Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              20     509
XP_005262424                                                           20     509
NP_000480                                                              16    5631
NP_612114                                                              16    5631
NP_937801                                                              16    5631
NP_001026850                                                           16    5631
NP_004341                                                              16    5631
NP_078966                                                              16    5631
NP_001013725                                                           16    5631
NP_060726                                                              16    5631
NP_001138624                                                           16    5631
NP_937821                                                              16    5631
NP_689628                                                              16    5631
NP_937802                                                              16    5631
NP_000239                                                              16    5631
NP_006713                                                              16    5631
NP_056386                                                              16    5631
NP_001010854                                                           16    5631
XP_006724730                                                           16    5631
XP_005262214                                                           16    5631
XP_005262213                                                           16    5631
XP_006724729                                                           16    5631
XP_005262212                                                           16    5631
XP_005262211                                                           16    5631
XP_005262210                                                           16    5631
XP_005254450                                                           16    5631
XP_005254449                                                           16    5631
XP_005267424                                                           16    5631
XP_006720122                                                           16    5631
XP_006720121                                                           16    5631
XP_005273458                                                           16    5631
XP_005273457                                                           16    5631
XP_006716349                                                           16    5631
XP_006716177                                                           16    5631
XP_006715520                                                           16    5631
XP_006713227                                                           16    5631
XP_005264812                                                           16    5631
XP_005264811                                                           16    5631
XP_005246081                                                           16    5631
NP_001093879                                                           16    5631
NP_001171896                                                           16    5631
NP_937820                                                              16    5631
NP_620063                                                              16    7355
NP_079079                                                              16    7355
NP_001165335                                                           16    7355
NP_000183                                                              15    9605
NP_001136233                                                           15    9605
NP_852259                                                              15    9605
NP_542448                                                              15    9605
NP_001092805                                                           15    9605
NP_055574                                                              15    9605
NP_150628                                                              15    9605
XP_005254813                                                           15    9605
XP_006716479                                                           15    9605
NP_543146                                                              15    9605
>NP_722576
          Length = 3080

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    MSLSTTDHT 9
            MS STTDHT
Sbjct: 2131 MSPSTTDHT 2139
>XP_005262424
          Length = 2875

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    MSLSTTDHT 9
            MS STTDHT
Sbjct: 1926 MSPSTTDHT 1934
>NP_000480
          Length = 2492

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    MSLSTTDHT 9
            MSLS+ D+T
Sbjct: 1920 MSLSSDDYT 1928
>NP_612114
          Length = 2454

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    MSLSTTDHT 9
            MSLS+ D+T
Sbjct: 1882 MSLSSDDYT 1890
>NP_937801
          Length = 413

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   MSLSTTDHT 9
           MS+  T+HT
Sbjct: 404 MSMEETEHT 412
>NP_001026850
          Length = 429

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SLSTTDH 8
           SLSTT H
Sbjct: 232 SLSTTSH 238
>NP_004341
          Length = 415

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SLSTTDH 8
           SLSTT H
Sbjct: 218 SLSTTSH 224
>NP_078966
          Length = 14507

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    SLSTTDH 8
            SLSTT H
Sbjct: 7745 SLSTTSH 7751
>NP_001013725
          Length = 1649

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   SLSTTDHT 9
           SLS  DHT
Sbjct: 205 SLSNQDHT 212
>NP_060726
          Length = 423

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   MSLSTTDHT 9
           +SLS T HT
Sbjct: 334 VSLSLTSHT 342
>NP_001138624
          Length = 372

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   MSLSTTDHT 9
           +S STT HT
Sbjct: 154 VSSSTTSHT 162
>NP_937821
          Length = 357

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   MSLSTTDHT 9
           MS+  T+HT
Sbjct: 348 MSMEETEHT 356
>NP_689628
          Length = 397

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   MSLSTTDHT 9
           +S STT HT
Sbjct: 179 VSSSTTSHT 187
>NP_937802
          Length = 520

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   MSLSTTDHT 9
           MS+  T+HT
Sbjct: 511 MSMEETEHT 519
>NP_000239
          Length = 419

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   MSLSTTDHT 9
           MS+  T+HT
Sbjct: 410 MSMEETEHT 418
>NP_006713
          Length = 519

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   MSLSTTDHT 9
           MS+  T+HT
Sbjct: 510 MSMEETEHT 518
>NP_056386
          Length = 1112

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SLSTTDHT 9
           SLS+T HT
Sbjct: 898 SLSSTHHT 905
>NP_001010854
          Length = 843

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SLSTTDH 8
           SLS TDH
Sbjct: 509 SLSPTDH 515
>XP_006724730
          Length = 2399

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    MSLSTTDHT 9
            MSLS+ D+T
Sbjct: 1827 MSLSSDDYT 1835
>XP_005262214
          Length = 2424

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    MSLSTTDHT 9
            MSLS+ D+T
Sbjct: 1852 MSLSSDDYT 1860
>XP_005262213
          Length = 2437

