Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000312                                                              20     299
NP_116200                                                              18    1482
XP_005271768                                                           18    1482
XP_005271766                                                           18    1482
NP_477352                                                              17    4312
XP_005261692                                                           17    4312
XP_005261691                                                           17    4312
NP_003861                                                              16    7355
NP_116188                                                              16    7355
NP_001188358                                                           16    7355
NP_036427                                                              16    7355
NP_036298                                                              16    7355
NP_001186210                                                           16    7355
NP_112591                                                              16    7355
NP_001139118                                                           16    7355
NP_036203                                                              16    7355
XP_006724246                                                           16    7355
XP_006724245                                                           16    7355
XP_006724244                                                           16    7355
XP_006724243                                                           16    7355
XP_005261477                                                           16    7355
XP_005261476                                                           16    7355
XP_005261474                                                           16    7355
XP_006724242                                                           16    7355
XP_005261473                                                           16    7355
XP_005261472                                                           16    7355
XP_005255041                                                           16    7355
XP_005251496                                                           16    7355
NP_001001712                                                           16    7355
NP_037412                                                              15    9605
NP_065874                                                              15    9605
NP_001123363                                                           15    9605
NP_001184225                                                           15    9605
NP_001184224                                                           15    9605
NP_849193                                                              15    9605
XP_005273918                                                           15    9605
XP_006713080                                                           15    9605
NP_001384                                                              15    9605
>NP_000312
          Length = 928

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   MYRLAYLRL 9
           +YRLAYLRL
Sbjct: 654 VYRLAYLRL 662
>NP_116200
          Length = 411

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  YRLAYLRL 9
          YRL YLRL
Sbjct: 34 YRLKYLRL 41
>XP_005271768
          Length = 211

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  YRLAYLRL 9
          YRL YLRL
Sbjct: 34 YRLKYLRL 41
>XP_005271766
          Length = 264

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  YRLAYLRL 9
          YRL YLRL
Sbjct: 34 YRLKYLRL 41
>NP_477352
          Length = 2102

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MYRLAYLRL 9
           +YRL Y+R+
Sbjct: 896 VYRLEYMRV 904
>XP_005261692
          Length = 1854

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MYRLAYLRL 9
           +YRL Y+R+
Sbjct: 924 VYRLEYMRV 932
>XP_005261691
          Length = 2099

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MYRLAYLRL 9
           +YRL Y+R+
Sbjct: 924 VYRLEYMRV 932
>NP_003861
          Length = 1657

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RLAYLR 8
           RLAYLR
Sbjct: 798 RLAYLR 803
>NP_116188
          Length = 267

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YRLAYLR 8
           +R+AYLR
Sbjct: 218 HRIAYLR 224
>NP_001188358
          Length = 2170

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    MYRLAYL 7
            +YRLA+L
Sbjct: 1480 LYRLAFL 1486
>NP_036427
          Length = 2220

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    MYRLAYL 7
            +YRLA+L
Sbjct: 1530 LYRLAFL 1536
>NP_036298
          Length = 956

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   MYRLAY 6
           MYRL+Y
Sbjct: 371 MYRLSY 376
>NP_001186210
          Length = 2220

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    MYRLAYL 7
            +YRLA+L
Sbjct: 1530 LYRLAFL 1536
>NP_112591
          Length = 257

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  MYRLAYLRL 9
          M+R AY +L
Sbjct: 85 MFRFAYYKL 93
>NP_001139118
          Length = 216

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  MYRLAYLRL 9
          M+R AY +L
Sbjct: 85 MFRFAYYKL 93
>NP_036203
          Length = 195

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   MYRLAYL 7
           MYR AYL
Sbjct: 144 MYRPAYL 150
>XP_006724246
          Length = 2103

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    MYRLAYL 7
            +YRLA+L
Sbjct: 1560 LYRLAFL 1566
>XP_006724245
          Length = 2191

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    MYRLAYL 7
            +YRLA+L
Sbjct: 1501 LYRLAFL 1507
>XP_006724244
          Length = 2191

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    MYRLAYL 7
            +YRLA+L
Sbjct: 1530 LYRLAFL 1536
>XP_006724243
          Length = 2196

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    MYRLAYL 7
            +YRLA+L
Sbjct: 1501 LYRLAFL 1507
>XP_005261477
          Length = 2200

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    MYRLAYL 7
            +YRLA+L
Sbjct: 1560 LYRLAFL 1566
>XP_005261476
          Length = 2210

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    MYRLAYL 7
            +YRLA+L
Sbjct: 1515 LYRLAFL 1521
>XP_005261474
          Length = 2225

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    MYRLAYL 7
            +YRLA+L
Sbjct: 1530 LYRLAFL 1536
>XP_006724242
          Length = 2226

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    MYRLAYL 7
            +YRLA+L
Sbjct: 1560 LYRLAFL 1566
>XP_005261473
          Length = 2250

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    MYRLAYL 7
            +YRLA+L
Sbjct: 1560 LYRLAFL 1566
>XP_005261472
          Length = 2255

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    MYRLAYL 7
            +YRLA+L
Sbjct: 1560 LYRLAFL 1566
>XP_005255041
          Length = 1191

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RLAYLR 8
           RLAYLR
Sbjct: 798 RLAYLR 803
>XP_005251496
          Length = 653

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   MYRLAY 6
           MYRL+Y
Sbjct: 371 MYRLSY 376
>NP_001001712
          Length = 200

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   YRLAYLRL 9
           Y L YLRL
Sbjct: 138 YGLVYLRL 145
>NP_037412
          Length = 674

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   YRLAYLRL 9
           +RL++LRL
Sbjct: 464 FRLSWLRL 471
>NP_065874
          Length = 612

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YRLAYLRL 9
           YRLA +RL
Sbjct: 139 YRLAPMRL 146
>NP_001123363
          Length = 535

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LAYLRL 9
           LAYLRL
Sbjct: 148 LAYLRL 153
>NP_001184225
          Length = 643

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LAYLRL 9
           LAYLRL
Sbjct: 444 LAYLRL 449
>NP_001184224
          Length = 677

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LAYLRL 9
           LAYLRL
Sbjct: 444 LAYLRL 449
>NP_849193
          Length = 826

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   MYRLAYLR 8
           MY+++Y R
Sbjct: 717 MYKMSYYR 724
>XP_005273918
          Length = 674

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   YRLAYLRL 9
           +RL++LRL
Sbjct: 464 FRLSWLRL 471
>XP_006713080
          Length = 804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   MYRLAYLR 8
           MY+++Y R
Sbjct: 717 MYKMSYYR 724
>NP_001384
          Length = 699

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LAYLRL 9
           LAYLRL
Sbjct: 466 LAYLRL 471
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.352    0.157    0.465 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 432,980
Number of extensions: 722
Number of successful extensions: 38
Number of sequences better than 10000.0: 38
Number of HSP's gapped: 38
Number of HSP's successfully gapped: 38
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.9 bits)
S2: 28 (15.4 bits)

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