Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000542                                                              20     509
NP_937799                                                              20     509
NP_001161340                                                           17    2528
NP_001161341                                                           17    2528
NP_001161342                                                           17    2528
NP_840101                                                              17    3301
XP_005256367                                                           17    3301
NP_006763                                                              17    4312
NP_001230280                                                           16    5631
NP_057202                                                              16    5631
XP_005250068                                                           16    5631
XP_005250067                                                           16    5631
NP_004704                                                              16    7355
NP_076944                                                              16    7355
NP_001157945                                                           16    7355
NP_001245149                                                           16    7355
NP_114141                                                              16    7355
NP_001245148                                                           16    7355
NP_001245146                                                           16    7355
NP_001245147                                                           16    7355
NP_060207                                                              16    7355
NP_001020119                                                           16    7355
XP_006721638                                                           16    7355
XP_005256855                                                           16    7355
XP_005256854                                                           16    7355
XP_005268258                                                           16    7355
XP_005268257                                                           16    7355
XP_005268256                                                           16    7355
XP_005267468                                                           16    7355
XP_005267467                                                           16    7355
XP_006710770                                                           16    7355
NP_001116801                                                           16    7355
NP_064592                                                              15    9605
NP_001010895                                                           15    9605
NP_060391                                                              15    9605
NP_001153517                                                           15    9605
NP_005260                                                              15    9605
NP_001161081                                                           15    9605
NP_001032                                                              15    9605
NP_001161339                                                           15    9605
NP_006495                                                              15    9605
NP_003732                                                              15    9605
NP_001161343                                                           15    9605
NP_060505                                                              15    9605
XP_006723321                                                           15    9605
XP_005268856                                                           15    9605
XP_006717995                                                           15    9605
XP_005252749                                                           15    9605
XP_005252748                                                           15    9605
XP_005247908                                                           15    9605
XP_005247907                                                           15    9605
XP_005247906                                                           15    9605
XP_005247905                                                           15    9605
NP_569119                                                              15    9605
>NP_000542
          Length = 213

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NYRRLDNVR 9
           NYRRLD VR
Sbjct: 174 NYRRLDIVR 182
>NP_937799
          Length = 172

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NYRRLDNVR 9
           NYRRLD VR
Sbjct: 133 NYRRLDIVR 141
>NP_001161340
          Length = 191

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NYRRLDNVR 9
           NY  LDN+R
Sbjct: 143 NYEGLDNLR 151
>NP_001161341
          Length = 185

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NYRRLDNVR 9
           NY  LDN+R
Sbjct: 137 NYEGLDNLR 145
>NP_001161342
          Length = 158

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NYRRLDNVR 9
           NY  LDN+R
Sbjct: 110 NYEGLDNLR 118
>NP_840101
          Length = 292

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  NYRRLDNVR 9
          NYRRL+  R
Sbjct: 17 NYRRLETQR 25
>XP_005256367
          Length = 312

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  NYRRLDNVR 9
          NYRRL+  R
Sbjct: 17 NYRRLETQR 25
>NP_006763
          Length = 1343

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NYRRLDNV 8
           N RR+DNV
Sbjct: 256 NSRRVDNV 263
>NP_001230280
          Length = 639

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RRLDNVR 9
           RRL+N+R
Sbjct: 455 RRLENIR 461
>NP_057202
          Length = 625

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RRLDNVR 9
           RRL+N+R
Sbjct: 455 RRLENIR 461
>XP_005250068
          Length = 615

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RRLDNVR 9
           RRL+N+R
Sbjct: 431 RRLENIR 437
>XP_005250067
          Length = 638

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RRLDNVR 9
           RRL+N+R
Sbjct: 454 RRLENIR 460
>NP_004704
          Length = 1076

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RRLDNVR 9
           ++LDNVR
Sbjct: 321 KKLDNVR 327
>NP_076944
          Length = 205

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NYRRLDNVR 9
           N R+L N+R
Sbjct: 184 NSRKLQNIR 192
>NP_001157945
          Length = 605

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   NYRRLDN 7
           +Y RLDN
Sbjct: 153 SYERLDN 159
>NP_001245149
          Length = 205

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NYRRLDNVR 9
           N R+L N+R
Sbjct: 184 NSRKLQNIR 192
>NP_114141
          Length = 5635

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YRRLDNV 8
           +RRLDN+
Sbjct: 826 WRRLDNM 832
>NP_001245148
          Length = 205

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NYRRLDNVR 9
           N R+L N+R
Sbjct: 184 NSRKLQNIR 192
>NP_001245146
          Length = 205

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NYRRLDNVR 9
           N R+L N+R
Sbjct: 184 NSRKLQNIR 192
>NP_001245147
          Length = 205

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NYRRLDNVR 9
           N R+L N+R
Sbjct: 184 NSRKLQNIR 192
>NP_060207
          Length = 547

