Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000537                                                              18    1135
NP_001263689                                                           18    1135
NP_001119584                                                           18    1135
NP_001119586                                                           18    1135
NP_001263625                                                           18    1135
NP_001119590                                                           18    1135
NP_001263690                                                           18    1135
NP_001119585                                                           18    1135
NP_001263624                                                           18    1135
NP_001119588                                                           18    1135
NP_001119587                                                           18    1135
NP_001119589                                                           18    1135
NP_001263627                                                           18    1135
NP_001263628                                                           18    1135
NP_001263626                                                           18    1135
NP_064551                                                              17    3301
XP_006713765                                                           17    3301
NP_001245143                                                           17    4312
NP_001245145                                                           17    4312
NP_001550                                                              17    4312
NP_653213                                                              17    4312
XP_005270885                                                           17    4312
XP_005270884                                                           17    4312
XP_005270882                                                           17    4312
NP_006368                                                              16    5631
XP_006716779                                                           16    5631
NP_000247                                                              16    7355
NP_060034                                                              16    7355
NP_689856                                                              16    7355
XP_006719539                                                           16    7355
XP_006718301                                                           16    7355
NP_001177203                                                           15    9605
NP_079409                                                              15    9605
NP_996555                                                              15    9605
NP_001241649                                                           15    9605
NP_001241647                                                           15    9605
NP_001241650                                                           15    9605
NP_001241652                                                           15    9605
NP_002456                                                              15    9605
NP_001241651                                                           15    9605
NP_996557                                                              15    9605
NP_001241648                                                           15    9605
NP_996556                                                              15    9605
NP_542415                                                              15    9605
NP_542416                                                              15    9605
NP_542414                                                              15    9605
NP_006255                                                              15    9605
NP_066928                                                              15    9605
NP_005083                                                              15    9605
XP_006719474                                                           15    9605
XP_005268933                                                           15    9605
XP_006719473                                                           15    9605
XP_006719472                                                           15    9605
XP_006719471                                                           15    9605
XP_006719470                                                           15    9605
XP_006719469                                                           15    9605
XP_006719468                                                           15    9605
XP_005263224                                                           15    9605
XP_005247595                                                           15    9605
XP_005264631                                                           15    9605
XP_005264630                                                           15    9605
XP_005264629                                                           15    9605
NP_000929                                                              15    9605
>NP_000537
          Length = 393

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NSFEVRVYA 9
           NSFEVRV A
Sbjct: 268 NSFEVRVCA 276
>NP_001263689
          Length = 354

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NSFEVRVYA 9
           NSFEVRV A
Sbjct: 229 NSFEVRVCA 237
>NP_001119584
          Length = 393

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NSFEVRVYA 9
           NSFEVRV A
Sbjct: 268 NSFEVRVCA 276
>NP_001119586
          Length = 341

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NSFEVRVYA 9
           NSFEVRV A
Sbjct: 268 NSFEVRVCA 276
>NP_001263625
          Length = 302

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NSFEVRVYA 9
           NSFEVRV A
Sbjct: 229 NSFEVRVCA 237
>NP_001119590
          Length = 354

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NSFEVRVYA 9
           NSFEVRV A
Sbjct: 229 NSFEVRVCA 237
>NP_001263690
          Length = 354

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NSFEVRVYA 9
           NSFEVRV A
Sbjct: 229 NSFEVRVCA 237
>NP_001119585
          Length = 346

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NSFEVRVYA 9
           NSFEVRV A
Sbjct: 268 NSFEVRVCA 276
>NP_001263624
          Length = 307

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NSFEVRVYA 9
           NSFEVRV A
Sbjct: 229 NSFEVRVCA 237
>NP_001119588
          Length = 209

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NSFEVRVYA 9
           NSFEVRV A
Sbjct: 136 NSFEVRVCA 144
>NP_001119587
          Length = 261

