Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001093859                                                           17    2528
NP_149972                                                              16    5631
NP_038347                                                              16    7355
NP_001275762                                                           16    7355
NP_075561                                                              16    7355
NP_001273433                                                           16    7355
NP_001273432                                                           16    7355
NP_954578                                                              16    7355
NP_006635                                                              16    7355
NP_001273434                                                           16    7355
NP_001269808                                                           16    7355
NP_065996                                                              16    7355
NP_001073981                                                           16    7355
XP_006726883                                                           16    7355
XP_006724993                                                           16    7355
XP_006724992                                                           16    7355
XP_006724991                                                           16    7355
XP_006724990                                                           16    7355
XP_006724989                                                           16    7355
XP_006724988                                                           16    7355
XP_006724987                                                           16    7355
XP_006724986                                                           16    7355
XP_006724985                                                           16    7355
XP_006724984                                                           16    7355
XP_006724983                                                           16    7355
XP_006724982                                                           16    7355
XP_006724981                                                           16    7355
XP_006724980                                                           16    7355
XP_006724979                                                           16    7355
XP_006724978                                                           16    7355
XP_006724977                                                           16    7355
XP_006724976                                                           16    7355
XP_006724460                                                           16    7355
XP_006724459                                                           16    7355
XP_005261947                                                           16    7355
XP_006724458                                                           16    7355
XP_005261945                                                           16    7355
XP_006724457                                                           16    7355
XP_006724456                                                           16    7355
XP_006724455                                                           16    7355
XP_006724431                                                           16    7355
XP_005261875                                                           16    7355
XP_005261874                                                           16    7355
XP_006724429                                                           16    7355
XP_005261872                                                           16    7355
XP_006724428                                                           16    7355
XP_006719820                                                           16    7355
XP_005266293                                                           16    7355
XP_005270227                                                           16    7355
XP_005270226                                                           16    7355
XP_005270223                                                           16    7355
XP_005270064                                                           16    7355
XP_005270062                                                           16    7355
XP_005270061                                                           16    7355
XP_006714553                                                           16    7355
XP_005248406                                                           16    7355
XP_005248404                                                           16    7355
XP_005248403                                                           16    7355
XP_006714552                                                           16    7355
XP_005248402                                                           16    7355
NP_038265                                                              16    7355
XP_006726511                                                           15    9605
XP_006716291                                                           15    9605
XP_006710245                                                           15    9605
>NP_001093859
          Length = 271

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HHSKVASR 9
           HHSK+ +R
Sbjct: 117 HHSKIRNR 124
>NP_149972
          Length = 381

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  HHSKVA 7
          HHSKV+
Sbjct: 68 HHSKVS 73
>NP_038347
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 532 HHTQIAS 538
>NP_001275762
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 532 HHTQIAS 538
>NP_075561
          Length = 3197

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   HSKVAS 8
           HSKVAS
Sbjct: 984 HSKVAS 989
>NP_001273433
          Length = 860

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   QHHSKVAS 8
           QH++K+A+
Sbjct: 726 QHYAKIAA 733
>NP_001273432
          Length = 814

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   QHHSKVAS 8
           QH++K+A+
Sbjct: 680 QHYAKIAA 687
>NP_954578
          Length = 218

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 181 HHTQIAS 187
>NP_006635
          Length = 858

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   QHHSKVAS 8
           QH++K+A+
Sbjct: 724 QHYAKIAA 731
>NP_001273434
          Length = 782

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   QHHSKVAS 8
           QH++K+A+
Sbjct: 648 QHYAKIAA 655
>NP_001269808
          Length = 252

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 215 HHTQIAS 221
>NP_065996
          Length = 3184

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2    HHSKV 6
            HHSKV
Sbjct: 2190 HHSKV 2194
>NP_001073981
          Length = 974

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QHHSKVAS 8
           Q+HS +AS
Sbjct: 962 QYHSDIAS 969
>XP_006726883
          Length = 225

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 188 HHTQIAS 194
>XP_006724993
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 532 HHTQIAS 538
>XP_006724992
          Length = 252

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 215 HHTQIAS 221
>XP_006724991
          Length = 321

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 284 HHTQIAS 290
>XP_006724990
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 366 HHTQIAS 372
>XP_006724989
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 366 HHTQIAS 372
>XP_006724988
          Length = 439

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 402 HHTQIAS 408
>XP_006724987
          Length = 439

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 402 HHTQIAS 408
>XP_006724986
          Length = 488