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   NYRRLDN 7
           +Y RLDN
Sbjct: 153 SYERLDN 159
>NP_001020119
          Length = 551

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   NYRRLDN 7
           +Y RLDN
Sbjct: 153 SYERLDN 159
>XP_006721638
          Length = 205

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NYRRLDNVR 9
           N R+L N+R
Sbjct: 184 NSRKLQNIR 192
>XP_005256855
          Length = 205

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NYRRLDNVR 9
           N R+L N+R
Sbjct: 184 NSRKLQNIR 192
>XP_005256854
          Length = 205

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NYRRLDNVR 9
           N R+L N+R
Sbjct: 184 NSRKLQNIR 192
>XP_005268258
          Length = 847

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  RRLDNVR 9
          ++LDNVR
Sbjct: 92 KKLDNVR 98
>XP_005268257
          Length = 862

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RRLDNVR 9
           ++LDNVR
Sbjct: 107 KKLDNVR 113
>XP_005268256
          Length = 1055

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RRLDNVR 9
           ++LDNVR
Sbjct: 321 KKLDNVR 327
>XP_005267468
          Length = 713

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NYRRLDNVR 9
           N+R+ D+VR
Sbjct: 643 NFRKHDHVR 651
>XP_005267467
          Length = 713

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NYRRLDNVR 9
           N+R+ D+VR
Sbjct: 643 NFRKHDHVR 651
>XP_006710770
          Length = 533

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   NYRRLDN 7
           +Y RLDN
Sbjct: 135 SYERLDN 141
>NP_001116801
          Length = 713

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NYRRLDNVR 9
           N+R+ D+VR
Sbjct: 643 NFRKHDHVR 651
>NP_064592
          Length = 1561

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NYRRLD 6
           +YRRLD
Sbjct: 561 DYRRLD 566
>NP_001010895
          Length = 712

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NYRRLD 6
           +YRRLD
Sbjct: 561 DYRRLD 566
>NP_060391
          Length = 608

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   YRRLDNV 8
           YR +DN+
Sbjct: 220 YRHVDNI 226
>NP_001153517
          Length = 978

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RRLDNVR 9
           RRL+N+R
Sbjct: 368 RRLENLR 374
>NP_005260
          Length = 1106

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RRLDNVR 9
           RRL+N+R
Sbjct: 496 RRLENLR 502
>NP_001161081
          Length = 1065

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RRLDNVR 9
           RRL+N+R
Sbjct: 455 RRLENLR 461
>NP_001032
          Length = 1827

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    NYRRLDNV 8
            NY R DN+
Sbjct: 1501 NYARWDNM 1508
>NP_001161339
          Length = 263

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NYRRLDNV 8
           NY  LDN+
Sbjct: 143 NYEGLDNL 150
>NP_006495
          Length = 700

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YRRLDNVR 9
           +R+L NVR
Sbjct: 430 FRKLTNVR 437
>NP_003732
          Length = 955

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NYRRLD 6
           +YRRLD
Sbjct: 201 SYRRLD 206
>NP_001161343
          Length = 230

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NYRRLDNV 8
           NY  LDN+
Sbjct: 110 NYEGLDNL 117
>NP_060505
          Length = 257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NYRRLDNV 8
           NY  LDN+
Sbjct: 137 NYEGLDNL 144
>XP_006723321
          Length = 236

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NYRRLDNV 8
           NY  LDN+
Sbjct: 116 NYEGLDNL 123
>XP_005268856
          Length = 978

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RRLDNVR 9
           RRL+N+R
Sbjct: 368 RRLENLR 374
>XP_006717995
          Length = 699

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YRRLDNVR 9
           +R+L NVR
Sbjct: 429 FRKLTNVR 436
>XP_005252749
          Length = 700

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YRRLDNVR 9
           +R+L NVR
Sbjct: 430 FRKLTNVR 437
>XP_005252748
          Length = 700

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YRRLDNVR 9
           +R+L NVR
Sbjct: 430 FRKLTNVR 437
>XP_005247908
          Length = 894

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NYRRLD 6
           +YRRLD
Sbjct: 201 SYRRLD 206
>XP_005247907
          Length = 954

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NYRRLD 6
           +YRRLD
Sbjct: 201 SYRRLD 206
>XP_005247906
          Length = 981

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NYRRLD 6
           +YRRLD
Sbjct: 201 SYRRLD 206
>XP_005247905
          Length = 982

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NYRRLD 6
           +YRRLD
Sbjct: 201 SYRRLD 206
>NP_569119
          Length = 642

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YRRLDNVR 9
           +R+L NVR
Sbjct: 372 FRKLTNVR 379
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.329    0.145    0.428 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 527,284
Number of extensions: 840
Number of successful extensions: 54
Number of sequences better than 10000.0: 54
Number of HSP's gapped: 54
Number of HSP's successfully gapped: 54
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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