Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001035351                                                           18    1935
NP_001035350                                                           18    1935
NP_006715                                                              18    1935
NP_005913                                                              18    1935
XP_005267046                                                           18    1935
XP_005267045                                                           18    1935
XP_005262843                                                           18    1935
XP_005262842                                                           18    1935
NP_001181966                                                           17    2528
NP_001071174                                                           17    2528
XP_006715535                                                           17    2528
NP_001240317                                                           17    4312
NP_001240316                                                           17    4312
NP_006605                                                              17    4312
XP_006713004                                                           17    4312
XP_006713003                                                           17    4312
XP_006713002                                                           17    4312
XP_006713001                                                           17    4312
NP_001274511                                                           16    5631
NP_001274512                                                           16    5631
NP_001781                                                              16    5631
NP_002937                                                              16    5631
XP_006714803                                                           16    5631
XP_006714802                                                           16    5631
XP_005272203                                                           16    5631
XP_005272202                                                           16    5631
XP_005246719                                                           16    5631
XP_005246718                                                           16    5631
XP_005246022                                                           16    5631
NP_060556                                                              16    5631
NP_004516                                                              16    7355
NP_006763                                                              16    7355
NP_892121                                                              16    7355
NP_056311                                                              16    7355
XP_006712591                                                           16    7355
XP_006712590                                                           16    7355
XP_006712589                                                           16    7355
NP_002323                                                              15    9605
NP_000607                                                              15    9605
NP_001257545                                                           15    9605
NP_002754                                                              15    9605
NP_061834                                                              15    9605
NP_001001895                                                           15    9605
XP_006724076                                                           15    9605
XP_006711518                                                           15    9605
XP_005273252                                                           15    9605
XP_005273253                                                           15    9605
XP_005273251                                                           15    9605
>NP_001035351
          Length = 783

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RCTASQLL 9
           RCTA Q+L
Sbjct: 656 RCTAGQIL 663
>NP_001035350
          Length = 766

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RCTASQLL 9
           RCTA Q+L
Sbjct: 639 RCTAGQIL 646
>NP_006715
          Length = 1558

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    MRCTASQLL 9
            MR TASQLL
Sbjct: 1538 MRWTASQLL 1546
>NP_005913
          Length = 1608

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    MRCTASQLL 9
            MR TASQLL
Sbjct: 1588 MRWTASQLL 1596
>XP_005267046
          Length = 1554

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    MRCTASQLL 9
            MR TASQLL
Sbjct: 1534 MRWTASQLL 1542
>XP_005267045
          Length = 1604

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    MRCTASQLL 9
            MR TASQLL
Sbjct: 1584 MRWTASQLL 1592
>XP_005262843
          Length = 765

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RCTASQLL 9
           RCTA Q+L
Sbjct: 638 RCTAGQIL 645
>XP_005262842
          Length = 782

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RCTASQLL 9
           RCTA Q+L
Sbjct: 655 RCTAGQIL 662
>NP_001181966
          Length = 904

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  MRCTASQL 8
          +RCT SQL
Sbjct: 52 LRCTKSQL 59
>NP_001071174
          Length = 904

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  MRCTASQL 8
          +RCT SQL
Sbjct: 52 LRCTKSQL 59
>XP_006715535
          Length = 946

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  MRCTASQL 8
          +RCT SQL
Sbjct: 52 LRCTKSQL 59
>NP_001240317
          Length = 1171

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RCTASQLL 9
           RCTAS  L
Sbjct: 325 RCTASNFL 332
>NP_001240316
          Length = 1208

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RCTASQLL 9
           RCTAS  L
Sbjct: 309 RCTASNFL 316
>NP_006605
          Length = 1224

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RCTASQLL 9
           RCTAS  L
Sbjct: 325 RCTASNFL 332
>XP_006713004
          Length = 1171

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RCTASQLL 9
           RCTAS  L
Sbjct: 325 RCTASNFL 332
>XP_006713003
          Length = 1224

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RCTASQLL 9
           RCTAS  L
Sbjct: 325 RCTASNFL 332
>XP_006713002
          Length = 1224

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RCTASQLL 9
           RCTAS  L
Sbjct: 325 RCTASNFL 332
>XP_006713001
          Length = 1224

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RCTASQLL 9
           RCTAS  L
Sbjct: 325 RCTASNFL 332
>NP_001274511
          Length = 473

