Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006715                                                              18    1935
NP_005913                                                              18    1935
XP_005267046                                                           18    1935
XP_005267045                                                           18    1935
NP_001263204                                                           17    4312
NP_001036004                                                           17    4312
NP_002374                                                              17    4312
XP_006721111                                                           17    4312
XP_006721110                                                           17    4312
XP_005254804                                                           16    5631
XP_006720791                                                           16    5631
XP_005254803                                                           16    5631
XP_005254800                                                           16    5631
XP_005254799                                                           16    5631
NP_003913                                                              16    5631
NP_001165375                                                           16    7355
NP_055518                                                              16    7355
XP_005276812                                                           16    7355
XP_006713491                                                           16    7355
XP_005276811                                                           16    7355
XP_006713490                                                           16    7355
XP_005276810                                                           16    7355
XP_005276809                                                           16    7355
XP_006713489                                                           16    7355
XP_005276808                                                           16    7355
NP_001269645                                                           15    9605
NP_036579                                                              15    9605
NP_001269646                                                           15    9605
NP_001269647                                                           15    9605
XP_005250173                                                           15    9605
>NP_006715
          Length = 1558

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   SLLSIKQL 9
           SLLSIKQL
Sbjct: 644 SLLSIKQL 651
>NP_005913
          Length = 1608

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   SLLSIKQL 9
           SLLSIKQL
Sbjct: 644 SLLSIKQL 651
>XP_005267046
          Length = 1554

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   SLLSIKQL 9
           SLLSIKQL
Sbjct: 644 SLLSIKQL 651
>XP_005267045
          Length = 1604

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   SLLSIKQL 9
           SLLSIKQL
Sbjct: 644 SLLSIKQL 651
>NP_001263204
          Length = 454

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LSLLSIKQL 9
           LSLLS+ QL
Sbjct: 210 LSLLSVPQL 218
>NP_001036004
          Length = 493

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LSLLSIKQL 9
           LSLLS+ QL
Sbjct: 233 LSLLSVPQL 241
>NP_002374
          Length = 477

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LSLLSIKQL 9
           LSLLS+ QL
Sbjct: 233 LSLLSVPQL 241
>XP_006721111
          Length = 401

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LSLLSIKQL 9
           LSLLS+ QL
Sbjct: 233 LSLLSVPQL 241
>XP_006721110
          Length = 470

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LSLLSIKQL 9
           LSLLS+ QL
Sbjct: 210 LSLLSVPQL 218
>XP_005254804
          Length = 4796

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    LSLLSIKQL 9
            LSLL+ KQL
Sbjct: 4650 LSLLTAKQL 4658
>XP_006720791
          Length = 4853

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    LSLLSIKQL 9
            LSLL+ KQL
Sbjct: 4707 LSLLTAKQL 4715
>XP_005254803
          Length = 4854

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    LSLLSIKQL 9
            LSLL+ KQL
Sbjct: 4708 LSLLTAKQL 4716
>XP_005254800
          Length = 4861

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    LSLLSIKQL 9
            LSLL+ KQL
Sbjct: 4715 LSLLTAKQL 4723
>XP_005254799
          Length = 4861

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    LSLLSIKQL 9
            LSLL+ KQL
Sbjct: 4715 LSLLTAKQL 4723
>NP_003913
          Length = 4861

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    LSLLSIKQL 9
            LSLL+ KQL
Sbjct: 4715 LSLLTAKQL 4723
>NP_001165375
          Length = 1506

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LSLLSIK 7
           LSLLSIK
Sbjct: 738 LSLLSIK 744
>NP_055518
          Length = 1507

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LSLLSIK 7
           LSLLSIK
Sbjct: 739 LSLLSIK 745
>XP_005276812
          Length = 1507

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LSLLSIK 7
           LSLLSIK
Sbjct: 739 LSLLSIK 745
>XP_006713491
          Length = 1425

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LSLLSIK 7
           LSLLSIK
Sbjct: 657 LSLLSIK 663
>XP_005276811
          Length = 1507

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LSLLSIK 7
           LSLLSIK
Sbjct: 739 LSLLSIK 745
>XP_006713490
          Length = 1507

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LSLLSIK 7
           LSLLSIK
Sbjct: 739 LSLLSIK 745
>XP_005276810
          Length = 1507

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LSLLSIK 7
           LSLLSIK
Sbjct: 739 LSLLSIK 745
>XP_005276809
          Length = 1507

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LSLLSIK 7
           LSLLSIK
Sbjct: 739 LSLLSIK 745
>XP_006713489
          Length = 1507

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LSLLSIK 7
           LSLLSIK
Sbjct: 739 LSLLSIK 745
>XP_005276808
          Length = 1507

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LSLLSIK 7
           LSLLSIK
Sbjct: 739 LSLLSIK 745
>NP_001269645
          Length = 1225

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LLSIKQL 9
           LLS+KQL
Sbjct: 929 LLSLKQL 935
>NP_036579
          Length = 1225

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LLSIKQL 9
           LLS+KQL
Sbjct: 929 LLSLKQL 935
>NP_001269646
          Length = 1226

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LLSIKQL 9
           LLS+KQL
Sbjct: 929 LLSLKQL 935
>NP_001269647
          Length = 1167

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LLSIKQL 9
           LLS+KQL
Sbjct: 871 LLSLKQL 877
>XP_005250173
          Length = 1222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LLSIKQL 9
           LLS+KQL
Sbjct: 929 LLSLKQL 935
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.324    0.140    0.308 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 302,529
Number of extensions: 287
Number of successful extensions: 30
Number of sequences better than 10000.0: 30
Number of HSP's gapped: 30
Number of HSP's successfully gapped: 30
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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