP_005040
          Length = 919

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QKMEISCSL 9
           ++ EISC+L
Sbjct: 641 KRFEISCNL 649
>XP_006723973
          Length = 919

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QKMEISCSL 9
           ++ EISC+L
Sbjct: 641 KRFEISCNL 649
>XP_006719943
          Length = 483

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   QKMEISCS 8
           +K+E++CS
Sbjct: 418 RKLEVACS 425
>XP_006719942
          Length = 483

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   QKMEISCS 8
           +K+E++CS
Sbjct: 418 RKLEVACS 425
>XP_005266629
          Length = 518

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   QKMEISCS 8
           +K+E++CS
Sbjct: 229 RKLEVACS 236
>XP_005266627
          Length = 534

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   QKMEISCS 8
           +K+E++CS
Sbjct: 418 RKLEVACS 425
>XP_005266626
          Length = 695

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   QKMEISCS 8
           +K+E++CS
Sbjct: 406 RKLEVACS 413
>XP_005266625
          Length = 707

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   QKMEISCS 8
           +K+E++CS
Sbjct: 418 RKLEVACS 425
>XP_005270439
          Length = 405

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QKMEISCSL 9
           QK+E+ C L
Sbjct: 331 QKVEVLCEL 339
>XP_005270438
          Length = 635

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QKMEISCSL 9
           QK+E+ C L
Sbjct: 331 QKVEVLCEL 339
>XP_006710159
          Length = 919

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QKMEISCSL 9
           ++ EISC+L
Sbjct: 641 KRFEISCNL 649
>NP_005384
          Length = 1909

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    QKMEISCSL 9
            QK++++C L
Sbjct: 1887 QKLQLACRL 1895
>NP_001073948
          Length = 1731

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3 MEISCS 8
         ME+SCS
Sbjct: 1 MELSCS 6
>NP_036291
          Length = 434

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KMEISCS 8
           K E+SCS
Sbjct: 374 KCEVSCS 380
>NP_001156729
          Length = 1932

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    QKMEISCSL 9
            QK++++C L
Sbjct: 1910 QKLQLACRL 1918
>NP_001171164
          Length = 1705

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3 MEISCS 8
         ME+SCS
Sbjct: 1 MELSCS 6
>XP_006714732
          Length = 1633

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3 MEISCS 8
         ME+SCS
Sbjct: 1 MELSCS 6
>NP_001137447
          Length = 393

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  MEISCSL 9
          +EISC+L
Sbjct: 61 LEISCNL 67
>NP_001153699
          Length = 2330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   KMEISC 7
           K+E+SC
Sbjct: 353 KLEVSC 358
>NP_079413
          Length = 2443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   KMEISC 7
           K+E+SC
Sbjct: 353 KLEVSC 358
>NP_001231118
          Length = 1644

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   QKMEISC 7
           + ME+SC
Sbjct: 421 ENMEVSC 427
>NP_001231121
          Length = 1504

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   QKMEISC 7
           + ME+SC
Sbjct: 324 ENMEVSC 330
>NP_055564
          Length = 1472

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   QKMEISC 7
           + ME+SC
Sbjct: 368 ENMEVSC 374
>NP_001231119
          Length = 1533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   QKMEISC 7
           + ME+SC
Sbjct: 353 ENMEVSC 359
>NP_001231120
          Length = 1463

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   QKMEISC 7
           + ME+SC
Sbjct: 283 ENMEVSC 289
>NP_001231122
          Length = 1347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   QKMEISC 7
           + ME+SC
Sbjct: 228 ENMEVSC 234
>NP_001160051
          Length = 252

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   MEISCSL 9
           ME+ CSL
Sbjct: 234 MELHCSL 240
>NP_001243183
          Length = 745

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KMEISCS 8
           KM+I CS
Sbjct: 318 KMKIGCS 324
>NP_001243181
          Length = 867

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KMEISCS 8
           KM+I CS
Sbjct: 407 KMKIGCS 413
>NP_001965
          Length = 886

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KMEISCS 8
           KM+I CS
Sbjct: 459 KMKIGCS 465
>NP_001243182
          Length = 821

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KMEISCS 8
           KM+I CS
Sbjct: 459 KMKIGCS 465
>NP_001243184
          Length = 709

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KMEISCS 8
           KM+I CS
Sbjct: 282 KMKIGCS 288
>NP_001079
          Length = 207

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   MEISCSL 9
           ME+ CSL
Sbjct: 189 MELHCSL 195
>XP_006720764
          Length = 1584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   KMEISC 7
           K+E+SC
Sbjct: 353 KLEVSC 358
>XP_005254752
          Length = 2357

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   KMEISC 7
           K+E+SC
Sbjct: 267 KLEVSC 272
>XP_006720763
          Length = 2395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   KMEISC 7
           K+E+SC
Sbjct: 353 KLEVSC 358
>XP_006720762
          Length = 2397

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   KMEISC 7
           K+E+SC
Sbjct: 353 KLEVSC 358
>XP_005254751
          Length = 2407

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   KMEISC 7
           K+E+SC
Sbjct: 353 KLEVSC 358
>XP_006720406
          Length = 1591

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   QKMEISC 7
           + ME+SC
Sbjct: 368 ENMEVSC 374
>XP_006720405
          Length = 1347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   QKMEISC 7
           + ME+SC
Sbjct: 368 ENMEVSC 374
>XP_006720404
          Length = 1477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   QKMEISC 7
           + ME+SC
Sbjct: 368 ENMEVSC 374
>XP_006720403
          Length = 1486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   QKMEISC 7
           + ME+SC
Sbjct: 368 ENMEVSC 374
>XP_006720402
          Length = 1487

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   QKMEISC 7
           + ME+SC
Sbjct: 368 ENMEVSC 374
>XP_006720401
          Length = 1504

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   QKMEISC 7
           + ME+SC
Sbjct: 368 ENMEVSC 374
>XP_006720400
          Length = 1526

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   QKMEISC 7
           + ME+SC
Sbjct: 368 ENMEVSC 374
>XP_006720399
          Length = 1548

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   QKMEISC 7
           + ME+SC
Sbjct: 368 ENMEVSC 374
>XP_005273939
          Length = 251

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3 MEISCS 8
         M+ISCS
Sbjct: 1 MQISCS 6
>NP_115879
          Length = 100

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1  QKMEISC 7
          QK+ +SC
Sbjct: 15 QKLRVSC 21
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.318    0.122    0.335 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 737,442
Number of extensions: 967
Number of successful extensions: 71
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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