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MRCTASQLL 9
           M+C+ +QLL
Sbjct: 119 MKCSPAQLL 127
>NP_001274512
          Length = 551

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MRCTASQLL 9
           M+C+ +QLL
Sbjct: 197 MKCSPAQLL 205
>NP_001781
          Length = 473

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MRCTASQLL 9
           M+C+ +QLL
Sbjct: 119 MKCSPAQLL 127
>NP_002937
          Length = 270

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  CTASQLL 9
          CT SQLL
Sbjct: 49 CTISQLL 55
>XP_006714803
          Length = 362

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  MRCTASQLL 9
          M+C+ +QLL
Sbjct: 8  MKCSPAQLL 16
>XP_006714802
          Length = 475

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MRCTASQLL 9
           M+C+ +QLL
Sbjct: 121 MKCSPAQLL 129
>XP_005272203
          Length = 490

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MRCTASQLL 9
           M+C+ +QLL
Sbjct: 136 MKCSPAQLL 144
>XP_005272202
          Length = 517

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MRCTASQLL 9
           M+C+ +QLL
Sbjct: 197 MKCSPAQLL 205
>XP_005246719
          Length = 748

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RCTASQL 8
           RC ASQL
Sbjct: 526 RCIASQL 532
>XP_005246718
          Length = 785

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RCTASQL 8
           RC ASQL
Sbjct: 563 RCIASQL 569
>XP_005246022
          Length = 278

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  CTASQLL 9
          CT SQLL
Sbjct: 57 CTISQLL 63
>NP_060556
          Length = 759

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RCTASQL 8
           RC ASQL
Sbjct: 537 RCIASQL 543
>NP_004516
          Length = 4655

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    MRCTASQ 7
            + CTASQ
Sbjct: 1185 LNCTASQ 1191
>NP_006763
          Length = 1343

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MRCTASQL 8
           ++CTAS L
Sbjct: 529 IKCTASSL 536
>NP_892121
          Length = 1147

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   RCTASQ 7
           RCTAS+
Sbjct: 780 RCTASE 785
>NP_056311
          Length = 1812

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   RCTASQ 7
           RCTAS+
Sbjct: 780 RCTASE 785
>XP_006712591
          Length = 3308

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    MRCTASQ 7
            + CTASQ
Sbjct: 1185 LNCTASQ 1191
>XP_006712590
          Length = 3897

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   MRCTASQ 7
           + CTASQ
Sbjct: 422 LNCTASQ 428
>XP_006712589
          Length = 4660

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    MRCTASQ 7
            + CTASQ
Sbjct: 1185 LNCTASQ 1191
>NP_002323
          Length = 4544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    CTASQLL 9
            CTASQ +
Sbjct: 3334 CTASQFV 3340
>NP_000607
          Length = 458

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  MRCTASQ 7
          + CTASQ
Sbjct: 39 LTCTASQ 45
>NP_001257545
          Length = 737

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   RCTASQLL 9
           RC  SQL+
Sbjct: 614 RCITSQLI 621
>NP_002754
          Length = 737

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   RCTASQLL 9
           RC  SQL+
Sbjct: 614 RCITSQLI 621
>NP_061834
          Length = 661

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RCTASQL 8
           RCTAS +
Sbjct: 564 RCTASMV 570
>NP_001001895
          Length = 623

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RCTASQL 8
           RCTAS +
Sbjct: 526 RCTASMV 532
>XP_006724076
          Length = 642

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RCTASQL 8
           RCTAS +
Sbjct: 545 RCTASMV 551
>XP_006711518
          Length = 680

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   RCTASQLL 9
           RC  SQL+
Sbjct: 614 RCITSQLI 621
>XP_005273252
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   RCTASQLL 9
           RC  SQL+
Sbjct: 614 RCITSQLI 621
>XP_005273253
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   RCTASQLL 9
           RC  SQL+
Sbjct: 614 RCITSQLI 621
>XP_005273251
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   RCTASQLL 9
           RC  SQL+
Sbjct: 614 RCITSQLI 621
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.336    0.127    0.382 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 462,589
Number of extensions: 316
Number of successful extensions: 48
Number of sequences better than 10000.0: 48
Number of HSP's gapped: 48
Number of HSP's successfully gapped: 48
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.6 bits)
S2: 28 (15.4 bits)

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