Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              18    1482
XP_006718908                                                           18    1482
XP_005271621                                                           18    1482
XP_006718907                                                           18    1482
XP_006718906                                                           18    1482
XP_005271619                                                           18    1482
XP_005271618                                                           18    1482
XP_005261914                                                           17    4312
NP_004277                                                              17    4312
NP_004777                                                              16    5631
XP_006722644                                                           16    5631
XP_006722643                                                           16    5631
XP_006712658                                                           16    5631
NP_001185871                                                           16    7355
NP_001185873                                                           16    7355
NP_065944                                                              16    7355
NP_036450                                                              16    7355
NP_076994                                                              16    7355
XP_006722475                                                           16    7355
XP_005258281                                                           16    7355
XP_006722474                                                           16    7355
XP_005258278                                                           16    7355
XP_005258275                                                           16    7355
XP_005258274                                                           16    7355
XP_006722468                                                           16    7355
XP_005258273                                                           16    7355
XP_006722467                                                           16    7355
XP_006722466                                                           16    7355
XP_006722465                                                           16    7355
XP_006722464                                                           16    7355
XP_006722462                                                           16    7355
XP_005258264                                                           16    7355
XP_006722461                                                           16    7355
XP_006722460                                                           16    7355
XP_006722459                                                           16    7355
XP_006722458                                                           16    7355
XP_005254133                                                           16    7355
XP_005254132                                                           16    7355
XP_005254131                                                           16    7355
XP_006713947                                                           16    7355
NP_002887                                                              15    9605
NP_001185773                                                           15    9605
NP_001185772                                                           15    9605
NP_005899                                                              15    9605
NP_001273145                                                           15    9605
NP_005688                                                              15    9605
NP_113680                                                              15    9605
NP_061969                                                              15    9605
NP_001273064                                                           15    9605
XP_006720432                                                           15    9605
XP_006715187                                                           15    9605
NP_803875                                                              15    9605
>NP_000042
          Length = 3056

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    MVKLFVNLL 9
            MVKL VNLL
Sbjct: 1644 MVKLVVNLL 1652
>XP_006718908
          Length = 1708

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   MVKLFVNLL 9
           MVKL VNLL
Sbjct: 296 MVKLVVNLL 304
>XP_005271621
          Length = 2708

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    MVKLFVNLL 9
            MVKL VNLL
Sbjct: 1296 MVKLVVNLL 1304
>XP_006718907
          Length = 3050

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    MVKLFVNLL 9
            MVKL VNLL
Sbjct: 1638 MVKLVVNLL 1646
>XP_006718906
          Length = 3056

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    MVKLFVNLL 9
            MVKL VNLL
Sbjct: 1644 MVKLVVNLL 1652
>XP_005271619
          Length = 3056

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    MVKLFVNLL 9
            MVKL VNLL
Sbjct: 1644 MVKLVVNLL 1652
>XP_005271618
          Length = 3056

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    MVKLFVNLL 9
            MVKL VNLL
Sbjct: 1644 MVKLVVNLL 1652
>XP_005261914
          Length = 557

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   MVKLFVNLL 9
           ++K+F+NLL
Sbjct: 263 LLKMFLNLL 271
>NP_004277
          Length = 669

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   MVKLFVNLL 9
           ++K+F+NLL
Sbjct: 375 LLKMFLNLL 383
>NP_004777
          Length = 289

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VKLFVNL 8
           VK+F+NL
Sbjct: 194 VKIFINL 200
>XP_006722644
          Length = 255

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VKLFVNL 8
           VK+F+NL
Sbjct: 194 VKIFINL 200
>XP_006722643
          Length = 292

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VKLFVNL 8
           VK+F+NL
Sbjct: 194 VKIFINL 200
>XP_006712658
          Length = 244

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1 MVKLFVNLL 9
         M+KLF+ LL
Sbjct: 1 MLKLFMTLL 9
>NP_001185871
          Length = 452

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  MVKLFVNLL 9
          ++KL+VN L
Sbjct: 61 LIKLYVNQL 69
>NP_001185873
          Length = 395

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  MVKLFVNLL 9
          ++KL+VN L
Sbjct: 61 LIKLYVNQL 69
>NP_065944
          Length = 1701

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MVKLFVNLL 9
           + +LFVNL+
Sbjct: 322 LAQLFVNLM 330
>NP_036450
          Length = 739

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VKLFVNLL 9
           VKLF N+L
Sbjct: 229 VKLFPNML 236
>NP_076994
          Length = 502

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VKLFVNL 8
           V+LFVNL
Sbjct: 230 VELFVNL 236
>XP_006722475
          Length = 443

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  MVKLFVNLL 9
          ++KL+VN L
Sbjct: 61 LIKLYVNQL 69
>XP_005258281
          Length = 500

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  MVKLFVNLL 9
          ++KL+VN L
Sbjct: 61 LIKLYVNQL 69
>XP_006722474
          Length = 503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  MVKLFVNLL 9
          ++KL+VN L
Sbjct: 64 LIKLYVNQL 72
>XP_005258278
          Length = 713

