Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006209                                                              20     390
XP_006713721                                                           20     390
NP_001124396                                                           18    1482
NP_001010866                                                           18    1482
XP_006710481                                                           18    1482
XP_006710480                                                           18    1482
NP_037523                                                              18    1935
XP_006714661                                                           18    1935
XP_006714660                                                           18    1935
XP_005248822                                                           17    2528
NP_078852                                                              17    2528
XP_006723711                                                           17    3301
NP_055387                                                              16    5631
NP_056081                                                              16    5631
NP_001247420                                                           16    5631
XP_006723821                                                           16    5631
XP_006723820                                                           16    5631
XP_006723819                                                           16    5631
XP_005266399                                                           16    5631
XP_006710230                                                           16    5631
NP_001609                                                              16    7355
NP_001275544                                                           16    7355
NP_570925                                                              16    7355
NP_570924                                                              16    7355
NP_570923                                                              16    7355
NP_002841                                                              16    7355
NP_001275545                                                           16    7355
XP_006722884                                                           16    7355
XP_005259667                                                           16    7355
XP_005259666                                                           16    7355
XP_006722883                                                           16    7355
XP_006722882                                                           16    7355
XP_006722881                                                           16    7355
XP_005259664                                                           16    7355
XP_005259663                                                           16    7355
XP_006722880                                                           16    7355
XP_006722879                                                           16    7355
XP_006722878                                                           16    7355
XP_006722877                                                           16    7355
XP_006722876                                                           16    7355
XP_006722875                                                           16    7355
XP_005259658                                                           16    7355
XP_005259657                                                           16    7355
XP_006722874                                                           16    7355
XP_006722873                                                           16    7355
XP_006722872                                                           16    7355
XP_006722871                                                           16    7355
XP_006720713                                                           16    7355
XP_006720712                                                           16    7355
XP_006720711                                                           16    7355
XP_005255029                                                           16    7355
XP_005255030                                                           16    7355
XP_006720710                                                           16    7355
XP_005255027                                                           16    7355
XP_005255028                                                           16    7355
XP_005255026                                                           16    7355
NP_694983                                                              15    9605
NP_001273567                                                           15    9605
NP_001258468                                                           15    9605
XP_006723716                                                           15    9605
XP_006723715                                                           15    9605
XP_006723714                                                           15    9605
XP_006723713                                                           15    9605
XP_006723712                                                           15    9605
XP_006723710                                                           15    9605
XP_006723709                                                           15    9605
XP_006719861                                                           15    9605
XP_006719860                                                           15    9605
XP_006719859                                                           15    9605
XP_006719858                                                           15    9605
>NP_006209
          Length = 1068

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QAALEYFMK 9
            Q ALEYFMK
Sbjct: 1033 QEALEYFMK 1041
>XP_006713721
          Length = 1068

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QAALEYFMK 9
            Q ALEYFMK
Sbjct: 1033 QEALEYFMK 1041
>NP_001124396
          Length = 666

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   QAALEYFMK 9
           QAA+EY++K
Sbjct: 168 QAAVEYYIK 176
>NP_001010866
          Length = 392

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   QAALEYFMK 9
           QAA+EY++K
Sbjct: 168 QAAVEYYIK 176
>XP_006710481
          Length = 542

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   QAALEYFMK 9
           QAA+EY++K
Sbjct: 168 QAAVEYYIK 176
>XP_006710480
          Length = 642

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   QAALEYFMK 9
           QAA+EY++K
Sbjct: 168 QAAVEYYIK 176
>NP_037523
          Length = 866

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QAALEYFMK 9
           +A LEYF+K
Sbjct: 739 EAGLEYFVK 747
>XP_006714661
          Length = 486

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QAALEYFMK 9
           +A LEYF+K
Sbjct: 359 EAGLEYFVK 367
>XP_006714660
          Length = 774

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QAALEYFMK 9
           +A LEYF+K
Sbjct: 739 EAGLEYFVK 747
>XP_005248822
          Length = 452