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 451 HHTQIAS 457
>XP_006724985
          Length = 496

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 459 HHTQIAS 465
>XP_006724984
          Length = 517

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 480 HHTQIAS 486
>XP_006724983
          Length = 525

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 488 HHTQIAS 494
>XP_006724982
          Length = 538

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 501 HHTQIAS 507
>XP_006724981
          Length = 565

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 528 HHTQIAS 534
>XP_006724980
          Length = 565

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 528 HHTQIAS 534
>XP_006724979
          Length = 565

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 528 HHTQIAS 534
>XP_006724978
          Length = 565

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 528 HHTQIAS 534
>XP_006724977
          Length = 565

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 528 HHTQIAS 534
>XP_006724976
          Length = 565

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 528 HHTQIAS 534
>XP_006724460
          Length = 574

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 537 HHTQIAS 543
>XP_006724459
          Length = 252

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 215 HHTQIAS 221
>XP_005261947
          Length = 321

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 284 HHTQIAS 290
>XP_006724458
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 366 HHTQIAS 372
>XP_005261945
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 366 HHTQIAS 372
>XP_006724457
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 366 HHTQIAS 372
>XP_006724456
          Length = 412

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 375 HHTQIAS 381
>XP_006724455
          Length = 439

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 402 HHTQIAS 408
>XP_006724431
          Length = 166

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 129 HHTQIAS 135
>XP_005261875
          Length = 241

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 204 HHTQIAS 210
>XP_005261874
          Length = 252

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 215 HHTQIAS 221
>XP_006724429
          Length = 269

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 232 HHTQIAS 238
>XP_005261872
          Length = 275

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 238 HHTQIAS 244
>XP_006724428
          Length = 303

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 266 HHTQIAS 272
>XP_006719820
          Length = 913

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   QHHSKVAS 8
           QH++K+A+
Sbjct: 779 QHYAKIAA 786
>XP_005266293
          Length = 816

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   QHHSKVAS 8
           QH++K+A+
Sbjct: 682 QHYAKIAA 689
>XP_005270227
          Length = 909

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QHHSKVAS 8
           Q+HS +AS
Sbjct: 897 QYHSDIAS 904
>XP_005270226
          Length = 927

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QHHSKVAS 8
           Q+HS +AS
Sbjct: 915 QYHSDIAS 922
>XP_005270223
          Length = 973

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QHHSKVAS 8
           Q+HS +AS
Sbjct: 961 QYHSDIAS 968
>XP_005270064
          Length = 1615

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   HHSKV 6
           HHSKV
Sbjct: 621 HHSKV 625
>XP_005270062
          Length = 3184

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2    HHSKV 6
            HHSKV
Sbjct: 2190 HHSKV 2194
>XP_005270061
          Length = 3184

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2    HHSKV 6
            HHSKV
Sbjct: 2190 HHSKV 2194
>XP_006714553
          Length = 2792

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   HSKVAS 8
           HSKVAS
Sbjct: 984 HSKVAS 989
>XP_005248406
          Length = 3214

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   HSKVAS 8
           HSKVAS
Sbjct: 984 HSKVAS 989
>XP_005248404
          Length = 3250

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   HSKVAS 8
           HSKVAS
Sbjct: 984 HSKVAS 989
>XP_005248403
          Length = 3250

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   HSKVAS 8
           HSKVAS
Sbjct: 984 HSKVAS 989
>XP_006714552
          Length = 3251

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   HSKVAS 8
           HSKVAS
Sbjct: 984 HSKVAS 989
>XP_005248402
          Length = 3251

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   HSKVAS 8
           HSKVAS
Sbjct: 984 HSKVAS 989
>NP_038265
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HHSKVAS 8
           HH+++AS
Sbjct: 532 HHTQIAS 538
>XP_006726511
          Length = 531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  QHHSKVASR 9
          Q HS+ ASR
Sbjct: 6  QLHSQTASR 14
>XP_006716291
          Length = 568

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  QHHSKVASR 9
          Q HS+ ASR
Sbjct: 6  QLHSQTASR 14
>XP_006710245
          Length = 327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  QHHSKVASR 9
          Q HS+ ASR
Sbjct: 6  QLHSQTASR 14
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.313    0.110    0.310 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 516,335
Number of extensions: 331
Number of successful extensions: 64
Number of sequences better than 10000.0: 64
Number of HSP's gapped: 64
Number of HSP's successfully gapped: 64
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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