Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_002824                                                              17    2528
NP_001008392                                                           17    4312
NP_065390                                                              16    7355
NP_056505                                                              16    7355
NP_056127                                                              16    7355
NP_001230242                                                           16    7355
XP_006714407                                                           16    7355
XP_006714405                                                           16    7355
XP_005263349                                                           16    7355
XP_005263348                                                           16    7355
XP_005263346                                                           16    7355
XP_005263345                                                           16    7355
XP_005263344                                                           16    7355
XP_005263343                                                           16    7355
XP_005263342                                                           16    7355
XP_005263341                                                           16    7355
XP_005263340                                                           16    7355
XP_005263339                                                           16    7355
XP_006712484                                                           16    7355
XP_006712483                                                           16    7355
XP_005246521                                                           16    7355
NP_079285                                                              15    9605
NP_006493                                                              15    9605
NP_001167560                                                           15    9605
NP_001275920                                                           15    9605
NP_443120                                                              15    9605
NP_114423                                                              15    9605
NP_001167561                                                           15    9605
NP_065879                                                              15    9605
NP_898898                                                              15    9605
NP_060900                                                              15    9605
NP_001275919                                                           15    9605
XP_005260914                                                           15    9605
XP_005260913                                                           15    9605
XP_005258580                                                           15    9605
XP_005256111                                                           15    9605
XP_005256110                                                           15    9605
XP_005256109                                                           15    9605
XP_005256108                                                           15    9605
XP_005256106                                                           15    9605
XP_006715181                                                           15    9605
XP_005249243                                                           15    9605
XP_005262777                                                           15    9605
XP_005262774                                                           15    9605
XP_005265845                                                           15    9605
XP_006714118                                                           15    9605
>NP_002824
          Length = 593

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LVSLLLKEK 9
           ++SLLLK+K
Sbjct: 201 IISLLLKDK 209
>NP_001008392
          Length = 1079

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VSLLLKEK 9
           +SLLLKE+
Sbjct: 928 ISLLLKER 935
>NP_065390
          Length = 317

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LVSLLLK 7
           LVSLLLK
Sbjct: 232 LVSLLLK 238
>NP_056505
          Length = 1315

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LVSLLLKE 8
           LVSL+LK+
Sbjct: 208 LVSLILKD 215
>NP_056127
          Length = 5005

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LVSLLLKEK 9
            LVS  LKEK
Sbjct: 4868 LVSAYLKEK 4876
>NP_001230242
          Length = 1294

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LVSLLLKE 8
           LVSL+LK+
Sbjct: 208 LVSLILKD 215
>XP_006714407
          Length = 5004

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LVSLLLKEK 9
            LVS  LKEK
Sbjct: 4867 LVSAYLKEK 4875
>XP_006714405
          Length = 4103

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LVSLLLKEK 9
            LVS  LKEK
Sbjct: 3966 LVSAYLKEK 3974
>XP_005263349
          Length = 4410

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LVSLLLKEK 9
            LVS  LKEK
Sbjct: 4273 LVSAYLKEK 4281
>XP_005263348
          Length = 4443

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LVSLLLKEK 9
            LVS  LKEK
Sbjct: 4306 LVSAYLKEK 4314
>XP_005263346
          Length = 4983

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LVSLLLKEK 9
            LVS  LKEK
Sbjct: 4846 LVSAYLKEK 4854
>XP_005263345
          Length = 4991

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LVSLLLKEK 9
            LVS  LKEK
Sbjct: 4854 LVSAYLKEK 4862
>XP_005263344
          Length = 5005

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LVSLLLKEK 9
            LVS  LKEK
Sbjct: 4868 LVSAYLKEK 4876
>XP_005263343
          Length = 5009

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LVSLLLKEK 9
            LVS  LKEK
Sbjct: 4872 LVSAYLKEK 4880
>XP_005263342
          Length = 5025

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LVSLLLKEK 9
            LVS  LKEK
Sbjct: 4888 LVSAYLKEK 4896
>XP_005263341
          Length = 5026

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LVSLLLKEK 9
            LVS  LKEK
Sbjct: 4889 LVSAYLKEK 4897
>XP_005263340
          Length = 5026

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LVSLLLKEK 9
            LVS  LKEK
Sbjct: 4889 LVSAYLKEK 4897
>XP_005263339
          Length = 5026

