Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_958441                                                              19     665
NP_958439                                                              19     665
NP_958440                                                              19     665
NP_005219                                                              19     665
NP_055068                                                              17    4312
NP_001156750                                                           17    4312
NP_001156751                                                           17    4312
NP_001008781                                                           17    4312
XP_006724788                                                           17    4312
XP_006718827                                                           17    4312
XP_005245394                                                           17    4312
NP_982258                                                              17    4312
NP_001276867                                                           16    5631
NP_001276866                                                           16    5631
NP_004439                                                              16    5631
NP_001276865                                                           16    5631
NP_001005862                                                           16    5631
NP_005236                                                              16    5631
XP_006721831                                                           16    5631
XP_006721830                                                           16    5631
XP_005257197                                                           16    5631
XP_006721828                                                           16    5631
XP_006714202                                                           16    5631
XP_005262892                                                           16    5631
XP_005262891                                                           16    5631
NP_065861                                                              16    7355
NP_001019832                                                           16    7355
NP_001278309                                                           16    7355
NP_001165689                                                           16    7355
NP_036368                                                              16    7355
NP_001165691                                                           16    7355
NP_001165690                                                           16    7355
NP_075389                                                              16    7355
NP_001026864                                                           16    7355
NP_001165692                                                           16    7355
NP_001165693                                                           16    7355
XP_006725017                                                           16    7355
XP_005267973                                                           16    7355
XP_006711144                                                           16    7355
XP_006710533                                                           16    7355
XP_006710532                                                           16    7355
XP_006710531                                                           16    7355
XP_006710530                                                           16    7355
XP_006710529                                                           16    7355
XP_006710528                                                           16    7355
XP_005270696                                                           16    7355
XP_006710527                                                           16    7355
XP_006710526                                                           16    7355
XP_006710525                                                           16    7355
NP_055979                                                              15    9605
NP_001398                                                              15    9605
NP_113584                                                              15    9605
NP_055893                                                              15    9605
NP_001243657                                                           15    9605
NP_001243656                                                           15    9605
NP_001243655                                                           15    9605
NP_001243654                                                           15    9605
NP_006581                                                              15    9605
XP_005262029                                                           15    9605
XP_005262028                                                           15    9605
XP_005262026                                                           15    9605
XP_006724637                                                           15    9605
XP_005262025                                                           15    9605
XP_005262024                                                           15    9605
XP_005262023                                                           15    9605
XP_005262022                                                           15    9605
XP_005269747                                                           15    9605
XP_005249356                                                           15    9605
XP_005245848                                                           15    9605
XP_005245847                                                           15    9605
>NP_958441
          Length = 705

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  NLEITYVLR 9
          NLEITYV R
Sbjct: 64 NLEITYVQR 72
>NP_958439
          Length = 628

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  NLEITYVLR 9
          NLEITYV R
Sbjct: 64 NLEITYVQR 72
>NP_958440
          Length = 405

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  NLEITYVLR 9
          NLEITYV R
Sbjct: 64 NLEITYVQR 72
>NP_005219
          Length = 1210

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  NLEITYVLR 9
          NLEITYV R
Sbjct: 64 NLEITYVQR 72
>NP_055068
          Length = 2725

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NLEITYVL 8
            NLE+TY L
Sbjct: 2452 NLELTYEL 2459
>NP_001156750
          Length = 2732

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NLEITYVL 8
            NLE+TY L
Sbjct: 2459 NLELTYEL 2466
>NP_001156751
          Length = 2731

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NLEITYVL 8
            NLE+TY L
Sbjct: 2458 NLELTYEL 2465
>NP_001008781
          Length = 4557

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    NLEITYVLR 9
            N E+TYVL+
Sbjct: 2116 NGEVTYVLQ 2124
>XP_006724788
          Length = 2570

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NLEITYVL 8
            NLE+TY L
Sbjct: 2297 NLELTYEL 2304
>XP_006718827
          Length = 3479