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MVKLFVNLL 9
           ++KL+VN L
Sbjct: 379 LIKLYVNQL 387
>XP_005258275
          Length = 760

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MVKLFVNLL 9
           ++KL+VN L
Sbjct: 379 LIKLYVNQL 387
>XP_005258274
          Length = 761

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MVKLFVNLL 9
           ++KL+VN L
Sbjct: 379 LIKLYVNQL 387
>XP_006722468
          Length = 764

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MVKLFVNLL 9
           ++KL+VN L
Sbjct: 382 LIKLYVNQL 390
>XP_005258273
          Length = 770

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MVKLFVNLL 9
           ++KL+VN L
Sbjct: 379 LIKLYVNQL 387
>XP_006722467
          Length = 773

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MVKLFVNLL 9
           ++KL+VN L
Sbjct: 382 LIKLYVNQL 390
>XP_006722466
          Length = 780

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MVKLFVNLL 9
           ++KL+VN L
Sbjct: 382 LIKLYVNQL 390
>XP_006722465
          Length = 780

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MVKLFVNLL 9
           ++KL+VN L
Sbjct: 382 LIKLYVNQL 390
>XP_006722464
          Length = 790

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MVKLFVNLL 9
           ++KL+VN L
Sbjct: 382 LIKLYVNQL 390
>XP_006722462
          Length = 814

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MVKLFVNLL 9
           ++KL+VN L
Sbjct: 382 LIKLYVNQL 390
>XP_005258264
          Length = 818

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MVKLFVNLL 9
           ++KL+VN L
Sbjct: 379 LIKLYVNQL 387
>XP_006722461
          Length = 821

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MVKLFVNLL 9
           ++KL+VN L
Sbjct: 382 LIKLYVNQL 390
>XP_006722460
          Length = 821

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MVKLFVNLL 9
           ++KL+VN L
Sbjct: 382 LIKLYVNQL 390
>XP_006722459
          Length = 821

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MVKLFVNLL 9
           ++KL+VN L
Sbjct: 382 LIKLYVNQL 390
>XP_006722458
          Length = 821

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MVKLFVNLL 9
           ++KL+VN L
Sbjct: 382 LIKLYVNQL 390
>XP_005254133
          Length = 283

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  VKLFVNL 8
          V+LFVNL
Sbjct: 11 VELFVNL 17
>XP_005254132
          Length = 466

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VKLFVNL 8
           V+LFVNL
Sbjct: 230 VELFVNL 236
>XP_005254131
          Length = 476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VKLFVNL 8
           V+LFVNL
Sbjct: 204 VELFVNL 210
>XP_006713947
          Length = 738

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VKLFVNLL 9
           VKLF N+L
Sbjct: 229 VKLFPNML 236
>NP_002887
          Length = 364

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1 MVKLFVNLL 9
         MVKLF+  L
Sbjct: 1 MVKLFIGNL 9
>NP_001185773
          Length = 173

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1 MVKLFVNLL 9
         MVKLF+  L
Sbjct: 1 MVKLFIGNL 9
>NP_001185772
          Length = 143

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1 MVKLFVNLL 9
         MVKLF+  L
Sbjct: 1 MVKLFIGNL 9
>NP_005899
          Length = 879

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   MVKLFVNL 8
           +V+LFVN+
Sbjct: 274 IVELFVNI 281
>NP_001273145
          Length = 514

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   MVKLFVNLL 9
           ++K+F+N+L
Sbjct: 296 LLKVFLNIL 304
>NP_005688
          Length = 329

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VKLFVNLL 9
           V LF+NLL
Sbjct: 161 VTLFLNLL 168
>NP_113680
          Length = 359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1 MVKLFVNLL 9
         MVKLF+  L
Sbjct: 1 MVKLFIGNL 9
>NP_061969
          Length = 602

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   MVKLFVNLL 9
           ++K+F+N+L
Sbjct: 384 LLKVFLNIL 392
>NP_001273064
          Length = 143

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1 MVKLFVNLL 9
         MVKLF+  L
Sbjct: 1 MVKLFIGNL 9
>XP_006720432
          Length = 372

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VKLFVNLL 9
           V LF+NLL
Sbjct: 204 VTLFLNLL 211
>XP_006715187
          Length = 554

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   MVKLFVNLL 9
           ++K+F+N+L
Sbjct: 336 LLKVFLNIL 344
>NP_803875
          Length = 4243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VKLFVNLL 9
            VK+FVN +
Sbjct: 1894 VKIFVNTI 1901
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.348    0.158    0.417 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 342,387
Number of extensions: 503
Number of successful extensions: 52
Number of sequences better than 10000.0: 52
Number of HSP's gapped: 52
Number of HSP's successfully gapped: 52
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.7 bits)
S2: 28 (15.4 bits)

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