Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001245210                                                           18    1135
NP_000242                                                              18    1135
XP_005264389                                                           18    1135
NP_055325                                                              17    3301
NP_149015                                                              17    3301
XP_006715989                                                           17    3301
NP_001171718                                                           16    7355
NP_062565                                                              16    7355
NP_001171715                                                           16    7355
NP_001171720                                                           16    7355
NP_001171714                                                           16    7355
NP_001171717                                                           16    7355
NP_001171716                                                           16    7355
NP_001171719                                                           16    7355
NP_001161846                                                           16    7355
NP_001161849                                                           16    7355
NP_055624                                                              16    7355
NP_001258468                                                           16    7355
NP_001161847                                                           16    7355
XP_006723717                                                           16    7355
XP_006723715                                                           16    7355
XP_006723712                                                           16    7355
XP_006723711                                                           16    7355
XP_006723710                                                           16    7355
XP_006723709                                                           16    7355
XP_006717541                                                           16    7355
XP_006717538                                                           16    7355
XP_006717537                                                           16    7355
XP_005252589                                                           16    7355
XP_006717536                                                           16    7355
XP_006717535                                                           16    7355
XP_006717534                                                           16    7355
XP_005252588                                                           16    7355
XP_005252587                                                           16    7355
XP_005252585                                                           16    7355
XP_006715350                                                           16    7355
XP_006715349                                                           16    7355
XP_005249561                                                           16    7355
NP_036509                                                              16    7355
NP_001180211                                                           15    9605
NP_958357                                                              15    9605
NP_115562                                                              15    9605
NP_057704                                                              15    9605
XP_005259910                                                           15    9605
XP_006722786                                                           15    9605
XP_006713948                                                           15    9605
XP_006711011                                                           15    9605
XP_006711010                                                           15    9605
XP_005271318                                                           15    9605
XP_005271317                                                           15    9605
XP_005271314                                                           15    9605
NP_945182                                                              15    9605
>NP_001245210
          Length = 868

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   MLETTSILR 9
           MLET SILR
Sbjct: 663 MLETASILR 671
>NP_000242
          Length = 934

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   MLETTSILR 9
           MLET SILR
Sbjct: 729 MLETASILR 737
>XP_005264389
          Length = 921

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   MLETTSILR 9
           MLET SILR
Sbjct: 729 MLETASILR 737
>NP_055325
          Length = 4935

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    LETTSILR 9
            LETT++LR
Sbjct: 2462 LETTAVLR 2469
>NP_149015
          Length = 5142

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    LETTSILR 9
            LETT++LR
Sbjct: 2462 LETTAVLR 2469
>XP_006715989
          Length = 5148

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    LETTSILR 9
            LETT++LR
Sbjct: 2462 LETTAVLR 2469
>NP_001171718
          Length = 1273

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    MLETTSILR 9
            MLET  +LR
Sbjct: 1197 MLETQELLR 1205
>NP_062565
          Length = 1356

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    MLETTSILR 9
            MLET  +LR
Sbjct: 1280 MLETQELLR 1288
>NP_001171715
          Length = 1340

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    MLETTSILR 9
            MLET  +LR
Sbjct: 1264 MLETQELLR 1272
>NP_001171720
          Length = 1244

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    MLETTSILR 9
            MLET  +LR
Sbjct: 1168 MLETQELLR 1176
>NP_001171714
          Length = 1353

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    MLETTSILR 9
            MLET  +LR
Sbjct: 1277 MLETQELLR 1285
>NP_001171717
          Length = 1310

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    MLETTSILR 9
            MLET  +LR
Sbjct: 1234 MLETQELLR 1242
>NP_001171716
          Length = 1319

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    MLETTSILR 9
            MLET  +LR
Sbjct: 1243 MLETQELLR 1251
>NP_001171719
          Length = 1266

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    MLETTSILR 9
            MLET  +LR
Sbjct: 1190 MLETQELLR 1198
>NP_001161846
          Length = 1063

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  LETTSILR 9
          LETT I+R
Sbjct: 31 LETTRIMR 38
>NP_001161849
          Length = 1011

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  LETTSILR 9
          LETT I+R
Sbjct: 40 LETTRIMR 47
>NP_055624
          Length = 1072

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  LETTSILR 9
          LETT I+R
Sbjct: 40 LETTRIMR 47
>NP_001258468
          Length = 575

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LETTSILR 9
           LETT +LR
Sbjct: 523 LETTHLLR 530
>NP_001161847
          Length = 1072

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  LETTSILR 9
          LETT I+R
Sbjct: 40 LETTRIMR 47
>XP_006723717
          Length = 353

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LETTSILR 9
           LETT +LR
Sbjct: 300 LETTHLLR 307
>XP_006723715
          Length = 576

