Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000236                                                              20     509
NP_001120972                                                           20     509
XP_006716054                                                           20     509
XP_006716053                                                           20     509
XP_006716052                                                           20     509
XP_006716051                                                           20     509
NP_005766                                                              17    4312
XP_006716331                                                           17    4312
XP_006716330                                                           17    4312
XP_006716329                                                           17    4312
XP_005273427                                                           17    4312
NP_736610                                                              16    5631
NP_938072                                                              16    5631
XP_006719366                                                           16    5631
XP_006719365                                                           16    5631
NP_056134                                                              16    5631
NP_001107854                                                           16    7355
NP_001070651                                                           16    7355
NP_000539                                                              16    7355
XP_005255589                                                           16    7355
XP_005255588                                                           16    7355
XP_005255587                                                           16    7355
XP_005255586                                                           16    7355
XP_005255585                                                           16    7355
XP_005255584                                                           16    7355
XP_005247977                                                           16    7355
NP_055594                                                              16    7355
NP_005958                                                              15    9605
NP_001009571                                                           15    9605
NP_060424                                                              15    9605
NP_001161412                                                           15    9605
NP_009143                                                              15    9605
NP_036417                                                              15    9605
NP_690848                                                              15    9605
NP_001092284                                                           15    9605
XP_005268951                                                           15    9605
XP_006716576                                                           15    9605
XP_005250867                                                           15    9605
XP_005250765                                                           15    9605
XP_005250764                                                           15    9605
XP_005250763                                                           15    9605
XP_005250762                                                           15    9605
XP_005250761                                                           15    9605
XP_005250760                                                           15    9605
XP_005250759                                                           15    9605
XP_005250758                                                           15    9605
XP_005250757                                                           15    9605
XP_005250756                                                           15    9605
XP_005250755                                                           15    9605
XP_005250754                                                           15    9605
XP_005250753                                                           15    9605
XP_005250752                                                           15    9605
XP_005245470                                                           15    9605
NP_002922                                                              15    9605
>NP_000236
          Length = 1390

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LVSARSISP 9
           LVSARS+SP
Sbjct: 983 LVSARSVSP 991
>NP_001120972
          Length = 1408

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LVSARSISP 9
            LVSARS+SP
Sbjct: 1001 LVSARSVSP 1009
>XP_006716054
          Length = 960

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LVSARSISP 9
           LVSARS+SP
Sbjct: 553 LVSARSVSP 561
>XP_006716053
          Length = 960

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LVSARSISP 9
           LVSARS+SP
Sbjct: 553 LVSARSVSP 561
>XP_006716052
          Length = 1409

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LVSARSISP 9
            LVSARS+SP
Sbjct: 1002 LVSARSVSP 1010
>XP_006716051
          Length = 1427

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LVSARSISP 9
            LVSARS+SP
Sbjct: 1020 LVSARSVSP 1028
>NP_005766
          Length = 671

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LVSARSISP 9
           L SARS+SP
Sbjct: 332 LGSARSLSP 340
>XP_006716331
          Length = 656

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LVSARSISP 9
           L SARS+SP
Sbjct: 317 LGSARSLSP 325
>XP_006716330
          Length = 671

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LVSARSISP 9
           L SARS+SP
Sbjct: 332 LGSARSLSP 340
>XP_006716329
          Length = 710

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LVSARSISP 9
           L SARS+SP
Sbjct: 371 LGSARSLSP 379
>XP_005273427
          Length = 725

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LVSARSISP 9
           L SARS+SP
Sbjct: 386 LGSARSLSP 394
>NP_736610
          Length = 1409

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LVSARSISP 9
            LVS  SISP
Sbjct: 1228 LVSQHSISP 1236
>NP_938072
          Length = 1285

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LVSARSISP 9
            LVS  SISP
Sbjct: 1104 LVSQHSISP 1112
>XP_006719366
          Length = 1418

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LVSARSISP 9
            LVS  SISP
Sbjct: 1237 LVSQHSISP 1245
>XP_006719365
          Length = 1428

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LVSARSISP 9
            LVS  SISP
Sbjct: 1247 LVSQHSISP 1255
>NP_056134
          Length = 1419

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LVSARSISP 9
            LVS  SISP
Sbjct: 1238 LVSQHSISP 1246
>NP_001107854
          Length = 1784

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VSARSISP 9
           V ARS+SP
Sbjct: 534 VMARSLSP 541
>NP_001070651
          Length = 1740

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VSARSISP 9
           V ARS+SP
Sbjct: 534 VMARSLSP 541
>NP_000539
          Length = 1807

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VSARSISP 9
           V ARS+SP
Sbjct: 534 VMARSLSP 541
>XP_005255589
          Length = 1831

