Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000224                                                              20     390
NP_000360                                                              20     390
XP_005268094                                                           20     390
XP_005264366                                                           20     390
XP_006712078                                                           20     390
NP_852111                                                              18    1135
NP_000136                                                              18    1135
NP_005062                                                              17    2528
XP_006722907                                                           17    2528
XP_006722906                                                           17    2528
XP_006722905                                                           17    2528
NP_001005197                                                           17    2528
NP_001005213                                                           17    2528
NP_001013376                                                           17    2528
NP_001001967                                                           17    3301
NP_078858                                                              17    4312
NP_001278232                                                           17    4312
NP_001278214                                                           17    4312
NP_004163                                                              17    4312
NP_001160167                                                           17    4312
NP_001276868                                                           17    4312
NP_001276869                                                           17    4312
XP_006714551                                                           17    4312
XP_005248399                                                           17    4312
NP_003688                                                              17    4312
NP_006059                                                              16    5631
NP_001718                                                              16    5631
NP_001004459                                                           16    5631
XP_005262522                                                           16    5631
XP_005262521                                                           16    5631
XP_005262694                                                           16    5631
XP_005262693                                                           16    5631
NP_001013375                                                           16    5631
NP_001005204                                                           16    5631
NP_001013374                                                           16    5631
NP_065866                                                              16    7355
NP_116586                                                              16    7355
NP_006197                                                              16    7355
NP_078966                                                              16    7355
NP_071407                                                              16    7355
NP_001275918                                                           16    7355
NP_001159451                                                           16    7355
NP_057425                                                              16    7355
XP_006718005                                                           16    7355
XP_006718004                                                           16    7355
XP_006718003                                                           16    7355
XP_006717953                                                           16    7355
XP_006717952                                                           16    7355
XP_006717951                                                           16    7355
XP_006717950                                                           16    7355
XP_006717949                                                           16    7355
XP_006717948                                                           16    7355
XP_006714104                                                           16    7355
XP_005265800                                                           16    7355
XP_006714103                                                           16    7355
XP_006714102                                                           16    7355
XP_005275746                                                           16    7355
XP_003403671                                                           16    7355
XP_006710003                                                           16    7355
NP_002539                                                              16    7355
NP_061822                                                              16    7355
NP_004239                                                              16    7355
NP_001005195                                                           16    7355
NP_001005280                                                           15    9605
NP_002021                                                              15    9605
NP_004707                                                              15    9605
NP_110409                                                              15    9605
XP_006719002                                                           15    9605
XP_006719001                                                           15    9605
XP_006714565                                                           15    9605
NP_001004477                                                           15    9605
>NP_000224
          Length = 699

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LSVYTLTVV 9
           LSVYTLTV+
Sbjct: 452 LSVYTLTVI 460
>NP_000360
          Length = 764

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LSVYTLTVV 9
           LSVYTLTV+
Sbjct: 507 LSVYTLTVI 515
>XP_005268094
          Length = 764

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LSVYTLTVV 9
           LSVYTLTV+
Sbjct: 507 LSVYTLTVI 515
>XP_005264366
          Length = 380

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LSVYTLTVV 9
           LSVYTLTV+
Sbjct: 133 LSVYTLTVI 141
>XP_006712078
          Length = 389

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LSVYTLTVV 9
           LSVYTLTV+
Sbjct: 142 LSVYTLTVI 150
>NP_852111
          Length = 669

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LSVYTLTVV 9
           LSVYTLT +
Sbjct: 429 LSVYTLTAI 437
>NP_000136
          Length = 695

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LSVYTLTVV 9
           LSVYTLT +
Sbjct: 455 LSVYTLTAI 463
>NP_005062
          Length = 564

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSVYTLTVV 9
           L +YTLTV+
Sbjct: 339 LGMYTLTVI 347
>XP_006722907
          Length = 564

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSVYTLTVV 9
           L +YTLTV+
Sbjct: 339 LGMYTLTVI 347
>XP_006722906
          Length = 564

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSVYTLTVV 9
           L +YTLTV+
Sbjct: 339 LGMYTLTVI 347
>XP_006722905
          Length = 564

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSVYTLTVV 9
           L +YTLTV+
Sbjct: 339 LGMYTLTVI 347
>NP_001005197
          Length = 314

