Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              18    1482
NP_001075109                                                           18    1482
NP_004932                                                              18    1935
XP_005257171                                                           18    1935
XP_005257170                                                           18    1935
NP_079350                                                              17    4312
NP_001159605                                                           17    4312
NP_009187                                                              17    4312
XP_006718490                                                           17    4312
XP_006714380                                                           17    4312
XP_006714379                                                           17    4312
XP_006714378                                                           17    4312
XP_006714377                                                           17    4312
NP_001138684                                                           17    4312
NP_001138683                                                           17    4312
NP_001001916                                                           17    4312
NP_005287                                                              16    7355
NP_001264929                                                           16    7355
NP_078881                                                              16    7355
XP_005262183                                                           16    7355
XP_006724702                                                           16    7355
XP_006717499                                                           16    7355
XP_005252492                                                           16    7355
XP_005252489                                                           16    7355
XP_005252488                                                           16    7355
XP_005263273                                                           16    7355
XP_005263272                                                           16    7355
XP_005263271                                                           16    7355
NP_061871                                                              15    9605
NP_001257438                                                           15    9605
NP_001243054                                                           15    9605
NP_002817                                                              15    9605
NP_001004128                                                           15    9605
NP_003456                                                              15    9605
NP_001137361                                                           15    9605
NP_001137360                                                           15    9605
NP_060515                                                              15    9605
NP_001137362                                                           15    9605
NP_001153514                                                           15    9605
NP_060604                                                              15    9605
NP_004466                                                              15    9605
NP_056996                                                              15    9605
NP_001185550                                                           15    9605
NP_001161771                                                           15    9605
NP_001010924                                                           15    9605
NP_919269                                                              15    9605
XP_005258010                                                           15    9605
XP_005258009                                                           15    9605
XP_005258007                                                           15    9605
XP_005266147                                                           15    9605
XP_005266146                                                           15    9605
XP_005250985                                                           15    9605
XP_006716634                                                           15    9605
XP_006716084                                                           15    9605
XP_005264966                                                           15    9605
XP_005271043                                                           15    9605
XP_005271042                                                           15    9605
>NP_008835
          Length = 4128

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LVQTLREPA 9
            LVQTL EPA
Sbjct: 1372 LVQTLCEPA 1380
>NP_001075109
          Length = 4097

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LVQTLREPA 9
            LVQTL EPA
Sbjct: 1372 LVQTLCEPA 1380
>NP_004932
          Length = 1220

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LVQTLREPA 9
          L+QT+R PA
Sbjct: 88 LIQTMRPPA 96
>XP_005257171
          Length = 1181

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LVQTLREPA 9
          L+QT+R PA
Sbjct: 88 LIQTMRPPA 96
>XP_005257170
          Length = 1218

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LVQTLREPA 9
          L+QT+R PA
Sbjct: 88 LIQTMRPPA 96
>NP_079350
          Length = 4012

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LVQTLREPA 9
            L+QTL+ PA
Sbjct: 1265 LLQTLQSPA 1273
>NP_001159605
          Length = 1976

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LVQTLREPA 9
            L+QTL+ PA
Sbjct: 1265 LLQTLQSPA 1273
>NP_009187
          Length = 709

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LVQTLREP 8
           L+QTLR P
Sbjct: 364 LLQTLRHP 371
>XP_006718490
          Length = 635

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LVQTLREP 8
           L+QTLR P
Sbjct: 364 LLQTLRHP 371
>XP_006714380
          Length = 3897

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LVQTLREPA 9
            L+QTL+ PA
Sbjct: 1265 LLQTLQSPA 1273
>XP_006714379
          Length = 3936

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LVQTLREPA 9
            L+QTL+ PA
Sbjct: 1265 LLQTLQSPA 1273
>XP_006714378
          Length = 3965

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LVQTLREPA 9
            L+QTL+ PA
Sbjct: 1218 LLQTLQSPA 1226
>XP_006714377
          Length = 4010

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LVQTLREPA 9
            L+QTL+ PA
Sbjct: 1265 LLQTLQSPA 1273
>NP_001138684
          Length = 565

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LVQTLREP 8
           L+QTLR P
Sbjct: 220 LLQTLRHP 227
>NP_001138683
          Length = 687

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LVQTLREP 8
           L+QTLR P
Sbjct: 342 LLQTLRHP 349
>NP_001001916
          Length = 311

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  QTLREP 8
          QTLREP
Sbjct: 55 QTLREP 60
>NP_005287
          Length = 370

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LVQTLREPA 9
           +++TLR+PA
Sbjct: 227 VLRTLRKPA 235
>NP_001264929
          Length = 370

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LVQTLREPA 9
           +++TLR+PA
Sbjct: 227 VLRTLRKPA 235
>NP_078881
          Length = 786

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VQTLREP 8
           VQT REP
Sbjct: 758 VQTSREP 764
>XP_005262183
          Length = 370

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LVQTLREPA 9
           +++TLR+PA
Sbjct: 227 VLRTLRKPA 235
>XP_006724702
          Length = 370