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NSFEVRVYA 9
           NSFEVRV A
Sbjct: 136 NSFEVRVCA 144
>NP_001119589
          Length = 214

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NSFEVRVYA 9
           NSFEVRV A
Sbjct: 136 NSFEVRVCA 144
>NP_001263627
          Length = 182

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NSFEVRVYA 9
           NSFEVRV A
Sbjct: 109 NSFEVRVCA 117
>NP_001263628
          Length = 187

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NSFEVRVYA 9
           NSFEVRV A
Sbjct: 109 NSFEVRVCA 117
>NP_001263626
          Length = 234

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NSFEVRVYA 9
           NSFEVRV A
Sbjct: 109 NSFEVRVCA 117
>NP_064551
          Length = 725

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NSFEVRVYA 9
           ++FE R+YA
Sbjct: 380 HAFEARIYA 388
>XP_006713765
          Length = 616

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NSFEVRVYA 9
           ++FE R+YA
Sbjct: 271 HAFEARIYA 279
>NP_001245143
          Length = 659

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FEVRVYA 9
           +E+RVYA
Sbjct: 495 YEIRVYA 501
>NP_001245145
          Length = 635

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FEVRVYA 9
           +E+RVYA
Sbjct: 495 YEIRVYA 501
>NP_001550
          Length = 862

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FEVRVYA 9
           +E+RVYA
Sbjct: 495 YEIRVYA 501
>NP_653213
          Length = 2211

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NSFEVRVY 8
           N +EV+VY
Sbjct: 172 NKYEVKVY 179
>XP_005270885
          Length = 862

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FEVRVYA 9
           +E+RVYA
Sbjct: 495 YEIRVYA 501
>XP_005270884
          Length = 862

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FEVRVYA 9
           +E+RVYA
Sbjct: 495 YEIRVYA 501
>XP_005270882
          Length = 862

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FEVRVYA 9
           +E+RVYA
Sbjct: 495 YEIRVYA 501
>NP_006368
          Length = 1591

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    NSFEVRV 7
            NSF+VR+
Sbjct: 1224 NSFQVRI 1230
>XP_006716779
          Length = 2399

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    NSFEVRV 7
            NSF+VR+
Sbjct: 2032 NSFQVRI 2038
>NP_000247
          Length = 1274

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FEVRVYA 9
           +E+RVYA
Sbjct: 842 YEMRVYA 848
>NP_060034
          Length = 2551

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  SFEVRVYA 9
          +FEVR Y+
Sbjct: 74 TFEVRTYS 81
>NP_689856
          Length = 1749

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   NSFEVRVYA 9
           N+FE  +Y+
Sbjct: 117 NTFEAHIYS 125
>XP_006719539
          Length = 2246

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  SFEVRVYA 9
          +FEVR Y+
Sbjct: 74 TFEVRTYS 81
>XP_006718301
          Length = 1268

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FEVRVYA 9
           +E+RVYA
Sbjct: 836 YEMRVYA 842
>NP_001177203
          Length = 927

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   FEVRVYA 9
           FEV+ YA
Sbjct: 482 FEVKAYA 488
>NP_079409
          Length = 843

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   FEVRVYA 9
           FEV+ YA
Sbjct: 398 FEVKAYA 404
>NP_996555
          Length = 1148

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   SFEVRVYA 9
           ++EVR++A
Sbjct: 714 AYEVRIFA 721
>NP_001241649
          Length = 1134

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   SFEVRVYA 9
           ++EVR++A
Sbjct: 677 AYEVRIFA 684
>NP_001241647
          Length = 1173

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   SFEVRVYA 9
           ++EVR++A
Sbjct: 689 AYEVRIFA 696
>NP_001241650
          Length = 1127

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   SFEVRVYA 9
           ++EVR++A
Sbjct: 670 AYEVRIFA 677
>NP_001241652
          Length = 1139

