Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005219                                                              22     103
NP_001036064                                                           19     869
NP_005226                                                              19     869
XP_005246434                                                           19     869
XP_005246433                                                           19     869
XP_005246432                                                           19     869
XP_006712427                                                           19     869
NP_443108                                                              17    3301
NP_068746                                                              17    3301
XP_006722695                                                           17    3301
XP_005259778                                                           17    3301
NP_055872                                                              17    4312
XP_006719852                                                           17    4312
XP_005266357                                                           17    4312
XP_006719851                                                           17    4312
XP_006719850                                                           17    4312
XP_006719849                                                           17    4312
XP_006719848                                                           17    4312
XP_005266356                                                           17    4312
XP_006719847                                                           17    4312
XP_006719846                                                           17    4312
XP_006719845                                                           17    4312
XP_006719844                                                           17    4312
XP_006719843                                                           17    4312
XP_006719842                                                           17    4312
XP_006711445                                                           17    4312
XP_006711444                                                           17    4312
NP_006203                                                              17    4312
NP_001018063                                                           17    4312
NP_000183                                                              16    7355
NP_852259                                                              16    7355
NP_542448                                                              16    7355
NP_001171455                                                           16    7355
NP_055006                                                              16    7355
NP_065744                                                              16    7355
XP_006719645                                                           16    7355
XP_006719619                                                           16    7355
NP_000098                                                              15    9605
NP_001076003                                                           15    9605
NP_064563                                                              15    9605
NP_001076002                                                           15    9605
NP_060854                                                              15    9605
NP_055178                                                              15    9605
NP_001264984                                                           15    9605
NP_002941                                                              15    9605
NP_001186506                                                           15    9605
NP_852469                                                              15    9605
NP_005641                                                              15    9605
NP_001073888                                                           15    9605
XP_006725846                                                           15    9605
XP_006725845                                                           15    9605
XP_006725844                                                           15    9605
XP_005277014                                                           15    9605
XP_005277013                                                           15    9605
XP_005277012                                                           15    9605
XP_005261781                                                           15    9605
XP_005261780                                                           15    9605
XP_006724377                                                           15    9605
XP_006724376                                                           15    9605
XP_005261779                                                           15    9605
XP_006722211                                                           15    9605
XP_006722210                                                           15    9605
XP_006722209                                                           15    9605
XP_006722207                                                           15    9605
XP_005257580                                                           15    9605
XP_005266395                                                           15    9605
XP_005274106                                                           15    9605
XP_005274105                                                           15    9605
XP_006718224                                                           15    9605
NP_002999                                                              15    9605
NP_056969                                                              15    9605
>NP_005219
          Length = 1210

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   NVGSQYLLN 9
           N+GSQYLLN
Sbjct: 808 NIGSQYLLN 816
>NP_001036064
          Length = 1292

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   NVGSQYLLN 9
           N+GSQ LLN
Sbjct: 814 NIGSQLLLN 822
>NP_005226
          Length = 1308

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   NVGSQYLLN 9
           N+GSQ LLN
Sbjct: 814 NIGSQLLLN 822
>XP_005246434
          Length = 1282

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   NVGSQYLLN 9
           N+GSQ LLN
Sbjct: 804 NIGSQLLLN 812
>XP_005246433
          Length = 1298

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   NVGSQYLLN 9
           N+GSQ LLN
Sbjct: 804 NIGSQLLLN 812
>XP_005246432
          Length = 1307

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   NVGSQYLLN 9
           N+GSQ LLN
Sbjct: 829 NIGSQLLLN 837
>XP_006712427
          Length = 1323

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   NVGSQYLLN 9
           N+GSQ LLN
Sbjct: 829 NIGSQLLLN 837
>NP_443108
          Length = 527

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NVGSQYLL 8
           NVG Q+LL
Sbjct: 93  NVGDQFLL 100
>NP_068746
          Length = 669

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   GSQYLLN 9
           G QYLLN
Sbjct: 131 GKQYLLN 137
>XP_006722695
          Length = 527

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NVGSQYLL 8
           NVG Q+LL
Sbjct: 93  NVGDQFLL 100
>XP_005259778
          Length = 527

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NVGSQYLL 8
           NVG Q+LL
Sbjct: 93  NVGDQFLL 100
>NP_055872
          Length = 4678

