Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_940857                                                              17    2528
NP_001025459                                                           17    4312
NP_056019                                                              17    4312
NP_003114                                                              17    4312
XP_005276570                                                           17    4312
XP_006715725                                                           17    4312
XP_006715724                                                           17    4312
XP_006715723                                                           17    4312
XP_006715722                                                           17    4312
NP_005667                                                              16    5631
NP_690595                                                              16    5631
NP_542382                                                              16    5631
NP_076418                                                              16    5631
NP_001191396                                                           16    5631
NP_001191395                                                           16    5631
NP_001191397                                                           16    5631
NP_001099009                                                           16    5631
NP_060184                                                              16    5631
XP_006724626                                                           16    5631
XP_005272736                                                           16    5631
XP_005272735                                                           16    5631
XP_005272734                                                           16    5631
XP_006723653                                                           16    5631
XP_006723652                                                           16    5631
XP_005251344                                                           16    5631
NP_002175                                                              16    7355
NP_001177910                                                           16    7355
NP_003743                                                              16    7355
NP_001254503                                                           16    7355
NP_001273407                                                           16    7355
NP_001032897                                                           16    7355
NP_149072                                                              16    7355
NP_001275701                                                           16    7355
NP_001186071                                                           16    7355
NP_001180298                                                           16    7355
NP_004561                                                              16    7355
NP_001093131                                                           16    7355
NP_001275703                                                           16    7355
XP_005255592                                                           16    7355
XP_005253450                                                           16    7355
XP_006719151                                                           16    7355
NP_060660                                                              15    9605
NP_061987                                                              15    9605
NP_789794                                                              15    9605
NP_542398                                                              15    9605
NP_001269690                                                           15    9605
XP_006717209                                                           15    9605
XP_006717208                                                           15    9605
XP_006717207                                                           15    9605
XP_005263163                                                           15    9605
XP_005264177                                                           15    9605
>NP_940857
          Length = 5147

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    PLLASEDRR 9
            PLLASE  R
Sbjct: 4568 PLLASEQHR 4576
>NP_001025459
          Length = 400

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   PLLASED 7
           PL+ASED
Sbjct: 375 PLVASED 381
>NP_056019
          Length = 1657

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PLLASEDRR 9
           PLL+ +D+R
Sbjct: 439 PLLSQQDKR 447
>NP_003114
          Length = 400

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   PLLASED 7
           PL+ASED
Sbjct: 375 PLVASED 381
>XP_005276570
          Length = 400

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   PLLASED 7
           PL+ASED
Sbjct: 375 PLVASED 381
>XP_006715725
          Length = 1516

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PLLASEDRR 9
           PLL+ +D+R
Sbjct: 439 PLLSQQDKR 447
>XP_006715724
          Length = 1533

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PLLASEDRR 9
           PLL+ +D+R
Sbjct: 439 PLLSQQDKR 447
>XP_006715723
          Length = 1559

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PLLASEDRR 9
           PLL+ +D+R
Sbjct: 439 PLLSQQDKR 447
>XP_006715722
          Length = 1614

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PLLASEDRR 9
           PLL+ +D+R
Sbjct: 439 PLLSQQDKR 447
>NP_005667
          Length = 930

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PLLASEDR 8
           P LAS+DR
Sbjct: 714 PKLASDDR 721
>NP_690595
          Length = 852

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PLLASEDR 8
           P LAS+DR
Sbjct: 636 PKLASDDR 643
>NP_542382
          Length = 178

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PLLASEDRR 9
           P  ASE+RR
Sbjct: 132 PRFASEERR 140
>NP_076418
          Length = 847

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PLLASEDRR 9
           PLLA  +RR
Sbjct: 113 PLLAERNRR 121
>NP_001191396
          Length = 929

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PLLASEDR 8
           P LAS+DR
Sbjct: 713 PKLASDDR 720
>NP_001191395
          Length = 853

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PLLASEDR 8
           P LAS+DR
Sbjct: 637 PKLASDDR 644
>NP_001191397
          Length = 995

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PLLASEDR 8
           P LAS+DR
Sbjct: 779 PKLASDDR 786
>NP_001099009
          Length = 871

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PLLASEDRR 9
           PLLA  +RR
Sbjct: 113 PLLAERNRR 121
>NP_060184
          Length = 420

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   PLLASED 7
           P LASED
Sbjct: 331 PFLASED 337
>XP_006724626
          Length = 727

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PLLASEDR 8
           P LAS+DR
Sbjct: 511 PKLASDDR 518
>XP_005272736
          Length = 917

