Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              20     299
XP_005271621                                                           20     299
XP_006718907                                                           20     299
XP_006718906                                                           20     299
XP_005271619                                                           20     299
XP_005271618                                                           20     299
NP_073609                                                              16    5631
NP_001076593                                                           16    5631
NP_001009612                                                           16    5631
XP_006718339                                                           16    5631
XP_006718338                                                           16    5631
XP_006718337                                                           16    5631
XP_006718336                                                           16    5631
XP_005272574                                                           16    5631
NP_001177951                                                           16    7355
NP_006556                                                              16    7355
NP_055840                                                              16    7355
NP_005099                                                              16    7355
NP_065789                                                              16    7355
XP_005255832                                                           16    7355
XP_005254442                                                           16    7355
XP_006713513                                                           16    7355
XP_006713512                                                           16    7355
XP_006713511                                                           16    7355
XP_006711931                                                           16    7355
XP_006711930                                                           16    7355
XP_006711929                                                           16    7355
XP_006711928                                                           16    7355
XP_006711927                                                           16    7355
XP_006711926                                                           16    7355
XP_006711925                                                           16    7355
NP_002364                                                              16    7355
NP_001035203                                                           15    9605
NP_074035                                                              15    9605
NP_001035202                                                           15    9605
NP_002465                                                              15    9605
NP_001078921                                                           15    9605
NP_573400                                                              15    9605
NP_008981                                                              15    9605
NP_056482                                                              15    9605
NP_001092880                                                           15    9605
NP_001092881                                                           15    9605
NP_055525                                                              15    9605
NP_001171656                                                           15    9605
NP_778255                                                              15    9605
NP_001191449                                                           15    9605
NP_001191448                                                           15    9605
NP_065928                                                              15    9605
NP_002552                                                              15    9605
NP_001107013                                                           15    9605
XP_006723752                                                           15    9605
XP_006723751                                                           15    9605
XP_006723750                                                           15    9605
XP_006723749                                                           15    9605
XP_006723748                                                           15    9605
XP_005256527                                                           15    9605
XP_006716914                                                           15    9605
NP_001138668                                                           15    9605
>NP_000042
          Length = 3056

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   NLMQVEDQS 9
           NLM+VEDQS
Sbjct: 845 NLMEVEDQS 853
>XP_005271621
          Length = 2708

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   NLMQVEDQS 9
           NLM+VEDQS
Sbjct: 497 NLMEVEDQS 505
>XP_006718907
          Length = 3050

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   NLMQVEDQS 9
           NLM+VEDQS
Sbjct: 845 NLMEVEDQS 853
>XP_006718906
          Length = 3056

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   NLMQVEDQS 9
           NLM+VEDQS
Sbjct: 845 NLMEVEDQS 853
>XP_005271619
          Length = 3056

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   NLMQVEDQS 9
           NLM+VEDQS
Sbjct: 845 NLMEVEDQS 853
>XP_005271618
          Length = 3056

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   NLMQVEDQS 9
           NLM+VEDQS
Sbjct: 845 NLMEVEDQS 853
>NP_073609
          Length = 715

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LMQVEDQS 9
           L+QV DQS
Sbjct: 93  LLQVNDQS 100
>NP_001076593
          Length = 1347

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   NLMQVEDQS 9
           +LMQ++D+S
Sbjct: 622 DLMQLQDES 630
>NP_001009612
          Length = 122

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  MQVEDQS 9
          MQ++DQS
Sbjct: 48 MQIQDQS 54
>XP_006718339
          Length = 546

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LMQVEDQS 9
           L+QV DQS
Sbjct: 93  LLQVNDQS 100
>XP_006718338
          Length = 715

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LMQVEDQS 9
           L+QV DQS
Sbjct: 93  LLQVNDQS 100
>XP_006718337
          Length = 715

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LMQVEDQS 9
           L+QV DQS
Sbjct: 93  LLQVNDQS 100
>XP_006718336
          Length = 715

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LMQVEDQS 9
           L+QV DQS
Sbjct: 93  LLQVNDQS 100
>XP_005272574
          Length = 1207

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   NLMQVEDQS 9
           +LMQ++D+S
Sbjct: 482 DLMQLQDES 490
>NP_001177951
          Length = 399

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LMQVEDQS 9
           ++QVEDQ+
Sbjct: 342 IIQVEDQN 349
>NP_006556
          Length = 727

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LMQVEDQS 9
           ++QVEDQ+
Sbjct: 670 IIQVEDQN 677
>NP_055840
          Length = 1184

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NLMQVEDQ 8
           NLM++E+Q
Sbjct: 381 NLMRLEEQ 388
>NP_005099
          Length = 536

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   NLMQVEDQ 8
           NL+Q++D+
Sbjct: 220 NLLQIQDK 227
>NP_065789
          Length = 1771

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    NLMQVEDQS 9
            NL+++ED S
Sbjct: 1613 NLIELEDDS 1621
>XP_005255832
          Length = 725

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LMQVEDQS 9
           ++QVEDQ+
Sbjct: 668 IIQVEDQN 675
>XP_005254442
          Length = 3041

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    NLMQVEDQS 9
            +LMQ ED S
Sbjct: 1477 HLMQAEDTS 1485
>XP_006713513
          Length = 399

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  NLMQVEDQ 8
          NL+Q++D+
Sbjct: 83 NLLQIQDK 90
>XP_006713512
          Length = 461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   NLMQVEDQ 8
           NL+Q++D+
Sbjct: 220 NLLQIQDK 227
>XP_006713511
          Length = 509

