Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_003961                                                              17    2528
XP_006716300                                                           17    2528
NP_001180291                                                           17    4312
NP_001180290                                                           17    4312
NP_001180289                                                           17    4312
NP_001180292                                                           17    4312
NP_060669                                                              17    4312
XP_005267875                                                           17    4312
XP_005267874                                                           17    4312
XP_006720253                                                           17    4312
NP_001244950                                                           16    5631
NP_001244948                                                           16    5631
NP_001244949                                                           16    5631
NP_001244951                                                           16    5631
NP_001244952                                                           16    5631
NP_000818                                                              16    5631
NP_001107655                                                           16    5631
NP_015564                                                              16    5631
NP_001070711                                                           16    5631
XP_006718886                                                           16    5631
XP_005271575                                                           16    5631
NP_000820                                                              16    5631
NP_000819                                                              16    5631
NP_001077088                                                           16    5631
NP_000817                                                              16    5631
NP_001077089                                                           16    5631
NP_038472                                                              16    7355
NP_001252516                                                           15    9605
NP_060037                                                              15    9605
NP_056106                                                              15    9605
NP_000822                                                              15    9605
NP_006461                                                              15    9605
NP_001020775                                                           15    9605
XP_005264472                                                           15    9605
XP_005264470                                                           15    9605
XP_005264469                                                           15    9605
>NP_003961
          Length = 1465

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   PFRSVGV 7
           PFRSVG+
Sbjct: 255 PFRSVGL 261
>XP_006716300
          Length = 1445

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   PFRSVGV 7
           PFRSVG+
Sbjct: 255 PFRSVGL 261
>NP_001180291
          Length = 621

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PFRSVGVS 8
           PFRS G+S
Sbjct: 291 PFRSKGMS 298
>NP_001180290
          Length = 621

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PFRSVGVS 8
           PFRS G+S
Sbjct: 291 PFRSKGMS 298
>NP_001180289
          Length = 621

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PFRSVGVS 8
           PFRS G+S
Sbjct: 291 PFRSKGMS 298
>NP_001180292
          Length = 621

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PFRSVGVS 8
           PFRS G+S
Sbjct: 291 PFRSKGMS 298
>NP_060669
          Length = 496

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PFRSVGVS 8
           PFRS G+S
Sbjct: 166 PFRSKGMS 173
>XP_005267875
          Length = 366

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  PFRSVGVS 8
          PFRS G+S
Sbjct: 36 PFRSKGMS 43
>XP_005267874
          Length = 496

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PFRSVGVS 8
           PFRS G+S
Sbjct: 166 PFRSKGMS 173
>XP_006720253
          Length = 621

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PFRSVGVS 8
           PFRS G+S
Sbjct: 291 PFRSKGMS 298
>NP_001244950
          Length = 916

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PFRSVGVS 8
           PF S+G+S
Sbjct: 518 PFMSLGIS 525
>NP_001244948
          Length = 826

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PFRSVGVS 8
           PF S+G+S
Sbjct: 428 PFMSLGIS 435
>NP_001244949
          Length = 811

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PFRSVGVS 8
           PF S+G+S
Sbjct: 413 PFMSLGIS 420
>NP_001244951
          Length = 916

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PFRSVGVS 8
           PF S+G+S
Sbjct: 518 PFMSLGIS 525
>NP_001244952
          Length = 837

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PFRSVGVS 8
           PF S+G+S
Sbjct: 439 PFMSLGIS 446
>NP_000818
          Length = 906

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PFRSVGVS 8
           PF S+G+S
Sbjct: 508 PFMSLGIS 515
>NP_001107655
          Length = 906

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PFRSVGVS 8
           PF S+G+S
Sbjct: 508 PFMSLGIS 515
>NP_015564
          Length = 894

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PFRSVGVS 8
           PF S+G+S
Sbjct: 524 PFMSLGIS 531
>NP_001070711
          Length = 884

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PFRSVGVS 8
           PF S+G+S
Sbjct: 516 PFMSLGIS 523
>XP_006718886
          Length = 902

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PFRSVGVS 8
           PF S+G+S
Sbjct: 516 PFMSLGIS 523
>XP_005271575
          Length = 902

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PFRSVGVS 8
           PF S+G+S
Sbjct: 516 PFMSLGIS 523
>NP_000820
          Length = 902

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PFRSVGVS 8
           PF S+G+S
Sbjct: 516 PFMSLGIS 523
>NP_000819
          Length = 894

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PFRSVGVS 8
           PF S+G+S
Sbjct: 524 PFMSLGIS 531
>NP_001077088
          Length = 883

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PFRSVGVS 8
           PF S+G+S
Sbjct: 515 PFMSLGIS 522
>NP_000817
          Length = 883

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PFRSVGVS 8
           PF S+G+S
Sbjct: 515 PFMSLGIS 522
>NP_001077089
          Length = 836

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PFRSVGVS 8
           PF S+G+S
Sbjct: 468 PFMSLGIS 475
>NP_038472
          Length = 624

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PFRSVGVSA 9
           PF SVG S+
Sbjct: 291 PFASVGSSS 299
>NP_001252516
          Length = 157

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  FRSVGVS 8
          F+SVG+S
Sbjct: 88 FQSVGIS 94
>NP_060037
          Length = 390

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PFRSVGVS 8
           P RS+G+S
Sbjct: 113 PLRSLGLS 120
>NP_056106
          Length = 782

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  PFRSVGVS 8
          P+R +GVS
Sbjct: 30 PYRVLGVS 37
>NP_000822
          Length = 919

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PFRSVGVS 8
           PF ++GVS
Sbjct: 534 PFMTLGVS 541
>NP_006461
          Length = 564

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   PFRSVGV 7
           PFR +GV
Sbjct: 491 PFRRLGV 497
>NP_001020775
          Length = 402

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  RSVGVSA 9
          RSVGV+A
Sbjct: 60 RSVGVNA 66
>XP_005264472
          Length = 293

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  PFRSVGVS 8
          P RS+G+S
Sbjct: 16 PLRSLGLS 23
>XP_005264470
          Length = 293

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  PFRSVGVS 8
          P RS+G+S
Sbjct: 16 PLRSLGLS 23
>XP_005264469
          Length = 293

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  PFRSVGVS 8
          P RS+G+S
Sbjct: 16 PLRSLGLS 23
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.321    0.134    0.387 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 441,230
Number of extensions: 660
Number of successful extensions: 36
Number of sequences better than 10000.0: 36
Number of HSP's gapped: 36
Number of HSP's successfully gapped: 36
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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