Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_659424                                                              17    2528
NP_000427                                                              17    3301
NP_003136                                                              17    3301
NP_001269596                                                           17    3301
NP_001269595                                                           17    3301
XP_005253308                                                           17    3301
NP_071403                                                              17    3301
NP_073581                                                              17    4312
XP_006718977                                                           17    4312
NP_001010892                                                           16    5631
NP_001948                                                              16    5631
NP_065882                                                              16    5631
NP_001269589                                                           16    5631
NP_001269590                                                           16    5631
NP_055085                                                              16    5631
NP_001229965                                                           16    5631
NP_001119807                                                           16    5631
NP_001019572                                                           16    5631
XP_005261751                                                           16    5631
XP_005261749                                                           16    5631
XP_005261748                                                           16    5631
XP_006723055                                                           16    5631
XP_005258525                                                           16    5631
XP_005255372                                                           16    5631
NP_001866                                                              16    7355
NP_001025169                                                           16    7355
NP_006523                                                              16    7355
NP_059138                                                              16    7355
NP_003671                                                              16    7355
NP_001258940                                                           16    7355
NP_001265585                                                           16    7355
NP_004166                                                              16    7355
NP_001116105                                                           16    7355
NP_001116106                                                           16    7355
NP_778226                                                              16    7355
NP_055041                                                              16    7355
NP_001271337                                                           16    7355
NP_001271336                                                           16    7355
NP_001271335                                                           16    7355
NP_060776                                                              16    7355
XP_006720291                                                           16    7355
XP_006720290                                                           16    7355
XP_006720289                                                           16    7355
XP_006720288                                                           16    7355
XP_005263333                                                           16    7355
XP_005247167                                                           16    7355
XP_006713312                                                           16    7355
NP_001360                                                              15    9605
NP_001004196                                                           15    9605
NP_055571                                                              15    9605
NP_001008938                                                           15    9605
NP_001135817                                                           15    9605
NP_001135815                                                           15    9605
NP_001135816                                                           15    9605
NP_057209                                                              15    9605
NP_612213                                                              15    9605
NP_068373                                                              15    9605
NP_001193856                                                           15    9605
XP_006723231                                                           15    9605
XP_005258877                                                           15    9605
XP_005258876                                                           15    9605
XP_006715067                                                           15    9605
XP_005248319                                                           15    9605
XP_006713711                                                           15    9605
XP_005247538                                                           15    9605
NP_004063                                                              15    9605
NP_054756                                                              15    9605
>NP_659424
          Length = 202

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SIGVPLLT 9
           +IGVPL+T
Sbjct: 150 TIGVPLIT 157
>NP_000427
          Length = 520

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSIGVPLL 8
           L IG+PLL
Sbjct: 321 LGIGIPLL 328
>NP_003136
          Length = 183

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SIGVPLL 8
           SIG+PLL
Sbjct: 160 SIGIPLL 166
>NP_001269596
          Length = 955

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LSIGVPLL 8
           LS+G+PLL
Sbjct: 914 LSLGLPLL 921
>NP_001269595
          Length = 976

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LSIGVPLL 8
           LS+G+PLL
Sbjct: 935 LSLGLPLL 942
>XP_005253308
          Length = 1012

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LSIGVPLL 8
           LS+G+PLL
Sbjct: 971 LSLGLPLL 978
>NP_071403
          Length = 517

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSIGVPLL 8
           L IG+PLL
Sbjct: 318 LGIGIPLL 325
>NP_073581
          Length = 468

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LSIGVPL 7
           LS+GVPL
Sbjct: 327 LSLGVPL 333
>XP_006718977
          Length = 293

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  SIGVPLLT 9
          S+G+PL+T
Sbjct: 30 SLGLPLIT 37
>NP_001010892
          Length = 716

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IGVPLLT 9
           +G+PLLT
Sbjct: 587 VGLPLLT 593
>NP_001948
          Length = 427

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IGVPLLT 9
           IG+PL+T
Sbjct: 196 IGIPLVT 202
>NP_065882
          Length = 931

