Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443179                                                              20     390
NP_001127880                                                           17    3301
NP_000824                                                              17    3301
NP_001127879                                                           17    3301
XP_005255325                                                           17    3301
XP_005255324                                                           17    3301
NP_777571                                                              17    4312
NP_653250                                                              17    4312
NP_115548                                                              17    4312
XP_006716571                                                           17    4312
XP_006716570                                                           17    4312
XP_005250852                                                           17    4312
XP_005250851                                                           17    4312
XP_005249940                                                           17    4312
XP_005249939                                                           17    4312
XP_006715854                                                           17    4312
XP_006715853                                                           17    4312
XP_005248008                                                           17    4312
XP_006713927                                                           17    4312
NP_660334                                                              17    4312
XP_006718977                                                           16    5631
NP_000236                                                              16    7355
NP_000171                                                              16    7355
NP_001120972                                                           16    7355
NP_002323                                                              16    7355
NP_001186308                                                           16    7355
NP_055748                                                              16    7355
NP_001186307                                                           16    7355
NP_001070676                                                           16    7355
NP_001070675                                                           16    7355
NP_001070674                                                           16    7355
NP_115545                                                              16    7355
NP_057295                                                              16    7355
NP_001177978                                                           16    7355
XP_006718112                                                           16    7355
XP_006716052                                                           16    7355
XP_006716051                                                           16    7355
XP_006714210                                                           16    7355
XP_006714209                                                           16    7355
XP_005262911                                                           16    7355
XP_005262909                                                           16    7355
XP_005262908                                                           16    7355
XP_005262907                                                           16    7355
XP_006714208                                                           16    7355
XP_005262906                                                           16    7355
XP_006714207                                                           16    7355
XP_006714206                                                           16    7355
XP_006714205                                                           16    7355
XP_006714204                                                           16    7355
XP_005262904                                                           16    7355
NP_006447                                                              15    9605
NP_002888                                                              15    9605
NP_058520                                                              15    9605
XP_005257011                                                           15    9605
XP_006712738                                                           15    9605
XP_006712737                                                           15    9605
XP_006712736                                                           15    9605
XP_005246797                                                           15    9605
XP_005246798                                                           15    9605
XP_005246796                                                           15    9605
XP_006712735                                                           15    9605
XP_005246795                                                           15    9605
XP_005246794                                                           15    9605
XP_006712734                                                           15    9605
>NP_443179
          Length = 2170

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   NHTLSLQSL 9
           NH+LSLQSL
Sbjct: 169 NHSLSLQSL 177
>NP_001127880
          Length = 1281

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   NHTLSLQ 7
           NHTLSL+
Sbjct: 380 NHTLSLR 386
>NP_000824
          Length = 1464

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   NHTLSLQ 7
           NHTLSL+
Sbjct: 380 NHTLSLR 386
>NP_001127879
          Length = 1464

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   NHTLSLQ 7
           NHTLSL+
Sbjct: 380 NHTLSLR 386
>XP_005255325
          Length = 1333

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   NHTLSLQ 7
           NHTLSL+
Sbjct: 432 NHTLSLR 438
>XP_005255324
          Length = 1516

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   NHTLSLQ 7
           NHTLSL+
Sbjct: 432 NHTLSLR 438
>NP_777571
          Length = 310

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NHTLSLQSL 9
           +HTL  QSL
Sbjct: 239 SHTLEFQSL 247
>NP_653250
          Length = 276

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   NHTLSLQS 8
           +H+LSLQS
Sbjct: 183 SHSLSLQS 190
>NP_115548
          Length = 1316

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  NHTLSL 6
          NHTLSL
Sbjct: 49 NHTLSL 54
>XP_006716571
          Length = 116

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  NHTLSLQS 8
          +H+LSLQS
Sbjct: 23 SHSLSLQS 30
>XP_006716570
          Length = 290

