Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000360                                                              20     509
XP_005268094                                                           20     509
NP_000224                                                              18    1135
XP_005264366                                                           18    1135
XP_006712078                                                           18    1135
NP_001167569                                                           17    3301
NP_060814                                                              17    3301
XP_006717973                                                           17    3301
NP_852111                                                              17    4312
NP_000136                                                              17    4312
NP_065394                                                              16    5631
NP_001159450                                                           16    5631
NP_653308                                                              16    5631
NP_001159449                                                           16    5631
NP_001007254                                                           16    5631
XP_005263937                                                           16    5631
XP_005263936                                                           16    5631
NP_443099                                                              16    7355
XP_006721172                                                           16    7355
XP_006720008                                                           16    7355
XP_006720007                                                           16    7355
XP_006720006                                                           16    7355
NP_055660                                                              15    9605
NP_000912                                                              15    9605
NP_001240658                                                           15    9605
NP_001240657                                                           15    9605
NP_001240656                                                           15    9605
NP_001240659                                                           15    9605
NP_001240662                                                           15    9605
NP_001240661                                                           15    9605
NP_067647                                                              15    9605
NP_002502                                                              15    9605
NP_001245213                                                           15    9605
XP_006720535                                                           15    9605
XP_005254948                                                           15    9605
XP_005254946                                                           15    9605
XP_006719149                                                           15    9605
NP_001138516                                                           15    9605
NP_037404                                                              15    9605
NP_001004452                                                           15    9605
>NP_000360
          Length = 764

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   MGMYLLLI 8
           MGMYLLLI
Sbjct: 463 MGMYLLLI 470
>XP_005268094
          Length = 764

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   MGMYLLLI 8
           MGMYLLLI
Sbjct: 463 MGMYLLLI 470
>NP_000224
          Length = 699

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   MGMYLLLI 8
           MG+YLLLI
Sbjct: 408 MGLYLLLI 415
>XP_005264366
          Length = 380

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1  MGMYLLLI 8
          MG+YLLLI
Sbjct: 89 MGLYLLLI 96
>XP_006712078
          Length = 389

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   MGMYLLLI 8
           MG+YLLLI
Sbjct: 98  MGLYLLLI 105
>NP_001167569
          Length = 258

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   MGMYLLL 7
           MG+YLLL
Sbjct: 245 MGLYLLL 251
>NP_060814
          Length = 475

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   MGMYLLL 7
           MG+YLLL
Sbjct: 245 MGLYLLL 251
>XP_006717973
          Length = 397

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   MGMYLLL 7
           MG+YLLL
Sbjct: 167 MGLYLLL 173
>NP_852111
          Length = 669

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   MGMYLLLI 8
           +G+YLLLI
Sbjct: 385 IGIYLLLI 392
>NP_000136
          Length = 695

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   MGMYLLLI 8
           +G+YLLLI
Sbjct: 411 IGIYLLLI 418
>NP_065394
          Length = 580

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GMYLLLIT 9
           G Y+LL+T
Sbjct: 353 GWYILLVT 360
>NP_001159450
          Length = 834

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GMYLLLI 8
           G+YLLL+
Sbjct: 114 GLYLLLV 120
>NP_653308
          Length = 834

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GMYLLLI 8
           G+YLLL+
Sbjct: 114 GLYLLLV 120
>NP_001159449
          Length = 834

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GMYLLLI 8
           G+YLLL+
Sbjct: 114 GLYLLLV 120
>NP_001007254
          Length = 604

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  MGMYLLLIT 9
          +GM +LLIT
Sbjct: 2  LGMNMLLIT 10
>XP_005263937
          Length = 758

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  GMYLLLI 8
          G+YLLL+
Sbjct: 38 GLYLLLV 44
>XP_005263936
          Length = 834

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GMYLLLI 8
           G+YLLL+
Sbjct: 114 GLYLLLV 120
>NP_443099
          Length = 1738

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    MGMYLLLI 8
            +GM+LLL+
Sbjct: 1340 VGMFLLLL 1347
>XP_006721172
          Length = 139

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  MGMYLLLI 8
          +G+YLLL+
Sbjct: 32 VGIYLLLL 39
>XP_006720008
          Length = 1645

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    MGMYLLLI 8
            +GM+LLL+
Sbjct: 1247 VGMFLLLL 1254
>XP_006720007
          Length = 1709

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    MGMYLLLI 8
            +GM+LLL+
Sbjct: 1311 VGMFLLLL 1318
>XP_006720006
          Length = 1713

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    MGMYLLLI 8
            +GM+LLL+
Sbjct: 1315 VGMFLLLL 1322
>NP_055660
          Length = 907

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GMYLLLIT 9
           G Y++LIT
Sbjct: 104 GYYIVLIT 111
>NP_000912
          Length = 1141

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   MGMYLL 6
           MG+YLL
Sbjct: 146 MGLYLL 151
>NP_001240658
          Length = 709

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MGMYLLLI 8
           MG+YL +I
Sbjct: 406 MGIYLFVI 413
>NP_001240657
          Length = 724

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MGMYLLLI 8
           MG+YL +I
Sbjct: 421 MGIYLFVI 428
>NP_001240656
          Length = 784

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MGMYLLLI 8
           MG+YL +I
Sbjct: 481 MGIYLFVI 488
>NP_001240659
          Length = 626

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MGMYLLLI 8
           MG+YL +I
Sbjct: 323 MGIYLFVI 330
>NP_001240662
          Length = 601

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MGMYLLLI 8
           MG+YL +I
Sbjct: 298 MGIYLFVI 305
>NP_001240661
          Length = 625

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MGMYLLLI 8
           MG+YL +I
Sbjct: 322 MGIYLFVI 329
>NP_067647
          Length = 757

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MGMYLLLI 8
           MG+YL +I
Sbjct: 454 MGIYLFVI 461
>NP_002502
          Length = 390

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  MYLLLIT 9
          +YLL+IT
Sbjct: 49 LYLLIIT 55
>NP_001245213
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MYLLLIT 9
           MY+L+IT
Sbjct: 139 MYVLMIT 145
>XP_006720535
          Length = 594

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   MYLLLI 8
           MYLLLI
Sbjct: 176 MYLLLI 181
>XP_005254948
          Length = 595

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  MYLLLI 8
          MYLLLI
Sbjct: 61 MYLLLI 66
>XP_005254946
          Length = 697

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   MYLLLI 8
           MYLLLI
Sbjct: 176 MYLLLI 181
>XP_006719149
          Length = 1087

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   MGMYLL 6
           MG+YLL
Sbjct: 146 MGLYLL 151
>NP_001138516
          Length = 692

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   MYLLLI 8
           MYLLLI
Sbjct: 176 MYLLLI 181
>NP_037404
          Length = 710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   MYLLLI 8
           MYLLLI
Sbjct: 176 MYLLLI 181
>NP_001004452
          Length = 313

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  MGMYLLLI 8
          +GMYL+ +
Sbjct: 32 LGMYLITV 39
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.345    0.158    0.447 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 394,860
Number of extensions: 707
Number of successful extensions: 40
Number of sequences better than 10000.0: 40
Number of HSP's gapped: 40
Number of HSP's successfully gapped: 40
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.6 bits)
S2: 28 (15.4 bits)

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