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   QAALEYFM 8
           Q+ALEYF+
Sbjct: 278 QSALEYFV 285
>NP_078852
          Length = 451

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   QAALEYFM 8
           Q+ALEYF+
Sbjct: 277 QSALEYFV 284
>XP_006723711
          Length = 670

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QAALEYFMK 9
           Q AL YF+K
Sbjct: 300 QKALHYFLK 308
>NP_055387
          Length = 1088

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QAALEYFMK 9
           +AALEY  K
Sbjct: 130 EAALEYISK 138
>NP_056081
          Length = 581

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ALEYFMK 9
           AL+YF+K
Sbjct: 260 ALDYFLK 266
>NP_001247420
          Length = 597

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ALEYFMK 9
           AL+YF+K
Sbjct: 276 ALDYFLK 282
>XP_006723821
          Length = 334

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  ALEYFMK 9
          AL+YF+K
Sbjct: 13 ALDYFLK 19
>XP_006723820
          Length = 334

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  ALEYFMK 9
          AL+YF+K
Sbjct: 13 ALDYFLK 19
>XP_006723819
          Length = 614

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ALEYFMK 9
           AL+YF+K
Sbjct: 293 ALDYFLK 299
>XP_005266399
          Length = 1088

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QAALEYFMK 9
           +AALEY  K
Sbjct: 130 EAALEYISK 138
>XP_006710230
          Length = 332

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  QAALEYFMK 9
          QAAL+ F+K
Sbjct: 15 QAALQNFLK 23
>NP_001609
          Length = 1014

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ALEYFMK 9
           A+E+FMK
Sbjct: 610 AIEHFMK 616
>NP_001275544
          Length = 447

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QAALEY 6
           QAALEY
Sbjct: 210 QAALEY 215
>NP_570925
          Length = 1505

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    QAALEY 6
            QAALEY
Sbjct: 1491 QAALEY 1496
>NP_570924
          Length = 1910

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    QAALEY 6
            QAALEY
Sbjct: 1896 QAALEY 1901
>NP_570923
          Length = 1501

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    QAALEY 6
            QAALEY
Sbjct: 1487 QAALEY 1492
>NP_002841
          Length = 1948

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    QAALEY 6
            QAALEY
Sbjct: 1934 QAALEY 1939
>NP_001275545
          Length = 447

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QAALEY 6
           QAALEY
Sbjct: 210 QAALEY 215
>XP_006722884
          Length = 1490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    QAALEY 6
            QAALEY
Sbjct: 1476 QAALEY 1481
>XP_005259667
          Length = 1497

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    QAALEY 6
            QAALEY
Sbjct: 1483 QAALEY 1488
>XP_005259666
          Length = 1501

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    QAALEY 6
            QAALEY
Sbjct: 1487 QAALEY 1492
>XP_006722883
          Length = 1510

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    QAALEY 6
            QAALEY
Sbjct: 1496 QAALEY 1501
>XP_006722882
          Length = 1522

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    QAALEY 6
            QAALEY
Sbjct: 1508 QAALEY 1513
>XP_006722881
          Length = 1526

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    QAALEY 6
            QAALEY
Sbjct: 1512 QAALEY 1517
>XP_005259664
          Length = 1906

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    QAALEY 6
            QAALEY
Sbjct: 1892 QAALEY 1897
>XP_005259663
          Length = 1910

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    QAALEY 6
            QAALEY
Sbjct: 1896 QAALEY 1901
>XP_006722880
          Length = 1915

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    QAALEY 6
            QAALEY
Sbjct: 1901 QAALEY 1906
>XP_006722879
          Length = 1917

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    QAALEY 6
            QAALEY
Sbjct: 1903 QAALEY 1908
>XP_006722878
          Length = 1924

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    QAALEY 6
            QAALEY
Sbjct: 1910 QAALEY 1915
>XP_006722877
          Length = 1928

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    QAALEY 6
            QAALEY
Sbjct: 1914 QAALEY 1919
>XP_006722876
          Length = 1933