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    NVGSQYL 7
            NVG QYL
Sbjct: 4027 NVGRQYL 4033
>XP_006719852
          Length = 4752

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    NVGSQYL 7
            NVG QYL
Sbjct: 4101 NVGRQYL 4107
>XP_005266357
          Length = 4600

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    NVGSQYL 7
            NVG QYL
Sbjct: 3949 NVGRQYL 3955
>XP_006719851
          Length = 4689

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    NVGSQYL 7
            NVG QYL
Sbjct: 4038 NVGRQYL 4044
>XP_006719850
          Length = 4697

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    NVGSQYL 7
            NVG QYL
Sbjct: 4046 NVGRQYL 4052
>XP_006719849
          Length = 4703

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    NVGSQYL 7
            NVG QYL
Sbjct: 4052 NVGRQYL 4058
>XP_006719848
          Length = 4737

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    NVGSQYL 7
            NVG QYL
Sbjct: 4086 NVGRQYL 4092
>XP_005266356
          Length = 4755

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    NVGSQYL 7
            NVG QYL
Sbjct: 4104 NVGRQYL 4110
>XP_006719847
          Length = 4761

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    NVGSQYL 7
            NVG QYL
Sbjct: 4110 NVGRQYL 4116
>XP_006719846
          Length = 4763

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    NVGSQYL 7
            NVG QYL
Sbjct: 4112 NVGRQYL 4118
>XP_006719845
          Length = 4772

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    NVGSQYL 7
            NVG QYL
Sbjct: 4121 NVGRQYL 4127
>XP_006719844
          Length = 4789

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    NVGSQYL 7
            NVG QYL
Sbjct: 4138 NVGRQYL 4144
>XP_006719843
          Length = 4794

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    NVGSQYL 7
            NVG QYL
Sbjct: 4143 NVGRQYL 4149
>XP_006719842
          Length = 4797

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    NVGSQYL 7
            NVG QYL
Sbjct: 4146 NVGRQYL 4152
>XP_006711445
          Length = 373

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NVGSQYLLN 9
           NVG ++L+N
Sbjct: 122 NVGQRFLVN 130
>XP_006711444
          Length = 407

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NVGSQYLLN 9
           NVG ++L+N
Sbjct: 122 NVGQRFLVN 130
>NP_006203
          Length = 505

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NVGSQYLLN 9
           NVG ++L+N
Sbjct: 220 NVGQRFLVN 228
>NP_001018063
          Length = 471

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NVGSQYLLN 9
           NVG ++L+N
Sbjct: 220 NVGQRFLVN 228
>NP_000183
          Length = 518

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NVGSQY 6
           N+GSQY
Sbjct: 286 NLGSQY 291
>NP_852259
          Length = 518

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NVGSQY 6
           N+GSQY
Sbjct: 286 NLGSQY 291
>NP_542448
          Length = 468

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NVGSQY 6
           N+GSQY
Sbjct: 236 NLGSQY 241
>NP_001171455
          Length = 1939

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VGSQYLLN 9
           VGS YL+N
Sbjct: 397 VGSFYLVN 404
>NP_055006
          Length = 1980

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VGSQYLLN 9
           VGS YL+N
Sbjct: 397 VGSFYLVN 404
>NP_065744
          Length = 2113

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    NVGSQYLL 8
            N G QYLL
Sbjct: 1316 NRGQQYLL 1323
>XP_006719645
          Length = 349

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NVGSQY 6
           N+GSQY
Sbjct: 286 NLGSQY 291
>XP_006719619
          Length = 1980

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VGSQYLLN 9
           VGS YL+N
Sbjct: 397 VGSFYLVN 404
>NP_000098
          Length = 427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NVGSQYLLN 9
           NVG+  LLN
Sbjct: 221 NVGNVILLN 229
>NP_001076003
          Length = 328

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   GSQYLLN 9
           GS++LLN
Sbjct: 142 GSEHLLN 148
>NP_064563
          Length = 328

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   GSQYLLN 9
           GS++LLN
Sbjct: 142 GSEHLLN 148
>NP_001076002
          Length = 328

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   GSQYLLN 9
           GS++LLN
Sbjct: 142 GSEHLLN 148
>NP_060854
          Length = 307

