Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000537                                                              19     665
NP_001263689                                                           19     665
NP_001119584                                                           19     665
NP_001119586                                                           19     665
NP_001263625                                                           19     665
NP_001119590                                                           19     665
NP_001263690                                                           19     665
NP_001119585                                                           19     665
NP_001263624                                                           19     665
NP_001119588                                                           19     665
NP_001119587                                                           19     665
NP_001119589                                                           19     665
NP_002172                                                              18    1935
NP_001008781                                                           17    3301
XP_006718827                                                           17    3301
NP_065173                                                              17    4312
NP_001438                                                              16    5631
XP_006726571                                                           16    5631
XP_006726570                                                           16    5631
XP_003960511                                                           16    5631
XP_005269723                                                           16    5631
XP_006717414                                                           16    5631
XP_006714824                                                           16    5631
XP_006710284                                                           16    5631
NP_000184                                                              16    7355
NP_055542                                                              16    7355
NP_001158067                                                           16    7355
XP_006723578                                                           16    7355
XP_006723577                                                           16    7355
XP_006723576                                                           16    7355
NP_110380                                                              15    9605
NP_001159403                                                           15    9605
NP_001025                                                              15    9605
NP_071342                                                              15    9605
NP_001094282                                                           15    9605
NP_690007                                                              15    9605
NP_001193499                                                           15    9605
NP_001013049                                                           15    9605
NP_001193501                                                           15    9605
NP_443150                                                              15    9605
NP_001193500                                                           15    9605
NP_001193498                                                           15    9605
NP_001078869                                                           15    9605
NP_001078868                                                           15    9605
NP_065694                                                              15    9605
NP_690008                                                              15    9605
NP_071907                                                              15    9605
XP_005259213                                                           15    9605
XP_005259212                                                           15    9605
XP_005259211                                                           15    9605
XP_006723388                                                           15    9605
XP_005259210                                                           15    9605
XP_006723387                                                           15    9605
XP_005259209                                                           15    9605
NP_690009                                                              15    9605
NP_775813                                                              15    9605
>NP_000537
          Length = 393

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PGTRVLAMA 9
           PGTRV AMA
Sbjct: 153 PGTRVRAMA 161
>NP_001263689
          Length = 354

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PGTRVLAMA 9
           PGTRV AMA
Sbjct: 114 PGTRVRAMA 122
>NP_001119584
          Length = 393

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PGTRVLAMA 9
           PGTRV AMA
Sbjct: 153 PGTRVRAMA 161
>NP_001119586
          Length = 341

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PGTRVLAMA 9
           PGTRV AMA
Sbjct: 153 PGTRVRAMA 161
>NP_001263625
          Length = 302

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PGTRVLAMA 9
           PGTRV AMA
Sbjct: 114 PGTRVRAMA 122
>NP_001119590
          Length = 354

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PGTRVLAMA 9
           PGTRV AMA
Sbjct: 114 PGTRVRAMA 122
>NP_001263690
          Length = 354

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PGTRVLAMA 9
           PGTRV AMA
Sbjct: 114 PGTRVRAMA 122
>NP_001119585
          Length = 346

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PGTRVLAMA 9
           PGTRV AMA
Sbjct: 153 PGTRVRAMA 161
>NP_001263624
          Length = 307

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PGTRVLAMA 9
           PGTRV AMA
Sbjct: 114 PGTRVRAMA 122
>NP_001119588
          Length = 209

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  PGTRVLAMA 9
          PGTRV AMA
Sbjct: 21 PGTRVRAMA 29
>NP_001119587
          Length = 261

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  PGTRVLAMA 9
          PGTRV AMA
Sbjct: 21 PGTRVRAMA 29
>NP_001119589
          Length = 214

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  PGTRVLAMA 9
          PGTRV AMA
Sbjct: 21 PGTRVRAMA 29
>NP_002172
          Length = 411

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   PGTRVLAM 8
           PG RVLAM
Sbjct: 225 PGDRVLAM 232
>NP_001008781
          Length = 4557

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    PGTRVLAM 8
            PGT+VLA+
Sbjct: 3251 PGTQVLAV 3258
>XP_006718827
          Length = 3479

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    PGTRVLAM 8
            PGT+VLA+
Sbjct: 2141 PGTQVLAV 2148
>NP_065173
          Length = 879

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   PGTRVLA 7
           PG+RVLA
Sbjct: 326 PGSRVLA 332
>NP_001438
          Length = 4349

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PGTRVLAM 8
           PGT VLA+
Sbjct: 473 PGTSVLAV 480
>XP_006726571
          Length = 3681

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PGTRVLAMA 9
           PG RVL +A
Sbjct: 682 PGGRVLTLA 690
>XP_006726570
          Length = 3722

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PGTRVLAMA 9
           PG RVL +A
Sbjct: 682 PGGRVLTLA 690
>XP_003960511
          Length = 3722

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PGTRVLAMA 9
           PG RVL +A
Sbjct: 682 PGGRVLTLA 690
>XP_005269723
          Length = 229

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1 PGTRVL 6
         PGTR+L
Sbjct: 3 PGTRIL 8
>XP_006717414
          Length = 5100