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    MSLSTTDHT 9
            MSLS+ D+T
Sbjct: 1865 MSLSSDDYT 1873
>XP_006724729
          Length = 2453

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    MSLSTTDHT 9
            MSLS+ D+T
Sbjct: 1881 MSLSSDDYT 1889
>XP_005262212
          Length = 2453

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    MSLSTTDHT 9
            MSLS+ D+T
Sbjct: 1881 MSLSSDDYT 1889
>XP_005262211
          Length = 2463

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    MSLSTTDHT 9
            MSLS+ D+T
Sbjct: 1891 MSLSSDDYT 1899
>XP_005262210
          Length = 2491

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    MSLSTTDHT 9
            MSLS+ D+T
Sbjct: 1919 MSLSSDDYT 1927
>XP_005254450
          Length = 1505

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   SLSTTDHT 9
           SLS  DHT
Sbjct: 205 SLSNQDHT 212
>XP_005254449
          Length = 1626

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   SLSTTDHT 9
           SLS  DHT
Sbjct: 205 SLSNQDHT 212
>XP_005267424
          Length = 656

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SLSTTDH 8
           SLS TDH
Sbjct: 251 SLSPTDH 257
>XP_006720122
          Length = 820

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SLSTTDH 8
           SLS TDH
Sbjct: 415 SLSPTDH 421
>XP_006720121
          Length = 851

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SLSTTDH 8
           SLS TDH
Sbjct: 517 SLSPTDH 523
>XP_005273458
          Length = 307

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  MSLSTTDHT 9
          +S STT HT
Sbjct: 89 VSSSTTSHT 97
>XP_005273457
          Length = 307

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  MSLSTTDHT 9
          +S STT HT
Sbjct: 89 VSSSTTSHT 97
>XP_006716349
          Length = 391

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   MSLSTTDHT 9
           +S STT HT
Sbjct: 179 VSSSTTSHT 187
>XP_006716177
          Length = 386

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SLSTTDHT 9
           S STT+HT
Sbjct: 222 SPSTTEHT 229
>XP_006715520
          Length = 1056

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SLSTTDHT 9
           SLS+T HT
Sbjct: 842 SLSSTHHT 849
>XP_006713227
          Length = 474

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   MSLSTTDHT 9
           MS+  T+HT
Sbjct: 465 MSMEETEHT 473
>XP_005264812
          Length = 510

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   MSLSTTDHT 9
           MS+  T+HT
Sbjct: 501 MSMEETEHT 509
>XP_005264811
          Length = 526

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   MSLSTTDHT 9
           MS+  T+HT
Sbjct: 517 MSMEETEHT 525
>XP_005246081
          Length = 429

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SLSTTDH 8
           SLSTT H
Sbjct: 232 SLSTTSH 238
>NP_001093879
          Length = 1105

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SLSTTDHT 9
           SLS+T HT
Sbjct: 891 SLSSTHHT 898
>NP_001171896
          Length = 468

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   MSLSTTDHT 9
           MS+  T+HT
Sbjct: 459 MSMEETEHT 467
>NP_937820
          Length = 504

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   MSLSTTDHT 9
           MS+  T+HT
Sbjct: 495 MSMEETEHT 503
>NP_620063
          Length = 666

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  SLSTTDH 8
          SLSTT H
Sbjct: 56 SLSTTHH 62
>NP_079079
          Length = 446

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   STTDHT 9
           STT+HT
Sbjct: 200 STTEHT 205
>NP_001165335
          Length = 406

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   STTDHT 9
           STT+HT
Sbjct: 160 STTEHT 165
>NP_000183
          Length = 518

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   STTDH 8
           STTDH
Sbjct: 332 STTDH 336
>NP_001136233
          Length = 286

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   STTDH 8
           STTDH
Sbjct: 241 STTDH 245
>NP_852259
          Length = 518

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   STTDH 8
           STTDH
Sbjct: 332 STTDH 336
>NP_542448
          Length = 468

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   STTDH 8
           STTDH
Sbjct: 282 STTDH 286
>NP_001092805
          Length = 330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   MSLSTTD 7
           MSLST D
Sbjct: 308 MSLSTAD 314
>NP_055574
          Length = 330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   MSLSTTD 7
           MSLST D
Sbjct: 308 MSLSTAD 314
>NP_150628
          Length = 316

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   STTDH 8
           STTDH
Sbjct: 241 STTDH 245
>XP_005254813
          Length = 169

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4  STTDH 8
          STTDH
Sbjct: 94 STTDH 98
>XP_006716479
          Length = 330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   MSLSTTD 7
           MSLST D
Sbjct: 308 MSLSTAD 314
>NP_543146
          Length = 1393

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  LSTTDH 8
          LST+DH
Sbjct: 41 LSTSDH 46
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.303    0.105    0.277 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 439,782
Number of extensions: 447
Number of successful extensions: 55
Number of sequences better than 10000.0: 55
Number of HSP's gapped: 55
Number of HSP's successfully gapped: 55
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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