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    QAALEY 6
            QAALEY
Sbjct: 1919 QAALEY 1924
>XP_006722875
          Length = 1935

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    QAALEY 6
            QAALEY
Sbjct: 1921 QAALEY 1926
>XP_005259658
          Length = 1935

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    QAALEY 6
            QAALEY
Sbjct: 1921 QAALEY 1926
>XP_005259657
          Length = 1935

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    QAALEY 6
            QAALEY
Sbjct: 1921 QAALEY 1926
>XP_006722874
          Length = 1940

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    QAALEY 6
            QAALEY
Sbjct: 1926 QAALEY 1931
>XP_006722873
          Length = 1944

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    QAALEY 6
            QAALEY
Sbjct: 1930 QAALEY 1935
>XP_006722872
          Length = 1944

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    QAALEY 6
            QAALEY
Sbjct: 1930 QAALEY 1935
>XP_006722871
          Length = 1944

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    QAALEY 6
            QAALEY
Sbjct: 1930 QAALEY 1935
>XP_006720713
          Length = 462

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QAALEY 6
           QAALEY
Sbjct: 225 QAALEY 230
>XP_006720712
          Length = 527

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QAALEY 6
           QAALEY
Sbjct: 210 QAALEY 215
>XP_006720711
          Length = 527

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QAALEY 6
           QAALEY
Sbjct: 210 QAALEY 215
>XP_005255029
          Length = 527

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QAALEY 6
           QAALEY
Sbjct: 210 QAALEY 215
>XP_005255030
          Length = 527

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QAALEY 6
           QAALEY
Sbjct: 210 QAALEY 215
>XP_006720710
          Length = 527

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QAALEY 6
           QAALEY
Sbjct: 210 QAALEY 215
>XP_005255027
          Length = 527

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QAALEY 6
           QAALEY
Sbjct: 210 QAALEY 215
>XP_005255028
          Length = 527

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QAALEY 6
           QAALEY
Sbjct: 210 QAALEY 215
>XP_005255026
          Length = 527

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QAALEY 6
           QAALEY
Sbjct: 210 QAALEY 215
>NP_694983
          Length = 354

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LEYFMK 9
           LEYF+K
Sbjct: 190 LEYFIK 195
>NP_001273567
          Length = 292

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LEYFMK 9
           LEYF+K
Sbjct: 127 LEYFIK 132
>NP_001258468
          Length = 575

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ALEYFMK 9
           AL YF+K
Sbjct: 321 ALHYFLK 327
>XP_006723716
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ALEYFMK 9
           AL YF+K
Sbjct: 321 ALHYFLK 327
>XP_006723715
          Length = 576

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ALEYFMK 9
           AL YF+K
Sbjct: 321 ALHYFLK 327
>XP_006723714
          Length = 590

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ALEYFMK 9
           AL YF+K
Sbjct: 321 ALHYFLK 327
>XP_006723713
          Length = 590

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ALEYFMK 9
           AL YF+K
Sbjct: 321 ALHYFLK 327
>XP_006723712
          Length = 604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ALEYFMK 9
           AL YF+K
Sbjct: 236 ALHYFLK 242
>XP_006723710
          Length = 688

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ALEYFMK 9
           AL YF+K
Sbjct: 321 ALHYFLK 327
>XP_006723709
          Length = 689

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ALEYFMK 9
           AL YF+K
Sbjct: 321 ALHYFLK 327
>XP_006719861
          Length = 286

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LEYFMK 9
           LEYF+K
Sbjct: 111 LEYFIK 116
>XP_006719860
          Length = 355

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LEYFMK 9
           LEYF+K
Sbjct: 190 LEYFIK 195
>XP_006719859
          Length = 364

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LEYFMK 9
           LEYF+K
Sbjct: 190 LEYFIK 195
>XP_006719858
          Length = 365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LEYFMK 9
           LEYF+K
Sbjct: 190 LEYFIK 195
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.329    0.132    0.355 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 375,328
Number of extensions: 352
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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