Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              21     229
NP_001075109                                                           21     229
XP_006726596                                                           17    3301
XP_006718819                                                           17    3301
XP_006710011                                                           17    3301
NP_001804                                                              17    4312
NP_001273663                                                           17    4312
NP_036428                                                              16    5631
NP_536739                                                              16    5631
NP_002030                                                              16    5631
NP_997006                                                              16    5631
NP_055793                                                              16    5631
NP_054828                                                              16    5631
XP_006718816                                                           16    5631
XP_005262939                                                           16    5631
XP_005262938                                                           16    5631
NP_003310                                                              16    7355
NP_597676                                                              16    7355
NP_596870                                                              16    7355
NP_001243779                                                           16    7355
NP_596869                                                              16    7355
NP_000020                                                              16    7355
NP_057195                                                              16    7355
NP_001005169                                                           16    7355
NP_001005170                                                           16    7355
XP_006721056                                                           16    7355
XP_006712787                                                           16    7355
XP_006712786                                                           16    7355
NP_001254479                                                           16    7355
NP_597681                                                              16    7355
NP_002213                                                              15    9605
NP_001093422                                                           15    9605
NP_001161744                                                           15    9605
NP_001273004                                                           15    9605
NP_004311                                                              15    9605
NP_775293                                                              15    9605
NP_001123520                                                           15    9605
NP_056111                                                              15    9605
NP_077734                                                              15    9605
NP_054829                                                              15    9605
XP_006720004                                                           15    9605
XP_005254093                                                           15    9605
XP_006720003                                                           15    9605
XP_006720002                                                           15    9605
XP_006720000                                                           15    9605
XP_005254091                                                           15    9605
XP_006719999                                                           15    9605
XP_006719998                                                           15    9605
XP_006719997                                                           15    9605
XP_006719996                                                           15    9605
XP_006719995                                                           15    9605
XP_006719994                                                           15    9605
XP_006719992                                                           15    9605
XP_006719991                                                           15    9605
XP_006719990                                                           15    9605
XP_006719989                                                           15    9605
XP_006719988                                                           15    9605
XP_006719987                                                           15    9605
XP_006719986                                                           15    9605
XP_006719985                                                           15    9605
XP_006713198                                                           15    9605
XP_006713197                                                           15    9605
XP_005265167                                                           15    9605
XP_006713196                                                           15    9605
XP_006713195                                                           15    9605
XP_005265166                                                           15    9605
XP_006713194                                                           15    9605
XP_005245325                                                           15    9605
XP_005245324                                                           15    9605
NP_003189                                                              15    9605
NP_001005186                                                           15    9605
>NP_008835
          Length = 4128

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    QIDSSISFN 9
            QIDSS+SFN
Sbjct: 1654 QIDSSVSFN 1662
>NP_001075109
          Length = 4097

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    QIDSSISFN 9
            QIDSS+SFN
Sbjct: 1654 QIDSSVSFN 1662
>XP_006726596
          Length = 242

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  IDSSISFN 9
          ++SSISFN
Sbjct: 59 VNSSISFN 66
>XP_006718819
          Length = 242

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  IDSSISFN 9
          ++SSISFN
Sbjct: 59 VNSSISFN 66
>XP_006710011
          Length = 242

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  IDSSISFN 9
          ++SSISFN
Sbjct: 59 VNSSISFN 66
>NP_001804
          Length = 2701

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  QIDSSISFN 9
          Q+D S SFN
Sbjct: 40 QVDGSKSFN 48
>NP_001273663
          Length = 2580

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  QIDSSISFN 9
          Q+D S SFN
Sbjct: 40 QVDGSKSFN 48
>NP_036428
          Length = 638

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  QIDSSISFN 9
          Q+D+ ++FN
Sbjct: 30 QVDAGLTFN 38
>NP_536739
          Length = 676

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  QIDSSISFN 9
          Q+D+ ++FN
Sbjct: 68 QVDAGLTFN 76
>NP_002030
          Length = 694

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  QIDSSISFN 9
          Q+D+ ++FN
Sbjct: 67 QVDAGLTFN 75
>NP_997006
          Length = 724

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  QIDSSISFN 9
          Q+D+ ++FN
Sbjct: 67 QVDAGLTFN 75
>NP_055793
          Length = 1222

