Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_115927                                                              19     869
XP_006715292                                                           19     869
NP_073728                                                              18    1935
XP_006712887                                                           18    1935
XP_005246168                                                           18    1935
NP_001157413                                                           16    5631
NP_848654                                                              16    5631
NP_775771                                                              16    7355
NP_078858                                                              16    7355
NP_001278232                                                           16    7355
NP_001278214                                                           16    7355
NP_001364                                                              16    7355
NP_060123                                                              16    7355
XP_006722555                                                           16    7355
XP_006722554                                                           16    7355
XP_006722553                                                           16    7355
XP_006722552                                                           16    7355
XP_006722551                                                           16    7355
XP_006722550                                                           16    7355
XP_006722549                                                           16    7355
XP_006722548                                                           16    7355
XP_006720466                                                           16    7355
XP_005254230                                                           16    7355
XP_006720465                                                           16    7355
XP_005254228                                                           16    7355
XP_006711798                                                           16    7355
NP_055928                                                              15    9605
NP_002936                                                              15    9605
NP_005867                                                              15    9605
XP_005276286                                                           15    9605
XP_005277590                                                           15    9605
XP_005256619                                                           15    9605
XP_006721549                                                           15    9605
XP_006721548                                                           15    9605
XP_005256618                                                           15    9605
XP_005256617                                                           15    9605
XP_005265698                                                           15    9605
XP_006712256                                                           15    9605
XP_005246298                                                           15    9605
XP_005246297                                                           15    9605
XP_005246299                                                           15    9605
XP_006712255                                                           15    9605
XP_005246296                                                           15    9605
XP_006712254                                                           15    9605
XP_005246295                                                           15    9605
XP_006712253                                                           15    9605
XP_006712252                                                           15    9605
XP_005246294                                                           15    9605
XP_006712251                                                           15    9605
XP_005246293                                                           15    9605
XP_005246292                                                           15    9605
XP_006712250                                                           15    9605
XP_005276004                                                           15    9605
>NP_115927
          Length = 1321

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PYYQLIMSV 9
           P YQLIMSV
Sbjct: 284 PDYQLIMSV 292
>XP_006715292
          Length = 759

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PYYQLIMSV 9
           P YQLIMSV
Sbjct: 271 PDYQLIMSV 279
>NP_073728
          Length = 1255

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   YYQLIMS 8
           YYQL+MS
Sbjct: 154 YYQLLMS 160
>XP_006712887
          Length = 1255

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   YYQLIMS 8
           YYQL+MS
Sbjct: 154 YYQLLMS 160
>XP_005246168
          Length = 1255

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   YYQLIMS 8
           YYQL+MS
Sbjct: 154 YYQLLMS 160
>NP_001157413
          Length = 1257

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YYQLIMS 8
           YY L+MS
Sbjct: 616 YYSLVMS 622
>NP_848654
          Length = 812

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YYQLIMS 8
           YY L+MS
Sbjct: 171 YYSLVMS 177
>NP_775771
          Length = 1244

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PYYQLIMSV 9
           P YQL+ SV
Sbjct: 271 PDYQLLTSV 279
>NP_078858
          Length = 4981

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   PYYQLIMSV 9
           P YQL++ V
Sbjct: 214 PQYQLLVEV 222
>NP_001278232
          Length = 4983

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   PYYQLIMSV 9
           P YQL++ V
Sbjct: 214 PQYQLLVEV 222
>NP_001278214
          Length = 4982

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   PYYQLIMSV 9
           P YQL++ V
Sbjct: 214 PQYQLLVEV 222
>NP_001364
          Length = 4515

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    PYYQLIMSV 9
            P+YQ+I  +
Sbjct: 1676 PHYQMIAEI 1684
>NP_060123
          Length = 669

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   PYYQLIMS 8
           PY Q IMS
Sbjct: 303 PYRQAIMS 310
>XP_006722555
          Length = 505

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   PYYQLIMS 8
           PY Q IMS
Sbjct: 303 PYRQAIMS 310
>XP_006722554
          Length = 557

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   PYYQLIMS 8
           PY Q IMS
Sbjct: 303 PYRQAIMS 310
>XP_006722553
          Length = 604

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   PYYQLIMS 8
           PY Q IMS
Sbjct: 303 PYRQAIMS 310
>XP_006722552
          Length = 608

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   PYYQLIMS 8
           PY Q IMS
Sbjct: 303 PYRQAIMS 310
>XP_006722551
          Length = 656

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   PYYQLIMS 8
           PY Q IMS
Sbjct: 303 PYRQAIMS 310
>XP_006722550
          Length = 668

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   PYYQLIMS 8
           PY Q IMS
Sbjct: 302 PYRQAIMS 309
>XP_006722549
          Length = 668

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   PYYQLIMS 8
           PY Q IMS
Sbjct: 302 PYRQAIMS 309
>XP_006722548
          Length = 669

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   PYYQLIMS 8
           PY Q IMS
Sbjct: 303 PYRQAIMS 310
>XP_006720466
          Length = 1175

