Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              19     665
NP_671714                                                              19     665
XP_006715890                                                           19     665
XP_005250160                                                           19     665
XP_005250159                                                           19     665
NP_694546                                                              17    4312
NP_006494                                                              17    4312
NP_001028774                                                           17    4312
NP_817123                                                              17    4312
NP_001127925                                                           17    4312
NP_000706                                                              16    5631
XP_005273308                                                           16    5631
XP_005273309                                                           16    5631
NP_001268669                                                           16    7355
NP_001257449                                                           16    7355
NP_055807                                                              16    7355
NP_079411                                                              16    7355
NP_001268668                                                           16    7355
NP_056996                                                              16    7355
XP_006722614                                                           16    7355
XP_005258412                                                           16    7355
XP_005258411                                                           16    7355
XP_005258409                                                           16    7355
XP_005258408                                                           16    7355
XP_005258407                                                           16    7355
XP_005258406                                                           16    7355
XP_005258405                                                           16    7355
XP_005258404                                                           16    7355
XP_005258403                                                           16    7355
XP_005267488                                                           16    7355
XP_005267487                                                           16    7355
XP_005250985                                                           16    7355
XP_006716634                                                           16    7355
NP_061735                                                              16    7355
NP_114382                                                              16    7355
NP_078858                                                              15    9605
NP_001278232                                                           15    9605
NP_001278214                                                           15    9605
NP_001177779                                                           15    9605
NP_001177776                                                           15    9605
NP_037448                                                              15    9605
NP_001177778                                                           15    9605
NP_057300                                                              15    9605
NP_066976                                                              15    9605
NP_001257957                                                           15    9605
NP_001136197                                                           15    9605
XP_006722504                                                           15    9605
XP_006722503                                                           15    9605
>NP_005742
          Length = 3907

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    MSSTLDRE 8
            MSSTLDRE
Sbjct: 3312 MSSTLDRE 3319
>NP_671714
          Length = 3899

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    MSSTLDRE 8
            MSSTLDRE
Sbjct: 3304 MSSTLDRE 3311
>XP_006715890
          Length = 3860

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    MSSTLDRE 8
            MSSTLDRE
Sbjct: 3265 MSSTLDRE 3272
>XP_005250160
          Length = 3939

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    MSSTLDRE 8
            MSSTLDRE
Sbjct: 3344 MSSTLDRE 3351
>XP_005250159
          Length = 3952

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    MSSTLDRE 8
            MSSTLDRE
Sbjct: 3357 MSSTLDRE 3364
>NP_694546
          Length = 387

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  STLDREL 9
          ST+DREL
Sbjct: 86 STIDREL 92
>NP_006494
          Length = 418

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   STLDREL 9
           ST+DREL
Sbjct: 117 STIDREL 123
>NP_001028774
          Length = 1379

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MSSTLDREL 9
           +SST+ REL
Sbjct: 110 LSSTIQREL 118
>NP_817123
          Length = 1040

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   MSSTLDRE 8
           MSS LDRE
Sbjct: 221 MSSFLDRE 228
>NP_001127925
          Length = 1059

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   MSSTLDRE 8
           MSS LDRE
Sbjct: 221 MSSFLDRE 228
>NP_000706
          Length = 597

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   STLDREL 9
           STLD+EL
Sbjct: 591 STLDKEL 597
>XP_005273308
          Length = 597

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   STLDREL 9
           STLD+EL
Sbjct: 591 STLDKEL 597
>XP_005273309
          Length = 597

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   STLDREL 9
           STLD+EL
Sbjct: 591 STLDKEL 597
>NP_001268669
          Length = 1622

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SSTLDRE 8
           SSTL+RE
Sbjct: 826 SSTLERE 832
>NP_001257449
          Length = 1068

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SSTLDREL 9
           +STLDR L
Sbjct: 325 NSTLDRHL 332
>NP_055807
          Length = 1078

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SSTLDREL 9
           +STLDR L
Sbjct: 325 NSTLDRHL 332
>NP_079411
          Length = 1439

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SSTLDRE 8
           SSTL+RE
Sbjct: 651 SSTLERE 657
>NP_001268668
          Length = 1422

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SSTLDRE 8
           SSTL+RE
Sbjct: 634 SSTLERE 640
>NP_056996
          Length = 1406