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LSVYTLTVV 9
          L +YT+TVV
Sbjct: 32 LGIYTVTVV 40
>NP_001005213
          Length = 305

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  LSVYTLTVV 9
          L VY+LTVV
Sbjct: 31 LGVYSLTVV 39
>NP_001013376
          Length = 305

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  LSVYTLTVV 9
          L VY+LTVV
Sbjct: 31 LGVYSLTVV 39
>NP_001001967
          Length = 314

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  LSVYTLTVV 9
          L VYT+TVV
Sbjct: 34 LFVYTVTVV 42
>NP_078858
          Length = 4981

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    LSVYTLTVV 9
            +S YTLTVV
Sbjct: 2117 VSNYTLTVV 2125
>NP_001278232
          Length = 4983

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    LSVYTLTVV 9
            +S YTLTVV
Sbjct: 2117 VSNYTLTVV 2125
>NP_001278214
          Length = 4982

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    LSVYTLTVV 9
            +S YTLTVV
Sbjct: 2117 VSNYTLTVV 2125
>NP_004163
          Length = 542

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LSVYTLTVV 9
           L++YT+TV+
Sbjct: 314 LAMYTVTVI 322
>NP_001160167
          Length = 497

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LSVYTLTVV 9
           L++YT+TV+
Sbjct: 314 LAMYTVTVI 322
>NP_001276868
          Length = 496

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LSVYTLTVV 9
           L++YT+TV+
Sbjct: 268 LAMYTVTVI 276
>NP_001276869
          Length = 430

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LSVYTLTVV 9
           L++YT+TV+
Sbjct: 202 LAMYTVTVI 210
>XP_006714551
          Length = 542

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LSVYTLTVV 9
           L++YT+TV+
Sbjct: 314 LAMYTVTVI 322
>XP_005248399
          Length = 542

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LSVYTLTVV 9
           L++YT+TV+
Sbjct: 314 LAMYTVTVI 322
>NP_003688
          Length = 314

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LSVYTLTVV 9
          L +YTLTV+
Sbjct: 32 LVIYTLTVL 40
>NP_006059
          Length = 796

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LSVYTLTVV 9
           L++Y LT++
Sbjct: 281 LNIYNLTII 289
>NP_001718
          Length = 399

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LSVYTLTVV 9
           +SV+TLT++
Sbjct: 133 VSVFTLTIL 141
>NP_001004459
          Length = 325

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LSVYTLTVV 9
          LS+Y +TVV
Sbjct: 45 LSMYVVTVV 53
>XP_005262522
          Length = 399

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LSVYTLTVV 9
           +SV+TLT++
Sbjct: 133 VSVFTLTIL 141
>XP_005262521
          Length = 399

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LSVYTLTVV 9
           +SV+TLT++
Sbjct: 133 VSVFTLTIL 141
>XP_005262694
          Length = 796

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LSVYTLTVV 9
           L++Y LT++
Sbjct: 281 LNIYNLTII 289
>XP_005262693
          Length = 796

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LSVYTLTVV 9
           L++Y LT++
Sbjct: 281 LNIYNLTII 289
>NP_001013375
          Length = 309

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LSVYTLTVV 9
          LS+Y  TVV
Sbjct: 32 LSIYLFTVV 40
>NP_001005204
          Length = 309

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LSVYTLTVV 9
          LS+Y  TVV
Sbjct: 32 LSIYLFTVV 40
>NP_001013374
          Length = 319

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LSVYTLTVV 9
          LS+Y  TVV
Sbjct: 32 LSIYLFTVV 40
>NP_065866
          Length = 896

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   YTLTVV 9
           YTLTVV
Sbjct: 429 YTLTVV 434
>NP_116586
          Length = 1040

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   YTLTVV 9
           YTLTVV
Sbjct: 429 YTLTVV 434
>NP_006197
          Length = 1089

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VYTLTV 8
           VYTLTV
Sbjct: 272 VYTLTV 277
>NP_078966
          Length = 14507

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SVYTLTV 8
           S YTLTV
Sbjct: 145 STYTLTV 151
>NP_071407
          Length = 3354

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    YTLTVV 9
            YTLTVV
Sbjct: 1385 YTLTVV 1390
>NP_001275918
          Length = 2286

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    SVYTLTVV 9
            +VY+LT+V
Sbjct: 1853 AVYSLTIV 1860
>NP_001159451
          Length = 1994