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LETTSILR 9
           LETT +LR
Sbjct: 523 LETTHLLR 530
>XP_006723712
          Length = 604

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LETTSILR 9
           LETT +LR
Sbjct: 551 LETTHLLR 558
>XP_006723711
          Length = 670

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LETTSILR 9
           LETT +LR
Sbjct: 617 LETTHLLR 624
>XP_006723710
          Length = 688

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LETTSILR 9
           LETT +LR
Sbjct: 636 LETTHLLR 643
>XP_006723709
          Length = 689

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LETTSILR 9
           LETT +LR
Sbjct: 636 LETTHLLR 643
>XP_006717541
          Length = 1295

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    MLETTSILR 9
            MLET  +LR
Sbjct: 1219 MLETQELLR 1227
>XP_006717538
          Length = 1235

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    MLETTSILR 9
            MLET  +LR
Sbjct: 1159 MLETQELLR 1167
>XP_006717537
          Length = 1296

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    MLETTSILR 9
            MLET  +LR
Sbjct: 1220 MLETQELLR 1228
>XP_005252589
          Length = 1309

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    MLETTSILR 9
            MLET  +LR
Sbjct: 1233 MLETQELLR 1241
>XP_006717536
          Length = 1314

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    MLETTSILR 9
            MLET  +LR
Sbjct: 1238 MLETQELLR 1246
>XP_006717535
          Length = 1316

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    MLETTSILR 9
            MLET  +LR
Sbjct: 1240 MLETQELLR 1248
>XP_006717534
          Length = 1321

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    MLETTSILR 9
            MLET  +LR
Sbjct: 1245 MLETQELLR 1253
>XP_005252588
          Length = 1323

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    MLETTSILR 9
            MLET  +LR
Sbjct: 1247 MLETQELLR 1255
>XP_005252587
          Length = 1338

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    MLETTSILR 9
            MLET  +LR
Sbjct: 1262 MLETQELLR 1270
>XP_005252585
          Length = 1352

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    MLETTSILR 9
            MLET  +LR
Sbjct: 1276 MLETQELLR 1284
>XP_006715350
          Length = 1040

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LETTSILR 9
           LETT I+R
Sbjct: 102 LETTRIMR 109
>XP_006715349
          Length = 1101

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LETTSILR 9
           LETT I+R
Sbjct: 102 LETTRIMR 109
>XP_005249561
          Length = 1134

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LETTSILR 9
           LETT I+R
Sbjct: 102 LETTRIMR 109
>NP_036509
          Length = 319

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MLETTSILR 9
           +LET +ILR
Sbjct: 157 LLETLTILR 165
>NP_001180211
          Length = 646

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LETTSILR 9
           L TT+ILR
Sbjct: 297 LNTTAILR 304
>NP_958357
          Length = 1327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    MLETTSILR 9
            M+E TS+L+
Sbjct: 1300 MVEVTSLLK 1308
>NP_115562
          Length = 105

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  MLETTSILR 9
          M+E TS+L+
Sbjct: 78 MVEVTSLLK 86
>NP_057704
          Length = 105

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  MLETTSILR 9
          M+E TS+L+
Sbjct: 78 MVEVTSLLK 86
>XP_005259910
          Length = 320

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MLETTSILR 9
           +LET ++LR
Sbjct: 157 LLETLTVLR 165
>XP_006722786
          Length = 370

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MLETTSILR 9
           +LET ++LR
Sbjct: 207 LLETLTVLR 215
>XP_006713948
          Length = 747

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LETTSILR 9
           L TT+ILR
Sbjct: 298 LNTTAILR 305
>XP_006711011
          Length = 105

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  MLETTSILR 9
          M+E TS+L+
Sbjct: 78 MVEVTSLLK 86
>XP_006711010
          Length = 105

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  MLETTSILR 9
          M+E TS+L+
Sbjct: 78 MVEVTSLLK 86
>XP_005271318
          Length = 1327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    MLETTSILR 9
            M+E TS+L+
Sbjct: 1300 MVEVTSLLK 1308
>XP_005271317
          Length = 1368

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    MLETTSILR 9
            M+E TS+L+
Sbjct: 1341 MVEVTSLLK 1349
>XP_005271314
          Length = 1368

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    MLETTSILR 9
            M+E TS+L+
Sbjct: 1341 MVEVTSLLK 1349
>NP_945182
          Length = 320

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MLETTSILR 9
           +LET ++LR
Sbjct: 157 LLETLTVLR 165
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.324    0.130    0.306 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 367,129
Number of extensions: 577
Number of successful extensions: 52
Number of sequences better than 10000.0: 52
Number of HSP's gapped: 52
Number of HSP's successfully gapped: 52
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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