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   NHTLSLQS 8
           +H+LSLQS
Sbjct: 197 SHSLSLQS 204
>XP_005250852
          Length = 294

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   NHTLSLQS 8
           +H+LSLQS
Sbjct: 201 SHSLSLQS 208
>XP_005250851
          Length = 295

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   NHTLSLQS 8
           +H+LSLQS
Sbjct: 202 SHSLSLQS 209
>XP_005249940
          Length = 737

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  NHTLSL 6
          NHTLSL
Sbjct: 49 NHTLSL 54
>XP_005249939
          Length = 1324

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  NHTLSL 6
          NHTLSL
Sbjct: 49 NHTLSL 54
>XP_006715854
          Length = 1327

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  NHTLSL 6
          NHTLSL
Sbjct: 49 NHTLSL 54
>XP_006715853
          Length = 1327

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  NHTLSL 6
          NHTLSL
Sbjct: 49 NHTLSL 54
>XP_005248008
          Length = 466

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   NHTLSLQS 8
           N TLSLQS
Sbjct: 131 NSTLSLQS 138
>XP_006713927
          Length = 765

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   NHTLSLQS 8
           N TLSLQS
Sbjct: 131 NSTLSLQS 138
>NP_660334
          Length = 765

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   NHTLSLQS 8
           N TLSLQS
Sbjct: 131 NSTLSLQS 138
>XP_006718977
          Length = 293

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  NHTLSLQS 8
          NH+LSL++
Sbjct: 9  NHSLSLEA 16
>NP_000236
          Length = 1390

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NHTLSLQS 8
           NHT  +QS
Sbjct: 149 NHTADIQS 156
>NP_000171
          Length = 1103

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    NHTLSLQSL 9
            NH +SLQ +
Sbjct: 1078 NHGISLQEI 1086
>NP_001120972
          Length = 1408

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NHTLSLQS 8
           NHT  +QS
Sbjct: 149 NHTADIQS 156
>NP_002323
          Length = 4544

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    NHTLSLQS 8
            NHT  +QS
Sbjct: 1218 NHTCQIQS 1225
>NP_001186308
          Length = 1855

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    HTLSLQSL 9
            HT+SLQ L
Sbjct: 1488 HTVSLQLL 1495
>NP_055748
          Length = 1220

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NHTLSLQSL 9
           +H LSLQ L
Sbjct: 712 SHPLSLQDL 720
>NP_001186307
          Length = 1856

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    HTLSLQSL 9
            HT+SLQ L
Sbjct: 1489 HTVSLQLL 1496
>NP_001070676
          Length = 1205

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NHTLSLQSL 9
           +H LSLQ L
Sbjct: 712 SHPLSLQDL 720
>NP_001070675
          Length = 1220

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NHTLSLQSL 9
           +H LSLQ L
Sbjct: 712 SHPLSLQDL 720
>NP_001070674
          Length = 1106

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NHTLSLQSL 9
           +H LSLQ L
Sbjct: 712 SHPLSLQDL 720
>NP_115545
          Length = 780

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   HTLSLQSL 9
           H+L++QSL
Sbjct: 157 HSLNIQSL 164
>NP_057295
          Length = 1181

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NHTLSLQSL 9
           +H LSLQ L
Sbjct: 673 SHPLSLQDL 681
>NP_001177978
          Length = 1200

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NHTLSLQSL 9
           +H LSLQ L
Sbjct: 707 SHPLSLQDL 715
>XP_006718112
          Length = 1889

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    HTLSLQSL 9
            HT+SLQ L
Sbjct: 1522 HTVSLQLL 1529
>XP_006716052
          Length = 1409

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NHTLSLQS 8
           NHT  +QS
Sbjct: 168 NHTADIQS 175
>XP_006716051
          Length = 1427

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NHTLSLQS 8
           NHT  +QS
Sbjct: 168 NHTADIQS 175
>XP_006714210
          Length = 897

