Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000360                                                              20     509
XP_005268094                                                           20     509
XP_005250044                                                           17    4312
XP_005250043                                                           17    4312
NP_001001802                                                           17    4312
NP_001005287                                                           17    4312
NP_000483                                                              16    7355
NP_073740                                                              16    7355
NP_001180268                                                           16    7355
NP_055994                                                              16    7355
NP_001138586                                                           16    7355
NP_001271266                                                           16    7355
XP_006715905                                                           16    7355
NP_996776                                                              16    7355
NP_055872                                                              15    9605
NP_057063                                                              15    9605
NP_001020029                                                           15    9605
NP_001139129                                                           15    9605
NP_036234                                                              15    9605
NP_001036147                                                           15    9605
NP_001036146                                                           15    9605
NP_005472                                                              15    9605
NP_004821                                                              15    9605
NP_001257451                                                           15    9605
NP_001257450                                                           15    9605
NP_001139130                                                           15    9605
NP_002876                                                              15    9605
XP_006722663                                                           15    9605
XP_006720304                                                           15    9605
XP_005268080                                                           15    9605
XP_006719852                                                           15    9605
XP_005266357                                                           15    9605
XP_006719851                                                           15    9605
XP_006719850                                                           15    9605
XP_006719849                                                           15    9605
XP_006719848                                                           15    9605
XP_005266356                                                           15    9605
XP_006719847                                                           15    9605
XP_006719846                                                           15    9605
XP_006719845                                                           15    9605
XP_006719844                                                           15    9605
XP_006719843                                                           15    9605
XP_006719842                                                           15    9605
XP_006717307                                                           15    9605
XP_006717306                                                           15    9605
XP_006717305                                                           15    9605
XP_005266153                                                           15    9605
XP_006717304                                                           15    9605
XP_005267280                                                           15    9605
XP_006710870                                                           15    9605
XP_005246013                                                           15    9605
XP_006710869                                                           15    9605
XP_005246012                                                           15    9605
XP_005246011                                                           15    9605
XP_006710868                                                           15    9605
XP_006710867                                                           15    9605
XP_006710717                                                           15    9605
XP_005263523                                                           15    9605
XP_005263522                                                           15    9605
XP_006710716                                                           15    9605
XP_005263521                                                           15    9605
NP_003077                                                              15    9605
>NP_000360
          Length = 764

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   PLALAHIVF 9
           PLALA+IVF
Sbjct: 577 PLALAYIVF 585
>XP_005268094
          Length = 764

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   PLALAHIVF 9
           PLALA+IVF
Sbjct: 577 PLALAYIVF 585
>XP_005250044
          Length = 310

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LALAHIV 8
           LALAH+V
Sbjct: 154 LALAHVV 160
>XP_005250043
          Length = 329

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LALAHIV 8
           LALAH+V
Sbjct: 173 LALAHVV 179
>NP_001001802
          Length = 310

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LALAHIV 8
           LALAH+V
Sbjct: 154 LALAHVV 160
>NP_001005287
          Length = 310

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LALAHIV 8
           LALAH+V
Sbjct: 154 LALAHVV 160
>NP_000483
          Length = 1480

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LALAHIVF 9
           LALAH V+
Sbjct: 195 LALAHFVW 202
>NP_073740
          Length = 602

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  PLALAHIVF 9
          PLAL  +VF
Sbjct: 24 PLALLPVVF 32
>NP_001180268
          Length = 552

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  PLALAHIVF 9
          PLAL  +VF
Sbjct: 24 PLALLPVVF 32
>NP_055994
          Length = 1297

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LALAHIVF 9
           LAL H++F
Sbjct: 922 LALTHLLF 929
>NP_001138586
          Length = 1236

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LALAHIVF 9
           LAL H++F
Sbjct: 861 LALTHLLF 868
>NP_001271266
          Length = 1197

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LALAHIVF 9
           LAL H++F
Sbjct: 822 LALTHLLF 829
>XP_006715905
          Length = 1588

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LALAHIVF 9
           LALAH V+
Sbjct: 303 LALAHFVW 310
>NP_996776
          Length = 267

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LALAHIVF 9
          +AL H+VF
Sbjct: 67 IALLHLVF 74
>NP_055872
          Length = 4678

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    PLALAHIV 8
            PL L H+V
Sbjct: 3157 PLTLQHLV 3164
>NP_057063
          Length = 1365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LALAHIVF 9
            LALAH V+
Sbjct: 1215 LALAHAVW 1222
>NP_001020029
          Length = 2328

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    PLALAHIV 8
            PLAL H +
Sbjct: 2235 PLALRHAI 2242
>NP_001139129
          Length = 681

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ALAHIVF 9
           AL H+VF
Sbjct: 108 ALGHLVF 114
>NP_036234
          Length = 1566

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PLALAHI 7
           PLA+ HI
Sbjct: 922 PLAMPHI 928
>NP_001036147
          Length = 1012

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PLALAHI 7
           PLA+ HI
Sbjct: 368 PLAMPHI 374
>NP_001036146
          Length = 1566

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PLALAHI 7
           PLA+ HI
Sbjct: 922 PLAMPHI 928
>NP_005472
          Length = 877

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LALAHIVF 9
           LAL H++F
Sbjct: 469 LALRHLLF 476
>NP_004821
          Length = 1368

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LALAHIVF 9
            LALAH V+
Sbjct: 1209 LALAHAVW 1216
>NP_001257451
          Length = 1364