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PYYQLIMSV 9
           P YQL+ SV
Sbjct: 202 PDYQLLTSV 210
>XP_005254230
          Length = 1175

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PYYQLIMSV 9
           P YQL+ SV
Sbjct: 202 PDYQLLTSV 210
>XP_006720465
          Length = 1239

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PYYQLIMSV 9
           P YQL+ SV
Sbjct: 266 PDYQLLTSV 274
>XP_005254228
          Length = 1250

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PYYQLIMSV 9
           P YQL+ SV
Sbjct: 277 PDYQLLTSV 285
>XP_006711798
          Length = 4586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    PYYQLIMSV 9
            P+YQ+I  +
Sbjct: 1693 PHYQMIAEI 1701
>NP_055928
          Length = 2961

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2    YYQLIM 7
            YYQL++
Sbjct: 1648 YYQLVL 1653
>NP_002936
          Length = 616

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  PYYQLIMS 8
          P Y+L+MS
Sbjct: 40 PRYRLLMS 47
>NP_005867
          Length = 3267

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    PYYQLIMSV 9
            PY Q+I S+
Sbjct: 2244 PYAQIIQSL 2252
>XP_005276286
          Length = 642

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   PYYQLI 6
           PY+QL+
Sbjct: 279 PYFQLL 284
>XP_005277590
          Length = 900

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   PYYQLI 6
           PY+QL+
Sbjct: 479 PYFQLL 484
>XP_005256619
          Length = 1581

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   YYQLIM 7
           YYQL++
Sbjct: 264 YYQLVL 269
>XP_006721549
          Length = 1581

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   YYQLIM 7
           YYQL++
Sbjct: 264 YYQLVL 269
>XP_006721548
          Length = 1886

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   YYQLIM 7
           YYQL++
Sbjct: 569 YYQLVL 574
>XP_005256618
          Length = 2962

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2    YYQLIM 7
            YYQL++
Sbjct: 1649 YYQLVL 1654
>XP_005256617
          Length = 2966

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2    YYQLIM 7
            YYQL++
Sbjct: 1649 YYQLVL 1654
>XP_005265698
          Length = 577

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   PYYQLI 6
           PY+QL+
Sbjct: 263 PYFQLL 268
>XP_006712256
          Length = 2418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    PYYQLIMSV 9
            PY Q+I S+
Sbjct: 1395 PYAQIIQSL 1403
>XP_005246298
          Length = 2418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    PYYQLIMSV 9
            PY Q+I S+
Sbjct: 1395 PYAQIIQSL 1403
>XP_005246297
          Length = 2418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    PYYQLIMSV 9
            PY Q+I S+
Sbjct: 1395 PYAQIIQSL 1403
>XP_005246299
          Length = 2480

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    PYYQLIMSV 9
            PY Q+I S+
Sbjct: 1457 PYAQIIQSL 1465
>XP_006712255
          Length = 2622

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    PYYQLIMSV 9
            PY Q+I S+
Sbjct: 2244 PYAQIIQSL 2252
>XP_005246296
          Length = 2475

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    PYYQLIMSV 9
            PY Q+I S+
Sbjct: 1452 PYAQIIQSL 1460
>XP_006712254
          Length = 2475

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    PYYQLIMSV 9
            PY Q+I S+
Sbjct: 1452 PYAQIIQSL 1460
>XP_005246295
          Length = 3114

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    PYYQLIMSV 9
            PY Q+I S+
Sbjct: 2091 PYAQIIQSL 2099
>XP_006712253
          Length = 3117

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    PYYQLIMSV 9
            PY Q+I S+
Sbjct: 2094 PYAQIIQSL 2102
>XP_006712252
          Length = 3163

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    PYYQLIMSV 9
            PY Q+I S+
Sbjct: 2140 PYAQIIQSL 2148
>XP_005246294
          Length = 3173

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    PYYQLIMSV 9
            PY Q+I S+
Sbjct: 2150 PYAQIIQSL 2158
>XP_006712251
          Length = 3176

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    PYYQLIMSV 9
            PY Q+I S+
Sbjct: 2153 PYAQIIQSL 2161
>XP_005246293
          Length = 3206

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    PYYQLIMSV 9
            PY Q+I S+
Sbjct: 2183 PYAQIIQSL 2191
>XP_005246292
          Length = 3208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    PYYQLIMSV 9
            PY Q+I S+
Sbjct: 2185 PYAQIIQSL 2193
>XP_006712250
          Length = 3248

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    PYYQLIMSV 9
            PY Q+I S+
Sbjct: 2225 PYAQIIQSL 2233
>XP_005276004
          Length = 584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   PYYQLI 6
           PY+QL+
Sbjct: 270 PYFQLL 275
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.331    0.144    0.434 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 477,508
Number of extensions: 360
Number of successful extensions: 53
Number of sequences better than 10000.0: 53
Number of HSP's gapped: 53
Number of HSP's successfully gapped: 53
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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