Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000305                                                              20     299
XP_006717989                                                           20     299
NP_056060                                                              17    4312
NP_001035882                                                           17    4312
NP_001265154                                                           17    4312
NP_060457                                                              17    4312
XP_006717975                                                           17    4312
XP_005270017                                                           17    4312
XP_005270016                                                           17    4312
XP_005270014                                                           17    4312
XP_005270013                                                           17    4312
XP_005270012                                                           17    4312
XP_006717974                                                           17    4312
XP_005270010                                                           17    4312
XP_005270009                                                           17    4312
XP_006715101                                                           17    4312
XP_006715100                                                           17    4312
XP_005249021                                                           17    4312
XP_006715099                                                           17    4312
XP_006715098                                                           17    4312
XP_006715097                                                           17    4312
XP_006715096                                                           17    4312
NP_056379                                                              16    5631
NP_597722                                                              16    5631
NP_001273965                                                           16    5631
NP_003244                                                              16    7355
NP_008966                                                              16    7355
XP_005261097                                                           16    7355
XP_005261096                                                           16    7355
XP_005261095                                                           16    7355
XP_005261094                                                           16    7355
NP_001002907                                                           16    7355
NP_001367                                                              15    9605
NP_004123                                                              15    9605
NP_001171131                                                           15    9605
NP_001026909                                                           15    9605
NP_078928                                                              15    9605
XP_006724528                                                           15    9605
XP_005274503                                                           15    9605
XP_005255036                                                           15    9605
>NP_000305
          Length = 403

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   QHTQITKV 8
           QHTQITKV
Sbjct: 396 QHTQITKV 403
>XP_006717989
          Length = 388

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   QHTQITKV 8
           QHTQITKV
Sbjct: 381 QHTQITKV 388
>NP_056060
          Length = 1134

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HTQITKVL 9
           HT++ KVL
Sbjct: 161 HTEVVKVL 168
>NP_001035882
          Length = 403

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QHTQITKV 8
           QH ++TKV
Sbjct: 237 QHLEVTKV 244
>NP_001265154
          Length = 379

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QHTQITKV 8
           QH ++TKV
Sbjct: 213 QHLEVTKV 220
>NP_060457
          Length = 641

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QHTQITKV 8
           QH ++TKV
Sbjct: 306 QHLEVTKV 313
>XP_006717975
          Length = 405

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QHTQITKV 8
           QH ++TKV
Sbjct: 306 QHLEVTKV 313
>XP_005270017
          Length = 438

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QHTQITKV 8
           QH ++TKV
Sbjct: 272 QHLEVTKV 279
>XP_005270016
          Length = 472

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QHTQITKV 8
           QH ++TKV
Sbjct: 306 QHLEVTKV 313
>XP_005270014
          Length = 572

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QHTQITKV 8
           QH ++TKV
Sbjct: 237 QHLEVTKV 244
>XP_005270013
          Length = 585

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QHTQITKV 8
           QH ++TKV
Sbjct: 306 QHLEVTKV 313
>XP_005270012
          Length = 590

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QHTQITKV 8
           QH ++TKV
Sbjct: 255 QHLEVTKV 262
>XP_006717974
          Length = 606

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QHTQITKV 8
           QH ++TKV
Sbjct: 271 QHLEVTKV 278
>XP_005270010
          Length = 607

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QHTQITKV 8
           QH ++TKV
Sbjct: 272 QHLEVTKV 279
>XP_005270009
          Length = 640

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QHTQITKV 8
           QH ++TKV
Sbjct: 305 QHLEVTKV 312
>XP_006715101
          Length = 1150

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HTQITKVL 9
           HT++ KVL
Sbjct: 161 HTEVVKVL 168
>XP_006715100
          Length = 1151

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HTQITKVL 9
           HT++ KVL
Sbjct: 161 HTEVVKVL 168
>XP_005249021
          Length = 1155

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HTQITKVL 9
           HT++ KVL
Sbjct: 182 HTEVVKVL 189
>XP_006715099
          Length = 1156

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HTQITKVL 9
           HT++ KVL
Sbjct: 182 HTEVVKVL 189
>XP_006715098
          Length = 1161

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HTQITKVL 9
           HT++ KVL
Sbjct: 182 HTEVVKVL 189
>XP_006715097
          Length = 1171

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HTQITKVL 9
           HT++ KVL
Sbjct: 182 HTEVVKVL 189
>XP_006715096
          Length = 1172

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HTQITKVL 9
           HT++ KVL
Sbjct: 182 HTEVVKVL 189
>NP_056379
          Length = 516

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   QHTQITKV 8
           +H Q+TK+
Sbjct: 213 EHNQLTKI 220
>NP_597722
          Length = 716

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HTQITKV 8
           HT ITK+
Sbjct: 443 HTDITKI 449
>NP_001273965
          Length = 744

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HTQITKV 8
           HT ITK+
Sbjct: 471 HTDITKI 477
>NP_003244
          Length = 1591

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    HTQITKVL 9
            HT++ KVL
Sbjct: 1149 HTKVPKVL 1156
>NP_008966
          Length = 352

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HTQITKV 8
           H Q+TKV
Sbjct: 271 HNQLTKV 277
>XP_005261097
          Length = 1452

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    HTQITKVL 9
            HT++ KVL
Sbjct: 1149 HTKVPKVL 1156
>XP_005261096
          Length = 1591

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    HTQITKVL 9
            HT++ KVL
Sbjct: 1149 HTKVPKVL 1156
>XP_005261095
          Length = 1591

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    HTQITKVL 9
            HT++ KVL
Sbjct: 1149 HTKVPKVL 1156
>XP_005261094
          Length = 1591

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    HTQITKVL 9
            HT++ KVL
Sbjct: 1149 HTKVPKVL 1156
>NP_001002907
          Length = 319

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  HTQITKV 8
          HT +TKV
Sbjct: 9  HTAVTKV 15
>NP_001367
          Length = 4646

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    QHTQITKV 8
            Q+TQIT +
Sbjct: 4062 QNTQITSI 4069
>NP_004123
          Length = 560

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HTQITKVL 9
           +TQ+TK L
Sbjct: 540 YTQVTKFL 547
>NP_001171131
          Length = 534

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HTQITKVL 9
           +TQ+TK L
Sbjct: 514 YTQVTKFL 521
>NP_001026909
          Length = 294

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QHTQITKVL 9
           QH +ITK++
Sbjct: 274 QHHKITKLV 282
>NP_078928
          Length = 2015

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    QHTQITKVL 9
            QH Q  K+L
Sbjct: 1905 QHLQAVKIL 1913
>XP_006724528
          Length = 265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QHTQITKVL 9
           QH +ITK++
Sbjct: 245 QHHKITKLV 253
>XP_005274503
          Length = 294

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QHTQITKVL 9
           QH +ITK++
Sbjct: 274 QHHKITKLV 282
>XP_005255036
          Length = 1310

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    QHTQITKVL 9
            QH Q  K+L
Sbjct: 1200 QHLQAVKIL 1208
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.321    0.125    0.332 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 449,408
Number of extensions: 499
Number of successful extensions: 40
Number of sequences better than 10000.0: 40
Number of HSP's gapped: 40
Number of HSP's successfully gapped: 40
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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