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NVGSQYLLN 9
           N+G  YLL+
Sbjct: 99  NIGDCYLLS 107
>NP_055178
          Length = 4579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    NVGSQYLLN 9
            N+G +Y+L+
Sbjct: 3588 NIGLKYILS 3596
>NP_001264984
          Length = 4432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    NVGSQYLLN 9
            N+G +Y+L+
Sbjct: 3441 NIGLKYILS 3449
>NP_002941
          Length = 607

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NVGSQYLL 8
           N+G QY L
Sbjct: 344 NLGDQYAL 351
>NP_001186506
          Length = 511

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NVGSQYLLN 9
           N+G  YLL+
Sbjct: 303 NIGDCYLLS 311
>NP_852469
          Length = 1938

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   NVGSQY 6
           N GSQY
Sbjct: 267 NAGSQY 272
>NP_005641
          Length = 1960

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   NVGSQY 6
           N GSQY
Sbjct: 267 NAGSQY 272
>NP_001073888
          Length = 810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VGSQYLLN 9
           VG++YL N
Sbjct: 424 VGAEYLKN 431
>XP_006725846
          Length = 1938

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   NVGSQY 6
           N GSQY
Sbjct: 267 NAGSQY 272
>XP_006725845
          Length = 1949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   NVGSQY 6
           N GSQY
Sbjct: 267 NAGSQY 272
>XP_006725844
          Length = 1960

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   NVGSQY 6
           N GSQY
Sbjct: 267 NAGSQY 272
>XP_005277014
          Length = 1938

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   NVGSQY 6
           N GSQY
Sbjct: 267 NAGSQY 272
>XP_005277013
          Length = 1949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   NVGSQY 6
           N GSQY
Sbjct: 267 NAGSQY 272
>XP_005277012
          Length = 1960

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   NVGSQY 6
           N GSQY
Sbjct: 267 NAGSQY 272
>XP_005261781
          Length = 1938

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   NVGSQY 6
           N GSQY
Sbjct: 267 NAGSQY 272
>XP_005261780
          Length = 1949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   NVGSQY 6
           N GSQY
Sbjct: 267 NAGSQY 272
>XP_006724377
          Length = 1960

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   NVGSQY 6
           N GSQY
Sbjct: 267 NAGSQY 272
>XP_006724376
          Length = 1960

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   NVGSQY 6
           N GSQY
Sbjct: 267 NAGSQY 272
>XP_005261779
          Length = 1960

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   NVGSQY 6
           N GSQY
Sbjct: 267 NAGSQY 272
>XP_006722211
          Length = 642

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VGSQYLLN 9
           VG++YL N
Sbjct: 256 VGAEYLKN 263
>XP_006722210
          Length = 642

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VGSQYLLN 9
           VG++YL N
Sbjct: 256 VGAEYLKN 263
>XP_006722209
          Length = 826

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VGSQYLLN 9
           VG++YL N
Sbjct: 440 VGAEYLKN 447
>XP_006722207
          Length = 839

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VGSQYLLN 9
           VG++YL N
Sbjct: 453 VGAEYLKN 460
>XP_005257580
          Length = 231

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  GSQYLLN 9
          GS++LLN
Sbjct: 45 GSEHLLN 51
>XP_005266395
          Length = 4588

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    NVGSQYLLN 9
            N+G +Y+L+
Sbjct: 3597 NIGLKYILS 3605
>XP_005274106
          Length = 1685

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  NVGSQYL 7
          NVG +YL
Sbjct: 83 NVGREYL 89
>XP_005274105
          Length = 1686

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  NVGSQYL 7
          NVG +YL
Sbjct: 83 NVGREYL 89
>XP_006718224
          Length = 427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NVGSQYLLN 9
           NVG+  LLN
Sbjct: 221 NVGNVILLN 229
>NP_002999
          Length = 582

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   GSQYLLN 9
           GSQ LLN
Sbjct: 102 GSQQLLN 108
>NP_056969
          Length = 1555

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  NVGSQYL 7
          NVG +YL
Sbjct: 83 NVGREYL 89
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.311    0.133    0.365 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 565,031
Number of extensions: 1143
Number of successful extensions: 71
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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