Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_444256                                                              19     869
NP_444254                                                              19     869
NP_444253                                                              19     869
NP_444255                                                              19     869
NP_444260                                                              19     869
NP_444259                                                              19     869
XP_005247551                                                           19     869
XP_005247550                                                           19     869
XP_006713712                                                           19     869
XP_005247549                                                           19     869
NP_005655                                                              18    1935
NP_001171134                                                           17    4312
NP_060621                                                              17    4312
NP_001171136                                                           17    4312
NP_694978                                                              17    4312
XP_006712674                                                           17    4312
XP_006712673                                                           17    4312
XP_006712672                                                           17    4312
XP_005246722                                                           17    4312
NP_001171135                                                           17    4312
NP_689801                                                              16    5631
XP_005268737                                                           16    5631
NP_000824                                                              16    7355
NP_001127879                                                           16    7355
NP_057736                                                              16    7355
XP_005255324                                                           16    7355
NP_001123918                                                           16    7355
NP_000292                                                              15    9605
NP_000568                                                              15    9605
NP_776214                                                              15    9605
NP_004813                                                              15    9605
NP_776213                                                              15    9605
NP_001269845                                                           15    9605
NP_056288                                                              15    9605
NP_689944                                                              15    9605
NP_001269848                                                           15    9605
NP_005348                                                              15    9605
NP_110398                                                              15    9605
NP_149022                                                              15    9605
NP_001073863                                                           15    9605
XP_005258998                                                           15    9605
XP_006723281                                                           15    9605
XP_005258997                                                           15    9605
XP_005258996                                                           15    9605
XP_005258995                                                           15    9605
XP_005258994                                                           15    9605
XP_006721658                                                           15    9605
XP_005256331                                                           15    9605
XP_006716507                                                           15    9605
XP_005251255                                                           15    9605
XP_005251254                                                           15    9605
XP_005251253                                                           15    9605
XP_005251252                                                           15    9605
XP_005251250                                                           15    9605
XP_005251248                                                           15    9605
XP_006716506                                                           15    9605
XP_005251246                                                           15    9605
XP_005248946                                                           15    9605
NP_001091643                                                           15    9605
NP_940884                                                              15    9605
NP_996763                                                              15    9605
NP_001245212                                                           15    9605
>NP_444256
          Length = 1794

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LSGRKSST 8
            LSGRKSST
Sbjct: 1647 LSGRKSST 1654
>NP_444254
          Length = 1845

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LSGRKSST 8
            LSGRKSST
Sbjct: 1698 LSGRKSST 1705
>NP_444253
          Length = 1914

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LSGRKSST 8
            LSGRKSST
Sbjct: 1767 LSGRKSST 1774
>NP_444255
          Length = 1863

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LSGRKSST 8
            LSGRKSST
Sbjct: 1716 LSGRKSST 1723
>NP_444260
          Length = 154

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  LSGRKSST 8
          LSGRKSST
Sbjct: 7  LSGRKSST 14
>NP_444259
          Length = 153

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  LSGRKSST 8
          LSGRKSST
Sbjct: 7  LSGRKSST 14
>XP_005247551
          Length = 1855

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LSGRKSST 8
            LSGRKSST
Sbjct: 1708 LSGRKSST 1715
>XP_005247550
          Length = 1856

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LSGRKSST 8
            LSGRKSST
Sbjct: 1709 LSGRKSST 1716
>XP_006713712
          Length = 1923

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LSGRKSST 8
            LSGRKSST
Sbjct: 1777 LSGRKSST 1784
>XP_005247549
          Length = 1924

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LSGRKSST 8
            LSGRKSST
Sbjct: 1777 LSGRKSST 1784
>NP_005655
          Length = 507

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LSGRKSSTE 9
           LSGRK +TE
Sbjct: 121 LSGRKMATE 129
>NP_001171134
          Length = 2446

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LSGRKSSTE 9
            +S RK+STE
Sbjct: 1178 ISSRKTSTE 1186
>NP_060621
          Length = 2472

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LSGRKSSTE 9
            +S RK+STE
Sbjct: 1178 ISSRKTSTE 1186
>NP_001171136
          Length = 2446

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LSGRKSSTE 9
            +S RK+STE
Sbjct: 1178 ISSRKTSTE 1186
>NP_694978
          Length = 242

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  LSGRKSST 8
          +SGRK+ST
Sbjct: 60 VSGRKNST 67
>XP_006712674
          Length = 2436

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LSGRKSSTE 9
            +S RK+STE
Sbjct: 1142 ISSRKTSTE 1150
>XP_006712673
          Length = 2441

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LSGRKSSTE 9
            +S RK+STE
Sbjct: 1147 ISSRKTSTE 1155
>XP_006712672
          Length = 2443

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LSGRKSSTE 9
            +S RK+STE
Sbjct: 1149 ISSRKTSTE 1157
>XP_005246722
          Length = 2472

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LSGRKSSTE 9
            +S RK+STE
Sbjct: 1178 ISSRKTSTE 1186
>NP_001171135
          Length = 2446

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LSGRKSSTE 9
            +S RK+STE
Sbjct: 1178 ISSRKTSTE 1186
>NP_689801
          Length = 836

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSGRKSSTE 9
           L+GRKS  E
Sbjct: 689 LTGRKSEAE 697
>XP_005268737
          Length = 719

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSGRKSSTE 9
           L+GRKS  E
Sbjct: 572 LTGRKSEAE 580
>NP_000824
          Length = 1464

