Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001245202                                                           19     665
NP_001245200                                                           19     665
NP_001161091                                                           19     665
NP_000240                                                              19     665
NP_001161090                                                           19     665
NP_001161089                                                           19     665
NP_001245203                                                           19     665
XP_005265223                                                           19     665
XP_005265221                                                           19     665
XP_005265220                                                           19     665
XP_005265218                                                           19     665
NP_056288                                                              16    5631
NP_001137386                                                           16    7355
NP_001137384                                                           16    7355
NP_001137385                                                           16    7355
NP_689873                                                              16    7355
NP_001137387                                                           16    7355
NP_001240721                                                           16    7355
NP_060807                                                              16    7355
NP_001073861                                                           16    7355
NP_001257419                                                           16    7355
NP_000970                                                              16    7355
NP_001269360                                                           16    7355
XP_005259093                                                           16    7355
XP_005259092                                                           16    7355
XP_005259091                                                           16    7355
NP_005728                                                              16    7355
NP_037398                                                              15    9605
NP_001120856                                                           15    9605
NP_056121                                                              15    9605
NP_004960                                                              15    9605
NP_001159418                                                           15    9605
XP_005269823                                                           15    9605
XP_006717870                                                           15    9605
XP_006717869                                                           15    9605
XP_005269774                                                           15    9605
XP_006717868                                                           15    9605
XP_006715232                                                           15    9605
XP_005249381                                                           15    9605
XP_005249380                                                           15    9605
XP_005249379                                                           15    9605
XP_005249377                                                           15    9605
XP_005249376                                                           15    9605
XP_005249375                                                           15    9605
XP_005249374                                                           15    9605
XP_005249373                                                           15    9605
XP_005249372                                                           15    9605
XP_005249371                                                           15    9605
XP_005249370                                                           15    9605
XP_005249369                                                           15    9605
XP_005249368                                                           15    9605
XP_005249367                                                           15    9605
XP_005270747                                                           15    9605
XP_006710574                                                           15    9605
XP_005270746                                                           15    9605
>NP_001245202
          Length = 515

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LVMLALDSP 9
           L MLALDSP
Sbjct: 344 LAMLALDSP 352
>NP_001245200
          Length = 687

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LVMLALDSP 9
           L MLALDSP
Sbjct: 585 LAMLALDSP 593
>NP_001161091
          Length = 515

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LVMLALDSP 9
           L MLALDSP
Sbjct: 344 LAMLALDSP 352
>NP_000240
          Length = 756

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LVMLALDSP 9
           L MLALDSP
Sbjct: 585 LAMLALDSP 593
>NP_001161090
          Length = 515

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LVMLALDSP 9
           L MLALDSP
Sbjct: 344 LAMLALDSP 352
>NP_001161089
          Length = 658

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LVMLALDSP 9
           L MLALDSP
Sbjct: 487 LAMLALDSP 495
>NP_001245203
          Length = 515

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LVMLALDSP 9
           L MLALDSP
Sbjct: 344 LAMLALDSP 352
>XP_005265223
          Length = 415

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LVMLALDSP 9
           L MLALDSP
Sbjct: 244 LAMLALDSP 252
>XP_005265221
          Length = 515

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LVMLALDSP 9
           L MLALDSP
Sbjct: 344 LAMLALDSP 352
>XP_005265220
          Length = 515

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LVMLALDSP 9
           L MLALDSP
Sbjct: 344 LAMLALDSP 352
>XP_005265218
          Length = 687

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LVMLALDSP 9
           L MLALDSP
Sbjct: 516 LAMLALDSP 524
>NP_056288
          Length = 2046

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LVMLALDSP 9
           LVM AL+SP
Sbjct: 860 LVMGALESP 868
>NP_001137386
          Length = 278

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LALDSP 9
           LALDSP
Sbjct: 176 LALDSP 181
>NP_001137384
          Length = 341

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LALDSP 9
           LALDSP
Sbjct: 239 LALDSP 244
>NP_001137385
          Length = 312

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LALDSP 9
           LALDSP
Sbjct: 210 LALDSP 215
>NP_689873
          Length = 307

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LALDSP 9
           LALDSP
Sbjct: 205 LALDSP 210
>NP_001137387
          Length = 227

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LALDSP 9
           LALDSP
Sbjct: 125 LALDSP 130
>NP_001240721
          Length = 326

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LALDSP 9
          LALDSP
Sbjct: 14 LALDSP 19
>NP_060807
          Length = 327

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LALDSP 9
          LALDSP
Sbjct: 14 LALDSP 19
>NP_001073861
          Length = 455

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VMLALDSP 9
           VML +D+P
Sbjct: 445 VMLVIDNP 452
>NP_001257419
          Length = 159

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LALDSP 9
           LALDSP
Sbjct: 97  LALDSP 102
>NP_000970
          Length = 188

