Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000360                                                              18    1135
XP_005268094                                                           18    1135
NP_001263629                                                           17    2528
NP_612202                                                              17    2528
NP_000224                                                              17    2528
XP_005264366                                                           17    2528
XP_006712078                                                           17    2528
NP_852111                                                              17    3301
NP_000136                                                              17    3301
NP_775922                                                              17    4312
NP_001005213                                                           16    5631
NP_001013376                                                           16    5631
NP_065394                                                              16    7355
NP_076411                                                              16    7355
NP_001004479                                                           16    7355
NP_000733                                                              15    9605
NP_060606                                                              15    9605
NP_001243502                                                           15    9605
NP_000735                                                              15    9605
NP_005497                                                              15    9605
NP_001269384                                                           15    9605
NP_001191184                                                           15    9605
NP_002502                                                              15    9605
NP_001245213                                                           15    9605
XP_005260248                                                           15    9605
XP_006720535                                                           15    9605
XP_005254948                                                           15    9605
XP_005254946                                                           15    9605
XP_005273454                                                           15    9605
XP_006716346                                                           15    9605
XP_006716345                                                           15    9605
NP_001138516                                                           15    9605
NP_037404                                                              15    9605
>NP_000360
          Length = 764

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   MYLLLITSV 9
           MYLLLI SV
Sbjct: 465 MYLLLIASV 473
>XP_005268094
          Length = 764

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   MYLLLITSV 9
           MYLLLI SV
Sbjct: 465 MYLLLIASV 473
>NP_001263629
          Length = 891

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   MYLLLITSV 9
           +YLL ITSV
Sbjct: 418 VYLLFITSV 426
>NP_612202
          Length = 892

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   MYLLLITSV 9
           +YLL ITSV
Sbjct: 418 VYLLFITSV 426
>NP_000224
          Length = 699

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   MYLLLITSV 9
           +YLLLI SV
Sbjct: 410 LYLLLIASV 418
>XP_005264366
          Length = 380

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  MYLLLITSV 9
          +YLLLI SV
Sbjct: 91 LYLLLIASV 99
>XP_006712078
          Length = 389

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   MYLLLITSV 9
           +YLLLI SV
Sbjct: 100 LYLLLIASV 108
>NP_852111
          Length = 669

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   MYLLLITSV 9
           +YLLLI SV
Sbjct: 387 IYLLLIASV 395
>NP_000136
          Length = 695

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   MYLLLITSV 9
           +YLLLI SV
Sbjct: 413 IYLLLIASV 421
>NP_775922
          Length = 6996

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    MYLLLITSV 9
            MYL+++TS+
Sbjct: 2639 MYLVVVTSL 2647
>NP_001005213
          Length = 305

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YLLLITSV 9
           YL +ITSV
Sbjct: 217 YLFIITSV 224
>NP_001013376
          Length = 305

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YLLLITSV 9
           YL +ITSV
Sbjct: 217 YLFIITSV 224
>NP_065394
          Length = 580

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YLLLITS 8
           Y+LL+TS
Sbjct: 355 YILLVTS 361
>NP_076411
          Length = 317

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MYLLLITSV 9
           + LLL+TSV
Sbjct: 131 LVLLLVTSV 139
>NP_001004479
          Length = 324

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   YLLLITSV 9
           Y+LL+T+V
Sbjct: 228 YILLLTAV 235
>NP_000733
          Length = 529

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MYLLLITSV 9
           ++LLLIT +
Sbjct: 309 VFLLLITEI 317
>NP_060606
          Length = 3477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    MYLLLITSV 9
            MY+ ++TSV
Sbjct: 1651 MYIHILTSV 1659
>NP_001243502
          Length = 451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MYLLLITSV 9
           ++LLLIT +
Sbjct: 111 VFLLLITEI 119
>NP_000735
          Length = 627

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MYLLLITSV 9
           ++LLLIT +
Sbjct: 287 VFLLLITEI 295
>NP_005497
          Length = 478

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  LLLITSV 9
          LLL+TSV
Sbjct: 15 LLLVTSV 21
>NP_001269384
          Length = 514

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MYLLLITSV 9
           ++LLLIT +
Sbjct: 294 VFLLLITEI 302
>NP_001191184
          Length = 335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  LLLITSV 9
          LLL+TSV
Sbjct: 15 LLLVTSV 21
>NP_002502
          Length = 390

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  MYLLLIT 7
          +YLL+IT
Sbjct: 49 LYLLIIT 55
>NP_001245213
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   MYLLLIT 7
           MY+L+IT
Sbjct: 139 MYVLMIT 145
>XP_005260248
          Length = 451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MYLLLITSV 9
           ++LLLIT +
Sbjct: 111 VFLLLITEI 119
>XP_006720535
          Length = 594

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   MYLLLI 6
           MYLLLI
Sbjct: 176 MYLLLI 181
>XP_005254948
          Length = 595

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  MYLLLI 6
          MYLLLI
Sbjct: 61 MYLLLI 66
>XP_005254946
          Length = 697

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   MYLLLI 6
           MYLLLI
Sbjct: 176 MYLLLI 181
>XP_005273454
          Length = 370

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MYLLLITSV 9
           ++LLLIT +
Sbjct: 150 VFLLLITEI 158
>XP_006716346
          Length = 426

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MYLLLITSV 9
           ++LLLIT +
Sbjct: 206 VFLLLITEI 214
>XP_006716345
          Length = 529

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MYLLLITSV 9
           ++LLLIT +
Sbjct: 309 VFLLLITEI 317
>NP_001138516
          Length = 692

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   MYLLLI 6
           MYLLLI
Sbjct: 176 MYLLLI 181
>NP_037404
          Length = 710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   MYLLLI 6
           MYLLLI
Sbjct: 176 MYLLLI 181
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.341    0.150    0.380 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 343,431
Number of extensions: 520
Number of successful extensions: 33
Number of sequences better than 10000.0: 33
Number of HSP's gapped: 33
Number of HSP's successfully gapped: 33
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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