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    LSGRKSS 7
            LSG+KSS
Sbjct: 1336 LSGKKSS 1342
>NP_001127879
          Length = 1464

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    LSGRKSS 7
            LSG+KSS
Sbjct: 1336 LSGKKSS 1342
>NP_057736
          Length = 848

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LSGRKSSTE 9
          L+GR  STE
Sbjct: 33 LAGRHGSTE 41
>XP_005255324
          Length = 1516

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    LSGRKSS 7
            LSG+KSS
Sbjct: 1388 LSGKKSS 1394
>NP_001123918
          Length = 176

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  GRKSSTE 9
          G KSSTE
Sbjct: 54 GEKSSTE 60
>NP_000292
          Length = 810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSGRKSSTE 9
           L+GR  STE
Sbjct: 735 LNGRVQSTE 743
>NP_000568
          Length = 159

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  SGRKSS 7
          SGRKSS
Sbjct: 10 SGRKSS 15
>NP_776214
          Length = 177

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  SGRKSS 7
          SGRKSS
Sbjct: 28 SGRKSS 33
>NP_004813
          Length = 604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LSGRKS 6
           LSGRKS
Sbjct: 359 LSGRKS 364
>NP_776213
          Length = 180

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  SGRKSS 7
          SGRKSS
Sbjct: 31 SGRKSS 36
>NP_001269845
          Length = 845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LSGRKS 6
           LSGRKS
Sbjct: 221 LSGRKS 226
>NP_056288
          Length = 2046

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSGRKSSTE 9
           L+G KSS E
Sbjct: 495 LTGHKSSPE 503
>NP_689944
          Length = 279

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSGRKSST 8
           L+G KSST
Sbjct: 211 LTGAKSST 218
>NP_001269848
          Length = 876

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LSGRKS 6
           LSGRKS
Sbjct: 231 LSGRKS 236
>NP_005348
          Length = 1076

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LSGRKS 6
           LSGRKS
Sbjct: 834 LSGRKS 839
>NP_110398
          Length = 373

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LSGRKS 6
           LSGRKS
Sbjct: 335 LSGRKS 340
>NP_149022
          Length = 513

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SGRKSS 7
           SGRKSS
Sbjct: 494 SGRKSS 499
>NP_001073863
          Length = 915

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LSGRKS 6
           LSGRKS
Sbjct: 291 LSGRKS 296
>XP_005258998
          Length = 775

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LSGRKS 6
           LSGRKS
Sbjct: 533 LSGRKS 538
>XP_006723281
          Length = 775

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LSGRKS 6
           LSGRKS
Sbjct: 533 LSGRKS 538
>XP_005258997
          Length = 775

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LSGRKS 6
           LSGRKS
Sbjct: 533 LSGRKS 538
>XP_005258996
          Length = 786

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LSGRKS 6
           LSGRKS
Sbjct: 544 LSGRKS 549
>XP_005258995
          Length = 821

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LSGRKS 6
           LSGRKS
Sbjct: 579 LSGRKS 584
>XP_005258994
          Length = 1000

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LSGRKS 6
           LSGRKS
Sbjct: 758 LSGRKS 763
>XP_006721658
          Length = 604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LSGRKS 6
           LSGRKS
Sbjct: 359 LSGRKS 364
>XP_005256331
          Length = 492

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SGRKSS 7
           SGRKSS
Sbjct: 402 SGRKSS 407
>XP_006716507
          Length = 665

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  LSGRKS 6
          LSGRKS
Sbjct: 41 LSGRKS 46
>XP_005251255
          Length = 665

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  LSGRKS 6
          LSGRKS
Sbjct: 41 LSGRKS 46
>XP_005251254
          Length = 741

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LSGRKS 6
           LSGRKS
Sbjct: 117 LSGRKS 122
>XP_005251253
          Length = 742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LSGRKS 6
           LSGRKS
Sbjct: 118 LSGRKS 123
>XP_005251252
          Length = 751

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LSGRKS 6
           LSGRKS
Sbjct: 127 LSGRKS 132
>XP_005251250
          Length = 815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LSGRKS 6
           LSGRKS
Sbjct: 291 LSGRKS 296
>XP_005251248
          Length = 848

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LSGRKS 6
           LSGRKS
Sbjct: 291 LSGRKS 296
>XP_006716506
          Length = 855

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LSGRKS 6
           LSGRKS
Sbjct: 231 LSGRKS 236
>XP_005251246
          Length = 883

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LSGRKS 6
           LSGRKS
Sbjct: 291 LSGRKS 296
>XP_005248946
          Length = 181

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSGRKSST 8
           L+G KSST
Sbjct: 113 LTGAKSST 120
>NP_001091643
          Length = 492

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SGRKSS 7
           SGRKSS
Sbjct: 402 SGRKSS 407
>NP_940884
          Length = 175

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  LSGRKSS 7
          L GRKSS
Sbjct: 36 LEGRKSS 42
>NP_996763
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  LSGRKS 6
          LSGRKS
Sbjct: 87 LSGRKS 92
>NP_001245212
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  LSGRKS 6
          LSGRKS
Sbjct: 87 LSGRKS 92
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.286    0.106    0.243 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 498,688
Number of extensions: 570
Number of successful extensions: 62
Number of sequences better than 10000.0: 62
Number of HSP's gapped: 62
Number of HSP's successfully gapped: 62
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.8 bits)
S2: 28 (15.4 bits)

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