Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_787954                                                              18    1135
NP_059130                                                              18    1135
XP_005254520                                                           18    1135
NP_001161206                                                           18    1482
NP_001161205                                                           18    1482
NP_065175                                                              18    1482
NP_001001788                                                           18    1935
NP_079494                                                              17    2528
XP_005267208                                                           17    2528
NP_694958                                                              17    2528
NP_001128130                                                           17    2528
NP_000929                                                              17    2528
NP_079493                                                              17    3301
XP_005267207                                                           17    3301
XP_005270863                                                           17    3301
XP_005270862                                                           17    3301
XP_006710667                                                           17    3301
XP_006710666                                                           17    3301
NP_001139108                                                           17    3301
NP_055318                                                              17    4312
NP_079467                                                              17    4312
XP_006719406                                                           17    4312
XP_005246874                                                           17    4312
XP_005245556                                                           17    4312
NP_001001891                                                           16    5631
NP_004275                                                              16    5631
NP_116202                                                              16    5631
NP_620636                                                              16    5631
NP_003062                                                              16    5631
NP_001073137                                                           16    5631
NP_001273382                                                           16    5631
XP_006720018                                                           16    5631
XP_005254139                                                           16    5631
XP_005254137                                                           16    5631
XP_006720017                                                           16    5631
XP_005247781                                                           16    5631
XP_006712621                                                           16    5631
XP_006711701                                                           16    5631
XP_006711700                                                           16    5631
XP_006711699                                                           16    5631
NP_001273767                                                           16    7355
NP_001501                                                              16    7355
NP_001273063                                                           16    7355
NP_068751                                                              16    7355
NP_001135741                                                           16    7355
NP_000812                                                              16    7355
NP_940966                                                              16    7355
NP_848599                                                              16    7355
NP_001487                                                              16    7355
XP_006722667                                                           16    7355
XP_006722666                                                           16    7355
XP_006718333                                                           16    7355
XP_005253109                                                           16    7355
XP_006714258                                                           16    7355
XP_006713081                                                           16    7355
XP_005264316                                                           16    7355
NP_000042                                                              15    9605
NP_001004434                                                           15    9605
NP_115902                                                              15    9605
NP_037498                                                              15    9605
NP_055178                                                              15    9605
NP_001264984                                                           15    9605
NP_001136279                                                           15    9605
NP_689753                                                              15    9605
NP_065934                                                              15    9605
XP_005266395                                                           15    9605
XP_005271621                                                           15    9605
XP_006718907                                                           15    9605
XP_006718906                                                           15    9605
XP_005271619                                                           15    9605
XP_005271618                                                           15    9605
>NP_787954
          Length = 1551

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   PLLSILSEW 9
           PL+S+LS W
Sbjct: 606 PLVSLLSAW 614
>NP_059130
          Length = 1551

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   PLLSILSEW 9
           PL+S+LS W
Sbjct: 606 PLVSLLSAW 614
>XP_005254520
          Length = 1235

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   PLLSILSEW 9
           PL+S+LS W
Sbjct: 290 PLVSLLSAW 298
>NP_001161206
          Length = 1093

 Score = 18.1 bits (35), Expect =  1482
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LLSILSEW 9
           ++S+LSEW
Sbjct: 472 IMSVLSEW 479
>NP_001161205
          Length = 923

 Score = 18.1 bits (35), Expect =  1482
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LLSILSEW 9
           ++S+LSEW
Sbjct: 302 IMSVLSEW 309
>NP_065175
          Length = 1063

 Score = 18.1 bits (35), Expect =  1482
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LLSILSEW 9
           ++S+LSEW
Sbjct: 442 IMSVLSEW 449
>NP_001001788
          Length = 334

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  PLLSILSEW 9
          PLL +LS W
Sbjct: 14 PLLLLLSSW 22
>NP_079494
          Length = 244

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  PLLSILSEW 9
          PLL +LS W
Sbjct: 14 PLLHLLSGW 22
>XP_005267208
          Length = 211

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  PLLSILSEW 9
          PLL +LS W
Sbjct: 14 PLLHLLSGW 22
>NP_694958
          Length = 364

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LLSILSEW 9
           +LS+L EW
Sbjct: 268 ILSVLGEW 275
>NP_001128130
          Length = 365

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LLSILSEW 9
           +LS+L EW
Sbjct: 269 ILSVLGEW 276
>NP_000929
          Length = 1174