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IDSSISF 8
           +DSSISF
Sbjct: 961 LDSSISF 967
>NP_054828
          Length = 1390

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QIDSSISFN 9
           Q+DSS+ F+
Sbjct: 418 QLDSSVRFD 426
>XP_006718816
          Length = 638

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  QIDSSISFN 9
          Q+D+ ++FN
Sbjct: 30 QVDAGLTFN 38
>XP_005262939
          Length = 721

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  QIDSSISFN 9
          Q+D+ ++FN
Sbjct: 67 QVDAGLTFN 75
>XP_005262938
          Length = 751

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  QIDSSISFN 9
          Q+D+ ++FN
Sbjct: 67 QVDAGLTFN 75
>NP_003310
          Length = 26926

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QIDSSISF 8
           QI+SSI F
Sbjct: 936 QIESSIDF 943
>NP_597676
          Length = 27051

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QIDSSISF 8
           QI+SSI F
Sbjct: 936 QIESSIDF 943
>NP_596870
          Length = 5604

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QIDSSISF 8
           QI+SSI F
Sbjct: 982 QIESSIDF 989
>NP_001243779
          Length = 34350

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QIDSSISF 8
           QI+SSI F
Sbjct: 982 QIESSIDF 989
>NP_596869
          Length = 33423

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QIDSSISF 8
           QI+SSI F
Sbjct: 982 QIESSIDF 989
>NP_000020
          Length = 485

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IDSSISFN 9
           +DS+++FN
Sbjct: 272 VDSTLAFN 279
>NP_057195
          Length = 837

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IDSSISF 8
           +DSS+SF
Sbjct: 207 LDSSVSF 213
>NP_001005169
          Length = 324

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  DSSISFN 9
          DSSISF+
Sbjct: 93 DSSISFS 99
>NP_001005170
          Length = 350

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   DSSISFN 9
           DSSISF+
Sbjct: 119 DSSISFS 125
>XP_006721056
          Length = 718

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IDSSISF 8
           +DSS+SF
Sbjct: 207 LDSSVSF 213
>XP_006712787
          Length = 33978

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QIDSSISF 8
           QI+SSI F
Sbjct: 983 QIESSIDF 990
>XP_006712786
          Length = 35484

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QIDSSISF 8
           QI+SSI F
Sbjct: 983 QIESSIDF 990
>NP_001254479
          Length = 35991

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QIDSSISF 8
           QI+SSI F
Sbjct: 982 QIESSIDF 989
>NP_597681
          Length = 27118

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QIDSSISF 8
           QI+SSI F
Sbjct: 936 QIESSIDF 943
>NP_002213
          Length = 2695

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    SSISFN 9
            SSISFN
Sbjct: 2222 SSISFN 2227
>NP_001093422
          Length = 2710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    SSISFN 9
            SSISFN
Sbjct: 2237 SSISFN 2242
>NP_001161744
          Length = 2743

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    SSISFN 9
            SSISFN
Sbjct: 2270 SSISFN 2275
>NP_001273004
          Length = 869

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   DSSISFN 9
           DSS+ FN
Sbjct: 297 DSSLDFN 303
>NP_004311
          Length = 994

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   DSSISFN 9
           DSS+ FN
Sbjct: 422 DSSLDFN 428
>NP_775293
          Length = 1001

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   DSSISFN 9
           DSS+ FN
Sbjct: 422 DSSLDFN 428
>NP_001123520
          Length = 2068

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IDSSISFN 9
            +D+S++FN
Sbjct: 1368 LDNSLTFN 1375
>NP_056111
          Length = 2069

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IDSSISFN 9
            +D+S++FN
Sbjct: 1369 LDNSLTFN 1376
>NP_077734
          Length = 749

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   IDSSISFN 9
           +DS ++FN
Sbjct: 548 VDSGLTFN 555
>NP_054829
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IDSSISF 8
           IDS++SF
Sbjct: 111 IDSTVSF 117
>XP_006720004
          Length = 1412

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IDSSISFN 9
            +D+S++FN
Sbjct: 1403 LDNSLTFN 1410
>XP_005254093
          Length = 2046