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LVSLLLKEK 9
            LVS  LKEK
Sbjct: 4889 LVSAYLKEK 4897
>XP_006712484
          Length = 851

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LVSLLLKE 8
           LVSL+LK+
Sbjct: 208 LVSLILKD 215
>XP_006712483
          Length = 1306

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LVSLLLKE 8
           LVSL+LK+
Sbjct: 208 LVSLILKD 215
>XP_005246521
          Length = 1315

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LVSLLLKE 8
           LVSL+LK+
Sbjct: 208 LVSLILKD 215
>NP_079285
          Length = 1140

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LVSLLLKEK 9
           +VSL+ KEK
Sbjct: 563 IVSLMEKEK 571
>NP_006493
          Length = 713

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   SLLLKEK 9
           SLLLK+K
Sbjct: 536 SLLLKQK 542
>NP_001167560
          Length = 875

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VSLLLKEK 9
           V+LLLKE+
Sbjct: 789 VALLLKEQ 796
>NP_001275920
          Length = 643

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VSLLLKEK 9
           +SLL KEK
Sbjct: 130 ISLLKKEK 137
>NP_443120
          Length = 947

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  LVSLLLKE 8
          L+SLL+KE
Sbjct: 17 LLSLLVKE 24
>NP_114423
          Length = 891

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VSLLLKEK 9
           V+LLLKE+
Sbjct: 805 VALLLKEQ 812
>NP_001167561
          Length = 918

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VSLLLKEK 9
           V+LLLKE+
Sbjct: 832 VALLLKEQ 839
>NP_065879
          Length = 868

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LVSLLLKEK 9
           LVSLL +EK
Sbjct: 276 LVSLLEQEK 284
>NP_898898
          Length = 544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LVSLLLKEK 9
           L+S++ KEK
Sbjct: 155 LISIVTKEK 163
>NP_060900
          Length = 658

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VSLLLKEK 9
           +SLL KEK
Sbjct: 145 ISLLKKEK 152
>NP_001275919
          Length = 712

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VSLLLKEK 9
           +SLL KEK
Sbjct: 199 ISLLKKEK 206
>XP_005260914
          Length = 856

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VSLLLKEK 9
           V+LLLKE+
Sbjct: 770 VALLLKEQ 777
>XP_005260913
          Length = 998

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VSLLLKEK 9
           V+LLLKE+
Sbjct: 912 VALLLKEQ 919
>XP_005258580
          Length = 322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LVSLLLKEK 9
           LVSLL +EK
Sbjct: 276 LVSLLEQEK 284
>XP_005256111
          Length = 522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  VSLLLKEK 9
          +SLL KEK
Sbjct: 9  ISLLKKEK 16
>XP_005256110
          Length = 522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  VSLLLKEK 9
          +SLL KEK
Sbjct: 9  ISLLKKEK 16
>XP_005256109
          Length = 554

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  VSLLLKEK 9
          +SLL KEK
Sbjct: 41 ISLLKKEK 48
>XP_005256108
          Length = 624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VSLLLKEK 9
           +SLL KEK
Sbjct: 111 ISLLKKEK 118
>XP_005256106
          Length = 675

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VSLLLKEK 9
           +SLL KEK
Sbjct: 199 ISLLKKEK 206
>XP_006715181
          Length = 561

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   SLLLKEK 9
           SLLLK+K
Sbjct: 384 SLLLKQK 390
>XP_005249243
          Length = 651

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   SLLLKEK 9
           SLLLK+K
Sbjct: 474 SLLLKQK 480
>XP_005262777
          Length = 332

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LVSLLLKEK 9
           L+S++ KEK
Sbjct: 155 LISIVTKEK 163
>XP_005262774
          Length = 562

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LVSLLLKEK 9
           L+S++ KEK
Sbjct: 155 LISIVTKEK 163
>XP_005265845
          Length = 783

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LVSLLLKEK 9
           +VSL+ KEK
Sbjct: 206 IVSLMEKEK 214
>XP_006714118
          Length = 1129

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LVSLLLKEK 9
           +VSL+ KEK
Sbjct: 552 IVSLMEKEK 560
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.317    0.140    0.314 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 526,782
Number of extensions: 806
Number of successful extensions: 46
Number of sequences better than 10000.0: 46
Number of HSP's gapped: 46
Number of HSP's successfully gapped: 46
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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