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    SSTLDREL 9
            SSTLD E+
Sbjct: 1081 SSTLDEEV 1088
>XP_006722614
          Length = 1589

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SSTLDRE 8
           SSTL+RE
Sbjct: 801 SSTLERE 807
>XP_005258412
          Length = 1401

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SSTLDRE 8
           SSTL+RE
Sbjct: 613 SSTLERE 619
>XP_005258411
          Length = 1409

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SSTLDRE 8
           SSTL+RE
Sbjct: 613 SSTLERE 619
>XP_005258409
          Length = 1430

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SSTLDRE 8
           SSTL+RE
Sbjct: 634 SSTLERE 640
>XP_005258408
          Length = 1447

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SSTLDRE 8
           SSTL+RE
Sbjct: 651 SSTLERE 657
>XP_005258407
          Length = 1533

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SSTLDRE 8
           SSTL+RE
Sbjct: 826 SSTLERE 832
>XP_005258406
          Length = 1559

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SSTLDRE 8
           SSTL+RE
Sbjct: 763 SSTLERE 769
>XP_005258405
          Length = 1597

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SSTLDRE 8
           SSTL+RE
Sbjct: 801 SSTLERE 807
>XP_005258404
          Length = 1605

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SSTLDRE 8
           SSTL+RE
Sbjct: 809 SSTLERE 815
>XP_005258403
          Length = 1614

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SSTLDRE 8
           SSTL+RE
Sbjct: 826 SSTLERE 832
>XP_005267488
          Length = 1078

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SSTLDREL 9
           +STLDR L
Sbjct: 325 NSTLDRHL 332
>XP_005267487
          Length = 1078

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SSTLDREL 9
           +STLDR L
Sbjct: 325 NSTLDRHL 332
>XP_005250985
          Length = 1406

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    SSTLDREL 9
            SSTLD E+
Sbjct: 1081 SSTLDEEV 1088
>XP_006716634
          Length = 1420

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    SSTLDREL 9
            SSTLD E+
Sbjct: 1095 SSTLDEEV 1102
>NP_061735
          Length = 931

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TLDREL 9
           TLDREL
Sbjct: 409 TLDREL 414
>NP_114382
          Length = 823

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TLDREL 9
           TLDREL
Sbjct: 409 TLDREL 414
>NP_078858
          Length = 4981

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  SSTLDRE 8
          +ST+DRE
Sbjct: 93 TSTIDRE 99
>NP_001278232
          Length = 4983

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  SSTLDRE 8
          +ST+DRE
Sbjct: 93 TSTIDRE 99
>NP_001278214
          Length = 4982

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  SSTLDRE 8
          +ST+DRE
Sbjct: 93 TSTIDRE 99
>NP_001177779
          Length = 713

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SSTLDR 7
           SSTLDR
Sbjct: 707 SSTLDR 712
>NP_001177776
          Length = 642

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SSTLDR 7
           SSTLDR
Sbjct: 636 SSTLDR 641
>NP_037448
          Length = 639

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SSTLDR 7
           SSTLDR
Sbjct: 633 SSTLDR 638
>NP_001177778
          Length = 710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SSTLDR 7
           SSTLDR
Sbjct: 704 SSTLDR 709
>NP_057300
          Length = 544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MSSTLDRE 8
           + ST+DRE
Sbjct: 483 VDSTIDRE 490
>NP_066976
          Length = 772

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SSTLDREL 9
           S++LDRE+
Sbjct: 425 SNSLDREI 432
>NP_001257957
          Length = 490

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SSTLDREL 9
           S++LDRE+
Sbjct: 425 SNSLDREI 432
>NP_001136197
          Length = 691

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   MSSTLD 6
           MSSTLD
Sbjct: 395 MSSTLD 400
>XP_006722504
          Length = 613

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SSTLDREL 9
           S++LDRE+
Sbjct: 425 SNSLDREI 432
>XP_006722503
          Length = 772

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SSTLDREL 9
           S++LDRE+
Sbjct: 425 SNSLDREI 432
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.309    0.120    0.283 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 433,336
Number of extensions: 376
Number of successful extensions: 48
Number of sequences better than 10000.0: 48
Number of HSP's gapped: 48
Number of HSP's successfully gapped: 48
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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