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NHTLSLQSL 9
           +H LSLQ L
Sbjct: 673 SHPLSLQDL 681
>XP_006714209
          Length = 936

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NHTLSLQSL 9
           +H LSLQ L
Sbjct: 712 SHPLSLQDL 720
>XP_005262911
          Length = 1067

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NHTLSLQSL 9
           +H LSLQ L
Sbjct: 673 SHPLSLQDL 681
>XP_005262909
          Length = 1166

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NHTLSLQSL 9
           +H LSLQ L
Sbjct: 673 SHPLSLQDL 681
>XP_005262908
          Length = 1194

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NHTLSLQSL 9
           +H LSLQ L
Sbjct: 673 SHPLSLQDL 681
>XP_005262907
          Length = 1205

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NHTLSLQSL 9
           +H LSLQ L
Sbjct: 712 SHPLSLQDL 720
>XP_006714208
          Length = 1207

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NHTLSLQSL 9
           +H LSLQ L
Sbjct: 686 SHPLSLQDL 694
>XP_005262906
          Length = 1218

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NHTLSLQSL 9
           +H LSLQ L
Sbjct: 712 SHPLSLQDL 720
>XP_006714207
          Length = 1220

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NHTLSLQSL 9
           +H LSLQ L
Sbjct: 699 SHPLSLQDL 707
>XP_006714206
          Length = 1233

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NHTLSLQSL 9
           +H LSLQ L
Sbjct: 712 SHPLSLQDL 720
>XP_006714205
          Length = 1233

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NHTLSLQSL 9
           +H LSLQ L
Sbjct: 712 SHPLSLQDL 720
>XP_006714204
          Length = 1233

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NHTLSLQSL 9
           +H LSLQ L
Sbjct: 712 SHPLSLQDL 720
>XP_005262904
          Length = 1233

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NHTLSLQSL 9
           +H LSLQ L
Sbjct: 712 SHPLSLQDL 720
>NP_006447
          Length = 374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NHTLSLQS 8
           NH LSL++
Sbjct: 350 NHDLSLEA 357
>NP_002888
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HTLSLQ 7
           HT+SLQ
Sbjct: 324 HTMSLQ 329
>NP_058520
          Length = 406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HTLSLQ 7
           HT+SLQ
Sbjct: 327 HTMSLQ 332
>XP_005257011
          Length = 346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NHTLSLQS 8
           NH LSL++
Sbjct: 322 NHDLSLEA 329
>XP_006712738
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HTLSLQ 7
           HT+SLQ
Sbjct: 324 HTMSLQ 329
>XP_006712737
          Length = 405

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HTLSLQ 7
           HT+SLQ
Sbjct: 326 HTMSLQ 331
>XP_006712736
          Length = 408

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HTLSLQ 7
           HT+SLQ
Sbjct: 329 HTMSLQ 334
>XP_005246797
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HTLSLQ 7
           HT+SLQ
Sbjct: 340 HTMSLQ 345
>XP_005246798
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HTLSLQ 7
           HT+SLQ
Sbjct: 340 HTMSLQ 345
>XP_005246796
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HTLSLQ 7
           HT+SLQ
Sbjct: 341 HTMSLQ 346
>XP_006712735
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HTLSLQ 7
           HT+SLQ
Sbjct: 342 HTMSLQ 347
>XP_005246795
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HTLSLQ 7
           HT+SLQ
Sbjct: 342 HTMSLQ 347
>XP_005246794
          Length = 422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HTLSLQ 7
           HT+SLQ
Sbjct: 343 HTMSLQ 348
>XP_006712734
          Length = 424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HTLSLQ 7
           HT+SLQ
Sbjct: 345 HTMSLQ 350
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.310    0.118    0.304 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 412,302
Number of extensions: 498
Number of successful extensions: 64
Number of sequences better than 10000.0: 64
Number of HSP's gapped: 64
Number of HSP's successfully gapped: 64
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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