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SIGVPLLT 9
           S G+PLLT
Sbjct: 821 STGLPLLT 828
>NP_001269589
          Length = 931

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SIGVPLLT 9
           S G+PLLT
Sbjct: 821 STGLPLLT 828
>NP_001269590
          Length = 881

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SIGVPLLT 9
           S G+PLLT
Sbjct: 771 STGLPLLT 778
>NP_055085
          Length = 487

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IGVPLLT 9
           IG+PL+T
Sbjct: 258 IGIPLVT 264
>NP_001229965
          Length = 487

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IGVPLLT 9
           IG+PL+T
Sbjct: 258 IGIPLVT 264
>NP_001119807
          Length = 487

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IGVPLLT 9
           IG+PL+T
Sbjct: 258 IGIPLVT 264
>NP_001019572
          Length = 424

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  GVPLLT 9
          GVPLLT
Sbjct: 28 GVPLLT 33
>XP_005261751
          Length = 931

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SIGVPLLT 9
           S G+PLLT
Sbjct: 821 STGLPLLT 828
>XP_005261749
          Length = 958

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SIGVPLLT 9
           S G+PLLT
Sbjct: 848 STGLPLLT 855
>XP_005261748
          Length = 966

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SIGVPLLT 9
           S G+PLLT
Sbjct: 856 STGLPLLT 863
>XP_006723055
          Length = 260

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  IGVPLLT 9
          IG+PL+T
Sbjct: 31 IGIPLVT 37
>XP_005258525
          Length = 278

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  IGVPLLT 9
          IG+PL+T
Sbjct: 49 IGIPLVT 55
>XP_005255372
          Length = 458

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  GVPLLT 9
          GVPLLT
Sbjct: 62 GVPLLT 67
>NP_001866
          Length = 1500

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    GVPLLT 9
            G+PLLT
Sbjct: 1460 GIPLLT 1465
>NP_001025169
          Length = 340

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   LSIGVPLL 8
           L++G+P+L
Sbjct: 280 LTLGIPML 287
>NP_006523
          Length = 621

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IGVPLLT 9
           +G+PLLT
Sbjct: 425 LGLPLLT 431
>NP_059138
          Length = 1032

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LSIGVPLL 8
           L +GVP+L
Sbjct: 828 LGLGVPML 835
>NP_003671
          Length = 528

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SIGVPL 7
           SIGVPL
Sbjct: 107 SIGVPL 112
>NP_001258940
          Length = 389

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GVPLLT 9
           G+PLLT
Sbjct: 216 GIPLLT 221
>NP_001265585
          Length = 126

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1 LSIGVPL 7
         +SIGVP+
Sbjct: 1 MSIGVPI 7
>NP_004166
          Length = 126

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1 LSIGVPL 7
         +SIGVP+
Sbjct: 1 MSIGVPI 7
>NP_001116105
          Length = 1506

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    GVPLLT 9
            G+PLLT
Sbjct: 1466 GIPLLT 1471
>NP_001116106
          Length = 1049

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    GVPLLT 9
            G+PLLT
Sbjct: 1009 GIPLLT 1014
>NP_778226
          Length = 431

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SIGVPLLT 9
           SIG+PL T
Sbjct: 222 SIGLPLKT 229
>NP_055041
          Length = 419

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GVPLLT 9
           G+PLLT
Sbjct: 246 GIPLLT 251
>NP_001271337
          Length = 157

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSIGVPLLT 9
           +S+GV LLT
Sbjct: 109 MSLGVGLLT 117
>NP_001271336
          Length = 203

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSIGVPLLT 9
           +S+GV LLT
Sbjct: 155 MSLGVGLLT 163
>NP_001271335
          Length = 249

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSIGVPLLT 9
           +S+GV LLT
Sbjct: 201 MSLGVGLLT 209
>NP_060776
          Length = 233

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSIGVPLLT 9
           +S+GV LLT
Sbjct: 185 MSLGVGLLT 193
>XP_006720291
          Length = 237