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LALDSP 9
           LALDSP
Sbjct: 126 LALDSP 131
>NP_001269360
          Length = 201

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LVMLALDS 8
          +VML LDS
Sbjct: 16 IVMLGLDS 23
>XP_005259093
          Length = 327

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LALDSP 9
          LALDSP
Sbjct: 14 LALDSP 19
>XP_005259092
          Length = 327

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LALDSP 9
          LALDSP
Sbjct: 14 LALDSP 19
>XP_005259091
          Length = 327

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LALDSP 9
          LALDSP
Sbjct: 14 LALDSP 19
>NP_005728
          Length = 192

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LVMLALDS 8
          +VML LDS
Sbjct: 16 IVMLGLDS 23
>NP_037398
          Length = 895

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LVMLALDS 8
           L+M ALDS
Sbjct: 796 LIMSALDS 803
>NP_001120856
          Length = 895

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LVMLALDS 8
           L+M ALDS
Sbjct: 796 LIMSALDS 803
>NP_056121
          Length = 2620

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LVMLALDSP 9
            LVMLA  SP
Sbjct: 1641 LVMLADSSP 1649
>NP_004960
          Length = 1019

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MLALDSP 9
           MLA+D+P
Sbjct: 943 MLAVDAP 949
>NP_001159418
          Length = 464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MLALDSP 9
           MLA+D+P
Sbjct: 388 MLAVDAP 394
>XP_005269823
          Length = 1019

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MLALDSP 9
           MLA+D+P
Sbjct: 943 MLAVDAP 949
>XP_006717870
          Length = 634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LVMLALDS 8
           L+M ALDS
Sbjct: 535 LIMSALDS 542
>XP_006717869
          Length = 634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LVMLALDS 8
           L+M ALDS
Sbjct: 535 LIMSALDS 542
>XP_005269774
          Length = 907

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LVMLALDS 8
           L+M ALDS
Sbjct: 808 LIMSALDS 815
>XP_006717868
          Length = 907

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LVMLALDS 8
           L+M ALDS
Sbjct: 808 LIMSALDS 815
>XP_006715232
          Length = 7498

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    VMLALDS 8
            +MLA+DS
Sbjct: 3500 IMLAIDS 3506
>XP_005249381
          Length = 7281

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    VMLALDS 8
            +MLA+DS
Sbjct: 3174 IMLAIDS 3180
>XP_005249380
          Length = 7607

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    VMLALDS 8
            +MLA+DS
Sbjct: 3500 IMLAIDS 3506
>XP_005249379
          Length = 7633

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    VMLALDS 8
            +MLA+DS
Sbjct: 3526 IMLAIDS 3532
>XP_005249377
          Length = 7640

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    VMLALDS 8
            +MLA+DS
Sbjct: 3533 IMLAIDS 3539
>XP_005249376
          Length = 7647

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    VMLALDS 8
            +MLA+DS
Sbjct: 3540 IMLAIDS 3546
>XP_005249375
          Length = 7680

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    VMLALDS 8
            +MLA+DS
Sbjct: 3573 IMLAIDS 3579
>XP_005249374
          Length = 7709

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    VMLALDS 8
            +MLA+DS
Sbjct: 3711 IMLAIDS 3717
>XP_005249373
          Length = 7723

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    VMLALDS 8
            +MLA+DS
Sbjct: 3616 IMLAIDS 3622
>XP_005249372
          Length = 7785

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    VMLALDS 8
            +MLA+DS
Sbjct: 3678 IMLAIDS 3684
>XP_005249371
          Length = 7788

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    VMLALDS 8
            +MLA+DS
Sbjct: 3711 IMLAIDS 3717
>XP_005249370
          Length = 7794

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    VMLALDS 8
            +MLA+DS
Sbjct: 3711 IMLAIDS 3717
>XP_005249369
          Length = 7797

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    VMLALDS 8
            +MLA+DS
Sbjct: 3690 IMLAIDS 3696
>XP_005249368
          Length = 7812

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    VMLALDS 8
            +MLA+DS
Sbjct: 3711 IMLAIDS 3717
>XP_005249367
          Length = 7818

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    VMLALDS 8
            +MLA+DS
Sbjct: 3711 IMLAIDS 3717
>XP_005270747
          Length = 2025

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LVMLALDSP 9
            LVMLA  SP
Sbjct: 1046 LVMLADSSP 1054
>XP_006710574
          Length = 2445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LVMLALDSP 9
            LVMLA  SP
Sbjct: 1466 LVMLADSSP 1474
>XP_005270746
          Length = 2443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LVMLALDSP 9
            LVMLA  SP
Sbjct: 1466 LVMLADSSP 1474
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.326    0.140    0.378 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 377,458
Number of extensions: 283
Number of successful extensions: 55
Number of sequences better than 10000.0: 55
Number of HSP's gapped: 55
Number of HSP's successfully gapped: 55
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package