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   NLMQVEDQ 8
           NL+Q++D+
Sbjct: 193 NLLQIQDK 200
>XP_006711931
          Length = 1162

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NLMQVEDQ 8
           NLM++E+Q
Sbjct: 381 NLMRLEEQ 388
>XP_006711930
          Length = 1186

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NLMQVEDQ 8
           NLM++E+Q
Sbjct: 381 NLMRLEEQ 388
>XP_006711929
          Length = 1186

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NLMQVEDQ 8
           NLM++E+Q
Sbjct: 381 NLMRLEEQ 388
>XP_006711928
          Length = 1188

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NLMQVEDQ 8
           NLM++E+Q
Sbjct: 381 NLMRLEEQ 388
>XP_006711927
          Length = 1207

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NLMQVEDQ 8
           NLM++E+Q
Sbjct: 381 NLMRLEEQ 388
>XP_006711926
          Length = 1207

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NLMQVEDQ 8
           NLM++E+Q
Sbjct: 381 NLMRLEEQ 388
>XP_006711925
          Length = 1209

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NLMQVEDQ 8
           NLM++E+Q
Sbjct: 381 NLMRLEEQ 388
>NP_002364
          Length = 2803

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    NLMQVEDQS 9
            +LMQ ED S
Sbjct: 1239 HLMQAEDTS 1247
>NP_001035203
          Length = 1979

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    LMQVEDQ 8
            L+QVED+
Sbjct: 1862 LLQVEDE 1868
>NP_074035
          Length = 1938

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    LMQVEDQ 8
            L+QVED+
Sbjct: 1855 LLQVEDE 1861
>NP_001035202
          Length = 1945

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    LMQVEDQ 8
            L+QVED+
Sbjct: 1862 LLQVEDE 1868
>NP_002465
          Length = 1972

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    LMQVEDQ 8
            L+QVED+
Sbjct: 1855 LLQVEDE 1861
>NP_001078921
          Length = 1361

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NLMQVEDQS 9
           +LMQ+ D+S
Sbjct: 636 DLMQLRDES 644
>NP_573400
          Length = 1460

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    NLMQVEDQ 8
            NL+Q E+Q
Sbjct: 1144 NLVQTEEQ 1151
>NP_008981
          Length = 1441

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    NLMQVEDQ 8
            NL+Q E+Q
Sbjct: 1125 NLVQTEEQ 1132
>NP_056482
          Length = 1347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NLMQVEDQS 9
           +LMQ+ D+S
Sbjct: 622 DLMQLRDES 630
>NP_001092880
          Length = 1395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MQVEDQS 9
           +QVED+S
Sbjct: 427 LQVEDES 433
>NP_001092881
          Length = 1395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MQVEDQS 9
           +QVED+S
Sbjct: 427 LQVEDES 433
>NP_055525
          Length = 1395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MQVEDQS 9
           +QVED+S
Sbjct: 427 LQVEDES 433
>NP_001171656
          Length = 1395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MQVEDQS 9
           +QVED+S
Sbjct: 427 LQVEDES 433
>NP_778255
          Length = 397

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NLMQVEDQS 9
           N+M V+D+S
Sbjct: 182 NVMDVKDRS 190
>NP_001191449
          Length = 398

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NLMQVEDQS 9
           N+M V+D+S
Sbjct: 183 NVMDVKDRS 191
>NP_001191448
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NLMQVEDQS 9
           N+M V+D+S
Sbjct: 206 NVMDVKDRS 214
>NP_065928
          Length = 4427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   NLMQVED 7
           NL+++ED
Sbjct: 423 NLLEIED 429
>NP_002552
          Length = 422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NLMQVEDQS 9
           N+M V+D+S
Sbjct: 207 NVMDVKDRS 215
>NP_001107013
          Length = 1347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NLMQVEDQS 9
           +LMQ+ D+S
Sbjct: 622 DLMQLRDES 630
>XP_006723752
          Length = 1387

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    NLMQVEDQ 8
            NL+Q E+Q
Sbjct: 1071 NLVQTEEQ 1078
>XP_006723751
          Length = 1427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    NLMQVEDQ 8
            NL+Q E+Q
Sbjct: 1111 NLVQTEEQ 1118
>XP_006723750
          Length = 1427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    NLMQVEDQ 8
            NL+Q E+Q
Sbjct: 1111 NLVQTEEQ 1118
>XP_006723749
          Length = 1428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    NLMQVEDQ 8
            NL+Q E+Q
Sbjct: 1112 NLVQTEEQ 1119
>XP_006723748
          Length = 1437

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    NLMQVEDQ 8
            NL+Q E+Q
Sbjct: 1121 NLVQTEEQ 1128
>XP_005256527
          Length = 4427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   NLMQVED 7
           NL+++ED
Sbjct: 423 NLLEIED 429
>XP_006716914
          Length = 848

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NLMQVEDQS 9
           +LMQ+ D+S
Sbjct: 123 DLMQLRDES 131
>NP_001138668
          Length = 1343

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NLMQVEDQS 9
           +LMQ+ D+S
Sbjct: 618 DLMQLRDES 626
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.301    0.116    0.275 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 548,842
Number of extensions: 975
Number of successful extensions: 58
Number of sequences better than 10000.0: 58
Number of HSP's gapped: 58
Number of HSP's successfully gapped: 58
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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