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  GVPLLT 9
          G+PLLT
Sbjct: 64 GIPLLT 69
>XP_006720290
          Length = 237

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  GVPLLT 9
          G+PLLT
Sbjct: 64 GIPLLT 69
>XP_006720289
          Length = 292

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GVPLLT 9
           G+PLLT
Sbjct: 246 GIPLLT 251
>XP_006720288
          Length = 293

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GVPLLT 9
           G+PLLT
Sbjct: 246 GIPLLT 251
>XP_005263333
          Length = 358

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   LSIGVPLL 8
           L++G+P+L
Sbjct: 280 LTLGIPML 287
>XP_005247167
          Length = 415

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SIGVPLLT 9
           SIG+PL T
Sbjct: 206 SIGLPLKT 213
>XP_006713312
          Length = 233

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSIGVPLLT 9
           +S+GV LLT
Sbjct: 185 MSLGVGLLT 193
>NP_001360
          Length = 4624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LSIGVPLL 8
            LS+G PLL
Sbjct: 3641 LSLGRPLL 3648
>NP_001004196
          Length = 294

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  SIGVPLLT 9
          +IG PLLT
Sbjct: 9  TIGGPLLT 16
>NP_055571
          Length = 1972

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/8 (37%), Positives = 8/8 (100%)

Query: 2   SIGVPLLT 9
           ++G+P++T
Sbjct: 941 NLGIPIIT 948
>NP_001008938
          Length = 2032

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/8 (37%), Positives = 8/8 (100%)

Query: 2   SIGVPLLT 9
           ++G+P++T
Sbjct: 941 NLGIPIIT 948
>NP_001135817
          Length = 373

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SIGVPLLT 9
           S+G+PL T
Sbjct: 295 SLGLPLAT 302
>NP_001135815
          Length = 373

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SIGVPLLT 9
           S+G+PL T
Sbjct: 295 SLGLPLAT 302
>NP_001135816
          Length = 373

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SIGVPLLT 9
           S+G+PL T
Sbjct: 295 SLGLPLAT 302
>NP_057209
          Length = 435

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LSIGVPLLT 9
           +S+G+ LLT
Sbjct: 173 ISLGIGLLT 181
>NP_612213
          Length = 409

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   SIGVPLL 8
           S+G+P+L
Sbjct: 333 SVGIPVL 339
>NP_068373
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   IGVPLLT 9
           IG PLLT
Sbjct: 270 IGPPLLT 276
>NP_001193856
          Length = 4707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LSIGVPLL 8
            LS+G PLL
Sbjct: 3723 LSLGRPLL 3730
>XP_006723231
          Length = 736

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IGVPLL 8
           +GVPLL
Sbjct: 152 VGVPLL 157
>XP_005258877
          Length = 736

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IGVPLL 8
           +GVPLL
Sbjct: 152 VGVPLL 157
>XP_005258876
          Length = 818

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IGVPLL 8
           +GVPLL
Sbjct: 234 VGVPLL 239
>XP_006715067
          Length = 4707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LSIGVPLL 8
            LS+G PLL
Sbjct: 3723 LSLGRPLL 3730
>XP_005248319
          Length = 4609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LSIGVPLL 8
            LS+G PLL
Sbjct: 3626 LSLGRPLL 3633
>XP_006713711
          Length = 176

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  SIGVPLLT 9
          +IG PLLT
Sbjct: 9  TIGGPLLT 16
>XP_005247538
          Length = 303

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  SIGVPLLT 9
          +IG PLLT
Sbjct: 9  TIGGPLLT 16
>NP_004063
          Length = 371

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SIGVPLLT 9
           S+G+PL T
Sbjct: 293 SLGLPLAT 300
>NP_054756
          Length = 736

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IGVPLL 8
           +GVPLL
Sbjct: 152 VGVPLL 157
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.324    0.149    0.413 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 649,821
Number of extensions: 1036
Number of successful extensions: 67
Number of sequences better than 10000.0: 67
Number of HSP's gapped: 67
Number of HSP's successfully gapped: 67
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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