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   PLLSILSEW 9
           P+L  L EW
Sbjct: 540 PILEFLEEW 548
>NP_079493
          Length = 246

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  PLLSILSEW 9
          PLL +LS W
Sbjct: 14 PLLLLLSGW 22
>XP_005267207
          Length = 246

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  PLLSILSEW 9
          PLL +LS W
Sbjct: 14 PLLLLLSGW 22
>XP_005270863
          Length = 391

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  LLSILSEW 9
          LLS L EW
Sbjct: 13 LLSFLQEW 20
>XP_005270862
          Length = 431

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  LLSILSEW 9
          LLS L EW
Sbjct: 13 LLSFLQEW 20
>XP_006710667
          Length = 446

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  LLSILSEW 9
          LLS L EW
Sbjct: 13 LLSFLQEW 20
>XP_006710666
          Length = 446

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  LLSILSEW 9
          LLS L EW
Sbjct: 13 LLSFLQEW 20
>NP_001139108
          Length = 440

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  LLSILSEW 9
          LLS L EW
Sbjct: 13 LLSFLQEW 20
>NP_055318
          Length = 2785

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    PLLSILSEW 9
            PLL ++S W
Sbjct: 1201 PLLKLISIW 1209
>NP_079467
          Length = 932

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PLLSILSEW 9
           P+ SIL++W
Sbjct: 909 PIDSILADW 917
>XP_006719406
          Length = 2380

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    PLLSILSEW 9
            PLL ++S W
Sbjct: 1201 PLLKLISIW 1209
>XP_005246874
          Length = 757

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  LSILSEW 9
          LSI+S+W
Sbjct: 7  LSIMSQW 13
>XP_005245556
          Length = 933

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PLLSILSEW 9
           P+ SIL++W
Sbjct: 910 PIDSILADW 918
>NP_001001891
          Length = 933

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   PLLSILSEW 9
           PL ++L+ W
Sbjct: 729 PLFALLNNW 737
>NP_004275
          Length = 897

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LSILSEW 9
           LS+LS W
Sbjct: 104 LSVLSNW 110
>NP_116202
          Length = 760

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   PLLSILSEW 9
           PL+  +S+W
Sbjct: 364 PLIKSISDW 372
>NP_620636
          Length = 1009

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LSILSEW 9
           LS+LS W
Sbjct: 484 LSVLSNW 490
>NP_003062
          Length = 1009

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LSILSEW 9
           LS+LS W
Sbjct: 484 LSVLSNW 490
>NP_001073137
          Length = 741

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   PLLSILSEW 9
           PL+  +S+W
Sbjct: 345 PLIKSISDW 353
>NP_001273382
          Length = 630

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   PLLSILSEW 9
           PL+  +S+W
Sbjct: 234 PLIKSISDW 242
>XP_006720018
          Length = 514

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   PLLSILSEW 9
           PL+  +S+W
Sbjct: 118 PLIKSISDW 126
>XP_005254139
          Length = 524

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   PLLSILSEW 9
           PL+  +S+W
Sbjct: 128 PLIKSISDW 136
>XP_005254137
          Length = 632

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   PLLSILSEW 9
           PL+  +S+W
Sbjct: 364 PLIKSISDW 372
>XP_006720017
          Length = 741

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   PLLSILSEW 9
           PL+  +S+W
Sbjct: 345 PLIKSISDW 353
>XP_005247781
          Length = 1008

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LSILSEW 9
           LS+LS W
Sbjct: 483 LSVLSNW 489
>XP_006712621
          Length = 932

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   PLLSILSEW 9
           PL ++L+ W
Sbjct: 728 PLFALLNNW 736
>XP_006711701
          Length = 792

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LSILSEW 9
           LS+LS W
Sbjct: 104 LSVLSNW 110
>XP_006711700
          Length = 803

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LSILSEW 9
           LS+LS W
Sbjct: 104 LSVLSNW 110
>XP_006711699
          Length = 825

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  LSILSEW 9
          LS+LS W
Sbjct: 32 LSVLSNW 38
>NP_001273767
          Length = 912

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  PLLSILSEW 9
          P L +LS W
Sbjct: 5  PFLLVLSVW 13
>NP_001501
          Length = 1007

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  PLLSILSEW 9
          P L +LS W
Sbjct: 5  PFLLVLSVW 13
>NP_001273063
          Length = 531

