Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000537                                                              17    3301
NP_001263689                                                           17    3301
NP_001119584                                                           17    3301
NP_001119586                                                           17    3301
NP_001263625                                                           17    3301
NP_001119590                                                           17    3301
NP_001263690                                                           17    3301
NP_001119585                                                           17    3301
NP_001263624                                                           17    3301
NP_001119588                                                           17    3301
NP_001119587                                                           17    3301
NP_001119589                                                           17    3301
NP_001263627                                                           17    3301
NP_001263628                                                           17    3301
NP_001263626                                                           17    3301
NP_000224                                                              16    5631
NP_000360                                                              16    5631
XP_005268094                                                           16    5631
XP_005264366                                                           16    5631
XP_006712078                                                           16    5631
NP_004952                                                              16    7355

>NP_000537
          Length = 393

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LTIITLEVS 9
           LTIITLE S
Sbjct: 252 LTIITLEDS 260



>NP_001263689
          Length = 354

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LTIITLEVS 9
           LTIITLE S
Sbjct: 213 LTIITLEDS 221



>NP_001119584
          Length = 393

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LTIITLEVS 9
           LTIITLE S
Sbjct: 252 LTIITLEDS 260



>NP_001119586
          Length = 341

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LTIITLEVS 9
           LTIITLE S
Sbjct: 252 LTIITLEDS 260



>NP_001263625
          Length = 302

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LTIITLEVS 9
           LTIITLE S
Sbjct: 213 LTIITLEDS 221



>NP_001119590
          Length = 354

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LTIITLEVS 9
           LTIITLE S
Sbjct: 213 LTIITLEDS 221



>NP_001263690
          Length = 354

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LTIITLEVS 9
           LTIITLE S
Sbjct: 213 LTIITLEDS 221



>NP_001119585
          Length = 346

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LTIITLEVS 9
           LTIITLE S
Sbjct: 252 LTIITLEDS 260



>NP_001263624
          Length = 307

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LTIITLEVS 9
           LTIITLE S
Sbjct: 213 LTIITLEDS 221



>NP_001119588
          Length = 209

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LTIITLEVS 9
           LTIITLE S
Sbjct: 120 LTIITLEDS 128



>NP_001119587
          Length = 261

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LTIITLEVS 9
           LTIITLE S
Sbjct: 120 LTIITLEDS 128



>NP_001119589
          Length = 214

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LTIITLEVS 9
           LTIITLE S
Sbjct: 120 LTIITLEDS 128



>NP_001263627
          Length = 182

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LTIITLEVS 9
           LTIITLE S
Sbjct: 93  LTIITLEDS 101



>NP_001263628
          Length = 187

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LTIITLEVS 9
           LTIITLE S
Sbjct: 93  LTIITLEDS 101



>NP_001263626
          Length = 234

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LTIITLEVS 9
           LTIITLE S
Sbjct: 93  LTIITLEDS 101



>NP_000224
          Length = 699

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LTIITLE 7
           LT+ITLE
Sbjct: 457 LTVITLE 463



>NP_000360
          Length = 764

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LTIITLE 7
           LT+ITLE
Sbjct: 512 LTVITLE 518



>XP_005268094
          Length = 764

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LTIITLE 7
           LT+ITLE
Sbjct: 512 LTVITLE 518



>XP_005264366
          Length = 380

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LTIITLE 7
           LT+ITLE
Sbjct: 138 LTVITLE 144



>XP_006712078
          Length = 389

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LTIITLE 7
           LT+ITLE
Sbjct: 147 LTVITLE 153



>NP_004952
          Length = 506

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   TIITLEVS 9
           T++T+E+S
Sbjct: 95  TVVTVEIS 102



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.321    0.137    0.312 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 342,410
Number of extensions: 380
Number of successful extensions: 21
Number of sequences better than 10000.0: 21
Number of HSP's gapped: 21
Number of HSP's successfully gapped: 21
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)