Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000537                                                              19     665
NP_001263689                                                           19     665
NP_001119584                                                           19     665
NP_001119586                                                           19     665
NP_001263625                                                           19     665
NP_001119590                                                           19     665
NP_001263690                                                           19     665
NP_001119585                                                           19     665
NP_001263624                                                           19     665
NP_001119588                                                           19     665
NP_001119587                                                           19     665
NP_001119589                                                           19     665
NP_001263627                                                           19     665
NP_001263628                                                           19     665
NP_001263626                                                           19     665
NP_001158307                                                           18    1935
NP_061952                                                              18    1935
NP_006429                                                              17    4312
NP_060337                                                              17    4312
NP_001177188                                                           16    5631
NP_004648                                                              16    5631
XP_005247328                                                           16    5631
NP_001547                                                              16    7355
NP_001229707                                                           16    7355
NP_001177649                                                           16    7355
NP_003702                                                              16    7355
NP_795714                                                              16    7355
XP_005273556                                                           16    7355
XP_005273555                                                           16    7355
XP_005273553                                                           16    7355
XP_005273552                                                           16    7355
XP_005273551                                                           16    7355
XP_005273550                                                           16    7355
XP_005273549                                                           16    7355
XP_005273548                                                           16    7355
XP_005273547                                                           16    7355
XP_006714787                                                           16    7355
NP_705838                                                              15    9605
NP_438112                                                              15    9605
NP_036348                                                              15    9605
NP_001271230                                                           15    9605
NP_001271231                                                           15    9605
NP_061155                                                              15    9605
NP_853514                                                              15    9605
NP_001073929                                                           15    9605
XP_005262119                                                           15    9605
XP_003403542                                                           15    9605
XP_005258568                                                           15    9605
XP_006717114                                                           15    9605
XP_006717113                                                           15    9605
XP_006717112                                                           15    9605
XP_005251965                                                           15    9605
XP_006715810                                                           15    9605
XP_006715809                                                           15    9605
XP_006713676                                                           15    9605
XP_005247478                                                           15    9605
XP_005246216                                                           15    9605
XP_006711947                                                           15    9605
XP_005273219                                                           15    9605
XP_006711444                                                           15    9605
XP_005272985                                                           15    9605
XP_005272984                                                           15    9605
XP_005277390                                                           15    9605
XP_003403793                                                           15    9605
NP_006203                                                              15    9605
NP_006459                                                              15    9605
NP_789781                                                              15    9605
>NP_000537
          Length = 393

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NLLRRNSFE 9
           NLL RNSFE
Sbjct: 263 NLLGRNSFE 271
>NP_001263689
          Length = 354

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NLLRRNSFE 9
           NLL RNSFE
Sbjct: 224 NLLGRNSFE 232
>NP_001119584
          Length = 393

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NLLRRNSFE 9
           NLL RNSFE
Sbjct: 263 NLLGRNSFE 271
>NP_001119586
          Length = 341

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NLLRRNSFE 9
           NLL RNSFE
Sbjct: 263 NLLGRNSFE 271
>NP_001263625
          Length = 302

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NLLRRNSFE 9
           NLL RNSFE
Sbjct: 224 NLLGRNSFE 232
>NP_001119590
          Length = 354

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NLLRRNSFE 9
           NLL RNSFE
Sbjct: 224 NLLGRNSFE 232
>NP_001263690
          Length = 354

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NLLRRNSFE 9
           NLL RNSFE
Sbjct: 224 NLLGRNSFE 232
>NP_001119585
          Length = 346

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NLLRRNSFE 9
           NLL RNSFE
Sbjct: 263 NLLGRNSFE 271
>NP_001263624
          Length = 307

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NLLRRNSFE 9
           NLL RNSFE
Sbjct: 224 NLLGRNSFE 232
>NP_001119588
          Length = 209

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NLLRRNSFE 9
           NLL RNSFE
Sbjct: 131 NLLGRNSFE 139
>NP_001119587
          Length = 261