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    PGTRVLAMA 9
            PG RVL +A
Sbjct: 2060 PGGRVLTLA 2068
>XP_006714824
          Length = 4349

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PGTRVLAM 8
           PGT VLA+
Sbjct: 473 PGTSVLAV 480
>XP_006710284
          Length = 945

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PGTRVLAMA 9
           PG RVL +A
Sbjct: 686 PGGRVLTLA 694
>NP_000184
          Length = 462

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   PGTRVLA 7
           PG RVLA
Sbjct: 220 PGDRVLA 226
>NP_055542
          Length = 2715

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    PGTRVLAM 8
            PG RVL++
Sbjct: 2170 PGVRVLSL 2177
>NP_001158067
          Length = 1036

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   PGTRVLA 7
           PG RVLA
Sbjct: 160 PGPRVLA 166
>XP_006723578
          Length = 1077

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PGTRVLAM 8
           PG RVL++
Sbjct: 532 PGVRVLSL 539
>XP_006723577
          Length = 1951

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    PGTRVLAM 8
            PG RVL++
Sbjct: 1406 PGVRVLSL 1413
>XP_006723576
          Length = 2313

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    PGTRVLAM 8
            PG RVL++
Sbjct: 2170 PGVRVLSL 2177
>NP_110380
          Length = 355

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  GTRVLA 7
          GTRVLA
Sbjct: 16 GTRVLA 21
>NP_001159403
          Length = 449

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   GTRVLA 7
           GTRVLA
Sbjct: 99  GTRVLA 104
>NP_001025
          Length = 389

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  GTRVLA 7
          GTRVLA
Sbjct: 39 GTRVLA 44
>NP_071342
          Length = 273

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  PGTRVLAM 8
          PG+RVL +
Sbjct: 26 PGSRVLLL 33
>NP_001094282
          Length = 273

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  PGTRVLAM 8
          PG+RVL +
Sbjct: 26 PGSRVLLL 33
>NP_690007
          Length = 667

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PGTRVLA 7
           PG R+LA
Sbjct: 382 PGPRILA 388
>NP_001193499
          Length = 1130

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    PGTRVLAMA 9
            PG RVL  A
Sbjct: 1075 PGVRVLVHA 1083
>NP_001013049
          Length = 1198

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    PGTRVLAMA 9
            PG RVL  A
Sbjct: 1075 PGVRVLVHA 1083
>NP_001193501
          Length = 1179

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    PGTRVLAMA 9
            PG RVL  A
Sbjct: 1075 PGVRVLVHA 1083
>NP_443150
          Length = 1168

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    PGTRVLAMA 9
            PG RVL  A
Sbjct: 1075 PGVRVLVHA 1083
>NP_001193500
          Length = 1159

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    PGTRVLAMA 9
            PG RVL  A
Sbjct: 1075 PGVRVLVHA 1083
>NP_001193498
          Length = 1179

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    PGTRVLAMA 9
            PG RVL  A
Sbjct: 1075 PGVRVLVHA 1083
>NP_001078869
          Length = 271

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  PGTRVLAMA 9
          PG+ VLA A
Sbjct: 7  PGSAVLAAA 15
>NP_001078868
          Length = 271

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  PGTRVLAMA 9
          PG+ VLA A
Sbjct: 7  PGSAVLAAA 15
>NP_065694
          Length = 467

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PGTRVLAM 8
           PG +VLA+
Sbjct: 155 PGDKVLAL 162
>NP_690008
          Length = 669

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PGTRVLA 7
           PG R+LA
Sbjct: 384 PGPRILA 390
>NP_071907
          Length = 600

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PGTRVLA 7
           PG R+LA
Sbjct: 315 PGPRILA 321
>XP_005259213
          Length = 587

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PGTRVLA 7
           PG R+LA
Sbjct: 428 PGPRILA 434
>XP_005259212
          Length = 587

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PGTRVLA 7
           PG R+LA
Sbjct: 428 PGPRILA 434
>XP_005259211
          Length = 600

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PGTRVLA 7
           PG R+LA
Sbjct: 315 PGPRILA 321
>XP_006723388
          Length = 600

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PGTRVLA 7
           PG R+LA
Sbjct: 315 PGPRILA 321
>XP_005259210
          Length = 612

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PGTRVLA 7
           PG R+LA
Sbjct: 333 PGPRILA 339
>XP_006723387
          Length = 667

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PGTRVLA 7
           PG R+LA
Sbjct: 382 PGPRILA 388
>XP_005259209
          Length = 713

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PGTRVLA 7
           PG R+LA
Sbjct: 428 PGPRILA 434
>NP_690009
          Length = 450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PGTRVLA 7
           PG R+LA
Sbjct: 315 PGPRILA 321
>NP_775813
          Length = 589

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PGTRVLAM 8
           PG+RVL +
Sbjct: 393 PGSRVLTI 400
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.325    0.133    0.384 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 487,078
Number of extensions: 478
Number of successful extensions: 56
Number of sequences better than 10000.0: 56
Number of HSP's gapped: 56
Number of HSP's successfully gapped: 56
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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