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IDSSISFN 9
            +D+S++FN
Sbjct: 1369 LDNSLTFN 1376
>XP_006720003
          Length = 2058

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IDSSISFN 9
            +D+S++FN
Sbjct: 1320 LDNSLTFN 1327
>XP_006720002
          Length = 2058

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IDSSISFN 9
            +D+S++FN
Sbjct: 1320 LDNSLTFN 1327
>XP_006720000
          Length = 2084

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IDSSISFN 9
            +D+S++FN
Sbjct: 1369 LDNSLTFN 1376
>XP_005254091
          Length = 2093

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IDSSISFN 9
            +D+S++FN
Sbjct: 1392 LDNSLTFN 1399
>XP_006719999
          Length = 2095

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IDSSISFN 9
            +D+S++FN
Sbjct: 1380 LDNSLTFN 1387
>XP_006719998
          Length = 2103

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IDSSISFN 9
            +D+S++FN
Sbjct: 1403 LDNSLTFN 1410
>XP_006719997
          Length = 2104

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IDSSISFN 9
            +D+S++FN
Sbjct: 1403 LDNSLTFN 1410
>XP_006719996
          Length = 2104

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IDSSISFN 9
            +D+S++FN
Sbjct: 1403 LDNSLTFN 1410
>XP_006719995
          Length = 2106

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IDSSISFN 9
            +D+S++FN
Sbjct: 1368 LDNSLTFN 1375
>XP_006719994
          Length = 2107

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IDSSISFN 9
            +D+S++FN
Sbjct: 1369 LDNSLTFN 1376
>XP_006719992
          Length = 2116

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IDSSISFN 9
            +D+S++FN
Sbjct: 1403 LDNSLTFN 1410
>XP_006719991
          Length = 2118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IDSSISFN 9
            +D+S++FN
Sbjct: 1380 LDNSLTFN 1387
>XP_006719990
          Length = 2118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IDSSISFN 9
            +D+S++FN
Sbjct: 1403 LDNSLTFN 1410
>XP_006719989
          Length = 2127

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IDSSISFN 9
            +D+S++FN
Sbjct: 1403 LDNSLTFN 1410
>XP_006719988
          Length = 2129

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IDSSISFN 9
            +D+S++FN
Sbjct: 1391 LDNSLTFN 1398
>XP_006719987
          Length = 2130

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IDSSISFN 9
            +D+S++FN
Sbjct: 1392 LDNSLTFN 1399
>XP_006719986
          Length = 2139

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IDSSISFN 9
            +D+S++FN
Sbjct: 1403 LDNSLTFN 1410
>XP_006719985
          Length = 2141

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IDSSISFN 9
            +D+S++FN
Sbjct: 1403 LDNSLTFN 1410
>XP_006713198
          Length = 2699

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    SSISFN 9
            SSISFN
Sbjct: 2226 SSISFN 2231
>XP_006713197
          Length = 2712

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    SSISFN 9
            SSISFN
Sbjct: 2239 SSISFN 2244
>XP_005265167
          Length = 2719

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    SSISFN 9
            SSISFN
Sbjct: 2246 SSISFN 2251
>XP_006713196
          Length = 2721

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    SSISFN 9
            SSISFN
Sbjct: 2248 SSISFN 2253
>XP_006713195
          Length = 2727

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    SSISFN 9
            SSISFN
Sbjct: 2254 SSISFN 2259
>XP_005265166
          Length = 2735

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    SSISFN 9
            SSISFN
Sbjct: 2262 SSISFN 2267
>XP_006713194
          Length = 2736

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    SSISFN 9
            SSISFN
Sbjct: 2263 SSISFN 2268
>XP_005245325
          Length = 689

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   IDSSISFN 9
           +DS ++FN
Sbjct: 488 VDSGLTFN 495
>XP_005245324
          Length = 712

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   IDSSISFN 9
           +DS ++FN
Sbjct: 511 VDSGLTFN 518
>NP_003189
          Length = 798

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SSISFN 9
           SSISFN
Sbjct: 737 SSISFN 742
>NP_001005186
          Length = 317

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QIDSSISFN 9
           ++ SSI+FN
Sbjct: 267 KVTSSINFN 275
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.311    0.124    0.307 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 375,399
Number of extensions: 538
Number of successful extensions: 71
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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