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PLLASEDR 8
           P LAS+DR
Sbjct: 701 PKLASDDR 708
>XP_005272735
          Length = 918

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PLLASEDR 8
           P LAS+DR
Sbjct: 702 PKLASDDR 709
>XP_005272734
          Length = 994

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PLLASEDR 8
           P LAS+DR
Sbjct: 778 PKLASDDR 785
>XP_006723653
          Length = 318

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   PLLASED 7
           P LASED
Sbjct: 229 PFLASED 235
>XP_006723652
          Length = 318

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   PLLASED 7
           P LASED
Sbjct: 229 PFLASED 235
>XP_005251344
          Length = 859

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PLLASEDRR 9
           PLLA  +RR
Sbjct: 113 PLLAERNRR 121
>NP_002175
          Length = 918

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PLLASEDR 8
           PLL SE+R
Sbjct: 785 PLLDSEER 792
>NP_001177910
          Length = 857

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PLLASEDR 8
           PLL SE+R
Sbjct: 724 PLLDSEER 731
>NP_003743
          Length = 913

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  PLLASED 7
          PLL SED
Sbjct: 35 PLLLSED 41
>NP_001254503
          Length = 913

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  PLLASED 7
          PLL SED
Sbjct: 35 PLLLSED 41
>NP_001273407
          Length = 903

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  PLLASED 7
          PLL SED
Sbjct: 35 PLLLSED 41
>NP_001032897
          Length = 913

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  PLLASED 7
          PLL SED
Sbjct: 35 PLLLSED 41
>NP_149072
          Length = 2240

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    ASEDRR 9
            ASEDRR
Sbjct: 2109 ASEDRR 2114
>NP_001275701
          Length = 1486

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PLLASEDRR 9
           PLL SE+++
Sbjct: 707 PLLLSEEKK 715
>NP_001186071
          Length = 913

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  PLLASED 7
          PLL SED
Sbjct: 35 PLLLSED 41
>NP_001180298
          Length = 2240

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    ASEDRR 9
            ASEDRR
Sbjct: 2109 ASEDRR 2114
>NP_004561
          Length = 1445

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PLLASEDRR 9
           PLL SE+++
Sbjct: 666 PLLLSEEKK 674
>NP_001093131
          Length = 914

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  PLLASED 7
          PLL SED
Sbjct: 35 PLLLSED 41
>NP_001275703
          Length = 1264

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PLLASEDRR 9
           PLL SE+++
Sbjct: 485 PLLLSEEKK 493
>XP_005255592
          Length = 914

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  PLLASED 7
          PLL SED
Sbjct: 35 PLLLSED 41
>XP_005253450
          Length = 1486

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PLLASEDRR 9
           PLL SE+++
Sbjct: 707 PLLLSEEKK 715
>XP_006719151
          Length = 1486

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PLLASEDRR 9
           PLL SE+++
Sbjct: 707 PLLLSEEKK 715
>NP_060660
          Length = 672

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PLLASEDR 8
           P+LA +DR
Sbjct: 163 PVLACQDR 170
>NP_061987
          Length = 900

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PLLASEDR 8
           P+L+S DR
Sbjct: 476 PVLSSSDR 483
>NP_789794
          Length = 715

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PLLASEDR 8
           P+LA +DR
Sbjct: 163 PVLACQDR 170
>NP_542398
          Length = 342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   PLLASED 7
           P+LA+ED
Sbjct: 99  PVLAAED 105
>NP_001269690
          Length = 367

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   PLLASED 7
           P+LA+ED
Sbjct: 124 PVLAAED 130
>XP_006717209
          Length = 812

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PLLASEDR 8
           P+L+S DR
Sbjct: 476 PVLSSSDR 483
>XP_006717208
          Length = 838

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PLLASEDR 8
           P+L+S DR
Sbjct: 476 PVLSSSDR 483
>XP_006717207
          Length = 861

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PLLASEDR 8
           P+L+S DR
Sbjct: 476 PVLSSSDR 483
>XP_005263163
          Length = 716

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PLLASEDR 8
           P+LA +DR
Sbjct: 163 PVLACQDR 170
>XP_005264177
          Length = 218

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   PLLASED 7
           P+LA+ED
Sbjct: 99  PVLAAED 105
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.135    0.367 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 563,886
Number of extensions: 966
Number of successful extensions: 51
Number of sequences better than 10000.0: 51
Number of HSP's gapped: 51
Number of HSP's successfully gapped: 51
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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