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    NLEITYVLR 9
            N E+TYVL+
Sbjct: 1006 NGEVTYVLQ 1014
>XP_005245394
          Length = 1741

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    LEITYVL 8
            LE+TY+L
Sbjct: 1705 LEVTYIL 1711
>NP_982258
          Length = 404

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  NLEITYVLR 9
          NL ++YVLR
Sbjct: 33 NLLVSYVLR 41
>NP_001276867
          Length = 603

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  NLEITYV 7
          NLE+TY+
Sbjct: 29 NLELTYL 35
>NP_001276866
          Length = 1055

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  NLEITYV 7
          NLE+TY+
Sbjct: 59 NLELTYL 65
>NP_004439
          Length = 1255

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  NLEITYV 7
          NLE+TY+
Sbjct: 59 NLELTYL 65
>NP_001276865
          Length = 1240

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  NLEITYV 7
          NLE+TY+
Sbjct: 44 NLELTYL 50
>NP_001005862
          Length = 1225

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  NLEITYV 7
          NLE+TY+
Sbjct: 29 NLELTYL 35
>NP_005236
          Length = 4588

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    NLEITYVL 8
            N EITY L
Sbjct: 3055 NAEITYTL 3062
>XP_006721831
          Length = 730

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NLEITYV 7
           NLE+TY+
Sbjct: 156 NLELTYL 162
>XP_006721830
          Length = 737

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NLEITYV 7
           NLE+TY+
Sbjct: 156 NLELTYL 162
>XP_005257197
          Length = 1225

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  NLEITYV 7
          NLE+TY+
Sbjct: 29 NLELTYL 35
>XP_006721828
          Length = 1336

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NLEITYV 7
           NLE+TY+
Sbjct: 156 NLELTYL 162
>XP_006714202
          Length = 4588

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    NLEITYVL 8
            N EITY L
Sbjct: 3055 NAEITYTL 3062
>XP_005262892
          Length = 4600

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    NLEITYVL 8
            N EITY L
Sbjct: 3055 NAEITYTL 3062
>XP_005262891
          Length = 4600

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    NLEITYVL 8
            N EITY L
Sbjct: 3055 NAEITYTL 3062
>NP_065861
          Length = 509

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NLEITY 6
           NLE+TY
Sbjct: 172 NLELTY 177
>NP_001019832
          Length = 474

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NLEITY 6
           NLE+TY
Sbjct: 297 NLELTY 302
>NP_001278309
          Length = 474

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NLEITY 6
           NLE+TY
Sbjct: 297 NLELTY 302
>NP_001165689
          Length = 577

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ITYVLR 9
           ITYVLR
Sbjct: 382 ITYVLR 387
>NP_036368
          Length = 591

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ITYVLR 9
           ITYVLR
Sbjct: 396 ITYVLR 401
>NP_001165691
          Length = 577

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ITYVLR 9
           ITYVLR
Sbjct: 382 ITYVLR 387
>NP_001165690
          Length = 648

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ITYVLR 9
           ITYVLR
Sbjct: 453 ITYVLR 458
>NP_075389
          Length = 474

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NLEITY 6
           NLE+TY
Sbjct: 297 NLELTY 302
>NP_001026864
          Length = 660

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ITYVLR 9
           ITYVLR
Sbjct: 443 ITYVLR 448
>NP_001165692
          Length = 599

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ITYVLR 9
           ITYVLR
Sbjct: 382 ITYVLR 387
>NP_001165693
          Length = 480

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ITYVLR 9
           ITYVLR
Sbjct: 285 ITYVLR 290
>XP_006725017
          Length = 229

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  NLEITY 6
          NLE+TY
Sbjct: 52 NLELTY 57
>XP_005267973
          Length = 537

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NLEITY 6
           NLE+TY
Sbjct: 200 NLELTY 205
>XP_006711144
          Length = 229

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  NLEITY 6
          NLE+TY
Sbjct: 52 NLELTY 57
>XP_006710533
          Length = 496

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ITYVLR 9
           ITYVLR
Sbjct: 453 ITYVLR 458
>XP_006710532
          Length = 514