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   PLLSILSE 8
           P+LS+L+E
Sbjct: 333 PVLSVLTE 340
>NP_068751
          Length = 537

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   PLLSILSE 8
           P+LS+L+E
Sbjct: 333 PVLSVLTE 340
>NP_001135741
          Length = 701

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   PLLSILSEW 9
           PLL  LS W
Sbjct: 447 PLLMDLSPW 455
>NP_000812
          Length = 758

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   PLLSILSEW 9
           PLL  LS W
Sbjct: 504 PLLMDLSPW 512
>NP_940966
          Length = 457

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   PLLSILSEW 9
           PL+ I  EW
Sbjct: 107 PLVPIQQEW 115
>NP_848599
          Length = 3092

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   PLLSILSEW 9
           PL+ I  EW
Sbjct: 107 PLVPIQQEW 115
>NP_001487
          Length = 400

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   PLLSILSEW 9
           PL+ +LS W
Sbjct: 392 PLILLLSLW 400
>XP_006722667
          Length = 173

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/9 (33%), Positives = 7/9 (77%)

Query: 1  PLLSILSEW 9
          P+L+++  W
Sbjct: 18 PILAVVESW 26
>XP_006722666
          Length = 173

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/9 (33%), Positives = 7/9 (77%)

Query: 1  PLLSILSEW 9
          P+L+++  W
Sbjct: 18 PILAVVESW 26
>XP_006718333
          Length = 421

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   PLLSILSE 8
           P+LS+L+E
Sbjct: 223 PVLSVLTE 230
>XP_005253109
          Length = 535

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   PLLSILSE 8
           P+LS+L+E
Sbjct: 337 PVLSVLTE 344
>XP_006714258
          Length = 994

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  PLLSILSEW 9
          P L +LS W
Sbjct: 5  PFLLVLSVW 13
>XP_006713081
          Length = 3964

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   PLLSILSEW 9
           PL+ I  EW
Sbjct: 107 PLVPIQQEW 115
>XP_005264316
          Length = 756

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   PLLSILSEW 9
           PLL  LS W
Sbjct: 504 PLLMDLSPW 512
>NP_000042
          Length = 3056

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PLLSILSE 8
           PLL ILS+
Sbjct: 434 PLLMILSQ 441
>NP_001004434
          Length = 372

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LLSILSEW 9
           L+S+LS W
Sbjct: 145 LVSVLSIW 152
>NP_115902
          Length = 323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LLSILSEW 9
           L+S+LS W
Sbjct: 96  LVSVLSIW 103
>NP_037498
          Length = 822

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  LLSILSEW 9
          L S+L EW
Sbjct: 67 LHSVLEEW 74
>NP_055178
          Length = 4579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    PLLSILSE 8
            P+LS+L E
Sbjct: 1727 PVLSVLKE 1734
>NP_001264984
          Length = 4432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    PLLSILSE 8
            P+LS+L E
Sbjct: 1580 PVLSVLKE 1587
>NP_001136279
          Length = 580

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 5/9 (55%)

Query: 1   PLLSILSEW 9
           PL  +L  W
Sbjct: 371 PLFGLLQNW 379
>NP_689753
          Length = 684

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   PLLSILSEW 9
           PLL  +++W
Sbjct: 514 PLLQKITDW 522
>NP_065934
          Length = 1185

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LLSILSEW 9
           L+SIL  W
Sbjct: 903 LVSILQSW 910
>XP_005266395
          Length = 4588

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    PLLSILSE 8
            P+LS+L E
Sbjct: 1736 PVLSVLKE 1743
>XP_005271621
          Length = 2708

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  PLLSILSE 8
          PLL ILS+
Sbjct: 86 PLLMILSQ 93
>XP_006718907
          Length = 3050

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PLLSILSE 8
           PLL ILS+
Sbjct: 434 PLLMILSQ 441
>XP_006718906
          Length = 3056

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PLLSILSE 8
           PLL ILS+
Sbjct: 434 PLLMILSQ 441
>XP_005271619
          Length = 3056

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PLLSILSE 8
           PLL ILS+
Sbjct: 434 PLLMILSQ 441
>XP_005271618
          Length = 3056

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PLLSILSE 8
           PLL ILS+
Sbjct: 434 PLLMILSQ 441
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.319    0.138    0.470 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 505,902
Number of extensions: 1061
Number of successful extensions: 71
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package