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LVQTLREPA 9
           +++TLR+PA
Sbjct: 227 VLRTLRKPA 235
>XP_006717499
          Length = 616

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   QTLREPA 9
           QTLR PA
Sbjct: 505 QTLRTPA 511
>XP_005252492
          Length = 650

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   QTLREPA 9
           QTLR PA
Sbjct: 539 QTLRTPA 545
>XP_005252489
          Length = 773

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   QTLREPA 9
           QTLR PA
Sbjct: 662 QTLRTPA 668
>XP_005252488
          Length = 796

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   QTLREPA 9
           QTLR PA
Sbjct: 685 QTLRTPA 691
>XP_005263273
          Length = 694

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VQTLREP 8
           VQT REP
Sbjct: 666 VQTSREP 672
>XP_005263272
          Length = 735

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VQTLREP 8
           VQT REP
Sbjct: 707 VQTSREP 713
>XP_005263271
          Length = 762

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VQTLREP 8
           VQT REP
Sbjct: 734 VQTSREP 740
>NP_061871
          Length = 566

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  VQTLRE 7
          VQTLRE
Sbjct: 85 VQTLRE 90
>NP_001257438
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LVQTLRE 7
           L+QTLR+
Sbjct: 332 LIQTLRQ 338
>NP_001243054
          Length = 447

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LVQTLRE 7
           L+QTLR+
Sbjct: 358 LIQTLRQ 364
>NP_002817
          Length = 747

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VQTLRE 7
           VQTLRE
Sbjct: 143 VQTLRE 148
>NP_001004128
          Length = 604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VQTLRE 7
           VQTLRE
Sbjct: 143 VQTLRE 148
>NP_003456
          Length = 466

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LVQTLRE 7
           L+QTLR+
Sbjct: 377 LIQTLRQ 383
>NP_001137361
          Length = 374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VQTLREPA 9
           V+TLRE A
Sbjct: 298 VETLREEA 305
>NP_001137360
          Length = 447

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VQTLREPA 9
           V+TLRE A
Sbjct: 371 VETLREEA 378
>NP_060515
          Length = 430

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VQTLREPA 9
           V+TLRE A
Sbjct: 354 VETLREEA 361
>NP_001137362
          Length = 335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VQTLREPA 9
           V+TLRE A
Sbjct: 259 VETLREEA 266
>NP_001153514
          Length = 546

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LVQTLREP 8
           L QTLR P
Sbjct: 270 LKQTLRSP 277
>NP_060604
          Length = 466

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LVQTLREP 8
           L QTLR P
Sbjct: 190 LKQTLRSP 197
>NP_004466
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVQTLREPA 9
           L+ T+R PA
Sbjct: 282 LIATVRRPA 290
>NP_056996
          Length = 1406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LVQTLREP 8
           L  TLREP
Sbjct: 644 LSSTLREP 651
>NP_001185550
          Length = 1121

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LVQTLREPA 9
           L  T+REPA
Sbjct: 175 LEATVREPA 183
>NP_001161771
          Length = 658

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2 VQTLRE 7
         VQTLRE
Sbjct: 4 VQTLRE 9
>NP_001010924
          Length = 890

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LVQTLREP 8
          + +TLREP
Sbjct: 20 VTKTLREP 27
>NP_919269
          Length = 1843

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LVQTLREPA 9
           L  T+REPA
Sbjct: 175 LEATVREPA 183
>XP_005258010
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVQTLREPA 9
           L+ T+R PA
Sbjct: 205 LIATVRRPA 213
>XP_005258009
          Length = 379

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVQTLREPA 9
           L+ T+R PA
Sbjct: 233 LIATVRRPA 241
>XP_005258007
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVQTLREPA 9
           L+ T+R PA
Sbjct: 282 LIATVRRPA 290
>XP_005266147
          Length = 658

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VQTLRE 7
           VQTLRE
Sbjct: 177 VQTLRE 182
>XP_005266146
          Length = 668

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VQTLRE 7
           VQTLRE
Sbjct: 177 VQTLRE 182
>XP_005250985
          Length = 1406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LVQTLREP 8
           L  TLREP
Sbjct: 644 LSSTLREP 651
>XP_006716634
          Length = 1420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LVQTLREP 8
           L  TLREP
Sbjct: 658 LSSTLREP 665
>XP_006716084
          Length = 615

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LVQTLREPA 9
          L+QT  EPA
Sbjct: 14 LIQTHLEPA 22
>XP_005264966
          Length = 1843

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LVQTLREPA 9
           L  T+REPA
Sbjct: 175 LEATVREPA 183
>XP_005271043
          Length = 457

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VQTLREPA 9
           V+TLRE A
Sbjct: 354 VETLREEA 361
>XP_005271042
          Length = 474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VQTLREPA 9
           V+TLRE A
Sbjct: 371 VETLREEA 378
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.318    0.132    0.349 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 671,593
Number of extensions: 1049
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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