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   SFEVRVYA 9
           ++EVR++A
Sbjct: 676 AYEVRIFA 683
>NP_002456
          Length = 1171

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   SFEVRVYA 9
           ++EVR++A
Sbjct: 714 AYEVRIFA 721
>NP_001241651
          Length = 1120

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   SFEVRVYA 9
           ++EVR++A
Sbjct: 663 AYEVRIFA 670
>NP_996557
          Length = 1123

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   SFEVRVYA 9
           ++EVR++A
Sbjct: 689 AYEVRIFA 696
>NP_001241648
          Length = 1146

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   SFEVRVYA 9
           ++EVR++A
Sbjct: 689 AYEVRIFA 696
>NP_996556
          Length = 1141

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   SFEVRVYA 9
           ++EVR++A
Sbjct: 689 AYEVRIFA 696
>NP_542415
          Length = 2294

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    NSFEVRVY 8
            N+FEV+++
Sbjct: 1307 NTFEVKLF 1314
>NP_542416
          Length = 2490

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    NSFEVRVY 8
            N+FEV+++
Sbjct: 1503 NTFEVKLF 1510
>NP_542414
          Length = 2485

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    NSFEVRVY 8
            N+FEV+++
Sbjct: 1498 NTFEVKLF 1505
>NP_006255
          Length = 2466

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    NSFEVRVY 8
            N+FEV+++
Sbjct: 1479 NTFEVKLF 1486
>NP_066928
          Length = 318

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NSFEVRVY 8
           NSF  RVY
Sbjct: 133 NSFGQRVY 140
>NP_005083
          Length = 199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   FEVRVY 8
           FEVR+Y
Sbjct: 135 FEVRLY 140
>XP_006719474
          Length = 1164

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   SFEVRVYA 9
           ++EVR++A
Sbjct: 689 AYEVRIFA 696
>XP_005268933
          Length = 1165

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   SFEVRVYA 9
           ++EVR++A
Sbjct: 702 AYEVRIFA 709
>XP_006719473
          Length = 1166

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   SFEVRVYA 9
           ++EVR++A
Sbjct: 714 AYEVRIFA 721
>XP_006719472
          Length = 1170

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   SFEVRVYA 9
           ++EVR++A
Sbjct: 689 AYEVRIFA 696
>XP_006719471
          Length = 1177

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   SFEVRVYA 9
           ++EVR++A
Sbjct: 714 AYEVRIFA 721
>XP_006719470
          Length = 1183

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   SFEVRVYA 9
           ++EVR++A
Sbjct: 702 AYEVRIFA 709
>XP_006719469
          Length = 1189

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   SFEVRVYA 9
           ++EVR++A
Sbjct: 714 AYEVRIFA 721
>XP_006719468
          Length = 1195

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   SFEVRVYA 9
           ++EVR++A
Sbjct: 714 AYEVRIFA 721
>XP_005263224
          Length = 2491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    NSFEVRVY 8
            N+FEV+++
Sbjct: 1504 NTFEVKLF 1511
>XP_005247595
          Length = 237

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  NSFEVRVY 8
          NSF  RVY
Sbjct: 52 NSFGQRVY 59
>XP_005264631
          Length = 926

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   FEVRVYA 9
           FEV+ YA
Sbjct: 481 FEVKAYA 487
>XP_005264630
          Length = 953

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   FEVRVYA 9
           FEV+ YA
Sbjct: 481 FEVKAYA 487
>XP_005264629
          Length = 954

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   FEVRVYA 9
           FEV+ YA
Sbjct: 482 FEVKAYA 488
>NP_000929
          Length = 1174

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EVRVYA 9
           EVR+YA
Sbjct: 414 EVRIYA 419
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.324    0.133    0.362 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 416,561
Number of extensions: 630
Number of successful extensions: 63
Number of sequences better than 10000.0: 63
Number of HSP's gapped: 63
Number of HSP's successfully gapped: 63
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package