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NLLRRNSFE 9
           NLL RNSFE
Sbjct: 131 NLLGRNSFE 139
>NP_001119589
          Length = 214

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NLLRRNSFE 9
           NLL RNSFE
Sbjct: 131 NLLGRNSFE 139
>NP_001263627
          Length = 182

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NLLRRNSFE 9
           NLL RNSFE
Sbjct: 104 NLLGRNSFE 112
>NP_001263628
          Length = 187

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NLLRRNSFE 9
           NLL RNSFE
Sbjct: 104 NLLGRNSFE 112
>NP_001263626
          Length = 234

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NLLRRNSFE 9
           NLL RNSFE
Sbjct: 104 NLLGRNSFE 112
>NP_001158307
          Length = 865

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NLLRRNSFE 9
           N+LR N FE
Sbjct: 265 NILRENDFE 273
>NP_061952
          Length = 865

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NLLRRNSFE 9
           N+LR N FE
Sbjct: 265 NILRENDFE 273
>NP_006429
          Length = 277

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  NLLRRNSF 8
          +LLRRN F
Sbjct: 6  SLLRRNQF 13
>NP_060337
          Length = 346

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NLLRRNSF 8
           NLL+RN F
Sbjct: 318 NLLKRNLF 325
>NP_001177188
          Length = 180

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  NLLRRNSF 8
          +LLR NSF
Sbjct: 4  SLLRENSF 11
>NP_004648
          Length = 425

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LLRRNSFE 9
           LLRRN F+
Sbjct: 149 LLRRNHFK 156
>XP_005247328
          Length = 165

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  NLLRRNSF 8
          +LLR NSF
Sbjct: 4  SLLRENSF 11
>NP_001547
          Length = 756

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   NLLRRNS 7
           NLLR NS
Sbjct: 457 NLLRNNS 463
>NP_001229707
          Length = 697

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   NLLRRNS 7
           NLLR NS
Sbjct: 398 NLLRNNS 404
>NP_001177649
          Length = 754

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   NLLRRNS 7
           NLLR NS
Sbjct: 455 NLLRNNS 461
>NP_003702
          Length = 284

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  NLLRRNSF 8
          NLL  NSF
Sbjct: 82 NLLHSNSF 89
>NP_795714
          Length = 285

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  NLLRRNSF 8
          NLL  NSF
Sbjct: 83 NLLHSNSF 90
>XP_005273556
          Length = 595

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   NLLRRNS 7
           NLLR NS
Sbjct: 247 NLLRNNS 253
>XP_005273555
          Length = 595

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   NLLRRNS 7
           NLLR NS
Sbjct: 247 NLLRNNS 253
>XP_005273553
          Length = 595

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   NLLRRNS 7
           NLLR NS
Sbjct: 247 NLLRNNS 253
>XP_005273552
          Length = 595

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   NLLRRNS 7
           NLLR NS
Sbjct: 247 NLLRNNS 253
>XP_005273551
          Length = 674

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   NLLRRNS 7
           NLLR NS
Sbjct: 457 NLLRNNS 463
>XP_005273550
          Length = 700

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   NLLRRNS 7
           NLLR NS
Sbjct: 352 NLLRNNS 358
>XP_005273549
          Length = 706

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   NLLRRNS 7
           NLLR NS
Sbjct: 457 NLLRNNS 463
>XP_005273548
          Length = 746

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   NLLRRNS 7
           NLLR NS
Sbjct: 398 NLLRNNS 404
>XP_005273547
          Length = 805

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   NLLRRNS 7
           NLLR NS
Sbjct: 457 NLLRNNS 463
>XP_006714787
          Length = 221

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  NLLRRNSF 8
          NLL  NSF
Sbjct: 19 NLLHSNSF 26
>NP_705838
          Length = 4069

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RRNSFE 9
           +RNSFE
Sbjct: 152 KRNSFE 157
>NP_438112
          Length = 705

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NLLRRNS 7
           NL++RNS
Sbjct: 249 NLVKRNS 255
>NP_036348
          Length = 735