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    SVYTLTVV 9
            +VY+LT+V
Sbjct: 1561 AVYSLTIV 1568
>NP_057425
          Length = 2302

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    SVYTLTVV 9
            +VY+LT+V
Sbjct: 1869 AVYSLTIV 1876
>XP_006718005
          Length = 3397

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    YTLTVV 9
            YTLTVV
Sbjct: 1428 YTLTVV 1433
>XP_006718004
          Length = 3399

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    YTLTVV 9
            YTLTVV
Sbjct: 1430 YTLTVV 1435
>XP_006718003
          Length = 3419

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    YTLTVV 9
            YTLTVV
Sbjct: 1450 YTLTVV 1455
>XP_006717953
          Length = 2008

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    SVYTLTVV 9
            +VY+LT+V
Sbjct: 1575 AVYSLTIV 1582
>XP_006717952
          Length = 2300

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    SVYTLTVV 9
            +VY+LT+V
Sbjct: 1867 AVYSLTIV 1874
>XP_006717951
          Length = 2315

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    SVYTLTVV 9
            +VY+LT+V
Sbjct: 1882 AVYSLTIV 1889
>XP_006717950
          Length = 2316

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    SVYTLTVV 9
            +VY+LT+V
Sbjct: 1883 AVYSLTIV 1890
>XP_006717949
          Length = 2316

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    SVYTLTVV 9
            +VY+LT+V
Sbjct: 1883 AVYSLTIV 1890
>XP_006717948
          Length = 2316

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    SVYTLTVV 9
            +VY+LT+V
Sbjct: 1883 AVYSLTIV 1890
>XP_006714104
          Length = 832

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VYTLTV 8
           VYTLTV
Sbjct: 297 VYTLTV 302
>XP_005265800
          Length = 1089

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VYTLTV 8
           VYTLTV
Sbjct: 272 VYTLTV 277
>XP_006714103
          Length = 1111

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VYTLTV 8
           VYTLTV
Sbjct: 294 VYTLTV 299
>XP_006714102
          Length = 1114

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VYTLTV 8
           VYTLTV
Sbjct: 297 VYTLTV 302
>XP_005275746
          Length = 3352

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    YTLTVV 9
            YTLTVV
Sbjct: 1383 YTLTVV 1388
>XP_003403671
          Length = 3354

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    YTLTVV 9
            YTLTVV
Sbjct: 1385 YTLTVV 1390
>XP_006710003
          Length = 3374

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    YTLTVV 9
            YTLTVV
Sbjct: 1405 YTLTVV 1410
>NP_002539
          Length = 312

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LSVYTLTVV 9
          LS+Y +TVV
Sbjct: 32 LSMYLVTVV 40
>NP_061822
          Length = 389

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SVYTLTVV 9
           S++TLTV+
Sbjct: 137 SIFTLTVM 144
>NP_004239
          Length = 370

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LSVYTLTVV 9
           +SV+TLT +
Sbjct: 147 VSVFTLTTI 155
>NP_001005195
          Length = 310

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LSVYTLTVV 9
          L  YT+TVV
Sbjct: 31 LGFYTVTVV 39
>NP_001005280
          Length = 316

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1  LSVYTLTVV 9
          L++YT+T++
Sbjct: 32 LAIYTVTLL 40
>NP_002021
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LSVYTLTVV 9
           +SVY +T++
Sbjct: 111 VSVYLITII 119
>NP_004707
          Length = 785

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   SVYTLTV 8
           S+YT+T+
Sbjct: 345 SIYTVTI 351
>NP_110409
          Length = 538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  LSVYTLT 7
          LSVYT T
Sbjct: 55 LSVYTTT 61
>XP_006719002
          Length = 597

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   SVYTLTV 8
           S+YT+T+
Sbjct: 345 SIYTVTI 351
>XP_006719001
          Length = 705

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   SVYTLTV 8
           S+YT+T+
Sbjct: 345 SIYTVTI 351
>XP_006714565
          Length = 565

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  LSVYTLT 7
          LSVYT T
Sbjct: 55 LSVYTTT 61
>NP_001004477
          Length = 326

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  YTLTVV 9
          YTLT+V
Sbjct: 89 YTLTIV 94
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.326    0.135    0.338 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 365,181
Number of extensions: 513
Number of successful extensions: 71
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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