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LALAHIVF 9
            LALAH V+
Sbjct: 1209 LALAHAVW 1216
>NP_001257450
          Length = 1359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LALAHIVF 9
            LALAH V+
Sbjct: 1209 LALAHAVW 1216
>NP_001139130
          Length = 727

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ALAHIVF 9
           AL H+VF
Sbjct: 172 ALGHLVF 178
>NP_002876
          Length = 663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ALAHIVF 9
           AL H+VF
Sbjct: 108 ALGHLVF 114
>XP_006722663
          Length = 877

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LALAHIVF 9
           LAL H++F
Sbjct: 469 LALRHLLF 476
>XP_006720304
          Length = 2328

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    PLALAHIV 8
            PLAL H +
Sbjct: 2235 PLALRHAI 2242
>XP_005268080
          Length = 2328

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    PLALAHIV 8
            PLAL H +
Sbjct: 2235 PLALRHAI 2242
>XP_006719852
          Length = 4752

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    PLALAHIV 8
            PL L H+V
Sbjct: 3234 PLTLQHLV 3241
>XP_005266357
          Length = 4600

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    PLALAHIV 8
            PL L H+V
Sbjct: 3082 PLTLQHLV 3089
>XP_006719851
          Length = 4689

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    PLALAHIV 8
            PL L H+V
Sbjct: 3168 PLTLQHLV 3175
>XP_006719850
          Length = 4697

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    PLALAHIV 8
            PL L H+V
Sbjct: 3176 PLTLQHLV 3183
>XP_006719849
          Length = 4703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    PLALAHIV 8
            PL L H+V
Sbjct: 3182 PLTLQHLV 3189
>XP_006719848
          Length = 4737

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    PLALAHIV 8
            PL L H+V
Sbjct: 3216 PLTLQHLV 3223
>XP_005266356
          Length = 4755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    PLALAHIV 8
            PL L H+V
Sbjct: 3234 PLTLQHLV 3241
>XP_006719847
          Length = 4761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    PLALAHIV 8
            PL L H+V
Sbjct: 3240 PLTLQHLV 3247
>XP_006719846
          Length = 4763

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    PLALAHIV 8
            PL L H+V
Sbjct: 3242 PLTLQHLV 3249
>XP_006719845
          Length = 4772

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    PLALAHIV 8
            PL L H+V
Sbjct: 3251 PLTLQHLV 3258
>XP_006719844
          Length = 4789

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    PLALAHIV 8
            PL L H+V
Sbjct: 3268 PLTLQHLV 3275
>XP_006719843
          Length = 4794

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    PLALAHIV 8
            PL L H+V
Sbjct: 3276 PLTLQHLV 3283
>XP_006719842
          Length = 4797

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    PLALAHIV 8
            PL L H+V
Sbjct: 3276 PLTLQHLV 3283
>XP_006717307
          Length = 873

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PLALAHI 7
           PL+L HI
Sbjct: 461 PLSLTHI 467
>XP_006717306
          Length = 1441

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    PLALAHI 7
            PL+L HI
Sbjct: 1029 PLSLTHI 1035
>XP_006717305
          Length = 1469

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    PLALAHI 7
            PL+L HI
Sbjct: 1057 PLSLTHI 1063
>XP_005266153
          Length = 1469

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    PLALAHI 7
            PL+L HI
Sbjct: 1057 PLSLTHI 1063
>XP_006717304
          Length = 1469

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    PLALAHI 7
            PL+L HI
Sbjct: 1057 PLSLTHI 1063
>XP_005267280
          Length = 1374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LALAHIVF 9
            LALAH V+
Sbjct: 1215 LALAHAVW 1222
>XP_006710870
          Length = 779

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ALAHIVF 9
           AL H+VF
Sbjct: 139 ALGHLVF 145
>XP_005246013
          Length = 800

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ALAHIVF 9
           AL H+VF
Sbjct: 245 ALGHLVF 251
>XP_006710869
          Length = 812

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ALAHIVF 9
           AL H+VF
Sbjct: 172 ALGHLVF 178
>XP_005246012
          Length = 818

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ALAHIVF 9
           AL H+VF
Sbjct: 245 ALGHLVF 251
>XP_005246011
          Length = 826

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ALAHIVF 9
           AL H+VF
Sbjct: 245 ALGHLVF 251
>XP_006710868
          Length = 877

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ALAHIVF 9
           AL H+VF
Sbjct: 245 ALGHLVF 251
>XP_006710867
          Length = 885

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ALAHIVF 9
           AL H+VF
Sbjct: 245 ALGHLVF 251
>XP_006710717
          Length = 1171

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PLALAHI 7
           PLA+ HI
Sbjct: 527 PLAMPHI 533
>XP_005263523
          Length = 1298

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PLALAHI 7
           PLA+ HI
Sbjct: 654 PLAMPHI 660
>XP_005263522
          Length = 1524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PLALAHI 7
           PLA+ HI
Sbjct: 880 PLAMPHI 886
>XP_006710716
          Length = 1566

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PLALAHI 7
           PLA+ HI
Sbjct: 922 PLAMPHI 928
>XP_005263521
          Length = 1566

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PLALAHI 7
           PLA+ HI
Sbjct: 922 PLAMPHI 928
>NP_003077
          Length = 1469

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    PLALAHI 7
            PL+L HI
Sbjct: 1057 PLSLTHI 1063
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.344    0.153    0.484 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 545,670
Number of extensions: 948
Number of successful extensions: 62
Number of sequences better than 10000.0: 62
Number of HSP's gapped: 62
Number of HSP's successfully gapped: 62
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.6 bits)
S2: 28 (15.4 bits)

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