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NLLRRNS 7
           NL++RNS
Sbjct: 249 NLVKRNS 255
>NP_001271230
          Length = 1087

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RRNSFE 9
            RRN+FE
Sbjct: 1015 RRNTFE 1020
>NP_001271231
          Length = 1086

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RRNSFE 9
            RRN+FE
Sbjct: 1014 RRNTFE 1019
>NP_061155
          Length = 1124

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RRNSFE 9
            RRN+FE
Sbjct: 1052 RRNTFE 1057
>NP_853514
          Length = 1732

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    LLRRNSF 8
            LLRRN++
Sbjct: 1012 LLRRNTY 1018
>NP_001073929
          Length = 560

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LRRNSFE 9
           L+RN FE
Sbjct: 172 LKRNQFE 178
>XP_005262119
          Length = 715

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NLLRRNS 7
           NL++RNS
Sbjct: 229 NLVKRNS 235
>XP_003403542
          Length = 846

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RRNSFE 9
           R+NSFE
Sbjct: 517 RKNSFE 522
>XP_005258568
          Length = 1029

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LLRRNSFE 9
           +LR+NS E
Sbjct: 822 ILRKNSLE 829
>XP_006717114
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  NLLRRNSFE 9
          NL+ R  FE
Sbjct: 31 NLMERKDFE 39
>XP_006717113
          Length = 486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  NLLRRNSFE 9
          NL+ R  FE
Sbjct: 31 NLMERKDFE 39
>XP_006717112
          Length = 486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  NLLRRNSFE 9
          NL+ R  FE
Sbjct: 31 NLMERKDFE 39
>XP_005251965
          Length = 486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  NLLRRNSFE 9
          NL+ R  FE
Sbjct: 31 NLMERKDFE 39
>XP_006715810
          Length = 1105

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RRNSFE 9
            RRN+FE
Sbjct: 1033 RRNTFE 1038
>XP_006715809
          Length = 1142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RRNSFE 9
            RRN+FE
Sbjct: 1070 RRNTFE 1075
>XP_006713676
          Length = 560

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LRRNSFE 9
           L+RN FE
Sbjct: 172 LKRNQFE 178
>XP_005247478
          Length = 560

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LRRNSFE 9
           L+RN FE
Sbjct: 172 LKRNQFE 178
>XP_005246216
          Length = 429

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  RRNSFE 9
          RRN+FE
Sbjct: 59 RRNNFE 64
>XP_006711947
          Length = 441

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  RRNSFE 9
          RRN+FE
Sbjct: 59 RRNNFE 64
>XP_005273219
          Length = 263

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   LRRNSF 8
           +RRNSF
Sbjct: 220 MRRNSF 225
>XP_006711444
          Length = 407

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   LRRNSF 8
           +RRNSF
Sbjct: 364 MRRNSF 369
>XP_005272985
          Length = 417

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   NLLRRNSFE 9
           NL+ R  FE
Sbjct: 328 NLIERRQFE 336
>XP_005272984
          Length = 417

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   NLLRRNSFE 9
           NL+ R  FE
Sbjct: 328 NLIERRQFE 336
>XP_005277390
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   NLLRRNSFE 9
           NL+ R  FE
Sbjct: 458 NLIERRQFE 466
>XP_003403793
          Length = 846

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RRNSFE 9
           R+NSFE
Sbjct: 517 RKNSFE 522
>NP_006203
          Length = 505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   LRRNSF 8
           +RRNSF
Sbjct: 462 MRRNSF 467
>NP_006459
          Length = 534

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   NLLRRNSFE 9
           NL+ R  FE
Sbjct: 445 NLIERRQFE 453
>NP_789781
          Length = 1048

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LLRRNSFE 9
           +LR+NS E
Sbjct: 822 ILRKNSLE 829
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.325    0.138    0.373 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 491,233
Number of extensions: 1024
Number of successful extensions: 67
Number of sequences better than 10000.0: 67
Number of HSP's gapped: 67
Number of HSP's successfully gapped: 67
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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