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ITYVLR 9
           ITYVLR
Sbjct: 453 ITYVLR 458
>XP_006710531
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ITYVLR 9
           ITYVLR
Sbjct: 352 ITYVLR 357
>XP_006710530
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ITYVLR 9
           ITYVLR
Sbjct: 352 ITYVLR 357
>XP_006710529
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ITYVLR 9
           ITYVLR
Sbjct: 352 ITYVLR 357
>XP_006710528
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ITYVLR 9
           ITYVLR
Sbjct: 352 ITYVLR 357
>XP_005270696
          Length = 599

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ITYVLR 9
           ITYVLR
Sbjct: 382 ITYVLR 387
>XP_006710527
          Length = 599

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ITYVLR 9
           ITYVLR
Sbjct: 382 ITYVLR 387
>XP_006710526
          Length = 613

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ITYVLR 9
           ITYVLR
Sbjct: 396 ITYVLR 401
>XP_006710525
          Length = 670

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ITYVLR 9
           ITYVLR
Sbjct: 453 ITYVLR 458
>NP_055979
          Length = 1019

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NLEITYVL 8
           NL++ YVL
Sbjct: 622 NLQLLYVL 629
>NP_001398
          Length = 3312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    NLEITYV 7
            N+E+TY+
Sbjct: 2308 NMELTYL 2314
>NP_113584
          Length = 4374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    EITYVLR 9
            EI Y+LR
Sbjct: 1866 EINYILR 1872
>NP_055893
          Length = 1114

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NLEITYVLR 9
           NL++ ++LR
Sbjct: 128 NLQLIFILR 136
>NP_001243657
          Length = 462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  EITYVLR 9
          +ITYVL+
Sbjct: 85 DITYVLK 91
>NP_001243656
          Length = 487

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EITYVLR 9
           +ITYVL+
Sbjct: 110 DITYVLK 116
>NP_001243655
          Length = 488

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EITYVLR 9
           +ITYVL+
Sbjct: 188 DITYVLK 194
>NP_001243654
          Length = 565

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EITYVLR 9
           +ITYVL+
Sbjct: 188 DITYVLK 194
>NP_006581
          Length = 565

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EITYVLR 9
           +ITYVL+
Sbjct: 188 DITYVLK 194
>XP_005262029
          Length = 4240

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    EITYVLR 9
            EI Y+LR
Sbjct: 1866 EINYILR 1872
>XP_005262028
          Length = 4341

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    EITYVLR 9
            EI Y+LR
Sbjct: 1866 EINYILR 1872
>XP_005262026
          Length = 4359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    EITYVLR 9
            EI Y+LR
Sbjct: 1866 EINYILR 1872
>XP_006724637
          Length = 4365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    EITYVLR 9
            EI Y+LR
Sbjct: 1857 EINYILR 1863
>XP_005262025
          Length = 4373

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    EITYVLR 9
            EI Y+LR
Sbjct: 1866 EINYILR 1872
>XP_005262024
          Length = 4374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    EITYVLR 9
            EI Y+LR
Sbjct: 1866 EINYILR 1872
>XP_005262023
          Length = 4374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    EITYVLR 9
            EI Y+LR
Sbjct: 1866 EINYILR 1872
>XP_005262022
          Length = 4374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    EITYVLR 9
            EI Y+LR
Sbjct: 1866 EINYILR 1872
>XP_005269747
          Length = 598

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   NLEITY 6
           N+E+TY
Sbjct: 312 NMEVTY 317
>XP_005249356
          Length = 198

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  NLEITYVL 8
          +LEI YVL
Sbjct: 32 SLEILYVL 39
>XP_005245848
          Length = 816

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NLEITYVL 8
           NL++ YVL
Sbjct: 419 NLQLLYVL 426
>XP_005245847
          Length = 999

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NLEITYVL 8
           NL++ YVL
Sbjct: 602 NLQLLYVL 609
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.328    0.146    0.389 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 398,356
Number of extensions: 530
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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