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VSARSISP 9
           V ARS+SP
Sbjct: 625 VMARSLSP 632
>XP_005255588
          Length = 1832

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VSARSISP 9
           V ARS+SP
Sbjct: 625 VMARSLSP 632
>XP_005255587
          Length = 1854

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VSARSISP 9
           V ARS+SP
Sbjct: 625 VMARSLSP 632
>XP_005255586
          Length = 1855

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VSARSISP 9
           V ARS+SP
Sbjct: 625 VMARSLSP 632
>XP_005255585
          Length = 1875

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VSARSISP 9
           V ARS+SP
Sbjct: 625 VMARSLSP 632
>XP_005255584
          Length = 1898

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VSARSISP 9
           V ARS+SP
Sbjct: 625 VMARSLSP 632
>XP_005247977
          Length = 756

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LVSARSIS 8
           +VSARS+S
Sbjct: 107 VVSARSVS 114
>NP_055594
          Length = 780

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LVSARSIS 8
           +VSARS+S
Sbjct: 107 VVSARSVS 114
>NP_005958
          Length = 525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SARSISP 9
           SARS SP
Sbjct: 154 SARSFSP 160
>NP_001009571
          Length = 1255

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SARSISP 9
          +ARS+SP
Sbjct: 53 AARSVSP 59
>NP_060424
          Length = 1296

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SARSISP 9
          +ARS+SP
Sbjct: 53 AARSVSP 59
>NP_001161412
          Length = 1300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SARSISP 9
          +ARS+SP
Sbjct: 53 AARSVSP 59
>NP_009143
          Length = 336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LVSARSISP 9
           LVS RS+ P
Sbjct: 94  LVSKRSLRP 102
>NP_036417
          Length = 1017

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LVSARSISP 9
           LVS+ S+SP
Sbjct: 772 LVSSPSLSP 780
>NP_690848
          Length = 1626

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VSARSISP 9
           ++ARS SP
Sbjct: 124 ITARSFSP 131
>NP_001092284
          Length = 473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SARSISP 9
           SARS SP
Sbjct: 155 SARSFSP 161
>XP_005268951
          Length = 461

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SARSISP 9
           SARS SP
Sbjct: 154 SARSFSP 160
>XP_006716576
          Length = 1319

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VSARSISP 9
           ++ARS SP
Sbjct: 124 ITARSFSP 131
>XP_005250867
          Length = 1606

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VSARSISP 9
           ++ARS SP
Sbjct: 124 ITARSFSP 131
>XP_005250765
          Length = 1250

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SARSISP 9
          +ARS+SP
Sbjct: 53 AARSVSP 59
>XP_005250764
          Length = 1258

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SARSISP 9
          +ARS+SP
Sbjct: 53 AARSVSP 59
>XP_005250763
          Length = 1260

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SARSISP 9
          +ARS+SP
Sbjct: 53 AARSVSP 59
>XP_005250762
          Length = 1260

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SARSISP 9
          +ARS+SP
Sbjct: 53 AARSVSP 59
>XP_005250761
          Length = 1265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SARSISP 9
          +ARS+SP
Sbjct: 53 AARSVSP 59
>XP_005250760
          Length = 1268

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SARSISP 9
          +ARS+SP
Sbjct: 53 AARSVSP 59
>XP_005250759
          Length = 1293

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SARSISP 9
          +ARS+SP
Sbjct: 53 AARSVSP 59
>XP_005250758
          Length = 1298

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SARSISP 9
          +ARS+SP
Sbjct: 53 AARSVSP 59
>XP_005250757
          Length = 1300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SARSISP 9
          +ARS+SP
Sbjct: 53 AARSVSP 59
>XP_005250756
          Length = 1301

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SARSISP 9
          +ARS+SP
Sbjct: 53 AARSVSP 59
>XP_005250755
          Length = 1303

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SARSISP 9
          +ARS+SP
Sbjct: 53 AARSVSP 59
>XP_005250754
          Length = 1305

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SARSISP 9
          +ARS+SP
Sbjct: 53 AARSVSP 59
>XP_005250753
          Length = 1305

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SARSISP 9
          +ARS+SP
Sbjct: 53 AARSVSP 59
>XP_005250752
          Length = 1308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SARSISP 9
          +ARS+SP
Sbjct: 53 AARSVSP 59
>XP_005245470
          Length = 287

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LVSARSISP 9
          LVS RS+ P
Sbjct: 45 LVSKRSLRP 53
>NP_002922
          Length = 406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LVSARSISP 9
          LVS RS+ P
Sbjct: 91 LVSKRSLRP 99
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.312    0.121    0.299 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 294,547
Number of extensions: 315
Number of successful extensions: 54
Number of sequences better than 10000.0: 54
Number of HSP's gapped: 54
Number of HSP's successfully gapped: 54
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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