Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000537                                                              18    1135
NP_001263689                                                           18    1135
NP_001119584                                                           18    1135
NP_001119586                                                           18    1135
NP_001263625                                                           18    1135
NP_001119590                                                           18    1135
NP_001263690                                                           18    1135
NP_001119585                                                           18    1135
NP_001263624                                                           18    1135
NP_001119588                                                           18    1135
NP_001119587                                                           18    1135
NP_001119589                                                           18    1135
NP_001263627                                                           18    1135
NP_001263628                                                           18    1135
NP_001263626                                                           18    1135
NP_057422                                                              17    4312
NP_001128251                                                           17    4312
NP_001269889                                                           16    5631
NP_000224                                                              16    5631
NP_003310                                                              16    5631
NP_597676                                                              16    5631
NP_001243779                                                           16    5631
NP_596869                                                              16    5631
NP_001269888                                                           16    5631
NP_060707                                                              16    5631
NP_000360                                                              16    5631
XP_005268094                                                           16    5631
XP_005246888                                                           16    5631
XP_006712788                                                           16    5631
XP_006712787                                                           16    5631
XP_006712786                                                           16    5631
XP_005264366                                                           16    5631
XP_006712078                                                           16    5631
NP_001254479                                                           16    5631
NP_597681                                                              16    5631
NP_001244126                                                           15    9605
NP_003581                                                              15    9605
NP_001244127                                                           15    9605
NP_055816                                                              15    9605
NP_001018110                                                           15    9605
NP_689664                                                              15    9605
NP_002363                                                              15    9605
NP_001018101                                                           15    9605
NP_001018100                                                           15    9605
NP_001272829                                                           15    9605
NP_001003811                                                           15    9605
XP_006712863                                                           15    9605
NP_112566                                                              15    9605
>NP_000537
          Length = 393

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTIITLENS 9
           LTIITLE+S
Sbjct: 252 LTIITLEDS 260
>NP_001263689
          Length = 354

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTIITLENS 9
           LTIITLE+S
Sbjct: 213 LTIITLEDS 221
>NP_001119584
          Length = 393

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTIITLENS 9
           LTIITLE+S
Sbjct: 252 LTIITLEDS 260
>NP_001119586
          Length = 341

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTIITLENS 9
           LTIITLE+S
Sbjct: 252 LTIITLEDS 260
>NP_001263625
          Length = 302

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTIITLENS 9
           LTIITLE+S
Sbjct: 213 LTIITLEDS 221
>NP_001119590
          Length = 354

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTIITLENS 9
           LTIITLE+S
Sbjct: 213 LTIITLEDS 221
>NP_001263690
          Length = 354

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTIITLENS 9
           LTIITLE+S
Sbjct: 213 LTIITLEDS 221
>NP_001119585
          Length = 346

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTIITLENS 9
           LTIITLE+S
Sbjct: 252 LTIITLEDS 260
>NP_001263624
          Length = 307

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTIITLENS 9
           LTIITLE+S
Sbjct: 213 LTIITLEDS 221
>NP_001119588
          Length = 209

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTIITLENS 9
           LTIITLE+S
Sbjct: 120 LTIITLEDS 128
>NP_001119587
          Length = 261

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTIITLENS 9
           LTIITLE+S
Sbjct: 120 LTIITLEDS 128
>NP_001119589
          Length = 214

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTIITLENS 9
           LTIITLE+S
Sbjct: 120 LTIITLEDS 128
>NP_001263627
          Length = 182

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTIITLENS 9
           LTIITLE+S
Sbjct: 93  LTIITLEDS 101
>NP_001263628
          Length = 187

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTIITLENS 9
           LTIITLE+S
Sbjct: 93  LTIITLEDS 101
>NP_001263626
          Length = 234

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTIITLENS 9
           LTIITLE+S
Sbjct: 93  LTIITLEDS 101
>NP_057422
          Length = 975

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LTIITLENS 9
           L ++TLENS
Sbjct: 670 LWLVTLENS 678
>NP_001128251
          Length = 1015

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LTIITLENS 9
           L ++TLENS
Sbjct: 710 LWLVTLENS 718
>NP_001269889
          Length = 1135

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    TIITLENS 9
            TI+ LENS
Sbjct: 1053 TILNLENS 1060
>NP_000224
          Length = 699

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LTIITLE 7
           LT+ITLE
Sbjct: 457 LTVITLE 463
>NP_003310
          Length = 26926

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3     IITLENS 9
             I+TLENS
Sbjct: 13268 ILTLENS 13274
>NP_597676
          Length = 27051

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3     IITLENS 9
             I+TLENS
Sbjct: 13393 ILTLENS 13399
>NP_001243779
          Length = 34350

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3     IITLENS 9
             I+TLENS
Sbjct: 20692 ILTLENS 20698
>NP_596869
          Length = 33423

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3     IITLENS 9
             I+TLENS
Sbjct: 19765 ILTLENS 19771
>NP_001269888
          Length = 1135

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    TIITLENS 9
            TI+ LENS
Sbjct: 1053 TILNLENS 1060
>NP_060707
          Length = 1150

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    TIITLENS 9
            TI+ LENS
Sbjct: 1068 TILNLENS 1075
>NP_000360
          Length = 764

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LTIITLE 7
           LT+ITLE
Sbjct: 512 LTVITLE 518
>XP_005268094
          Length = 764

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LTIITLE 7
           LT+ITLE
Sbjct: 512 LTVITLE 518
>XP_005246888
          Length = 22663

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    IITLENS 9
            I+TLENS
Sbjct: 9005 ILTLENS 9011
>XP_006712788
          Length = 24022

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3     IITLENS 9
             I+TLENS
Sbjct: 10364 ILTLENS 10370
>XP_006712787
          Length = 33978

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3     IITLENS 9
             I+TLENS
Sbjct: 20320 ILTLENS 20326
>XP_006712786
          Length = 35484

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3     IITLENS 9
             I+TLENS
Sbjct: 21826 ILTLENS 21832
>XP_005264366
          Length = 380

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LTIITLE 7
           LT+ITLE
Sbjct: 138 LTVITLE 144
>XP_006712078
          Length = 389

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LTIITLE 7
           LT+ITLE
Sbjct: 147 LTVITLE 153
>NP_001254479
          Length = 35991

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3     IITLENS 9
             I+TLENS
Sbjct: 22333 ILTLENS 22339
>NP_597681
          Length = 27118

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3     IITLENS 9
             I+TLENS
Sbjct: 13460 ILTLENS 13466
>NP_001244126
          Length = 702

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TIITLENS 9
           TI+ +ENS
Sbjct: 209 TIVEMENS 216
>NP_003581
          Length = 768

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TIITLENS 9
           TI+ +ENS
Sbjct: 275 TIVEMENS 282
>NP_001244127
          Length = 774

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TIITLENS 9
           TI+ +ENS
Sbjct: 281 TIVEMENS 288
>NP_055816
          Length = 3664

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1    LTIITLENS 9
            +T++TLE++
Sbjct: 1642 VTVVTLESA 1650
>NP_001018110
          Length = 466

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LTIITLENS 9
           L  +TLENS
Sbjct: 178 LVDVTLENS 186
>NP_689664
          Length = 438

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LTIITLENS 9
           L  +TLENS
Sbjct: 178 LVDVTLENS 186
>NP_002363
          Length = 1144

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ITLENS 9
           ITLENS
Sbjct: 758 ITLENS 763
>NP_001018101
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LTIITLENS 9
           L  +TLENS
Sbjct: 178 LVDVTLENS 186
>NP_001018100
          Length = 550

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LTIITLENS 9
           L  +TLENS
Sbjct: 178 LVDVTLENS 186
>NP_001272829
          Length = 765

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LTIITLENS 9
           L  +TLENS
Sbjct: 178 LVDVTLENS 186
>NP_001003811
          Length = 940

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   IITLEN 8
           IITLEN
Sbjct: 514 IITLEN 519
>XP_006712863
          Length = 795

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TIITLENS 9
           TI+ +ENS
Sbjct: 302 TIVEMENS 309
>NP_112566
          Length = 925

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   IITLEN 8
           IITLEN
Sbjct: 499 IITLEN 504
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.312    0.130    0.304 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 446,445
Number of extensions: 780
Number of successful extensions: 48
Number of sequences better than 10000.0: 48
Number of HSP's gapped: 48
Number of HSP's successfully gapped: 48
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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